{"id":"https://openalex.org/W2178314928","doi":"https://doi.org/10.1371/journal.pone.0143627","title":"Total Binding Affinity Profiles of Regulatory Regions Predict Transcription Factor Binding and Gene Expression in Human Cells","display_name":"Total Binding Affinity Profiles of Regulatory Regions Predict Transcription Factor Binding and Gene Expression in Human Cells","publication_year":2015,"publication_date":"2015-11-24","ids":{"openalex":"https://openalex.org/W2178314928","doi":"https://doi.org/10.1371/journal.pone.0143627","mag":"2178314928","pmid":"https://pubmed.ncbi.nlm.nih.gov/26599758","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4658012"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0143627","doi":"https://doi.org/10.1371/journal.pone.0143627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143627&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049648750","display_name":"Elena Grassi","orcid":"https://orcid.org/0000-0003-1066-927X","observed_orcids":["https://orcid.org/0000-0003-1066-927X"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Grassi","raw_affiliation_strings":["Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004534002","display_name":"Ettore Zapparoli","orcid":"https://orcid.org/0000-0003-4170-7902","observed_orcids":["https://orcid.org/0000-0003-4170-7902"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ettore Zapparoli","raw_affiliation_strings":["Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003294860","display_name":"Ivan Molineris","orcid":"https://orcid.org/0000-0003-2102-0804","observed_orcids":["https://orcid.org/0000-0003-2102-0804"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ivan Molineris","raw_affiliation_strings":["Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063120064","display_name":"Paolo Provero","orcid":"https://orcid.org/0000-0001-8664-8630","observed_orcids":["https://orcid.org/0000-0001-8664-8630"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paolo Provero","raw_affiliation_strings":["Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, Italy","Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Dept. of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063120064"],"corresponding_institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I55143463"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.3461,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.5612402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"11","first_page":"e0143627","last_page":"e0143627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.8949999809265137},{"id":"https://openalex.org/keywords/regulatory-elements","display_name":"regulatory elements","score":0.6589999794960022},{"id":"https://openalex.org/keywords/gene-expression-prediction","display_name":"gene expression prediction","score":0.8579999804496765},{"id":"https://openalex.org/keywords/chip-seq","display_name":"ChIP-seq","score":0.7770000100135803},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-seq","score":0.9240000247955322},{"id":"https://openalex.org/keywords/chromatin-state","display_name":"chromatin state","score":0.8939999938011169},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9800000190734863},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.6990000009536743},{"id":"https://openalex.org/keywords/human-cells","display_name":"human cells","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7271448373794556},{"id":"https://openalex.org/C190796033","wikidata":"https://www.wikidata.org/wiki/Q1093165","display_name":"Cis-regulatory module","level":5,"score":0.6756546497344971},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.6047356724739075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5538102388381958},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5339022874832153},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.520537257194519},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5194754004478455},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5024278163909912},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4845272898674011},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.48167693614959717},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46954450011253357},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.45406574010849},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4540199041366577},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.29203760623931885},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.20229065418243408}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0143627","doi":"https://doi.org/10.1371/journal.pone.0143627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3642380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4658012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4658012","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4658012","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26599758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26599758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/1694743","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1694743","pdf_url":"https://iris.unito.it/bitstream/2318/1694743/1/journal.pone.0143627.PDF","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.1813","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.1813","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d9/af/pone.0143627.PMC4658012.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8032712e211940d5862f790bdba18dbc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8032712e211940d5862f790bdba18dbc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 11, p e0143627 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1611489","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Total_Binding_Affinity_Profiles_of_Regulatory_Regions_Predict_Transcription_Factor_Binding_and_Gene_Expression_in_Human_Cells_/1611489","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0143627","doi":"https://doi.org/10.1371/journal.pone.0143627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324041","display_name":"Universit\u00e0 degli Studi di Torino","ror":"https://ror.org/048tbm396"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2178314928.pdf","grobid_xml":"https://content.openalex.org/works/W2178314928.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964733653","https://openalex.org/W1980253661","https://openalex.org/W1988871238","https://openalex.org/W2000515602","https://openalex.org/W2002122781","https://openalex.org/W2013449615","https://openalex.org/W2025943989","https://openalex.org/W2026690931","https://openalex.org/W2027458139","https://openalex.org/W2085640231","https://openalex.org/W2089865437","https://openalex.org/W2104601239","https://openalex.org/W2105796031","https://openalex.org/W2105924780","https://openalex.org/W2107292147","https://openalex.org/W2112621436","https://openalex.org/W2115260093","https://openalex.org/W2116467413","https://openalex.org/W2117792884","https://openalex.org/W2127021450","https://openalex.org/W2146042781","https://openalex.org/W2147946837","https://openalex.org/W2158485480","https://openalex.org/W2158485828","https://openalex.org/W2159026625","https://openalex.org/W2166724957","https://openalex.org/W2287365612","https://openalex.org/W4294541781","https://openalex.org/W4399547815"],"related_works":["https://openalex.org/W7097578144","https://openalex.org/W2142410561","https://openalex.org/W2152296813","https://openalex.org/W7046100699","https://openalex.org/W28214446","https://openalex.org/W4282011047","https://openalex.org/W1792980474","https://openalex.org/W2064569650","https://openalex.org/W2611054505","https://openalex.org/W1982881824"],"abstract_inverted_index":{"Transcription":[0],"factors":[1,47],"regulate":[2],"gene":[3,84],"expression":[4,85],"by":[5,76],"binding":[6,14,43,62,73],"regulatory":[7,24,34,97],"DNA.":[8],"Understanding":[9],"the":[10,21,58,68,81],"rules":[11],"governing":[12],"such":[13],"is":[15],"an":[16],"essential":[17],"step":[18],"in":[19,36,91],"describing":[20,33],"network":[22],"of":[23,38,41,60,70,83],"interactions,":[25],"and":[26,79],"its":[27],"pathological":[28],"alterations.":[29],"We":[30],"show":[31],"that":[32],"regions":[35,98],"terms":[37],"their":[39],"profile":[40],"total":[42],"affinities":[44],"for":[45],"transcription":[46,71],"leads":[48],"to":[49,54,67,80],"increased":[50],"predictive":[51,92],"power":[52,93],"compared":[53],"methods":[55],"based":[56,101],"on":[57,102],"identification":[59],"discrete":[61],"sites.":[63],"This":[64],"applies":[65],"both":[66],"prediction":[69,82],"factor":[72],"as":[74],"revealed":[75],"ChIP-seq":[77],"experiments":[78],"through":[86],"RNA-seq.":[87],"Further":[88],"significant":[89],"improvements":[90],"are":[94,99],"obtained":[95],"when":[96],"defined":[100],"chromatin":[103],"states":[104],"inferred":[105],"from":[106],"histone":[107],"modification":[108],"data.":[109]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}