{"id":"https://openalex.org/W2178197654","doi":"https://doi.org/10.1002/cmdc.201500360","title":"Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9\u2010Epipolygodial against Drug\u2010Resistant Cancer Cells","display_name":"Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9\u2010Epipolygodial against Drug\u2010Resistant Cancer Cells","publication_year":2015,"publication_date":"2015-10-05","ids":{"openalex":"https://openalex.org/W2178197654","doi":"https://doi.org/10.1002/cmdc.201500360","mag":"2178197654","pmid":"https://pubmed.ncbi.nlm.nih.gov/26434977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831215"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201500360","doi":"https://doi.org/10.1002/cmdc.201500360","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201500360","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831215","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113634654","display_name":"Ramesh Dasari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13511017","display_name":"Texas State University","ror":"https://ror.org/05h9q1g27","country_code":"US","type":"education","lineage":["https://openalex.org/I13511017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Dasari","raw_affiliation_strings":["Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA","institution_ids":["https://openalex.org/I13511017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101474907","display_name":"Annelise Carvalho","orcid":"https://orcid.org/0000-0003-2859-0017","observed_orcids":["https://orcid.org/0000-0003-2859-0017"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Annelise De\u2005Carvalho","raw_affiliation_strings":["Laboratoire de Canc\u00e9rologie et de Toxicologie Exp\u00e9rimentale Facult\u00e9 de Pharmacie Universit\u00e9 Libre de Bruxelles  1050 Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Canc\u00e9rologie et de Toxicologie Exp\u00e9rimentale Facult\u00e9 de Pharmacie Universit\u00e9 Libre de Bruxelles  1050 Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084829441","display_name":"Derek C. Medellin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13511017","display_name":"Texas State University","ror":"https://ror.org/05h9q1g27","country_code":"US","type":"education","lineage":["https://openalex.org/I13511017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek C. Medellin","raw_affiliation_strings":["Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA","institution_ids":["https://openalex.org/I13511017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077533063","display_name":"Kelsey N. Middleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13511017","display_name":"Texas State University","ror":"https://ror.org/05h9q1g27","country_code":"US","type":"education","lineage":["https://openalex.org/I13511017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey N. Middleton","raw_affiliation_strings":["Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA","institution_ids":["https://openalex.org/I13511017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111559931","display_name":"Fr\u00e9d\u00e9ric Hague","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401041597","display_name":"Laboratoire de physiologie cellulaire et mol\u00e9culaire","ror":"https://ror.org/03vv60b83","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401041597","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Hague","raw_affiliation_strings":["Laboratoire de Physiologie Cellulaire et Mol\u00e9culaire Facult\u00e9 des Sciences Universit\u00e9 de Picardie Jules Verne  80000 Amiens France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie Cellulaire et Mol\u00e9culaire Facult\u00e9 des Sciences Universit\u00e9 de Picardie Jules Verne  80000 Amiens France","institution_ids":["https://openalex.org/I4401041597","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009572470","display_name":"Marie N.M. Volmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marie N. M. Volmar","raw_affiliation_strings":["Neurosurgical Research University Clinics Munich  Marchioninistr.\u200515 81377 Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgical Research University Clinics Munich  Marchioninistr.\u200515 81377 Munich Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053078484","display_name":"Liliya V. Frolova","orcid":"https://orcid.org/0000-0003-1673-6365","observed_orcids":["https://orcid.org/0000-0003-1673-6365"]},"institutions":[{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liliya V. Frolova","raw_affiliation_strings":["Departments of Chemistry and Biology New Mexico Institute of Mining and Technology  801\u2005Leroy Place Socorro NM 87801 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biology New Mexico Institute of Mining and Technology  801\u2005Leroy Place Socorro NM 87801 USA","institution_ids":["https://openalex.org/I207123951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103461853","display_name":"Mateus Fortes Rossato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mateus F. Rossato","raw_affiliation_strings":["Center of Innovation and Preclinical Studies  Av. Luiz Boiteux Piazza 1302, Cachoeira do Bom Jesus Florian\u00f3polis SC 88056-000 Brazil","Department