{"id":"https://openalex.org/W2177640580","doi":"https://doi.org/10.1210/en.2015-1673","title":"Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons","display_name":"Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons","publication_year":2015,"publication_date":"2015-09-24","ids":{"openalex":"https://openalex.org/W2177640580","doi":"https://doi.org/10.1210/en.2015-1673","mag":"2177640580","pmid":"https://pubmed.ncbi.nlm.nih.gov/26402844","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4655217"},"language":"en","primary_location":{"id":"doi:10.1210/en.2015-1673","doi":"https://doi.org/10.1210/en.2015-1673","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2015-1673","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4655217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053058372","display_name":"Yuncai Chen","orcid":"https://orcid.org/0000-0002-4862-3704","observed_orcids":["https://orcid.org/0000-0002-4862-3704","https://orcid.org/0000-0003-4304-9034"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuncai Chen","raw_affiliation_strings":["Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","Departments of Pediatrics (Y.C., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Departments of Pediatrics (Y.C., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053425014","display_name":"Jenny Molet","orcid":"https://orcid.org/0000-0001-6997-6712","observed_orcids":["https://orcid.org/0000-0001-6997-6712"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Molet","raw_affiliation_strings":["Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054542246","display_name":"Benjamin G. Gunn","orcid":"https://orcid.org/0000-0002-3598-9977","observed_orcids":["https://orcid.org/0000-0002-3598-9977"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin G. Gunn","raw_affiliation_strings":["Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","Departments of Pediatrics (Y.C., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Departments of Pediatrics (Y.C., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073581575","display_name":"Kerry James Ressler","orcid":"https://orcid.org/0000-0002-5158-1103","observed_orcids":["https://orcid.org/0000-0002-5158-1103"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerry Ressler","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences (K.R.), Emory University, Atlanta, Georgia 30322-4250"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences (K.R.), Emory University, Atlanta, Georgia 30322-4250","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051388310","display_name":"Tallie Z. Baram","orcid":"https://orcid.org/0000-0003-0771-8616","observed_orcids":["https://orcid.org/0000-0003-0771-8616"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tallie Z. Baram","raw_affiliation_strings":["Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","Departments of Pediatrics (Y.C., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy/Neurobiology (Y.C., J.M., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Departments of Pediatrics (Y.C., B.G.G., T.Z.B.), University of California, Irvine, Irvine, California 92697-4475","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051388310","https://openalex.org/A5053058372"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":5.0461,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.96930074,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"156","issue":"12","first_page":"4769","last_page":"4780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/transgenic-mouse-lines","display_name":"transgenic mouse lines","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tdtomato","display_name":"tdTomato","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cre-loxp-system","display_name":"Cre-loxP system","score":0.36899998784065247},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bed-nucleus-of-the-stria-terminalis","display_name":"bed nucleus of the stria terminalis","score":0.972000002861023},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.724657416343689},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.6935540437698364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6625945568084717},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6525413990020752},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5383725166320801},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5114701986312866},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40583547949790955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39949655532836914},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3920106291770935},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.37500882148742676},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.2430066466331482},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.201584130525589},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10971274971961975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.060442954301834106}],"mesh":[{"descriptor_ui":"D000067556","descriptor_name":"Internal Ribosome Entry Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010286","descriptor_name":"Paraventricular Hypothalamic Nucleus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010286","descriptor_name":"Paraventricular Hypothalamic Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012686","descriptor_name":"Septal Nuclei","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1210/en.2015-1673","doi":"https://doi.org/10.1210/en.2015-1673","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2015-1673","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4655217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4655217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:26402844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26402844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt5r06v9kb","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5r06v9kb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology, vol 156, iss 12","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1g45w7nv","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1g45w7nv","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5r06v9kb","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5r06v9kb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology, vol 156, iss 