{"id":"https://openalex.org/W2176496044","doi":"https://doi.org/10.1073/pnas.1422015112","title":"Estrogen receptor-\u03b1 directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer","display_name":"Estrogen receptor-\u03b1 directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer","publication_year":2015,"publication_date":"2015-11-23","ids":{"openalex":"https://openalex.org/W2176496044","doi":"https://doi.org/10.1073/pnas.1422015112","mag":"2176496044","pmid":"https://pubmed.ncbi.nlm.nih.gov/26598706","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4679044"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1422015112","doi":"https://doi.org/10.1073/pnas.1422015112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1422015112","pdf_url":"https://www.pnas.org/content/pnas/112/49/15172.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pnas.org/content/pnas/112/49/15172.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061426227","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0002-4233-3220","observed_orcids":["https://orcid.org/0000-0002-4233-3220"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":["Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;","Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016623796","display_name":"Alaa M. AlTahan","orcid":"https://orcid.org/0000-0002-8835-0392","observed_orcids":["https://orcid.org/0000-0002-8835-0392"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alaa AlTahan","raw_affiliation_strings":["Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011978635","display_name":"Dylan T. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dylan T. Jones","raw_affiliation_strings":["Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075865182","display_name":"Francesca Meteora Buffa","orcid":"https://orcid.org/0000-0003-0409-406X","observed_orcids":["https://orcid.org/0000-0003-0409-406X"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesca M. Buffa","raw_affiliation_strings":["Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023518824","display_name":"Esther Bridges","orcid":"https://orcid.org/0000-0002-6958-6279","observed_orcids":["https://orcid.org/0000-0002-6958-6279"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Esther Bridges","raw_affiliation_strings":["Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080668999","display_name":"Rodrigo B. Interiano","orcid":"https://orcid.org/0000-0003-3238-1517","observed_orcids":["https://orcid.org/0000-0003-3238-1517"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo B. Interiano","raw_affiliation_strings":["Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033248637","display_name":"Chunxu Qu","orcid":"https://orcid.org/0000-0002-7569-0945","observed_orcids":["https://orcid.org/0000-0002-7569-0945"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunxu Qu","raw_affiliation_strings":["Department of Bioinformatics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nathan Vogt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Vogt","raw_affiliation_strings":["Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694079","display_name":"Ji\u2010Liang Li","orcid":"https://orcid.org/0000-0001-6200-1007","observed_orcids":["https://orcid.org/0000-0001-6200-1007"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ji-Liang Li","raw_affiliation_strings":["Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110206779","display_name":"Dilair F. Baban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dilair Baban","raw_affiliation_strings":["Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom;","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044600248","display_name":"Jiannis Ragoussis","orcid":"https://orcid.org/0000-0002-8515-0934","observed_orcids":["https://orcid.org/0000-0002-8515-0934"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jiannis Ragoussis","raw_affiliation_strings":["Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom;","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113528089","display_name":"Robert I. Nicholson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152034","display_name":"Tenovus Cancer Care","ror":"https://ror.org/041t5x242","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210152034"]},{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Nicholson","raw_affiliation_strings":["Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3NB, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3NB, United Kingdom","institution_ids":["https://openalex.org/I4210152034","https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063456712","display_name":"Andrew M. Davidoff","orcid":"https://orcid.org/0000-0001-7900-2794","observed_orcids":["https://orcid.org/0000-0001-7900-2794"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Davidoff","raw_affiliation_strings":["Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079633934","display_name":"Adrian Llewellyn Harris","orcid":"https://orcid.org/0000-0003-1376-8409","observed_orcids":["https://orcid.org/0000-0003-1376-8409","https://orcid.org/0000-0002-5222-4765"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adrian L. Harris","raw_affiliation_strings":["Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.162,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":{"value":0.92767669,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"112","issue":"49","first_page":"15172","last_page":"15177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.18469999730587006,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7229999899864197},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.9620000123977661},{"id":"https://openalex.org/keywords/estrogen-response-element","display_name":"estrogen response element","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hypoxia-response-element","display_name":"hypoxia response element","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.9357481598854065},{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.928017258644104},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7248788475990295},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.7201430797576904},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6153695583343506},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5126775503158569},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5055994987487793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4769943356513977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4717567563056946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42040789127349854},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4174354374408722},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4045233130455017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3821817636489868},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1921168565750122},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1073/pnas.1422015112","doi":"https://doi.org/10.1073/pnas.1422015112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1422015112","pdf_url":"https://www.pnas.org/content/pnas/112/49/15172.