{"id":"https://openalex.org/W2177683036","doi":null,"title":"Association and functional studies on promoter polymorphisms within the apolipoprotein E gene, regarding lipid metabolism and atherosclerosis","display_name":"Association and functional studies on promoter polymorphisms within the apolipoprotein E gene, regarding lipid metabolism and atherosclerosis","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2177683036","mag":"2177683036"},"language":"en","primary_location":{"id":"pmh:oai:trepo.tuni.fi:10024/67859","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67859","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67859/1/978-951-44-7354-8.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://trepo.tuni.fi/bitstream/10024/67859/1/978-951-44-7354-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072289816","display_name":"Leena E. Viiri","orcid":"https://orcid.org/0000-0003-2279-0392","observed_orcids":["https://orcid.org/0000-0003-2279-0392"]},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Leena E. Viiri","raw_affiliation_strings":["UNIVERSITY OF TAMPERE"],"raw_orcid":"https://orcid.org/0000-0003-2279-0392","affiliations":[{"raw_affiliation_string":"UNIVERSITY OF TAMPERE","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072289816"],"corresponding_institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4387153886"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e-gene","display_name":"apolipoprotein E gene","score":0.8970000147819519},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.8930000066757202},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7799999713897705},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9620000123977661},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.6349999904632568},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.5979999899864197},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.7129999995231628},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.49900001287460327},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4309999942779541},{"id":"https://openalex.org/keywords/apoe-genotype","display_name":"APOE genotype","score":0.4000000059604645},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.5080000162124634},{"id":"https://openalex.org/keywords/finnish-population","display_name":"Finnish population","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.9368249177932739},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5534154772758484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5089473724365234},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.49933314323425293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48181238770484924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44776496291160583},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.42195743322372437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3742690682411194},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3599628806114197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34527772665023804},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3078152537345886},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07853671908378601}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:trepo.tuni.fi:10024/67859","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67859","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67859/1/978-951-44-7354-8.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"pmh:oai:tampub.uta.fi:10024/67859","doi":null,"is_oa":false,"landing_page_url":"http://tampub.uta.fi/handle/10024/67859","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"mag:2177683036","doi":null,"is_oa":false,"landing_page_url":"https://trepo.tuni.fi/bitstream/10024/67859/1/978-951-44-7354-8.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:trepo.tuni.fi:10024/67859","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67859","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67859/1/978-951-44-7354-8.