{"id":"https://openalex.org/W217808949","doi":null,"title":"Hydrogen peroxide modulation of angiogenic factors in tumor cells","display_name":"Hydrogen peroxide modulation of angiogenic factors in tumor cells","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W217808949","mag":"217808949"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/10793","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/10793","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10451/10793","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026253787","display_name":"Ana Maria Jer\u00f3nimo Gameiro de Sousa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ana Maria Jer\u00f3nimo Gameiro de Sousa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026253787"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/catalase-overexpression","display_name":"catalase overexpression","score":0.8059999942779541},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/delta-like-ligand-4","display_name":"DLL4","score":0.7049999833106995},{"id":"https://openalex.org/keywords/jagged1","display_name":"Jagged1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/notch3","display_name":"Notch3","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/timp-3","display_name":"TIMP-3","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bai1","display_name":"BAI1","score":0.6140000224113464},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7680000066757202},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.921999990940094},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.8700793981552124},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.587099552154541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4416259825229645},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3793736696243286},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3364136815071106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3323787450790405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29161110520362854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22475042939186096},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.17418694496154785},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.07415053248405457}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.ulisboa.pt:10451/10793","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/10793","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:217808949","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.ul.pt/bitstream/10451/10793/1/ulfc106708_tm_Ana_Maria_Sousa.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/10793","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/10793","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W41770144","https://openalex.org/W167923352","https://openalex.org/W1506621956","https://openalex.org/W1534805598","https://openalex.org/W1538419182","https://openalex.org/W1539571840","https://openalex.org/W1809723326","https://openalex.org/W1966796558","https://openalex.org/W1966931906","https://openalex.org/W1968044382","https://openalex.org/W1968673560","https://openalex.org/W1971324461","https://openalex.org/W1972779889","https://openalex.org/W1978926183","https://openalex.org/W1980387702","https://openalex.org/W1983137233","https://openalex.org/W1988357840","https://openalex.org/W1988655372","https://openalex.org/W1995199032","https://openalex.org/W1995986855","https://openalex.org/W1999806882","https://openalex.org/W1999851893","https://openalex.org/W2000292756","https://openalex.org/W2002015567","https://openalex.org/W2009476974","https://openalex.org/W2012142572","https://openalex.org/W2012713600","https://