12","raw_type":"article"},{"id":"mag:2977401936","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt1g45w7nv/qt1g45w7nv.pdf?t=pwzthx","pdf_url":null,"source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Neuropsychopharmacology","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4655217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4655217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1118057587","display_name":null,"funder_award_id":"NS 28912","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1418461711","display_name":"Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities","funder_award_id":"P50MH096889","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2866947254","display_name":"CRH in stress-induced hippocampal neuroplasticity","funder_award_id":"R01NS028912","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4041544287","display_name":null,"funder_award_id":"MH73136","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8131357280","display_name":"Effects of Early-Life Experience: Role of CRH","funder_award_id":"R01MH073136","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1509046486","https://openalex.org/W1662235811","https://openalex.org/W1931443173","https://openalex.org/W1965337556","https://openalex.org/W1977630276","https://openalex.org/W1994143964","https://openalex.org/W1999989426","https://openalex.org/W2002542669","https://openalex.org/W2004846311","https://openalex.org/W2009259412","https://openalex.org/W2009486024","https://openalex.org/W2010704206","https://openalex.org/W2013391829","https://openalex.org/W2014554123","https://openalex.org/W2015034616","https://openalex.org/W2017400430","https://openalex.org/W2017495352","https://openalex.org/W2023989159","https://openalex.org/W2025299701","https://openalex.org/W2026763299","https://openalex.org/W2029988864","https://openalex.org/W2031394080","https://openalex.org/W2037823544","https://openalex.org/W2037940663","https://openalex.org/W2040574649","https://openalex.org/W2045649095","https://openalex.org/W2046818677","https://openalex.org/W2050558334","https://openalex.org/W2051089361","https://openalex.org/W2051370124","https://openalex.org/W2056072979","https://openalex.org/W2061622320","https://openalex.org/W2064055939","https://openalex.org/W2064910482","https://openalex.org/W2067203693","https://openalex.org/W2072531628","https://openalex.org/W2076443641","https://openalex.org/W2078682888","https://openalex.org/W2080496806","https://openalex.org/W2087164445","https://openalex.org/W2088468969","https://openalex.org/W2101607104","https://openalex.org/W2106505481","https://openalex.org/W2107970169","https://openalex.org/W2109242838","https://openalex.org/W2112336919","https://openalex.org/W2112374693","https://openalex.org/W2119951209","https://openalex.org/W2138655843","https://openalex.org/W2140986639","https://openalex.org/W2141682070","https://openalex.org/W2144159889","https://openalex.org/W2162743207","https://openalex.org/W2175205943","https://openalex.org/W7098068180"],"related_works":["https://openalex.org/W2112336919","https://openalex.org/W2893479903","https://openalex.org/W2747883516","https://openalex.org/W2037940663","https://openalex.org/W2013391829","https://openalex.org/W4405544361","https://openalex.org/W4415697198","https://openalex.org/W2084255057","https://openalex.org/W7034537969","https://openalex.org/W2066423352"],"abstract_inverted_index":{"Transgenic":[0],"mice,":[1,154,177,199],"including":[2,129],"lines":[3],"targeting":[4],"corticotropin-releasing":[5],"factor":[6],"(CRF":[7],"or":[8,208],"CRH),":[9],"have":[10],"been":[11],"extensively":[12],"employed":[13,108],"to":[14,23],"study":[15],"stress":[16],"neurobiology.":[17],"These":[18,213,231],"powerful":[19],"tools":[20],"are":[21],"poised":[22],"revolutionize":[24],"our":[25],"understanding":[26],"of":[27,32,39,48,61,79,134,142,179,203,221,245],"the":[28,36,62,109,124,135,159,162,182,200,243],"localization":[29],"and":[30,35,43,65,91,104,138,149,173,181,223],"connectivity":[31],"CRH-expressing":[33,156],"neurons,":[34],"crucial":[37],"roles":[38],"CRH":[40,90,110,144,180,207,225],"in":[41,95,170,186,192,218,236],"normal":[42],"pathological":[44],"conditions.":[45],"Accurate":[46],"interpretation":[47],"studies":[49],"using":[50,119],"cell":[51],"type-specific":[52],"transgenic":[53,98,150,229],"mice":[54],"vitally":[55],"depends":[56],"on":[57,126],"congruence":[58],"between":[59],"expression":[60,69,93,220],"endogenous":[63,143,224],"peptide":[64],"reporter.":[66],"If":[67],"reporter":[68,92,163,183,222],"does":[70],"not":[71],"faithfully":[72],"reproduce":[73],"native":[74],"gene":[75],"expression,":[76],"then":[77],"effects":[78],"manipulating":[80],"unintentionally":[81],"targeted":[82],"cells":[83,169],"may":[84],"be":[85,234],"misattributed.":[86],"Here,":[87],"we":[88],"studied":[89],"patterns":[94,141],"3":[96,227],"adult":[97],"mice:":[99],"Crh-IRES-Cre;Ai14":[100],"(tdTomato":[101],"mouse),":[102],"Crfp3.0CreGFP,":[103],"Crh-GFP":[105,197],"BAC.":[106],"We":[107,122],"antiserum":[111],"generated":[112],"by":[113],"Vale":[114],"after":[115],"validating":[116],"its":[117],"specificity":[118],"CRH-null":[120],"mice.":[121,151,230],"focused":[123],"analyses":[125],"stress-salient":[127],"regions,":[128],"hypothalamus,":[130],"amygdala,":[131],"bed":[132],"nucleus":[133],"stria":[136],"terminalis,":[137],"hippocampus.":[139],"Expression":[140],"were":[145],"consistent":[146],"among":[147,226],"wild-type":[148],"In":[152,175,196],"tdTomato":[153],"most":[155],"neurons":[157,204],"coexpressed":[158],"reporter,":[160,209],"yet":[161],"identified":[164],"a":[165],"few":[166],"non-CRH-expressing":[167],"pyramidal-like":[168],"hippocampal":[171],"CA1":[172],"CA3.":[174],"Crfp3.0CreGFP":[176],"coexpression":[178],"was":[184],"found":[185],"central":[187],"amygdala":[188],"and,":[189],"less":[190],"commonly,":[191],"other":[193],"evaluated":[194],"regions.":[195],"BAC":[198],"large":[201],"majority":[202],"expressed":[205],"either":[206],"with":[210],"little":[211],"overlap.":[212],"data":[214],"highlight":[215],"significant":[216],"diversity":[217],"concordant":[219],"available":[228],"findings":[232,240],"should":[233],"instrumental":[235],"interpreting":[237],"important":[238],"scientific":[239],"emerging":[241],"from":[242],"use":[244],"these":[246],"potent":[247],"neurobiological":[248],"tools.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}