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309883","display_name":"Foundation for Cardiovascular Research","ror":"https://ror.org/0393a9736"},{"id":"https://openalex.org/F4320310751","display_name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0593mby10"},{"id":"https://openalex.org/F4320311795","display_name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0574hzg66"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322305","display_name":"Juho Vainion S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/05jf66d94"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320323333","display_name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/020apt798"},{"id":"https://openalex.org/F4320326518","display_name":"Tays","ror":"https://ror.org/02hvt5f17"},{"id":"https://openalex.org/F4320331826","display_name":"Turun Yliopistos\u00e4\u00e4ti\u00f6","ror":"https://ror.org/02kjggt26"},{"id":"https://openalex.org/F4320335025","display_name":"Pirkanmaan Rahasto","ror":"https://ror.org/027xav248"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2177683036.pdf","grobid_xml":"https://content.openalex.org/works/W2177683036.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1037053322","https://openalex.org/W1483346790","https://openalex.org/W1489901721","https://openalex.org/W1928577537","https://openalex.org/W1948965777","https://openalex.org/W1965849733","https://openalex.org/W1979485513","https://openalex.org/W1985859760","https://openalex.org/W2003854546","https://openalex.org/W2007624510","https://openalex.org/W2010923817","https://openalex.org/W2010963174","https://openalex.org/W2034343264","https://openalex.org/W2035914863","https://openalex.org/W2036468300","https://openalex.org/W2047923046","https://openalex.org/W2049691341","https://openalex.org/W2055079541","https://openalex.org/W2058762551","https://openalex.org/W2061503084","https://openalex.org/W2066949598","https://openalex.org/W2070721758","https://openalex.org/W2076169759","https://openalex.org/W2083878136","https://openalex.org/W2084110368","https://openalex.org/W2088036472","https://openalex.org/W2100023507","https://openalex.org/W2106611664","https://openalex.org/W2109501834","https://openalex.org/W2110755408","https://openalex.org/W2116404316","https://openalex.org/W2118356043","https://openalex.org/W2119504151","https://openalex.org/W2124927788","https://openalex.org/W2127259777","https://openalex.org/W2127260761","https://openalex.org/W2129148616","https://openalex.org/W2133591735","https://openalex.org/W2136392032","https://openalex.org/W2139110550","https://openalex.org/W2141583641","https://openalex.org/W2143112632","https://openalex.org/W2154971149","https://openalex.org/W2171284332","https://openalex.org/W2186194609","https://openalex.org/W2316167515","https://openalex.org/W2343863031","https://openalex.org/W2413601010"],"related_works":["https://openalex.org/W2278579017","https://openalex.org/W2969666205","https://openalex.org/W2044862084","https://openalex.org/W2555847875","https://openalex.org/W2376977079","https://openalex.org/W2072211953","https://openalex.org/W3144697573","https://openalex.org/W2092074084","https://openalex.org/W2472908927","https://openalex.org/W2393587286"],"abstract_inverted_index":{"Ateroskleroosissa":[0],"eli":[1,68,82,195,206],"valtimonkovettumataudissa":[2],"valtimon":[3],"sein\u00e4m\u00e4\u00e4n":[4],"kertyy":[5],"v\u00e4hitellen":[6,14],"rasvat\u00e4ytteisi\u00e4":[7],"vaahtosoluja,":[8],"fibroottista":[9],"soluv\u00e4liainetta":[10],"ja":[11,23,42,107,116,137,147,158,183,198,237,255,294,313],"kalkkeutumia,":[12],"jotka":[13,101,245],"muodostavat":[15],"verisuonta":[16],"tukkivan":[17],"aterooman.":[18],"T\u00e4m\u00e4":[19],"on":[20,55,63,72,97,240,299,310],"perusta":[21],"sepel-":[22],"aivovaltimoiden":[24],"kovettumataudin":[25],"kehittymiselle.":[26],"Ateroskleroosin":[27],"riski\u00e4":[28],"lis\u00e4\u00e4v\u00e4t":[29],"monet":[30],"eri":[31],"tekij\u00e4t":[32,45],"kuten":[33,46,291],"korkea":[34,37,40],"ik\u00e4,":[35],"miessukupuoli,":[36],"verenpaine,":[38],"tupakointi,":[39],"LDL-kolesteroli":[41],"er\u00e4\u00e4t":[43],"geneettiset":[44],"apolipoproteiini":[47],"E":[48,53],"geenin":[49,95,105,132,166,212],"(APOE)":[50],"\u03b54-alleeli.":[51],"Apolipoproteiini":[52],"(apoE)":[54],"rasvojen":[56],"kuljetukseen":[57],"osallistuva":[58],"proteiini,":[59],"jota":[60],"koodittavasta":[61],"geenist\u00e4":[62],"l\u00f6ydetty":[64],"useita":[65,99],"muuntelevia":[66],"kohtia":[67],"polymorfioita.":[69],"Tunnetuin":[70],"n\u00e4ist\u00e4":[71],"\u03b52/\u03b53/\u03b5-4-alleelien":[73],"muuntelu,":[74],"jonka":[75,287],"seurauksena":[76],"voi":[77],"synty\u00e4":[78],"kuusi":[79],"erilaista":[80],"alleeli-yhdistelm\u00e4\u00e4":[81],"genotyyppi\u00e4.":[83],"Yleisint\u00e4":[84],"APOE":[85,94,131,153,165,171,211,264],"genotyyppi\u00e4":[86],"\u03b53/\u03b53":[87],"kantaa":[88],"noin":[89],"60":[90],"%":[91],"suomalaisista.":[92],"My\u00f6s":[93],"s\u00e4\u00e4telyalueelta":[96],"tunnistettu":[98],"polymorfioita,":[100],"voivat":[102],"vaikuttaa":[103],"esimerkiksi":[104],"luentaan":[106],"sit\u00e4":[108],"kautta":[109],"apoE-proteiinin":[110],"m\u00e4\u00e4r\u00e4\u00e4n":[111],"verenkierrossa.