{"id":"https://openalex.org/W2177447453","doi":null,"title":"[Therapy with dehidroepiandrosterone improves symptoms in perimenopausal women].","display_name":"[Therapy with dehidroepiandrosterone improves symptoms in perimenopausal women].","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2177447453","mag":"2177447453","pmid":"https://pubmed.ncbi.nlm.nih.gov/21966763"},"language":"es","primary_location":{"id":"pmid:21966763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21966763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ginecologia y obstetricia de Mexico","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111447127","display_name":"Marcelino Hern\u00e1ndez Valencia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Marcelino Hern\u00e1ndez Valencia","raw_affiliation_strings":["Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Centro M\u00e9dico Nacional, Instituto Mexicano del Seguro Social, DF M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Centro M\u00e9dico Nacional, Instituto Mexicano del Seguro Social, DF M\u00e9xico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014283313","display_name":"Leobardo \u00c1ngeles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leobardo Angeles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056299326","display_name":"Renata Saucedo","orcid":"https://orcid.org/0000-0001-5167-6156","observed_orcids":["https://orcid.org/0000-0001-5167-6156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renata Saucedo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087556155","display_name":"Lourdes Basurto","orcid":"https://orcid.org/0000-0002-2991-0433","observed_orcids":["https://orcid.org/0000-0002-2991-0433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lourdes Basurto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020605086","display_name":"Arturo Z\u00e1rate","orcid":"https://orcid.org/0000-0003-3606-0390","observed_orcids":["https://orcid.org/0000-0003-3606-0390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arturo Z\u00e1rate","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"5","first_page":"245","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.972000002861023},{"id":"https://openalex.org/keywords/dhea-supplementation","display_name":"DHEA supplementation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/perimenopause","display_name":"perimenopause","score":0.9829999804496765},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.8370000123977661},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.8930000066757202},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8029999732971191},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.6959999799728394},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dhea-sulfate","display_name":"DHEA sulfate","score":0.8529999852180481},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7173558473587036},{"id":"https://openalex.org/C198454886","wikidata":"https://www.wikidata.org/wiki/Q1431745","display_name":"Climacteric","level":3,"score":0.6970273852348328},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.6840113401412964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5818498134613037},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5282917022705078},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5196972489356995},{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.5101795196533203},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.48715493083000183},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.48173025250434875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4677177965641022},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.44655174016952515},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.4438965618610382},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.43901675939559937},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.4208296835422516},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33116644620895386},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2664297819137573},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1934400200843811},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.1336149275302887},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.09909141063690186},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000342","descriptor_name":"Affective Symptoms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000342","descriptor_name":"Affective Symptoms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019314","descriptor_name":"Dehydroepiandrosterone Sulfate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019584","descriptor_name":"Hot Flashes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D047648","descriptor_name":"Perimenopause","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21966763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21966763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ginecologia y obstetricia de Mexico","raw_type":"Comparative Study"},{"id":"mag:2177447453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21966763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1968546477","https://openalex.org/W1970025509","https://openalex.org/W1985168335","https://openalex.org/W1998635062","https://openalex.org/W1999200355","https://openalex.org/W2005656145","https://openalex.org/W2007276566","https://openalex.org/W2012761038","https://openalex.org/W2037938885","https://openalex.org/W2058350561","https://openalex.org/W2086838075","https://openalex.org/W2102346853","https://openalex.org/W2114438201","https://openalex.org/W2124079471","https://openalex.org/W2130095506","https://openalex.org/W2138758697","https://openalex.org/W2413003133"],"related_works":["https://openalex.org/W2005656145","https://openalex.org/W1965260099","https://openalex.org/W2083072190","https://openalex.org/W2150341741","https://openalex.org/W1935362226","https://openalex.org/W4387608396","https://openalex.org/W244068227","https://openalex.org/W4392489252","https://openalex.org/W1963724927","https://openalex.org/W3092500006"],"abstract_inverted_index":{"BACKGROUND:":[0],"Depressive":[1],"symptoms":[2,39,127,156],"that":[3],"occur":[4],"with":[5],"the":[6,30,48,81,147,150],"onset":[7],"of":[8,32,40,98,102,115,132,149,154,167],"menopause":[9],"are":[10,21],"accompanied":[11],"by":[12,140],"changes":[13],"in":[14,53,159,231],"circulating":[15,51],"neurotransmitters":[16,52],"levels;":[17],"these":[18],"biochemical":[19],"variations":[20],"considered":[22],"to":[23,122,182,190,200],"cause":[24],"psychoemotional":[25,155],"symptoms.":[26],"OBJECTIVE:":[27],"To":[28],"assess":[29],"effect":[31],"DHEAsupplementation":[33],"and":[34,42,73,93,113,125,128,136,145,171,195,221,224,228],"its":[35],"efficacy":[36],"for":[37,105,110],"relieving":[38],"emotional":[41,124,220],"psychological":[43,126,222],"distress,":[44],"as":[45,47,77],"well":[46],"action":[49],"on":[50],"perimenopausal":[54,66,232],"women.":[55,164,233],"PATIENTS":[56],"AND":[57],"METHODS:":[58],"An":[59],"open,":[60],"comparative,":[61],"clinical":[62],"study":[63],"included":[64],"twenty":[65],"women":[67,75,112],"who":[68],"received":[69],"oral":[70,99],"DHEA":[71,100,218],"doses":[72,101],"ten":[74],"acted":[76],"comparison":[78],"group.":[79],"SETTING:":[80],"Endocrine":[82],"Research":[83],"Unit,":[84],"Instituto":[85],"Mexicano":[86],"del":[87],"Seguro":[88],"Social,":[89],"Mexico":[90],"City.":[91],"Interventions":[92],"main":[94],"outcome":[95],"measures":[96],"consisted":[97],"50":[103],"mg/day":[104],"six":[106],"months.":[107],"Green":[108],"scale":[109],"climacteric":[111],"Quality":[114],"Life":[116],"Menopause":[117],"Scale":[118],"(QUALMS)":[119],"were":[120,138,215],"used":[121],"measure":[123],"well-being.":[129],"Serum":[130],"levels":[131,166,214,230],"DHEA-S,":[133,169],"dopamine,":[134],"serotonin,":[135],"beta-endorphin":[137,172,229],"quantified":[139],"specific":[141],"assays":[142],"at":[143,146],"baseline":[144],"end":[148],"treatment.":[151,210],"RESULTS:":[152],"Alleviation":[153],"was":[157],"observed":[158],"all":[160],"but":[161],"4":[162],"treated":[163],"Baseline":[165],"serum":[168],"serotonin":[170,227],"increased":[173],"significantly":[174],"(p":[175],"<":[176],"0.001)":[177],"from":[178,196],"2.1":[179,185,199],"+/-":[180,184,188,198,202,207],"0.5":[181],"8.3":[183],"micromol/L,":[186],"215.3":[187],"86.4":[189],"310.4":[191],"+":[192],"150.1":[193],"ng/mL,":[194],"9.8":[197],"16.2":[201],"7.1":[203],"pmol/L":[204],"respectively":[205],"(means":[206],"SE)":[208],"after":[209],"In":[211],"contrast,":[212],"dopamine":[213],"unchanged.":[216],"CONCLUSIONS:":[217],"relieved":[219],"symptoms,":[223],"elevated":[225],"both":[226]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}