{"id":"https://openalex.org/W2176720133","doi":"https://doi.org/10.1186/s13613-015-0085-5","title":"Personalizing blood pressure management in septic shock","display_name":"Personalizing blood pressure management in septic shock","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2176720133","doi":"https://doi.org/10.1186/s13613-015-0085-5","mag":"2176720133","pmid":"https://pubmed.ncbi.nlm.nih.gov/26573630","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646890"},"language":"en","primary_location":{"id":"doi:10.1186/s13613-015-0085-5","doi":"https://doi.org/10.1186/s13613-015-0085-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13613-015-0085-5","pdf_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/s13613-015-0085-5","source":{"id":"https://openalex.org/S113872774","display_name":"Annals of Intensive Care","issn_l":"2110-5820","issn":["2110-5820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Intensive Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/s13613-015-0085-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087204179","display_name":"Ryotaro Kato","orcid":"https://orcid.org/0000-0003-4025-6740","observed_orcids":["https://orcid.org/0000-0003-4025-6740"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryotaro Kato","raw_affiliation_strings":["Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA. ryotarokato@gmail.com","Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA. ryotarokato@gmail.com","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053558278","display_name":"Michael R. Pinsky","orcid":"https://orcid.org/0000-0001-6166-700X","observed_orcids":["https://orcid.org/0000-0001-6166-700X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Pinsky","raw_affiliation_strings":["Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA. pinskymr@upmc.edu","Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA. pinskymr@upmc.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053558278"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":11.4487,"has_fulltext":true,"cited_by_count":146,"citation_normalized_percentile":{"value":0.98980301,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"41","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sepsis-resuscitation","display_name":"sepsis resuscitation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chronic-hypertension","display_name":"chronic hypertension","score":0.7929999828338623},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cerebral-perfusion-pressure","display_name":"cerebral perfusion pressure","score":0.7910000085830688},{"id":"https://openalex.org/keywords/renal-perfusion-pressure","display_name":"renal perfusion pressure","score":0.8320000171661377},{"id":"https://openalex.org/keywords/liver-perfusion","display_name":"liver perfusion","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tissue-perfusion","display_name":"tissue perfusion","score":0.7450000047683716},{"id":"https://openalex.org/keywords/pressure-flow-relationship","display_name":"pressure-flow relationship","score":0.6779999732971191},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8743085861206055},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7612124085426331},{"id":"https://openalex.org/C2775849017","wikidata":"https://www.wikidata.org/wiki/Q4121920","display_name":"Splanchnic","level":3,"score":0.7293059825897217},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.6800954341888428},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.6741015911102295},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6478617191314697},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5974782705307007},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5967900156974792},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.553020179271698},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5516921281814575},{"id":"https://openalex.org/C154281038","wikidata":"https://www.wikidata.org/wiki/Q629232","display_name":"Cerebral perfusion pressure","level":3,"score":0.5364964604377747},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3914661407470703},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37939298152923584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36868712306022644},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.36346572637557983},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.09559142589569092}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13613-015-0085-5","doi":"https://doi.org/10.1186/s13613-015-0085-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13613-015-0085-5","pdf_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/s13613-015-0085-5","source":{"id":"https://openalex.org/S113872774","display_name":"Annals of Intensive Care","issn_l":"2110-5820","issn":["2110-5820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Intensive Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3627772","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646890","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26573630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26573630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of intensive care","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4646890","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4646890/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Intensive Care","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13613-015-0085-5","doi":"https://doi.org/10.1186/s13613-015-0085-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13613-015-0085-5","pdf_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/s13613-015-0085-5","source":{"id":"https://openalex.org/S113872774","display_name":"Annals of Intensive Care","issn_l":"2110-5820","issn":["2110-5820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Intensive Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2176720133.pdf","grobid_xml":"https://content.openalex.org/works/W2176720133.