{"id":"https://openalex.org/W2178336546","doi":null,"title":"Role of -463G/A Promoter Polymorphism of Myeloperoxidase in the Development of Atherosclerosis","display_name":"Role of -463G/A Promoter Polymorphism of Myeloperoxidase in the Development of Atherosclerosis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2178336546","mag":"2178336546"},"language":"en","primary_location":{"id":"pmh:oai:trepo.tuni.fi:10024/66433","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66433","pdf_url":"https://trepo.tuni.fi/bitstream/10024/66433/1/978-951-44-7598-6.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://trepo.tuni.fi/bitstream/10024/66433/1/978-951-44-7598-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089348256","display_name":"Riikka M\u00e4kel\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Riikka M\u00e4kel\u00e4","raw_affiliation_strings":["UNIVERSITY OF TAMPERE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF TAMPERE","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089348256"],"corresponding_institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4387153886"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.14159999787807465,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5649999976158142},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.375},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.7900000214576721},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.43700000643730164},{"id":"https://openalex.org/keywords/thoracic-aorta","display_name":"thoracic aorta","score":0.7310000061988831},{"id":"https://openalex.org/keywords/abdominal-aorta","display_name":"abdominal aorta","score":0.8479999899864197},{"id":"https://openalex.org/keywords/aortic-wall-thickness","display_name":"aortic wall thickness","score":0.39800000190734863},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.75},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.6338047981262207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4899994432926178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39350518584251404},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21401944756507874},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.17848190665245056}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:trepo.tuni.fi:10024/66433","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66433","pdf_url":"https://trepo.tuni.fi/bitstream/10024/66433/1/978-951-44-7598-6.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"pmh:oai:tampub.uta.fi:10024/66433","doi":null,"is_oa":false,"landing_page_url":"http://tampub.uta.fi/handle/10024/66433","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"mag:2178336546","doi":null,"is_oa":false,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66433","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:trepo.tuni.fi:10024/66433","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66433","pdf_url":"https://trepo.tuni.fi/bitstream/10024/66433/1/978-951-44-7598-6.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309883","display_name":"Foundation for Cardiovascular Research","ror":"https://ror.org/0393a9736"},{"id":"https://openalex.org/F4320311816","display_name":"Finska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/04vbzm272"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322305","display_name":"Juho Vainion S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/05jf66d94"},{"id":"https://openalex.org/F4320322592","display_name":"Tampereen Yliopisto","ror":"https://ror.org/033003e23"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320323333","display_name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/020apt798"},{"id":"https://openalex.org/F4320325094","display_name":"Suomalainen L\u00e4\u00e4k\u00e4riseura