of Pharmacology Federal University of Santa Catarina  Florian\u00f3polis SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Innovation and Preclinical Studies  Av. Luiz Boiteux Piazza 1302, Cachoeira do Bom Jesus Florian\u00f3polis SC 88056-000 Brazil","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology Federal University of Santa Catarina  Florian\u00f3polis SC Brazil","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073130548","display_name":"Jorge J. De La Chapa","orcid":"https://orcid.org/0000-0001-7610-1252","observed_orcids":["https://orcid.org/0000-0001-7610-1252"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge J. De\u2005La\u2005Chapa","raw_affiliation_strings":["Department of Comprehensive Dentistry Cancer Therapy and Research Center University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comprehensive Dentistry Cancer Therapy and Research Center University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038905065","display_name":"Nicholas F. Dybdal\u2010Hargreaves","orcid":"https://orcid.org/0000-0002-5847-5231","observed_orcids":["https://orcid.org/0000-0002-5847-5231"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas F. Dybdal\u2010Hargreaves","raw_affiliation_strings":["Department of Pharmacology University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014100362","display_name":"Akshita Pillai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110323","display_name":"University of Illinois Chicago, Rockford campus","ror":"https://ror.org/02437s643","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210110323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akshita Pillai","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine University of Illinois  1601\u2005Parkview Ave. Rockford IL 61107 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine University of Illinois  1601\u2005Parkview Ave. Rockford IL 61107 USA","institution_ids":["https://openalex.org/I4210110323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110518019","display_name":"V\u00e9ronique Mathieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Mathieu","raw_affiliation_strings":["Laboratoire de Canc\u00e9rologie et de Toxicologie Exp\u00e9rimentale Facult\u00e9 de Pharmacie Universit\u00e9 Libre de Bruxelles  1050 Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Canc\u00e9rologie et de Toxicologie Exp\u00e9rimentale Facult\u00e9 de Pharmacie Universit\u00e9 Libre de Bruxelles  1050 Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058939223","display_name":"Snezna Rogelj","orcid":"https://orcid.org/0000-0001-5717-8297","observed_orcids":["https://orcid.org/0000-0001-5717-8297"]},"institutions":[{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Snezna Rogelj","raw_affiliation_strings":["Departments of Chemistry and Biology New Mexico Institute of Mining and Technology  801\u2005Leroy Place Socorro NM 87801 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biology New Mexico Institute of Mining and Technology  801\u2005Leroy Place Socorro NM 87801 USA","institution_ids":["https://openalex.org/I207123951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063077669","display_name":"Cara B. Gonzales","orcid":"https://orcid.org/0000-0002-1739-4574","observed_orcids":["https://orcid.org/0000-0002-1739-4574"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cara B. Gonzales","raw_affiliation_strings":["Department of Comprehensive Dentistry Cancer Therapy and Research Center University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comprehensive Dentistry Cancer Therapy and Research Center University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043712906","display_name":"Jo\u00e3o \u0392. Calixto","orcid":"https://orcid.org/0000-0003-4041-7153","observed_orcids":["https://orcid.org/0000-0003-4041-7153"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o B. Calixto","raw_affiliation_strings":["Center of Innovation and Preclinical Studies  Av. Luiz Boiteux Piazza 1302, Cachoeira do Bom Jesus Florian\u00f3polis SC 88056-000 Brazil","Department of Pharmacology Federal University of Santa Catarina  Florian\u00f3polis SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Innovation and Preclinical Studies  Av. Luiz Boiteux Piazza 1302, Cachoeira do Bom Jesus Florian\u00f3polis SC 88056-000 Brazil","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology Federal University of Santa Catarina  Florian\u00f3polis SC Brazil","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052002042","display_name":"Antonio Evidente","orcid":"https://orcid.org/0000-0001-9110-1656","observed_orcids":["https://orcid.org/0000-0001-9110-1656"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Evidente","raw_affiliation_strings":["Dipartimento di Scienze Chimiche Universit\u00e0 di Napoli Federico II Complesso Universitario Monte Sant'Angelo  Via Cintia\u20054 80126 Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche Universit\u00e0 di Napoli Federico II Complesso Universitario Monte Sant'Angelo  Via Cintia\u20054 80126 Napoli Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070991360","display_name":"Mathieu