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W200494176","https://openalex.org/W1519128654","https://openalex.org/W1802302318","https://openalex.org/W1930275516","https://openalex.org/W1954463628","https://openalex.org/W1964109762","https://openalex.org/W1964171066","https://openalex.org/W1964655784","https://openalex.org/W1964828477","https://openalex.org/W1965821059","https://openalex.org/W1965949370","https://openalex.org/W1970562480","https://openalex.org/W1971636155","https://openalex.org/W1973247633","https://openalex.org/W1977495126","https://openalex.org/W1983678801","https://openalex.org/W1983788174","https://openalex.org/W1989326580","https://openalex.org/W1992536611","https://openalex.org/W1994067722","https://openalex.org/W2000167232","https://openalex.org/W2001404503","https://openalex.org/W2006919847","https://openalex.org/W2010829342","https://openalex.org/W2014014797","https://openalex.org/W2022036219","https://openalex.org/W2023203069","https://openalex.org/W2023729026","https://openalex.org/W2023771867","https://openalex.org/W2023902879","https://openalex.org/W2023915714","https://openalex.org/W2025238785","https://openalex.org/W2028546766","https://openalex.org/W2029427893","https://openalex.org/W2031082712","https://openalex.org/W2034636095","https://openalex.org/W2037878371","https://openalex.org/W2039627981","https://openalex.org/W2040427814","https://openalex.org/W2043513395","https://openalex.org/W2052127416","https://openalex.org/W2056873925","https://openalex.org/W2057364247","https://openalex.org/W2059092640","https://openalex.org/W2059765045","https://openalex.org/W2061429069","https://openalex.org/W2062906868","https://openalex.org/W2065269562","https://openalex.org/W2067090053","https://openalex.org/W2069398444","https://openalex.org/W2074772121","https://openalex.org/W2075423220","https://openalex.org/W2078397137","https://openalex.org/W2083266188","https://openalex.org/W2087578679","https://openalex.org/W2087803497","https://openalex.org/W2088427111","https://openalex.org/W2088955692","https://openalex.org/W2093048503","https://openalex.org/W2093569692","https://openalex.org/W2094460858","https://openalex.org/W2095944485","https://openalex.org/W2096350581","https://openalex.org/W2099422322","https://openalex.org/W2104978347","https://openalex.org/W2106763736","https://openalex.org/W2108153775","https://openalex.org/W2111351132","https://openalex.org/W2117872501","https://openalex.org/W2119396182","https://openalex.org/W2124888829","https://openalex.org/W2127204804","https://openalex.org/W2128855592","https://openalex.org/W2129056646","https://openalex.org/W2133212152","https://openalex.org/W2134219545","https://openalex.org/W2143034699","https://openalex.org/W2143650227","https://openalex.org/W2147311248","https://openalex.org/W2151517451","https://openalex.org/W2155164384","https://openalex.org/W2156828671","https://openalex.org/W2159933802","https://openalex.org/W2163738693","https://openalex.org/W2171694388","https://openalex.org/W2256991736","https://openalex.org/W2271705642","https://openalex.org/W2284873362","https://openalex.org/W2287726087","https://openalex.org/W2296966034","https://openalex.org/W2321296273","https://openalex.org/W2402644254","https://openalex.org/W2413235337","https://openalex.org/W2419360016","https://openalex.org/W2434271235","https://openalex.org/W2442246762","https://openalex.org/W2522738478","https://openalex.org/W2581605534","https://openalex.org/W3023757607","https://openalex.org/W4229649350","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2320685962","https://openalex.org/W2036990324","https://openalex.org/W7155017239","https://openalex.org/W2510036031","https://openalex.org/W2171694388","https://openalex.org/W2131531817","https://openalex.org/W4410502234","https://openalex.org/W2025238785","https://openalex.org/W2106181379","https://openalex.org/W1496811490"],"abstract_inverted_index":{"This":[0],"review":[1],"examines":[2],"the":[3,103,128,161],"available":[4],"evidence":[5],"for":[6,102,113,117,123],"targeting":[7,22,50],"a":[8,40,51,76,111],"specific":[9],"mean":[10],"arterial":[11],"pressure":[12,97,140],"(MAP)":[13],"in":[14,28,45,85],"sepsis":[15],"resuscitation.":[16],"The":[17],"clinical":[18],"data":[19],"suggest":[20],"that":[21],"an":[23],"MAP":[24,53,69,148,152],"of":[25,54,66,78,163],"65-70":[26],"mmHg":[27,56,101,116,122],"patients":[29,46],"with":[30,47,63],"septic":[31],"shock":[32],"who":[33],"do":[34],"not":[35,72],"have":[36,137],"chronic":[37,48],"hypertension":[38],"is":[39,150],"reasonable":[41],"first":[42],"approximation.":[43],"Whereas":[44],"hypertension,":[49],"higher":[52],"80-85":[55],"minimizes":[57],"renal":[58,118],"injury,":[59],"but":[60],"it":[61],"comes":[62],"increased":[64],"risk":[65],"arrhythmias.":[67],"Importantly,":[68],"alone":[70],"should":[71,153],"be":[73,93,154],"used":[74],"as":[75,110],"surrogate":[77,112],"organ":[79,164],"perfusion":[80,96,119,139],"pressure,":[81],"especially":[82],"under":[83],"conditions":[84],"which":[86],"intracranial,":[87],"intra-abdominal":[88],"or":[89,157],"tissue":[90,167],"pressures":[91],"may":[92,136],"elevated.":[94],"Organ-specific":[95],"targets":[98],"include":[99],"50-70":[100],"brain":[104,108],"based":[105,159],"on":[106,160],"trauma":[107],"injury":[109],"sepsis,":[114],"65":[115],"and":[120,132,141,166],">50":[121],"hepato-splanchnic":[124],"flow.":[125],"Even":[126],"at":[127],"same":[129],"MAP,":[130],"organs":[131,135],"regions":[133],"within":[134],"different":[138],"pressure-flow":[142],"relationships.":[143],"Thus,":[144],"once":[145],"this":[146],"initial":[147],"target":[149],"achieved,":[151],"titrated":[155],"up":[156],"down":[158],"measures":[162],"function":[165],"perfusion.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}