Duodecim","ror":"https://ror.org/056xr2125"},{"id":"https://openalex.org/F4320326518","display_name":"Tays","ror":"https://ror.org/02hvt5f17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2178336546.pdf","grobid_xml":"https://content.openalex.org/works/W2178336546.grobid-xml"},"referenced_works_count":413,"referenced_works":["https://openalex.org/W9802559","https://openalex.org/W54179694","https://openalex.org/W75304703","https://openalex.org/W80633752","https://openalex.org/W97463538","https://openalex.org/W125359692","https://openalex.org/W139152919","https://openalex.org/W161272754","https://openalex.org/W166301865","https://openalex.org/W174630865","https://openalex.org/W181687194","https://openalex.org/W185775189","https://openalex.org/W271981794","https://openalex.org/W279032466","https://openalex.org/W989016558","https://openalex.org/W1002512956","https://openalex.org/W1486096725","https://openalex.org/W1487941099","https://openalex.org/W1515001810","https://openalex.org/W1517408457","https://openalex.org/W1521885247","https://openalex.org/W1523213544","https://openalex.org/W1547916425","https://openalex.org/W1597610606","https://openalex.org/W1600783018","https://openalex.org/W1644991946","https://openalex.org/W1725300350","https://openalex.org/W1759706356","https://openalex.org/W1843270395","https://openalex.org/W1845299120","https://openalex.org/W1847045479","https://openalex.org/W1857052429","https://openalex.org/W1886998470","https://openalex.org/W1928283413","https://openalex.org/W1952634910","https://openalex.org/W1963603983","https://openalex.org/W1963712961","https://openalex.org/W1964457547","https://openalex.org/W1964568991","https://openalex.org/W1964808179","https://openalex.org/W1965340455","https://openalex.org/W1968171440","https://openalex.org/W1968893448","https://openalex.org/W1969823606","https://openalex.org/W1971131796","https://openalex.org/W1971193426","https://openalex.org/W1971527431","https://openalex.org/W1972182067","https://openalex.org/W1972327604","https://openalex.org/W1972545405","https://openalex.org/W1972814375","https://openalex.org/W1973376761","https://openalex.org/W1973789859","https://openalex.org/W1973981214","https://openalex.org/W1975149587","https://openalex.org/W1975336261","https://openalex.org/W1975515113","https://openalex.org/W1975571684","https://openalex.org/W1976616659","https://openalex.org/W1976770302","https://openalex.org/W1977240425","https://openalex.org/W1978617840","https://openalex.org/W1979259571","https://openalex.org/W1980108735","https://openalex.org/W1980462348","https://openalex.org/W1980550304","https://openalex.org/W1981027567","https://openalex.org/W1982638309","https://openalex.org/W1983431912","https://openalex.org/W1988346971","https://openalex.org/W1988379272","https://openalex.org/W1988518747","https://openalex.org/W1989133148","https://openalex.org/W1989796584","https://openalex.org/W1991252586","https://openalex.org/W1991405839","https://openalex.org/W1991541318","https://openalex.org/W1992085688","https://openalex.org/W1992375300","https://openalex.org/W1992415335","https://openalex.org/W1993724662","https://openalex.org/W1994164919","https://openalex.org/W1995678264","https://openalex.org/W1996256691","https://openalex.org/W1996268254","https://openalex.org/W1996323798","https://openalex.org/W1996471647","https://openalex.org/W1996629039","https://openalex.org/W1996854958","https://openalex.org/W1996866382","https://openalex.org/W1996967702","https://openalex.org/W1997600840","https://openalex.org/W1997745709","https://openalex.org/W1998634450","https://openalex.org/W1999382514","https://openalex.org/W2000332946","https://openalex.org/W2001187363","https://openalex.org/W2002807084","https://openalex.org/W2003219549","https://openalex.org/W2003329407","https://openalex.org/W2003330221","https://openalex.org/W2004331215","https://openalex.org/W2005230846","https://openalex.org/W2006037647","https://openalex.org/W2006218070","https://openalex.org/W2008403905","https://openalex.org/W2008588972","https://openalex.org/W2009170266","https://openalex.org/W2009978724","https://openalex.org/W2010220972","https://openalex.org/W2011522496","https://openalex.org/W2011814255","https://openalex.org/W2012607933","https://openalex.org/W2012677944","https://openalex.org/W2013001335","https://openalex.org/W2013204959","https://openalex.org/W