{"id":"https://openalex.org/W2176797709","doi":"https://doi.org/10.1152/jappl.1985.59.6.1698","title":"Mechanism of transient nocturnal hypoxemia in hypoxic chronic bronchitis and emphysema","display_name":"Mechanism of transient nocturnal hypoxemia in hypoxic chronic bronchitis and emphysema","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W2176797709","doi":"https://doi.org/10.1152/jappl.1985.59.6.1698","mag":"2176797709","pmid":"https://pubmed.ncbi.nlm.nih.gov/4077777"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1985.59.6.1698","doi":"https://doi.org/10.1152/jappl.1985.59.6.1698","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1985.59.6.1698","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113476710","display_name":"James R. Catterall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. R. Catterall","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007976050","display_name":"Peter M.A. Calverley","orcid":"https://orcid.org/0000-0003-4676-9993","observed_orcids":["https://orcid.org/0000-0003-4676-9993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. M. Calverley","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. MacNee","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112086013","display_name":"P M Warren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. M. Warren","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103084382","display_name":"Colin M. Shapiro","orcid":"https://orcid.org/0000-0002-2231-0427","observed_orcids":["https://orcid.org/0000-0002-2231-0427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. M. Shapiro","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110264993","display_name":"Neil J Douglas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. J. Douglas","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112402921","display_name":"D. C. Flenley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. C. Flenley","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.341,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.89118989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"59","issue":"6","first_page":"1698","last_page":"1703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.3411000072956085,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.3411000072956085,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.32589998841285706,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.3107999861240387,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nocturnal-hypoxemia","display_name":"nocturnal hypoxemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chronic-bronchitis","display_name":"chronic bronchitis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypoventilation","display_name":"hypoventilation","score":0.925000011920929},{"id":"https://openalex.org/keywords/arterial-oxygen-tension","display_name":"arterial oxygen tension","score":0.6850000023841858},{"id":"https://openalex.org/keywords/paco2","display_name":"PaCO2","score":0.843999981880188},{"id":"https://openalex.org/keywords/arteriovenous-oxygen-difference","display_name":"arteriovenous oxygen difference","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ventilation-perfusion-distribution","display_name":"ventilation-perfusion distribution","score":0.6930000185966492},{"id":"https://openalex.org/keywords/sleep-disordered-breathing","display_name":"sleep-disordered breathing","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2776779939","wikidata":"https://www.wikidata.org/wiki/Q1479485","display_name":"Hypoxemia","level":2,"score":0.6672748923301697},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6563287973403931},{"id":"https://openalex.org/C2779594553","wikidata":"https://www.wikidata.org/wiki/Q1641494","display_name":"Hypoventilation","level":3,"score":0.6502827405929565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6221771240234375},{"id":"https://openalex.org/C2777140959","wikidata":"https://www.wikidata.org/wiki/Q10343041","display_name":"pCO2","level":2,"score":0.5829423069953918},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47023624181747437},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.4572976529598236},{"id":"https://openalex.org/C2777449187","wikidata":"https://www.wikidata.org/wiki/Q575168","display_name":"Hyperventilation","level":2,"score":0.448818564414978},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.4334532916545868},{"id":"https://openalex.org/C2992694001","wikidata":"https://www.wikidata.org/wiki/Q173022","display_name":"Chronic bronchitis","level":2,"score":0.4197283387184143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37030458450317383},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.25926077365875244},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004646","descriptor_name":"Emphysema","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1985.59.6.1698","doi":"https://doi.org/10.1152/jappl.1985.59.6.1698","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1985.59.6.1698","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:4077777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4077777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2045383926","https://openalex.org/W2922199531","https://openalex.org/W47750904","https://openalex.org/W2231588963","https://openalex.org/W2195248937","https://openalex.org/W2914887654","https://openalex.org/W2408157177","https://openalex.org/W2404228533","https://openalex.org/W2135461623","https://openalex.org/W2038895430"],"abstract_inverted_index":{"In":[0],"five":[1],"patients":[2,192],"with":[3,56,65,193],"hypoxic":[4],"chronic":[5,194],"bronchitis":[6,195],"and":[7,20,25,42,136,196],"emphysema":[8,197],"we":[9],"measured":[10],"ear":[11],"O2":[12,104],"saturation":[13],"(SaO2),":[14],"chest":[15,62],"movement,":[16,63],"oronasal":[17],"airflow,":[18],"arterial":[19,69,88],"mixed":[21],"venous":[22],"gas":[23],"tensions,":[24],"cardiac":[26,130],"output":[27],"during":[28,43,79,116,138,148,188,203],"nine":[29,53],"hypoxemic":[30],"episodes":[31,59],"(HE;":[32],"SaO2":[33],"falls":[34],"greater":[35,99,177],"than":[36,84,100,121,164,178],"10%)":[37],"in":[38,49,129,134,144,191,212],"rapid-eye-movement":[39],"(REM)":[40],"sleep":[41,66,190,205],"preceding":[44],"periods":[45],"of":[46,60,114,151,210,214],"stable":[47],"oxygenation":[48],"non-REM":[50],"sleep.":[51],"All":[52],"HE":[54,81,118,139],"occurred":[55],"recurrent":[57],"short":[58],"reduced":[61],"none":[64],"apnea.":[67],"The":[68,102],"PO2":[70],"(PaO2)":[71],"fell":[72,107,156],"by":[73,92,108,157,170,201,220],"6.0":[74],"+/-":[75,95,110,159,173],"1.9":[76],"(SD)":[77],"Torr":[78,97,161,175],"the":[80,117,183,208],"(P":[82,98,119,162,176],"less":[83,120,163],"0.01),":[85],"but":[86,123,166,206],"mean":[87,167],"PCO2":[89],"(PaCO2)":[90],"rose":[91,169],"only":[93,171],"1.4":[94],"2.4":[96],"0.4).":[101,179],"arteriovenous":[103],"content":[105],"difference":[106],"0.64":[109],"0.43":[111],"ml/100":[112],"ml":[113],"blood":[115],"0.05),":[122,165],"there":[124],"was":[125],"no":[126],"significant":[127],"change":[128],"output.":[131],"Changes":[132],"observed":[133],"PaO2":[135,155],"PaCO2":[137,168],"were":[140],"similar":[141],"to":[142],"those":[143],"four":[145],"normal":[146],"subjects":[147],"90":[149],"s":[150],"voluntary":[152],"hypoventilation,":[153],"when":[154],"12.3":[158],"5.6":[160],"2.8":[172],"2.1":[174],"We":[180],"suggest":[181],"that":[182,207],"transient":[184],"hypoxemia":[185],"which":[186],"occurs":[187],"REM":[189,204],"could":[198],"be":[199,218],"explained":[200],"hypoventilation":[202],"importance":[209],"changes":[211],"distribution":[213],"ventilation-perfusion":[215],"ratios":[216],"cannot":[217],"assessed":[219],"presently":[221],"available":[222],"techniques.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}