{"id":"https://openalex.org/W2176945815","doi":"https://doi.org/10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","title":"Chromosome Aberrations in the Blood Lymphocytes of Astronauts after Space Flight","display_name":"Chromosome Aberrations in the Blood Lymphocytes of Astronauts after Space Flight","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2176945815","doi":"https://doi.org/10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","mag":"2176945815","pmid":"https://pubmed.ncbi.nlm.nih.gov/11741497"},"language":"en","primary_location":{"id":"doi:10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","doi":"https://doi.org/10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022856162","display_name":"Kerry A. George","orcid":"https://orcid.org/0000-0002-9318-9839","observed_orcids":["https://orcid.org/0000-0002-9318-9839"]},"institutions":[{"id":"https://openalex.org/I2800075897","display_name":"Kelsey-Seybold Clinic","ror":"https://ror.org/0499w7e46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800075897"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. George","raw_affiliation_strings":["Wyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058, USA. kerry.a.george1@jsc.nasa.gov","aWyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058","bKelsey-Seybold Clinic, Building 8, Johnson Space Center, Houston, Texas 77058"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058, USA. kerry.a.george1@jsc.nasa.gov","institution_ids":[]},{"raw_affiliation_string":"aWyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058","institution_ids":[]},{"raw_affiliation_string":"bKelsey-Seybold Clinic, Building 8, Johnson Space Center, Houston, Texas 77058","institution_ids":["https://openalex.org/I2800075897","https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055277438","display_name":"Marco Durante","orcid":"https://orcid.org/0000-0002-4615-553X","observed_orcids":["https://orcid.org/0000-0002-4615-553X"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Durante","raw_affiliation_strings":["cUniversity of Naples \u201cFederico II\u201d, Department of Physics, Naples, 80126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cUniversity of Naples \u201cFederico II\u201d, Department of Physics, Naples, 80126, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102866745","display_name":"Heng Wu","orcid":"https://orcid.org/0000-0001-8995-7551","observed_orcids":["https://orcid.org/0000-0001-8995-7551","https://orcid.org/0000-0002-6569-4651"]},"institutions":[{"id":"https://openalex.org/I2800075897","display_name":"Kelsey-Seybold Clinic","ror":"https://ror.org/0499w7e46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800075897"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"H. Wu","raw_affiliation_strings":["bKelsey-Seybold Clinic, Building 8, Johnson Space Center, Houston, Texas 77058","cUniversity of Naples \u201cFederico II\u201d, Department of Physics, Naples, 80126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bKelsey-Seybold Clinic, Building 8, Johnson Space Center, Houston, Texas 77058","institution_ids":["https://openalex.org/I2800075897","https://openalex.org/I4210149382"]},{"raw_affiliation_string":"cUniversity of Naples \u201cFederico II\u201d, Department of Physics, Naples, 80126, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038180688","display_name":"V. Willingham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Willingham","raw_affiliation_strings":["aWyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058","dNASA, Johnson Space Center, NASA Road 1, Houston, Texas 77058"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aWyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058","institution_ids":[]},{"raw_affiliation_string":"dNASA, Johnson Space Center, NASA Road 1, Houston, Texas 77058","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017406413","display_name":"G. D. Badhwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Badhwar","raw_affiliation_strings":["dNASA, Johnson Space Center, NASA Road 1, Houston, Texas 77058"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dNASA, Johnson Space Center, NASA Road 1, Houston, Texas 77058","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109883541","display_name":"Francis A. Cucinotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. A. Cucinotta","raw_affiliation_strings":["dNASA, Johnson Space Center, NASA Road 1, Houston, Texas 77058"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dNASA, Johnson Space Center, NASA Road 1, Houston, Texas 77058","institution_ids":["https://openalex.org/I4210149382"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022856162"],"corresponding_institution_ids":["https://openalex.org/I2800075897","https://openalex.org/I4210149382"],"apc_list":null,"apc_paid":null,"fwci":5.5859,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.96182001,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"156","issue":"6","first_page":"731","last_page":"738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.36550000309944153,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/space-radiation","display_name":"space radiation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/astronaut-health","display_name":"astronaut health","score":0.3370000123977661},{"id":"https://openalex.org/keywords/blood-lymphocytes","display_name":"blood lymphocytes","score":0.8090000152587891},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"chromosomal translocation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/radiation-quality-factor","display_name":"radiation quality factor","score":0.5690000057220459},{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.9010000228881836},{"id":"https://openalex.org/keywords/high-let-radiation","display_name":"high-LET radiation","score":0.972000002861023},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cell-cycle-delay","display_name":"cell cycle