2013287270","https://openalex.org/W2013897731","https://openalex.org/W2013925870","https://openalex.org/W2014663082","https://openalex.org/W2014724702","https://openalex.org/W2014914292","https://openalex.org/W2014950417","https://openalex.org/W2015156934","https://openalex.org/W2016126953","https://openalex.org/W2017090505","https://openalex.org/W2017315967","https://openalex.org/W2017419560","https://openalex.org/W2017825293","https://openalex.org/W2017886856","https://openalex.org/W2017992707","https://openalex.org/W2018542299","https://openalex.org/W2019140140","https://openalex.org/W2020208584","https://openalex.org/W2020744745","https://openalex.org/W2021171040","https://openalex.org/W2021533203","https://openalex.org/W2021769399","https://openalex.org/W2022043783","https://openalex.org/W2022185157","https://openalex.org/W2022384805","https://openalex.org/W2022439153","https://openalex.org/W2022605831","https://openalex.org/W2022712405","https://openalex.org/W2023483032","https://openalex.org/W2024653871","https://openalex.org/W2025267708","https://openalex.org/W2026425756","https://openalex.org/W2027955807","https://openalex.org/W2028084693","https://openalex.org/W2028257547","https://openalex.org/W2028283951","https://openalex.org/W2028407769","https://openalex.org/W2029314163","https://openalex.org/W2029945308","https://openalex.org/W2030747750","https://openalex.org/W2031899050","https://openalex.org/W2031967567","https://openalex.org/W2032092394","https://openalex.org/W2032207767","https://openalex.org/W2032255457","https://openalex.org/W2032536106","https://openalex.org/W2032786707","https://openalex.org/W2032974881","https://openalex.org/W2033525453","https://openalex.org/W2034450617","https://openalex.org/W2034866231","https://openalex.org/W2035299293","https://openalex.org/W2035720710","https://openalex.org/W2035961359","https://openalex.org/W2036101828","https://openalex.org/W2036704125","https://openalex.org/W2037571918","https://openalex.org/W2039149291","https://openalex.org/W2039562073","https://openalex.org/W2040443301","https://openalex.org/W2040579726","https://openalex.org/W2041157072","https://openalex.org/W2042111739","https://openalex.org/W2042474992","https://openalex.org/W2045166620","https://openalex.org/W2046727522","https://openalex.org/W2047487512","https://openalex.org/W2047932752","https://openalex.org/W2050070243","https://openalex.org/W2050734204","https://openalex.org/W2050846920","https://openalex.org/W2050981615","https://openalex.org/W2051048068","https://openalex.org/W2051086756","https://openalex.org/W2051291943","https://openalex.org/W2051337736","https://openalex.org/W2051481532","https://openalex.org/W2051674344","https://openalex.org/W2052133728","https://openalex.org/W2052365898","https://openalex.org/W2053100793","https://openalex.org/W2053802334","https://openalex.org/W2054232428","https://openalex.org/W2055338937","https://openalex.org/W2056529545","https://openalex.org/W2056916216","https://openalex.org/W2057116025","https://openalex.org/W2057572769","https://openalex.org/W2058091835","https://openalex.org/W2058220872","https://openalex.org/W2059149560","https://openalex.org/W2059350161","https://openalex.org/W2059571803","https://openalex.org/W2060489945","https://openalex.org/W2061242359","https://openalex.org/W2062209757","https://openalex.org/W2062313858","https://openalex.org/W2062880720","https://openalex.org/W2063017984","https://openalex.org/W2063187143","https://openalex.org/W2063657879","https://openalex.org/W2066057446","https://openalex.org/W2066669827","https://openalex.org/W2066711466","https://openalex.org/W2066963386","https://openalex.org/W2069936148","https://openalex.org/W2070548987","https://openalex.org/W2070692648","https://openalex.org/W2071238433","https://openalex.org/W2072171498","https://openalex.org/W2072500504","https://openalex.org/W2073128002","https://openalex.org/W2073913945","https://openalex.org/W2074963078","https://openalex.org/W2075034126","https://openalex.org/W2075347434","https://openalex.org/W2076822867","https://openalex