{"id":"https://openalex.org/W2176685607","doi":"https://doi.org/10.5281/zenodo.1044174","title":"Brain Journal - The Brain And Propranolol Pharmacokinetics In The Elderly","display_name":"Brain Journal - The Brain And Propranolol Pharmacokinetics In The Elderly","publication_year":2015,"publication_date":"2015-09-03","ids":{"openalex":"https://openalex.org/W2176685607","doi":"https://doi.org/10.5281/zenodo.1044174","mag":"2176685607","pmid":"https://pubmed.ncbi.nlm.nih.gov/26609425","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4655970"},"language":"en","primary_location":{"id":"pmid:26609425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26609425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : broad research in artificial intelligence and neuroscience","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4655970/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Eugene, Andy R.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene, Andy R.","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Gonda 19, Mayo Clinic","Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Gonda 19, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA, Tel.: +1-507-284-2790;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Gonda 19, Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Gonda 19, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA, Tel.: +1-507-284-2790;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031480179","display_name":"Wayne T. Nicholson","orcid":"https://orcid.org/0000-0002-3418-4253","observed_orcids":["https://orcid.org/0000-0002-3418-4253"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholson, Wayne T.","raw_affiliation_strings":["Department of Anesthesiology, Mayo Clinic","Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.3266,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63754156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"6","issue":"1-4","first_page":"5","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.972000002861023},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7429999709129333},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.7590000033378601},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.6570000052452087},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9879999756813049},{"id":"https://openalex.org/keywords/age-related-drug-metabolism","display_name":"age-related drug metabolism","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8807963132858276},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.8126901388168335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5892730355262756},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.42003053426742554},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35375165939331055},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2711476683616638},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1483558714389801}],"mesh":[],"locations_count":8,"locations":[{"id":"pmid:26609425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26609425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : broad research in artificial intelligence and neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4655970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4655970/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Brain (Bacau)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3d65b487ac19415baa212d6e866b8892","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3d65b487ac19415baa212d6e866b8892","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain: Broad Research in Artificial Intelligence and Neuroscience, Vol 6, Iss 1-2, Pp 5-13 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7074e9b521b647e7bf413521d60b63a8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7074e9b521b647e7bf413521d60b63a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain: Broad Research in Artificial Intelligence and Neuroscience, Vol 6, Iss 1-2, Pp 5-13 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9a720597874f4b76bc7fc49fcc5da4ac","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9a720597874f4b76bc7fc49fcc5da4ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain: Broad Research in Artificial Intelligence and Neuroscience, Vol 6, Iss 1-2, Pp 5-13 (2015)","raw_type":"article"},{"id":"pmh:oai:zenodo.org:1044175","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/1044175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BRAIN - Broad Research in Artificial Intelligence and Neuroscience 6(1-2) 5-13","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.1044174","doi":"https://doi.org/10.5281/zenodo.1044174","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.1044174","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.1044175","doi":"https://doi.org/10.5281/zenodo.1044175","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.1044175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4655970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4655970/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Brain (Bacau)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000914747","display_name":"Training Grant in Clinical Pharmacology","funder_award_id":"T32GM008685","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1971918464","https://openalex.org/W1974348021","https://openalex.org/W1996821898","https://openalex.org/W1997181163","https://openalex.org/W2011241344","https://openalex.org/W2014574850","https://openalex.org/W2018711737","https://openalex.org/W2021378306","https://openalex.org/W2022090382","https://openalex.org/W2022818180","https://openalex.org/W2026396276","https://openalex.org/W2045370357","https://openalex.org/W2046161680","https://openalex.org/W2047570180","https://openalex.org/W2063909696","https://openalex.org/W2068900946","https://openalex.org/W2076947415","https://openalex.org/W2078599937","https://openalex.org/W2089542180","https://openalex.org/W2104710971","https://openalex.org/W2107531381","https://openalex.org/W2130778699","https://openalex.org/W2148716279","https://openalex.org/W2149154265","https://openalex.org/W2404323359","https://openalex.org/W2404872647","https://openalex.org/W2416036576"],"related_works":["https://openalex.org/W6892477654","https://openalex.org/W2130778699","https://openalex.org/W2049373950","https://openalex.org/W2436913866","https://openalex.org/W2039856801","https://openalex.org/W1966640282","https://openalex.org/W2397167066","https://openalex.org/W2500697236","https://openalex.org/W1986442864","https://openalex.org/W2074829805"],"abstract_inverted_index":{"Propranolol,":[0],"a":[1,9,86,112,130],"non-selective":[2],"\u03b2-blocker,":[3],"has":[4,16,56,95,119],"been":[5,45,57,96],"found":[6,97,125],"to":[7,69,78,84],"have":[8,44],"tremendous":[10],"array":[11],"of":[12,74],"indications.":[13],"Recent":[14],"evidence":[15],"suggested":[17],"that":[18],"propranolol":[19],"may":[20],"be":[21],"effective":[22],"in":[23,33,48,63,82,98,116,126],"patients":[24,128],"suffering":[25],"from":[26],"post-traumatic":[27],"stress":[28],"disorder":[29],"by":[30],"suppressing":[31],"activity":[32],"the":[34,49,64,70,92,103,107,117],"amygdala":[35],"and":[36,51,109],"thereby":[37],"inhibiting":[38],"emotional":[39],"memory":[40],"formation.":[41],"Dosage":[42],"requirements":[43],"well":[46],"established":[47],"pediatric":[50],"adult":[52],"population,":[53],"however,":[54],"there":[55],"no":[58],"definitive":[59],"geriatric":[60],"dose":[61,115],"recommended":[62],"package":[65],"inserts":[66],"made":[67],"available":[68],"public.":[71],"The":[72],"aim":[73],"this":[75],"paper":[76],"is":[77],"use":[79],"pharmacokinetic":[80,87,122],"simulations":[81,105],"order":[83],"establish":[85],"profile":[88],"dosage":[89],"equivalent":[90],"for":[91,106],"elderly":[93,108,118],"as":[94,124],"young":[99,110,127],"patients.":[100],"After":[101],"completing":[102],"Monte-Carlo":[104],"patients,":[111],"single":[113,132],"10mg":[114],"shown":[120],"comparable":[121],"profiles":[123],"administered":[129],"40mg":[131],"dose.":[133]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