Gautier","orcid":"https://orcid.org/0000-0001-8971-5683","observed_orcids":["https://orcid.org/0000-0001-8971-5683"]},"institutions":[{"id":"https://openalex.org/I4401041597","display_name":"Laboratoire de physiologie cellulaire et mol\u00e9culaire","ror":"https://ror.org/03vv60b83","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401041597","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathieu Gautier","raw_affiliation_strings":["Laboratoire de Physiologie Cellulaire et Mol\u00e9culaire Facult\u00e9 des Sciences Universit\u00e9 de Picardie Jules Verne  80000 Amiens France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie Cellulaire et Mol\u00e9culaire Facult\u00e9 des Sciences Universit\u00e9 de Picardie Jules Verne  80000 Amiens France","institution_ids":["https://openalex.org/I4401041597","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074246595","display_name":"Gnanasekar Munirathinam","orcid":"https://orcid.org/0000-0002-1445-6311","observed_orcids":["https://orcid.org/0000-0002-1445-6311"]},"institutions":[{"id":"https://openalex.org/I4210110323","display_name":"University of Illinois Chicago, Rockford campus","ror":"https://ror.org/02437s643","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210110323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gnanasekar Munirathinam","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine University of Illinois  1601\u2005Parkview Ave. Rockford IL 61107 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine University of Illinois  1601\u2005Parkview Ave. Rockford IL 61107 USA","institution_ids":["https://openalex.org/I4210110323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010606382","display_name":"Rainer Gla\u00df","orcid":"https://orcid.org/0000-0002-1258-2584","observed_orcids":["https://orcid.org/0000-0002-1258-2584"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Glass","raw_affiliation_strings":["Neurosurgical Research University Clinics Munich  Marchioninistr.\u200515 81377 Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgical Research University Clinics Munich  Marchioninistr.\u200515 81377 Munich Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040385786","display_name":"Patr\u00edcia Burth","orcid":"https://orcid.org/0000-0003-4433-9375","observed_orcids":["https://orcid.org/0000-0003-4433-9375"]},"institutions":[{"id":"https://openalex.org/I161127581","display_name":"Universidade Federal Fluminense","ror":"https://ror.org/02rjhbb08","country_code":"BR","type":"education","lineage":["https://openalex.org/I161127581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patricia Burth","raw_affiliation_strings":["Departamento de Biologia Celular e Molecular Instituto de Biologia Universidade Federal Fluminense  Outeiro de S\u00e3o Jo\u00e3o Batista, s/n Campus do Valonguinho Centro-Niter\u00f3i RJ 24020-140 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biologia Celular e Molecular Instituto de Biologia Universidade Federal Fluminense  Outeiro de S\u00e3o Jo\u00e3o Batista, s/n Campus do Valonguinho Centro-Niter\u00f3i RJ 24020-140 Brazil","institution_ids":["https://openalex.org/I161127581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040477247","display_name":"Stephen C. Pelly","orcid":"https://orcid.org/0000-0001-5930-4939","observed_orcids":["https://orcid.org/0000-0001-5930-4939"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Stephen C. Pelly","raw_affiliation_strings":["Department of Chemistry and Polymer Science Stellenbosch University  Stellenbosch Private Bag\u2005X1, Matieland 7602 South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Polymer Science Stellenbosch University  Stellenbosch Private Bag\u2005X1, Matieland 7602 South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084802244","display_name":"Willem A. L. van Otterlo","orcid":"https://orcid.org/0000-0002-3300-6463","observed_orcids":["https://orcid.org/0000-0002-3300-6463"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Willem A. L. van\u2005Otterlo","raw_affiliation_strings":["Department of Chemistry and Polymer Science Stellenbosch University  Stellenbosch Private Bag\u2005X1, Matieland 7602 South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Polymer Science Stellenbosch University  Stellenbosch Private Bag\u2005X1, Matieland 7602 South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102917329","display_name":"Robert Kiss A","orcid":"https://orcid.org/0000-0003-0692-3191","observed_orcids":["https://orcid.org/0000-0003-0692-3191","https://orcid.org/0000-0002-2879-6325","https://orcid.org/0000-0003-0209-3004"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Robert Kiss","raw_affiliation_strings":["Laboratoire de Canc\u00e9rologie et de Toxicologie Exp\u00e9rimentale Facult\u00e9 de Pharmacie Universit\u00e9 Libre de Bruxelles  1050 Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Canc\u00e9rologie et de Toxicologie Exp\u00e9rimentale Facult\u00e9 de Pharmacie Universit\u00e9 Libre de Bruxelles  1050 Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009000319","display_name":"Alexander Kornienko","orcid":"https://orcid.org/0000-0003-2041-7367","observed_orcids":["https://orcid.org/0000-0003-2041-7367"]},"institutions":[{"id":"https://openalex.org/I13511017","display_name":"Texas State University","ror":"https://ror.org/05h9q1g27","country_code":"US","type":"education","lineage":["https://openalex.org/I13511017"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander Kornienko","raw_affiliation_strings":["Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Texas State University San Marcos TX 78666 USA","institution_ids":["https://openalex.org/I13511017"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5009000319"],"corresponding_institution_ids":["https://openalex.org/I13511017"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.101,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.73855163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"12","first_page":"2014","last_page":"2026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.0966000035405159,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.06639999896287918,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygodial","display_name":"polygodial","score":0.9879999756813049},{"id":"https://openalex.org/keywords/trpv1-agonists","display_name":"TRPV1 agonists","score":0.9369999766349792},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7519999742507935},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.8240000009536743},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/polygonum-hydropiper","display_name":"Polygonum hydropiper","score":0.8069999814033508},{"id":"https://openalex.org/keywords/natural-product-derivatives","display_name":"natural product derivatives","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.6681934595108032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6607996225357056},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.5270612239837646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4693663418292999},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4660996198654175},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.4586576819419861},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4578162729740143},{"id":"https://openalex.org/C2776211264","wikidata":"https://www.wikidata.org/wiki/Q80218","display_name":"Sesquiterpene","level":2,"score":0.44282519817352295},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.43745923042297363},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.41627931594848633},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3878934383392334},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26135319471359253},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23795375227928162},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.15148016810417175}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/cmdc.201500360","doi":"https://doi.org/10.1002/cmdc.201500360","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201500360","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:26434977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26434977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4053508","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831215","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4831215","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831215","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04542555v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04542555","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ChemMedChem, 2015, 10 (12), pp.2014-2026. &#x27E8;10.1002/cmdc.201500360&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/226616","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/226616","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ChemMedChem, 10 (12","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4053508","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831215","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6200000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3056538093","display_name":"Notch signaling and anticancer drug sensitivity in oral squamous cell carcinoma","funder_award_id":"F30DE025535","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3517606695","display_name":"Institute for Integration of Medicine & Science: A Partnership to Improve Health","funder_award_id":"UL1TR001120","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G380793897","display_name":null,"funder_award_id":"AI0045","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G4023307058","display_name":null,"funder_award_id":"P20M103451","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4744606257","display_name":null,"funder_award_id":"CA186046\u201001A1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7137122645","display_name":"Mode of Action of the Amaryllidaceae Alkaloid Lycorine-Promising Anticancer Agent","funder_award_id":"R15CA186046","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8759028581","display_name":null,"funder_award_id":"P20M103451","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G9000889884","display_name":"Craniofacial Oral-biology Student Training in Academic Research (COSTAR)","funder_award_id":"T32DE014318","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000907293","display_name":"New Mexico IDeA Networks of Biomedical Research Excellence (INBRE)","funder_award_id":"P20GM103451","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320322663","display_name":"Universiteit