.org/W2079620512","https://openalex.org/W2079731016","https://openalex.org/W2079735654","https://openalex.org/W2080696801","https://openalex.org/W2080943041","https://openalex.org/W2081343055","https://openalex.org/W2081478025","https://openalex.org/W2082709211","https://openalex.org/W2083154566","https://openalex.org/W2084155565","https://openalex.org/W2084408440","https://openalex.org/W2085860656","https://openalex.org/W2086009946","https://openalex.org/W2086812897","https://openalex.org/W2088400951","https://openalex.org/W2088424323","https://openalex.org/W2089483927","https://openalex.org/W2089789027","https://openalex.org/W2090155923","https://openalex.org/W2090455996","https://openalex.org/W2090578530","https://openalex.org/W2090883509","https://openalex.org/W2091126023","https://openalex.org/W2091308279","https://openalex.org/W2091352465","https://openalex.org/W2091437867","https://openalex.org/W2093664978","https://openalex.org/W2094723810","https://openalex.org/W2094941678","https://openalex.org/W2095160367","https://openalex.org/W2095712584","https://openalex.org/W2096578491","https://openalex.org/W2096943764","https://openalex.org/W2097078416","https://openalex.org/W2098883620","https://openalex.org/W2099445613","https://openalex.org/W2099463369","https://openalex.org/W2099903211","https://openalex.org/W2100270535","https://openalex.org/W2102069095","https://openalex.org/W2102469433","https://openalex.org/W2102673684","https://openalex.org/W2103110099","https://openalex.org/W2104215271","https://openalex.org/W2104573407","https://openalex.org/W2104969274","https://openalex.org/W2105501391","https://openalex.org/W2105936580","https://openalex.org/W2107117207","https://openalex.org/W2107165713","https://openalex.org/W2108361166","https://openalex.org/W2108425550","https://openalex.org/W2108834458","https://openalex.org/W2109173122","https://openalex.org/W2109539718","https://openalex.org/W2109571250","https://openalex.org/W2109698138","https://openalex.org/W2110248987","https://openalex.org/W2110944832","https://openalex.org/W2112761396","https://openalex.org/W2113015414","https://openalex.org/W2113626865","https://openalex.org/W2114349116","https://openalex.org/W2114490800","https://openalex.org/W2115268091","https://openalex.org/W2115431576","https://openalex.org/W2115723679","https://openalex.org/W2115907155","https://openalex.org/W2116071061","https://openalex.org/W2116404316","https://openalex.org/W2116676275","https://openalex.org/W2117307804","https://openalex.org/W2117490971","https://openalex.org/W2118480498","https://openalex.org/W2118666907","https://openalex.org/W2119868790","https://openalex.org/W2120042225","https://openalex.org/W2120812889","https://openalex.org/W2120891974","https://openalex.org/W2121276192","https://openalex.org/W2121734411","https://openalex.org/W2121811672","https://openalex.org/W2122691482","https://openalex.org/W2123130467","https://openalex.org/W2123403285","https://openalex.org/W2123799914","https://openalex.org/W2124582458","https://openalex.org/W2124597426","https://openalex.org/W2125064850","https://openalex.org/W2125605952","https://openalex.org/W2126473492","https://openalex.org/W2126873224","https://openalex.org/W2128439338","https://openalex.org/W2129761607","https://openalex.org/W2130277084","https://openalex.org/W2131103140","https://openalex.org/W2131343690","https://openalex.org/W2132609081","https://openalex.org/W2132989642","https://openalex.org/W2134293572","https://openalex.org/W2134551277","https://openalex.org/W2134738076","https://openalex.org/W2135714529","https://openalex.org/W2137432775","https://openalex.org/W2137570167","https://openalex.org/W2137623306","https://openalex.org/W2137776860","https://openalex.org/W2139240734","https://openalex.org/W2139397108","https://openalex.org/W2139922949","https://openalex.org/W2140176715","https://openalex.org/W2141409038","https://openalex.org/W2142008513","https://openalex.org/W2142527036","https://openalex.org/W2143180162","https://openalex.org/W2143330294","https://openalex.org/W2143336458","https://openalex.org/W2144093179","https://openalex.org/W2144921766","https://openalex.org/W2145301422","https://openalex.org/W2147929482","https://openalex.org/W2147993424","https://openalex.org/W2148876140","https://openalex.org/W2149307753","https://openalex.org/W2151840391","https://openalex.org/W2156779809","https://openalex.org/W2157165682","https://openalex.org/W2157902031","https://openalex.org/W2158020124","https://openalex.org/W2158069865","https://openalex.org/W2158464715","https://openalex.org/W2158820616","https://openalex.org/W2159087408","https://openalex.org/W2159403368","https://openalex.org/W2159506419","https://openalex.org/W2159641950","https://openalex.org/W2161477191","https://openalex.org/W2162986958","https://openalex.org/W2163350010","https://openalex.org/W2164720318","https://openalex.org/W2165201727","https://openalex.org/W2165280103","https://openalex.org/W2165832427","https://openalex.org/W2165884492","https://openalex.org/W2166432285","https://openalex.org/W2166646911","https://openalex.org/W2166816681","https://openalex.org/W2167967163","https://openalex.org/W2168549718","https://openalex.org/W2169177269","https://openalex.org/W2169462078","https://openalex.org/W2173935737","https://openalex.org/W2183356613","https://openalex.org/W2185429958","https://openalex.org/W2250037010","https://openalex.org/W2265277925","https://openalex.org/W2269464315","https://openalex.org/W2270153170","https://openalex.org/W2291786253","https://openalex.org/W2300701274","https://openalex.org/W2312895757","https://openalex.org/W2320686605","https://openalex.org/W2324841714","https://openalex.org/W2327269495","https://openalex.org/W2327795065","https://openalex.org/W2341049818","https://openalex.org/W2341817708","https://openalex.org/W2397839274","https://openalex.org/W2410337138","https://openalex.org/W2410861909","https://openalex.org/W2411083179","https://openalex.org/W2416545661","https://openalex.org/W2424688682","https://openalex.org/W2471578896","https://openalex.org/W2483631733","https://openalex.org/W3022958147","https://openalex.org/W3023642540","https://openalex.org/W3153495156","https://openalex.org/W3183750436","https://openalex.org/W4255659358"],"related_works":["https://openalex.org/W2177683036","https://openalex.org/W2063657879","https://openalex.org/W1141072642","https://openalex.org/W2125064850","https://openalex.org/W2365716212","https://openalex.org/W2165280103","https://openalex.org/W1973342003","https://openalex.org/W2048589935","https://openalex.org/W2356675768","https://openalex.org/W2793433087"],"abstract_inverted_index":{"Valtimonkovettumatauti":[0],"eli":[1,67],"ateroskleroosi":[2],"on":[3,9,38,49,94,341],"vuosikymmenien":[4],"aikana":[5,209],"kehittyv\u00e4":[6],"sairaus,":[7],"jolle":[8],"tyypillist\u00e4":[10],"rasvan":[11],"ja":[12,31,35,42,117,179,192,270,345],"tulehdussolujen":[13],"kertyminen":[14],"suonen":[15],"sein\u00e4m\u00e4\u00e4n.":[16],"Ateroskleroosin":[17],"kliiniset":[18],"ilmenemismuodot,":[19],"kuten":[20],"sepelvaltimotauti,":[21],"aivoverenkiertoh\u00e4iri\u00f6t":[22],"sek\u00e4":[23,83,115,135],"raajojen":[24],"valtimoiden":[25],"ahtautuminen":[26],"ovat":[27],"merkitt\u00e4vi\u00e4":[28],"toimintakyvyn":[29],"laskun":[30],"kuolleisuuden":[32],"aiheuttajia":[33],"Suomessa":[34],"muissa":[36],"l\u00e4nsimaissa.\\n\\nAteroskleroosimuutoksista":[37],"tunnistettu":[39],"neutrofiilien,":[40],"monosyyttien":[41],"makrofagien":[43],"eritt\u00e4m\u00e4\u00e4":[44],"hemientsyymi\u00e4,":[45],"myeloperoksidaasia":[46],"(MPO).":[47],"MPO":[48,130,153,169,188,203,221,337,350],"osa":[50],"immuunipuolustuksen":[51],"hapettamisj\u00e4rjestelm\u00e4\u00e4":[52],"joka":[53],"kykenee":[54],"hapettamaan":[55],"verisuonen":[56],"sein\u00e4m\u00e4\u00e4n":[57],"kertynytt\u00e4":[58],"low":[59],"density":[60],"lipoproteiinia":[61],"(LDL).":[62],"MPO-entsyymi\u00e4":[63],"koodaavan":[64],"geenin":[65],"s\u00e4\u00e4telij\u00e4-":[66],"promoottorialueella":[68],"esiintyy":[69,82],"perinn\u00f6llist\u00e4":[70],"vaihtelua,":[71],"polymorfismia.":[72],"Geenin":[73],"aktiivisuuteen":[74],"vaikuttavasta":[75],"promoottorialueen":[76],"pistemutaatiosta":[77],"-463G/A":[78,338,351],"(rs2333227)":[79,339],"johtuen":[80],"v\u00e4est\u00f6ss\u00e4":[81],"GG,":[84],"AG":[85],"ett\u00e4":[86,336],"AA":[87],"genotyyppien":[88,258],"kantajia.":[89],"A-alleelin":[90,239,251,266,326,353],"kantajilla":[91,246,267,278,290,302,317,327],"MPO-geenin":[92,104],"aktiivisuus":[93],"alentunut":[95],"moninkertaisesti":[96],"verrattuna":[97,321],"GG":[98,230,244,276,288,300,315,361],"genotyypin":[99,131,154,170,189,204,222,245,277,289,301,316,362],"kantajiin.