\\n\\nV\u00e4it\u00f6skirjaty\u00f6ss\u00e4":[112],"k\u00e4ytettiin":[113],"kolmea":[114],"kliinist\u00e4":[115],"kahta":[117],"ruumiinavausaineistoa,":[118],"joista":[119,318],"tutkittiin":[120,151],"yhteens\u00e4":[121],"yli":[122],"2500":[123],"henkil\u00f6\u00e4.":[124],"Tarkoituksena":[125],"oli":[126,175,250,276],"selvitt\u00e4\u00e4":[127],"assosiaatioanalyysin":[128],"avulla,":[129],"yhdistyv\u00e4tk\u00f6":[130],"s\u00e4\u00e4telyalueen":[133,167,179,213],"kaksi":[134],"polymorfiaa":[135],"-219G/T":[136],"+113G/C":[138,192,308],"seerumin":[139,216],"lipoproteiinitasoihin,":[140],"kaulavaltimoiden":[141],"varhaisiin":[142],"ateroskleroottisiin":[143],"muutoksiin":[144],"sek\u00e4":[145],"aivoinfarkti-":[146],"aivoateroskleroosiriskiin.":[148],"Viimeisess\u00e4":[149],"osaty\u00f6ss\u00e4":[150],"my\u00f6s":[152,189,305],"geeni-tupakointi":[154],"interaktion":[155],"yhteytt\u00e4":[156],"sepelvaltimoiden":[157],"vatsa-aortan":[159,266,278],"rasvajuosteiden":[160,267],"pinta-alaan.":[161],"Ty\u00f6ss\u00e4":[162],"keskityttiin":[163],"tutkimaan":[164],"polymorfioita":[168],"kaikista":[169],"yleisimm\u00e4n":[170],"\u03b53/\u03b53-genotyyppiryhm\u00e4n":[172],"sis\u00e4ll\u00e4.":[173],"Siten":[174],"mahdollista":[176],"keskitty\u00e4":[177],"etsim\u00e4\u00e4n":[178],"polymorfioiden":[180],"itsen\u00e4isi\u00e4":[181],"vaikutuksia":[182],"neutraloida":[184],"\u03b52/\u03b53/\u03b54-":[185],"muuntelun":[186],"vaikutus.":[187],"Haluttiin":[188],"selvitt\u00e4\u00e4,":[190],"vaikuttaako":[191],"polymorfia":[193],"geeniluennan":[194],"transkription":[196],"tehokkuuteen":[197],"sitooko":[199],"alue":[200],"mahdollisesti":[201],"joitain":[202],"transkriptioon":[203],"vaikuttavia":[204],"s\u00e4\u00e4telyproteiineja":[205],"transkriptiotekij\u00f6it\u00e4.\\n\\nTulokset":[207],"osoittivat,":[208],"ett\u00e4":[209,235,307,314],"tutkitut":[210],"polymorfiat":[214],"yhdistyv\u00e4t":[215],"lipoproteiinitasoihin":[217],"niin":[218],"poikkileikkaus-":[219],"kuin":[220,280],"pitkitt\u00e4istutkimuksessakin":[221],"(21-vuotisseurantatutkimus)":[222],"mutta":[223],"ne":[224],"eiv\u00e4t":[225],"silti":[226],"selitt\u00e4neet":[227],"kaulavaltimon":[228],"varhaisia":[229],"ateroskleroottisia":[230],"muutoksia.":[231],"Kuitenkin":[232],"voitiin":[233],"osoittaa,":[234],"-219G-":[236],"+113G-alleelien":[238],"kantajilla":[239],"kohonnut":[241],"aivoinfarktiriski.":[242],"Toisaalta":[243],"miehill\u00e4,":[244],"kantoivat":[246],"-219T-":[247],"tai":[248,272],"+113C-alleelia":[249],"vaikeampi":[251],"aivoateroskleroosi":[252],"verrattuna":[253],"-219G/G":[254],"+113G/G":[256],"genotyyppien":[257],"kantajiin.":[258],"Tutkimuksessa":[259],"tuli":[260],"esille":[261],"mielenkiintoinen":[262],"havainto":[263],"geeni-tupakointi-interaktiosta":[265],"suhteen:":[268],"tiettyjen":[269],"genotyyppiryhmien":[270],"(-219G/G":[271],"+113G/G)":[273],"sis\u00e4ll\u00e4":[274],"tupakoitsijoilla":[275],"suuremmat":[277],"rasvajuosteet":[279],"ei-tupakoitsijoilla.":[281],"N\u00e4m\u00e4":[282],"tulokset":[283],"siis":[284],"vahvistavat":[285],"k\u00e4sityst\u00e4,":[286],"mukaan":[288],"monitekij\u00e4isiss\u00e4":[289],"sairauksissa":[290],"ateroskleroosissa,":[292],"geenien":[293],"ymp\u00e4rist\u00f6n":[295],"v\u00e4linen":[296],"monimutkainen":[297],"vuorovaikutus":[298],"t\u00e4rke\u00e4":[300],"tekij\u00e4":[301],"taudin":[302],"kehittymisess\u00e4.":[303],"Pystyttiin":[304],"osoittamaan,":[306],"polymorfialla":[309],"vaikutusta":[311],"geenitranskriptioon":[312],"se":[315],"sitoo":[316],"transkriptiotekij\u00f6it\u00e4,":[317],"yhdeksi":[319],"mahdolliseksi":[320],"tunnistettiin":[321],"RBP-J\u03ba.":[322]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}