Stellenbosch","ror":"https://ror.org/05bk57929"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1514125758","https://openalex.org/W1516339906","https://openalex.org/W1883044208","https://openalex.org/W1972656091","https://openalex.org/W1972940377","https://openalex.org/W1973796039","https://openalex.org/W1974768397","https://openalex.org/W1979455808","https://openalex.org/W1982284880","https://openalex.org/W1985008572","https://openalex.org/W1987418164","https://openalex.org/W1988239155","https://openalex.org/W1988633516","https://openalex.org/W1988945297","https://openalex.org/W1997413767","https://openalex.org/W1999407700","https://openalex.org/W1999521736","https://openalex.org/W1999706763","https://openalex.org/W2000013449","https://openalex.org/W2001544973","https://openalex.org/W2002937040","https://openalex.org/W2004519217","https://openalex.org/W2005296272","https://openalex.org/W2006170800","https://openalex.org/W2008640291","https://openalex.org/W2010993054","https://openalex.org/W2015128691","https://openalex.org/W2016574214","https://openalex.org/W2018607339","https://openalex.org/W2018671779","https://openalex.org/W2019419708","https://openalex.org/W2023864024","https://openalex.org/W2023971821","https://openalex.org/W2026924355","https://openalex.org/W2028026752","https://openalex.org/W2034111553","https://openalex.org/W2034328391","https://openalex.org/W2036164831","https://openalex.org/W2041294276","https://openalex.org/W2041392396","https://openalex.org/W2045481582","https://openalex.org/W2047218877","https://openalex.org/W2047343730","https://openalex.org/W2048542407","https://openalex.org/W2051917121","https://openalex.org/W2052185232","https://openalex.org/W2060551076","https://openalex.org/W2061233338","https://openalex.org/W2063095520","https://openalex.org/W2064876412","https://openalex.org/W2066300890","https://openalex.org/W2075832560","https://openalex.org/W2076315294","https://openalex.org/W2077612148","https://openalex.org/W2078585784","https://openalex.org/W2083479805","https://openalex.org/W2096618735","https://openalex.org/W2103826070","https://openalex.org/W2104680439","https://openalex.org/W2109293109","https://openalex.org/W2120350646","https://openalex.org/W2123837094","https://openalex.org/W2124078079","https://openalex.org/W2124141753","https://openalex.org/W2125598231","https://openalex.org/W2134742719","https://openalex.org/W2143626153","https://openalex.org/W2143877481","https://openalex.org/W2144586991","https://openalex.org/W2158136044","https://openalex.org/W2160121991","https://openalex.org/W2161321562","https://openalex.org/W2167414381","https://openalex.org/W2169816570","https://openalex.org/W2176283452","https://openalex.org/W2330300395","https://openalex.org/W4255298747"],"related_works":["https://openalex.org/W2894771446","https://openalex.org/W1900238446","https://openalex.org/W2155215477","https://openalex.org/W2028854819","https://openalex.org/W2286499238","https://openalex.org/W2068168026","https://openalex.org/W4413190375","https://openalex.org/W2102063934","https://openalex.org/W2020616080","https://openalex.org/W3020319317"],"abstract_inverted_index":{"Polygodial,":[0],"a":[1,10,24,92,96,109],"terpenoid":[2],"dialdehyde":[3],"isolated":[4],"from":[5],"Polygonum":[6],"hydropiper":[7],"L.,":[8],"is":[9],"known":[11],"agonist":[12],"of":[13,26,44,53,84,86,91,108,142,149,152,155],"the":[14,42,70,76,80,89,100,106,140,147],"transient":[15],"receptor":[16],"potential":[17],"vanilloid":[18],"1":[19],"(TRPV1).":[20],"In":[21,74],"this":[22,136],"investigation":[23],"series":[25],"polygodial":[27,111,124],"analogues":[28],"were":[29],"prepared":[30],"and":[31,35,119,125],"investigated":[32],"for":[33,79],"TRPV1-agonist":[34],"anticancer":[36],"activities.":[37],"These":[38,114,129],"experiments":[39],"led":[40],"to":[41,58],"identification":[43],"9-epipolygodial,":[45],"which":[46],"has":[47],"antiproliferative":[48],"potency":[49,60],"significantly":[50],"exceeding":[51],"that":[52],"polygodial.":[54],"9-Epipolygodial":[55],"was":[56,103],"found":[57],"maintain":[59],"against":[61],"apoptosis-resistant":[62],"cancer":[63],"cells":[64],"as":[65,67],"well":[66],"those":[68],"displaying":[69],"multidrug-resistant":[71],"(MDR)":[72],"phenotype.":[73],"addition,":[75],"chemical":[77,118],"feasibility":[78],"previously":[81],"proposed":[82],"mechanism":[83],"action":[85],"polygodial,":[87],"involving":[88],"formation":[90],"Paal-Knorr":[93],"pyrrole":[94,112],"with":[95,123,158],"lysine":[97],"residue":[98],"on":[99],"target":[101],"protein,":[102],"demonstrated":[104],"by":[105],"synthesis":[107],"stable":[110],"derivative.":[113],"studies":[115],"reveal":[116],"rich":[117],"biological":[120,156],"properties":[121],"associated":[122],"its":[126],"direct":[127],"derivatives.":[128],"compounds":[130],"should":[131],"inspire":[132],"further":[133],"work":[134],"in":[135],"area":[137],"aimed":[138],"at":[139],"development":[141],"new":[143],"pharmacological":[144],"agents,":[145],"or":[146],"exploration":[148],"novel":[150],"mechanisms":[151],"covalent":[153],"modification":[154],"molecules":[157],"natural":[159],"products.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