delay","score":0.7649999856948853},{"id":"https://openalex.org/keywords/premature-chromosome-condensation","display_name":"premature chromosome condensation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/long-duration-spaceflight","display_name":"long-duration spaceflight","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.6840240955352783},{"id":"https://openalex.org/C2780179797","wikidata":"https://www.wikidata.org/wiki/Q345844","display_name":"Crew","level":2,"score":0.6678897142410278},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.5859276056289673},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.5744497776031494},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.48318615555763245},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.47889843583106995},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.4403787851333618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42185208201408386},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.3629980981349945},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.32914865016937256},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30865710973739624},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.24218374490737915},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.13703995943069458},{"id":"https://openalex.org/C178802073","wikidata":"https://www.wikidata.org/wiki/Q8421","display_name":"Aeronautics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003359","descriptor_name":"Cosmic Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","doi":"https://doi.org/10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:11741497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11741497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"},{"id":"pmh:10.1667/0033-7587(2001)156[0731:CAITBL]2.0.CO;2","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1667/0033-7587%282001%29156%5B0731%3ACAITBL%5D2.0.CO%3B2","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W210709404","https://openalex.org/W1600796448","https://openalex.org/W1970274412","https://openalex.org/W1973365622","https://openalex.org/W1984074774","https://openalex.org/W1984869523","https://openalex.org/W1988066275","https://openalex.org/W2000624321","https://openalex.org/W2023383321","https://openalex.org/W2025912239","https://openalex.org/W2031600297","https://openalex.org/W2042667845","https://openalex.org/W2042735057","https://openalex.org/W2061765808","https://openalex.org/W2067070260","https://openalex.org/W2070924075","https://openalex.org/W2098288954","https://openalex.org/W2108293847","https://openalex.org/W2108994753","https://openalex.org/W2110109660","https://openalex.org/W2127507270","https://openalex.org/W2142749162","https://openalex.org/W2143475643","https://openalex.org/W2160100749","https://openalex.org/W2163640163","https://openalex.org/W2169078090","https://openalex.org/W2169264325","https://openalex.org/W2169956082","https://openalex.org/W2170686180","https://openalex.org/W2171245681","https://openalex.org/W2176453278","https://openalex.org/W2205206171","https://openalex.org/W2348313778","https://openalex.org/W4244781680","https://openalex.org/W4300769704","https://openalex.org/W4300852916"],"related_works":["https://openalex.org/W2143475643","https://openalex.org/W331382047","https://openalex.org/W2107673908","https://openalex.org/W775195167","https://openalex.org/W2083283134","https://openalex.org/W931409130","https://openalex.org/W1977768506","https://openalex.org/W802917054","https://openalex.org/W7155601801","https://openalex.org/W834110905"],"abstract_inverted_index":{"Cytogenetic":[0],"analysis":[1],"of":[2,5,11,27,41,79,119,136,153,163,204],"the":[3,25,38,67,77,91,111,120,161],"lymphocytes":[4,40],"astronauts":[6],"provides":[7],"a":[8,125,178,199],"direct":[9,117],"measurement":[10],"space":[12,48],"radiation":[13,131,174],"damage":[14,183],"in":[15,37,52,62,71,167,186,211,216],"vivo,":[16],"which":[17,146],"takes":[18],"into":[19],"account":[20],"individual":[21],"radiosensitivity":[22],"and":[23,29,81,90,130,197],"considers":[24],"influence":[26],"microgravity":[28],"other":[30],"stress":[31],"conditions.":[32],"Chromosome":[33],"exchanges":[34,83,206],"were":[35,64,108],"measured":[36,99,166],"blood":[39],"eight":[42],"crew":[43,194,221],"members":[44,195],"after":[45,66,144,170,198,207],"their":[46],"respective":[47],"missions,":[49],"using":[50,84,124],"fluorescence":[51],"situ":[53],"hybridization":[54],"(FISH)":[55],"with":[56,97],"chromosome":[57,182,189],"painting":[58],"probes.":[59],"Significant":[60],"increases":[61],"aberrations":[63,137,165],"observed":[65],"long-duration":[68],"missions.":[69],"The":[70,103,134,202],"vivo":[72],"dose":[73],"was":[74,93,141,175,184,209],"derived":[75],"from":[76,116,192],"frequencies":[78],"translocations":[80],"total":[82],"calibration":[85],"curves":[86],"determined":[87],"before":[88,196],"flight,":[89,145],"RBE":[92,107],"estimated":[94],"by":[95,177],"comparison":[96],"individually":[98],"physical":[100],"absorbed":[101],"doses.":[102],"values":[104],"for":[105,219],"average":[106,112],"compared":[109],"to":[110,149,155,172],"quality":[113],"factor":[114],"(Q)":[115],"measurements":[118],"lineal":[121],"energy":[122],"spectra":[123],"tissue-equivalent":[126],"proportional":[127],"counter":[128],"(TEPC)":[129],"transport":[132],"codes.":[133],"ratio":[135],"identified":[138],"as":[139],"complex":[140,164,205],"slightly":[142],"higher":[143,210],"is":[147],"thought":[148],"be":[150],"an":[151],"indication":[152],"exposure":[154,171],"high-LET":[156,173],"radiation.":[157],"To":[158],"determine":[159],"whether":[160],"frequency":[162,203],"metaphase":[168,217],"spreads":[169],"influenced":[176],"cell":[179],"cycle":[180],"delay,":[181],"analyzed":[185],"prematurely":[187,212],"condensed":[188,213],"samples":[190],"collected":[191],"two":[193],"short-duration":[200],"mission.":[201],"flight":[208],"chromosomes":[214],"than":[215],"cells":[218],"one":[220],"member.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
