{"id":"https://openalex.org/W2176842093","doi":null,"title":"The Role of Exosome Communication in Normal Ocular Function and Disease","display_name":"The Role of Exosome Communication in Normal Ocular Function and Disease","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2176842093","mag":"2176842093"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/579294","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/579294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013146200","display_name":"Christina Locke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christina Locke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5013146200"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/exosome-release","display_name":"exosome secretion","score":0.796999990940094},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ciliary-body","display_name":"ciliary body","score":1.0},{"id":"https://openalex.org/keywords/myocilin","display_name":"myocilin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.984000027179718},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gpr143","display_name":"GPR143","score":0.9919999837875366},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/eye-diseases","display_name":"eye diseases","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5430377125740051},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44202250242233276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4023208022117615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3451727628707886},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.341507226228714},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.3391362726688385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2504192590713501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15149462223052979}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/579294","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/579294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis"},{"id":"mag:2176842093","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/579294","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1560607431","https://openalex.org/W1951092263","https://openalex.org/W1970841297","https://openalex.org/W1988327113","https://openalex.org/W1989090719","https://openalex.org/W2002769152","https://openalex.org/W2004700953","https://openalex.org/W2005662230","https://openalex.org/W2006520238","https://openalex.org/W2010823420","https://openalex.org/W2016584341","https://openalex.org/W2018719587","https://openalex.org/W2022118535","https://openalex.org/W2032124492","https://openalex.org/W2032735323","https://openalex.org/W2033647568","https://openalex.org/W2035641748","https://openalex.org/W2042437146","https://openalex.org/W2054083019","https://openalex.org/W2056859782","https://openalex.org/W2067577774","https://openalex.org/W2070181056","https://openalex.org/W2075204681","https://openalex.org/W2082325637","https://openalex.org/W2087739626","https://openalex.org/W2121354606","https://openalex.org/W2134954483"],"related_works":["https://openalex.org/W2033647568","https://openalex.org/W831612019","https://openalex.org/W3157163570","https://openalex.org/W2802370819","https://openalex.org/W973553152","https://openalex.org/W3029094204","https://openalex.org/W3037260404","https://openalex.org/W4408384390","https://openalex.org/W4384560022","https://openalex.org/W2997305130"],"abstract_inverted_index":{"Purpose:":[0],"Age-related":[1],"macular":[2],"degeneration":[3],"(AMD)":[4],"and":[5,11,31,52,69,79,93,103,125,127,156,169,193],"glaucoma":[6],"are":[7,26,107],"respectively":[8],"the":[9,18,23,40,67,74,80,123,154,166,177],"first":[10],"second":[12],"leading":[13],"causes":[14,114],"of":[15,42,59,71,99,143,159,176],"blindness":[16],"in":[17,22,49,57,88,101,118,133,138,152,184],"United":[19],"States.":[20],"Mutations":[21],"protein":[24],"myocilin":[25,32],"known":[27,44],"to":[28,84,165,190],"cause":[29,129],"glaucoma,":[30],"is":[33,136,162],"only":[34],"released":[35],"from":[36,73,109,121],"ocular":[37,191],"tissues":[38],"on":[39],"surface":[41],"nanovesicles":[43],"as":[45],"exosomes.":[46],"Exosomes":[47],"function":[48],"cell-cell":[50],"communication,":[51],"likely":[53,163,188],"play":[54],"a":[55,115,130],"role":[56],"both":[58,122,153],"these":[60,104],"disease.":[61],"In":[62],"this":[63],"study,":[64],"I":[65],"investigate":[66],"release":[68,96,120,142,161,180,187],"regulation":[70],"exosomes":[72,100],"retinal":[75],"pigment":[76],"epithelium":[77],"(RPE)":[78],"ciliary":[81],"body":[82],"(CB)":[83],"characterize":[85],"exosome":[86,119,160,179,186],"production":[87],"healthy":[89],"tissues.":[90],"Results:":[91],"RPE":[92,124,134,155],"CB":[94],"constitutively":[95],"large":[97],"quantities":[98],"situ,":[102],"exosomal":[105,144],"populations":[106],"different":[108],"one":[110],"another.":[111],"L-DOPA":[112,151],"stimulation":[113],"drastic":[116],"reduction":[117,132],"CB,":[126],"dopamine":[128],"similar":[131],"but":[135],"variable":[137],"CB.":[139,157],"Conclusion:":[140],"The":[141],"communication":[145],"vesicles":[146],"can":[147],"be":[148],"controlled":[149],"using":[150],"Regulation":[158],"tied":[164],"GPCR":[167],"GPR143":[168],"its":[170],"signaling,":[171],"such":[172],"that":[173],"during":[174],"endocytosis":[175],"receptor":[178],"cannot":[181],"occur.":[182],"Disruptions":[183],"proper":[185],"relate":[189],"disease,":[192],"warrant":[194],"further":[195],"study.":[196]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}