\\n\\nV\u00e4it\u00f6skirjaty\u00f6n":[100],"tavoitteena":[101],"oli":[102],"selvitt\u00e4\u00e4":[103],"perinn\u00f6llisen":[105],"vaihtelun":[106],"yhteytt\u00e4":[107,171,190,223,330],"LDL:n":[108,133,206],"hapettumiseen,":[109],"sepelvaltimoiden":[110],"virtauksen":[111],"reserviin,":[112],"kaulavaltimoiden":[113,172],"sein\u00e4m\u00e4paksuuteen":[114],"rinta-":[116],"vatsa-aortan":[118],"ateroskleroottisiin":[119,194],"muutoksiin.":[120],"Koska":[121],"estrogeenireseptori":[122],"alfan":[123],"(ER?)":[124],"tiedet\u00e4\u00e4n":[125],"sitoutuvan":[126],"tehokkaammin":[127],"A-alleeliin,":[128],"tutkittiin":[129,152,168,202,216],"vaikutusta":[132,155,205],"hapettumiseen":[134,207],"ateroskleroosin":[136,310,343,347],"etenemiseen":[137,226],"my\u00f6s":[138],"pitk\u00e4aikaisen":[139],"hormonikorvaushoidon":[140,208,227],"aikana.\\n\\nTutkimus":[141],"perustuu":[142],"viiteen":[143],"tutkimussarjaan,":[144],"joihin":[145],"kuului":[146],"yhteens\u00e4":[147],"685":[148],"tutkittavaa.":[149],"Ensimm\u00e4isess\u00e4":[150],"osaty\u00f6ss\u00e4":[151,167,186,201,215,229,242,264,284,308],"selpelvaltimokierron":[156],"reserviin":[157],"liev\u00e4sti":[158],"hyperkolesterolemisten":[159],"mutta":[160,253,279],"muutoin":[161],"terveiden":[162],"49":[163],"miehen":[164,183,198],"aineistossa.":[165,184,213],"Toisessa":[166,241],"ultra\u00e4\u00e4nitutkimuksen":[173],"tulokseen":[174],"tyypin":[175,254],"2":[176,255],"diabetesta":[177],"sairastavilla":[178],"ei-diabeetikoilla":[180],"196":[181],"keski-ik\u00e4isen":[182,197],"Kolmannessa":[185,263],"selvitettiin":[187],"vatsa-":[191],"rinta-aortan":[193],"muutoksiin":[195],"266":[196],"ruumiinavausaineistossa.":[199],"Nelj\u00e4nness\u00e4":[200,283],"87":[210,218],"postmenopausaalisen":[211],"naisen":[212,219],"Viidenness\u00e4":[214,307],"samassa":[217],"aineistossa":[220],"ateroskleroottisten":[224],"muutosten":[225],"aikana.\\n\\nEnsimm\u00e4isess\u00e4":[228],"genotyyppi\u00e4":[231],"kantavilla":[232],"miehill\u00e4":[233],"todettiin":[234,243,265,285,309],"alhaisempi":[235],"sepelvaltimokierron":[236],"reservi":[237],"kuin":[238,250,275,298],"kantajilla.":[240],"matalampi":[247],"kaulasuonten":[248],"sein\u00e4m\u00e4paksuus":[249],"kantajilla,":[252],"diabeetikoilla":[256],"eroa":[257],"v\u00e4lill\u00e4":[259],"ei":[260,328],"tullut":[261],"esiin.":[262],"suuremmat":[268],"fibroottiset":[269],"kalkkeutuneet":[271],"ateroskleroottiset":[272],"muutokset":[273],"vatsa-aortassa":[274],"yhteys":[280],"heikkeni":[281],"ik\u00e4riippuvaisesti.":[282],"hormonikorvaushoitoa":[286,320],"saavilla":[287],"korkeammat":[291],"hapettunutta":[292],"LDL:a":[293],"vastaan":[294],"muodostuneiden":[295],"vasta-aineiden":[296],"tasot":[297],"niill\u00e4":[299,314],"jotka":[303,318],"eiv\u00e4t":[304],"saaneet":[305],"hormonikorvaushoitoa.":[306],"etenemisen":[311],"olevan":[312],"hitaampaa":[313],"saivat":[319],"l\u00e4\u00e4kkeett\u00f6miin":[322],"kontrolleihin,":[323],"kun":[324],"taas":[325],"vastaavaa":[329],"todettu.\\n\\nYhteenvetona":[331],"v\u00e4it\u00f6skirjatutkimuksen":[332],"tuloksista":[333],"voi":[334],"todeta":[335],"polymorfismi":[340],"yhteydess\u00e4":[342],"ilmiasuun":[344],"toimii":[346],"geneettisen\u00e4":[348],"markkerina.":[349],"polymorfismin":[352],"kantajien":[354],"saama":[355],"hy\u00f6ty":[356],"postmenopausaalisesta":[357],"hormonikorvaushoidosta":[358],"saattaa":[359],"j\u00e4\u00e4d\u00e4":[360],"kantajia":[363],"v\u00e4h\u00e4isemm\u00e4ksi.":[364]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}