{"id":"https://openalex.org/W2177476941","doi":"https://doi.org/10.1242/jcs.91.2.313","title":"In vitro modulation of endothelial fenestrae: Opposing effects of retinoic acid and transforming grow h factor \u03b2","display_name":"In vitro modulation of endothelial fenestrae: Opposing effects of retinoic acid and transforming grow h factor \u03b2","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W2177476941","doi":"https://doi.org/10.1242/jcs.91.2.313","mag":"2177476941","pmid":"https://pubmed.ncbi.nlm.nih.gov/3267700"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.91.2.313","doi":"https://doi.org/10.1242/jcs.91.2.313","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.91.2.313","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081766337","display_name":"Tommaso Lombardi","orcid":"https://orcid.org/0000-0001-9347-3736","observed_orcids":["https://orcid.org/0000-0001-9347-3736"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"T. Lombardi","raw_affiliation_strings":["University of Geneva Medical School, 1211 Geneva 4 1 institute of Histology and Embryology , , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Geneva Medical School, 1211 Geneva 4 1 institute of Histology and Embryology , , Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053740828","display_name":"Roberto Montesano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R. Montesano","raw_affiliation_strings":["University of Geneva Medical School, 1211 Geneva 4 1 institute of Histology and Embryology , , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Geneva Medical School, 1211 Geneva 4 1 institute of Histology and Embryology , , Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111886652","display_name":"Martha B. Furie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"M. B. Furie","raw_affiliation_strings":["State University of New York, Stony Brook 2 Department of Pathology , , NY 11794, USA","Institute of Histology and Embryology, University of Geneva Medical School, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York, Stony Brook 2 Department of Pathology , , NY 11794, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva Medical School, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113836046","display_name":"Samuel C. Silverstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"S. C. Silverstein","raw_affiliation_strings":["Columbia University, NY 10032 3 Department of Physiology and Cellular Biophysics , , USA","Institute of Histology and Embryology, University of Geneva Medical School, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, NY 10032 3 Department of Physiology and Cellular Biophysics , , USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva Medical School, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034171652","display_name":"Lelio Orci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"L. Orci","raw_affiliation_strings":["University of Geneva Medical School, 1211 Geneva 4 1 institute of Histology and Embryology , , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Geneva Medical School, 1211 Geneva 4 1 institute of Histology and Embryology , , Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2539,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.80114998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"91","issue":"2","first_page":"313","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-fenestrae","display_name":"endothelial fenestrae","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fenestrated-capillaries","display_name":"fenestrated capillaries","score":0.8859999775886536},{"id":"https://openalex.org/keywords/endothelial-cell-differentiation","display_name":"endothelial differentiation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.9200000166893005},{"id":"https://openalex.org/keywords/capillary-endothelium","display_name":"capillary endothelium","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8866554498672485},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7908035516738892},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6746511459350586},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6386158466339111},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5624370574951172},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5446675419807434},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5382354855537415},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5319260358810425},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4920317828655243},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.22612696886062622},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21003592014312744},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1206318736076355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05928105115890503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005614","descriptor_name":"Freeze Fracturing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1242/jcs.91.2.313","doi":"https://doi.org/10.1242/jcs.91.2.313","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.91.2.313","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:3267700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3267700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W142482983","https://openalex.org/W395192615","https://openalex.org/W646584774","https://openalex.org/W1480727199","https://openalex.org/W1481944906","https://openalex.org/W1506352984","https://openalex.org/W1521909328","https://openalex.org/W1524114372","https://openalex.org/W1566360505","https://openalex.org/W1904616042","https://openalex.org/W1965094170","https://openalex.org/W1968997237","https://openalex.org/W1975173778","https://openalex.org/W1980235826","https://openalex.org/W1987445229","https://openalex.org/W1987726188","https://openalex.org/W1993266399","https://openalex.org/W1993641339","https://openalex.org/W1998454879","https://openalex.org/W1999340769","https://openalex.org/W1999635909","https://openalex.org/W2007768242","https://openalex.org/W2013456954","https://openalex.org/W2018650295","https://openalex.org/W2020774254","https://openalex.org/W2022196977","https://openalex.org/W2035819392","https://openalex.org/W2037817950","https://openalex.org/W2055305230","https://openalex.org/W2055696022","https://openalex.org/W2057898381","https://openalex.org/W2058168835","https://openalex.org/W2065418754","https://openalex.org/W2075178323","https://openalex.org/W2083153927","https://openalex.org/W2087863947","https://openalex.org/W2092222240","https://openalex.org/W2101467051","https://openalex.org/W2108104357","https://openalex.org/W2121621281","https://openalex.org/W2137518304","https://openalex.org/W2139741936","https://openalex.org/W2146857566","https://openalex.org/W2150404521","https://openalex.org/W2158952440","https://openalex.org/W2169048611","https://openalex.org/W2196524012","https://openalex.org/W2312235522","https://openalex.org/W2327005458","https://openalex.org/W2402330440","https://openalex.org/W2413226263","https://openalex.org/W2502955353","https://openalex.org/W2917236252"],"related_works":["https://openalex.org/W1989172121","https://openalex.org/W2022196977","https://openalex.org/W2052351740","https://openalex.org/W2112726396","https://openalex.org/W1984172347","https://openalex.org/W2006541103","https://openalex.org/W2403774597","https://openalex.org/W2022034062","https://openalex.org/W1968577782","https://openalex.org/W2396004575"],"abstract_inverted_index":{"Cultured":[0],"endothelial":[1,48,74,104],"cells":[2],"isolated":[3],"from":[4],"fenestrated":[5],"capillaries":[6],"express":[7],"many":[8],"properties":[9],"characteristic":[10],"of":[11,20,24,44,55,73,94,103,126,129],"their":[12],"in":[13,46,69,90,123,132],"vivo":[14],"differentiated":[15],"phenotype,":[16],"including":[17],"the":[18,41,56,70,91,101,124],"formation":[19],"a":[21,64,87],"limited":[22],"number":[23],"fenestrae.":[25],"In":[26],"this":[27],"study,":[28],"we":[29],"have":[30,51],"investigated":[31],"whether":[32],"physiological":[33,112],"factors":[34],"that":[35,53,100,116],"control":[36],"cell":[37],"differentiation":[38],"might":[39],"regulate":[40],"surface":[42,71,92],"density":[43,72,93,128],"fenestrae":[45,105],"capillary":[47,130],"cells.":[49],"We":[50],"found":[52],"treatment":[54],"cultures":[57],"with":[58],"retinoic":[59],"acid":[60],"(10":[61],"microM)":[62],"induces":[63],"more":[65],"than":[66],"threefold":[67],"increase":[68],"fenestrae,":[75],"whereas":[76],"transforming":[77],"growth":[78],"factor":[79],"beta":[80,120],"(TGF":[81],"beta)":[82],"(2":[83],"ng":[84],"ml-1)":[85],"causes":[86],"sevenfold":[88],"decrease":[89],"these":[95],"structures.":[96],"These":[97],"results":[98],"show":[99],"expression":[102],"is":[106],"susceptible":[107],"to":[108],"bidirectional":[109],"modulation":[110],"by":[111],"signals,":[113],"and":[114,118],"suggest":[115],"retinoids":[117],"TGF":[119],"may":[121],"participate":[122],"regulation":[125],"fenestral":[127],"endothelium":[131],"vivo.":[133]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