openalex.org/W2015088673","https://openalex.org/W2015872072","https://openalex.org/W2016471469","https://openalex.org/W2017300339","https://openalex.org/W2019369653","https://openalex.org/W2022471892","https://openalex.org/W2023348750","https://openalex.org/W2024267687","https://openalex.org/W2028263171","https://openalex.org/W2031951436","https://openalex.org/W2032635496","https://openalex.org/W2033675476","https://openalex.org/W2041574386","https://openalex.org/W2049658984","https://openalex.org/W2049861779","https://openalex.org/W2058004680","https://openalex.org/W2064663184","https://openalex.org/W2069463594","https://openalex.org/W2070143299","https://openalex.org/W2073533593","https://openalex.org/W2079294573","https://openalex.org/W2081617951","https://openalex.org/W2087220149","https://openalex.org/W2088006216","https://openalex.org/W2093683863","https://openalex.org/W2093776019","https://openalex.org/W2094420450","https://openalex.org/W2101466169","https://openalex.org/W2102472842","https://openalex.org/W2106787323","https://openalex.org/W2110539420","https://openalex.org/W2111487756","https://openalex.org/W2115610840","https://openalex.org/W2115708356","https://openalex.org/W2117692326","https://openalex.org/W2118758371","https://openalex.org/W2119159602","https://openalex.org/W2132270233","https://openalex.org/W2132566055","https://openalex.org/W2139923937","https://openalex.org/W2140676103","https://openalex.org/W2141517388","https://openalex.org/W2145663629","https://openalex.org/W2156494900","https://openalex.org/W2161431747","https://openalex.org/W2165643859","https://openalex.org/W2170958514","https://openalex.org/W2171476567","https://openalex.org/W2314203153","https://openalex.org/W2325048800","https://openalex.org/W7095745927"],"related_works":["https://openalex.org/W3102819184","https://openalex.org/W2264618213","https://openalex.org/W2746991909","https://openalex.org/W4233003517","https://openalex.org/W2337406770","https://openalex.org/W2290714186","https://openalex.org/W1993340627","https://openalex.org/W3144252825","https://openalex.org/W7019292421","https://openalex.org/W4235719985"],"abstract_inverted_index":{"O":[0,133],"desenvolvimento":[1,438],"e":[2,20,47,78,85,124,184,205,223,244,249,275,289],"dissemina\u00e7\u00e3o":[3],"de":[4,10,18,23,44,55,58,68,100,105,109,112,121,129,155,164,169,172,182,212,215,262,283,285,290,298,315,320,330,354,361,370,373,377,386,405,409,414,421,432,439],"tumores":[5],"s\u00f3lidos":[6],"dependem":[7],"da":[8,103,147,185,202,226,260,267,323,332,366,368,381,384],"forma\u00e7\u00e3o":[9],"uma":[11,117,286,291,374],"rede":[12],"vascular":[13],"que":[14,35,63,94,178,236,306,327,351,400],"permita":[15],"o":[16,37,159,210,224,246,250,276,352,426,437,444],"aporte":[17],"oxig\u00e9nio":[19,59],"nutrientes,":[21],"atrav\u00e9s":[22,102,171,365,420],"um":[24,52,176,422],"processo":[25,29,160],"denominado":[26],"angiog\u00e9nese.":[27,148,324],"Este":[28],"\u00e9":[30,311,359,412],"regulado":[31],"por":[32,191,232,394],"diversos":[33],"factores":[34,321],"comp\u00f5em":[36],"microambiente":[38,61],"tumoral":[39,62],"tais":[40],"como":[41,70],"os":[42,138,241,328,342],"n\u00edveis":[43,98,329,404],"oxig\u00e9nio,":[45],"acidifica\u00e7\u00e3o":[46],"stress":[48],"oxidativo.":[49],"Sabe-se":[50],"existir":[51],"n\u00edvel":[53,353],"elevado":[54],"esp\u00e9cies":[56],"reactivas":[57],"no":[60,90],"ao":[64],"promover":[65],"a":[66,71,73,76,82,95,116,180,219,254,270,307,363,401,416],"desregula\u00e7\u00e3o":[67],"processos":[69],"prolifera\u00e7\u00e3o,":[72],"motilidade":[74],"celular,":[75],"sobreviv\u00eancia":[77],"angiog\u00e9nese":[79,213,364],"contribui":[80],"para":[81,436],"inicia\u00e7\u00e3o,":[83],"progress\u00e3o":[84],"promo\u00e7\u00e3o":[86],"tumoral.":[87],"Estudos":[88],"realizados":[89],"nosso":[91],"laborat\u00f3rio":[92],"demonstraram":[93],"diminui\u00e7\u00e3o":[96,118],"dos":[97,403,428],"celulares":[99],"H2O2,":[101,389],"sobreexpress\u00e3o":[104,282],"catalase":[106,170,183,284],"em":[107,131,162],"c\u00e9lulas":[108,122,165,238,336,357,410],"carcinoma":[110],"mam\u00e1rio":[111],"ratinho":[113],"4T1,":[114],"leva":[115],"do":[119,142,198],"recrutamento":[120],"endoteliais":[123],"invas\u00e3o":[125],"vascular,":[126],"num":[127],"modelo":[128],"xenotransplante":[130],"peixe-zebra.":[132],"presente":[134],"estudo":[135],"pretende":[136],"identificar":[137,194],"mecanismos":[139,429],"moleculares":[140,430],"dependentes":[141,431],"H2O2":[143,199,355,406,433],"respons\u00e1veis":[144],"pela":[145,281],"regula\u00e7\u00e3o":[146,308,319,382],"Para":[149,379],"isso":[150],"analisamos":[151],"altera\u00e7\u00f5es":[152],"na":[153,318],"express\u00e3o":[154,256,271,297,331,369,385],"genes":[156],"relacionados":[157],"com":[158,167,175],"angiog\u00e9nico":[161],"popula\u00e7\u00f5es":[163],"4T1":[166,239,337],"sobrexpress\u00e3o":[168,261],"transfec\u00e7\u00e3o":[173],"transiente":[174],"plasm\u00eddeo":[177],"permite":[179],"co-express\u00e3o":[181],"prote\u00edna":[186,333],"reporter":[187],"mCherry.":[188],"A":[189,295],"an\u00e1lise":[190],"PCR-array":[192],"permitiu":[193],"v\u00e1rios":[195],"alvos":[196],"putativos":[197],"incluindo":[200,209],"efectores":[201],"via":[203,268],"Notch":[204],"v\u00e1rias":[206],"mol\u00e9culas":[207,371],"antiangiog\u00e9nicas":[208],"inibidor":[211,225],"espec\u00edfico":[214],"c\u00e9rebro":[216],"1":[217,221],"(Bai1),":[218],"Trombospondina":[220],"(Thbs1)":[222],"metaloproteinase":[227],"3":[228],"(Timp3).":[229],"Foi":[230],"observado":[231,392],"hibrida\u00e7\u00e3o":[233],"in":[234],"situ":[235],"as":[237],"expressam":[240],"ligandos":[242],"Dll4":[243],"Jagged1,":[245],"receptor":[247],"Notch3":[248],"efector":[251],"Hes1":[252],"mas":[253],"sua":[255],"parece":[257],"ser":[258,279],"independente":[259,312,376],"cat\u00e1lase.":[263],"Contrariamente":[264],"aos":[265],"componentes":[266],"Notch,":[269],"das":[272],"prote\u00ednas":[273,310,387],"Thbs1":[274],"Timp3":[277],"mostraram":[278,350],"regulados":[280],"forma":[287,292,375],"n\u00e3o-aut\u00f3noma":[288],"aut\u00f3noma,":[293],"respectivamente.":[294],"baixa":[296],"HIF-1\u03b1":[299],"nas":[300,335,356],"condi\u00e7\u00f5es":[301],"experimentais":[302],"deste":[303,313],"trabalho":[304,349,398],"indica":[305],"destas":[309],"factor":[314],"transcri\u00e7\u00e3o":[316],"chave":[317],"reguladores":[322],"Verificou-se":[325],"tamb\u00e9m":[326],"Bai1":[334],"s\u00e3o":[338],"demasiado":[339],"baixos":[340],"impossibilitando":[341],"estudos":[343],"subsequentes.":[344],"Os":[345],"resultados":[346],"obtidos":[347],"neste":[348],"tumorais":[358,411],"capaz":[360,413],"regular":[362],"modela\u00e7\u00e3o":[367],"anti-angiog\u00e9nicas,":[372],"HIF-1\u03b1.":[378],"al\u00e9m":[380],"aut\u00f3noma":[383],"pelo":[388],"efeito":[390],"j\u00e1":[391],"anteriormente":[393],"outros":[395],"autores,":[396],"este":[397],"revela":[399],"altera\u00e7\u00e3o":[402],"numa":[407],"subpopula\u00e7\u00e3o":[408],"condicionar":[415],"resposta":[417],"angiog\u00e9nica":[418],"global":[419],"mecanismo":[423],"n\u00e3o-aut\u00f3nomo.":[424],"Assim":[425],"conhecimento":[427],"torna-se":[434],"essencial":[435],"terapias":[440],"mais":[441],"eficazes":[442],"contra":[443],"cancro.":[445]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