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3862191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4679044","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4679044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4679044","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:26598706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26598706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pearl.plymouth.ac.uk:10026.1/5244","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10026.1/5244","pdf_url":"http://hdl.handle.net/10026.1/5244","source":{"id":"https://openalex.org/S4306402507","display_name":"PEARL (University of Plymouth)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I897542642","host_organization_name":"University of Plymouth","host_organization_lineage":["https://openalex.org/I897542642"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal-article"},{"id":"pmh:oai:pearl.plymouth.ac.uk:pms-research-2585","doi":null,"is_oa":true,"landing_page_url":"https://pearl.plymouth.ac.uk/pms-research/1586","pdf_url":"https://pearl.plymouth.ac.uk/context/pms-research/article/2585/viewcontent/Fan_20SJ_20Oncogene_202016.pdf","source":{"id":"https://openalex.org/S4306402507","display_name":"PEARL (University of Plymouth)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I897542642","host_organization_name":"University of Plymouth","host_organization_lineage":["https://openalex.org/I897542642"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Peninsula Medical School","raw_type":"article"},{"id":"pmh:oai:iris.unibocconi.it:11565/4062601","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11565/4062601","pdf_url":null,"source":{"id":"https://openalex.org/S7407055170","display_name":"Archivio istituzionale della Ricerca - Bocconi","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1422015112","doi":"https://doi.org/10.1073/pnas.1422015112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1422015112","pdf_url":"https://www.pnas.org/content/pnas/112/49/15172.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1425849753","display_name":null,"funder_award_id":"11359","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G235642025","display_name":null,"funder_award_id":"A9093","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2720012520","display_name":null,"funder_award_id":"A6174","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3120789051","display_name":null,"funder_award_id":"C7713/A6174","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3227480637","display_name":null,"funder_award_id":"A12278","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4019336415","display_name":null,"funder_award_id":"A6181","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5920461105","display_name":null,"funder_award_id":"16466","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6019703709","display_name":null,"funder_award_id":"C38302/A12278","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6146789693","display_name":"Regulation and functions of male-derived shed microvesicles in Drosophila reproduction","funder_award_id":"BB/L007096/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7499079676","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0611-10163","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G7757960659","display_name":null,"funder_award_id":"BB/L007096/1","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G816216598","display_name":null,"funder_award_id":"C19591/A9093","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G9000195363","display_name":null,"funder_award_id":"FP6-IST-026996","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320322572","display_name":"Studienstiftung des Deutschen Volkes","ror":"https://ror.org/05xwwfy96"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2176496044.pdf","grobid_xml":"https://content.openalex.org/works/W2176496044.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1826222652","https://openalex.org/W1892496998","https://openalex.org/W1969734439","https://openalex.org/W1982395222","https://openalex.org/W1983486852","https://openalex.org/W1988548899","https://openalex.org/W1997046615","https://openalex.org/W2000954918","https://openalex.org/W2001401534","https://openalex.org/W2002262418","https://openalex.org/W2002842589","https://openalex.org/W2013956549","https://openalex.org/W2018235415","https://openalex.org/W2021145743","https://openalex.org/W2030437674","https://openalex.org/W2042714596","https://openalex.org/W2044702943","https://openalex.org/W2056279621","https://openalex.org/W2057083103","https://openalex.org/W2068543804","https://openalex.org/W2073292880","https://openalex.org/W2073367400","https://openalex.org/W2076459300","https://openalex.org/W2082939195","https://openalex.org/W2084116712","https://openalex.org/W2085934079","https://openalex.org/W2102217018","https://openalex.org/W2104989791","https://openalex.org/W2106391833","https://openalex.org/W2122927637","https://openalex.org/W2131606388","https://openalex.org/W2143017330","https://openalex.org/W2150533948","https://openalex.org/W2153562609","https://openalex.org/W2154968323","https://openalex.org/W2156453405","https://openalex.org/W2159831588","https://openalex.org/W2162121911","https://openalex.org/W2163069245","https://openalex.org/W2163325952","https://openalex.org/W2168014041","https://openalex.org/W2322526574","https://openalex.org/W2560367415","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W4303685375","https://openalex.org/W2152800203","https://openalex.org/W2603940135","https://openalex.org/W1605172632","https://openalex.org/W7095633816","https://openalex.org/W2269627255","https://openalex.org/W2065892129","https://openalex.org/W2548769923","https://openalex.org/W2338352605","https://openalex.org/W2321820268"],"abstract_inverted_index":{"A":[0],"majority":[1],"of":[2,38,43,59,63,106],"breast":[3,26,126,138],"cancers":[4],"are":[5,49,74],"driven":[6],"by":[7,76,99],"estrogen":[8,10,71,90],"via":[9],"receptor-\u03b1":[11],"(ER\u03b1).":[12],"Our":[13,141],"previous":[14],"studies":[15],"indicate":[16],"that":[17,56,104],"hypoxia-inducible":[18],"factor":[19],"1\u03b1":[20],"(HIF-1\u03b1)":[21],"cooperates":[22],"with":[23,117],"ER\u03b1":[24,31,77,156],"in":[25,34,45,78,124,164],"cancer":[27,139],"cells.":[28,140],"However,":[29],"whether":[30],"is":[32,96,115],"implicated":[33],"the":[35,41,83,107,145],"direct":[36,152],"regulation":[37],"HIF-1\u03b1":[39,44,60,84,108,128],"and":[40,70,80,93,157],"role":[42],"endocrine":[46,122,133],"therapy":[47,134],"response":[48,68,72,91,163],"unknown.":[50],"In":[51],"this":[52],"study":[53],"we":[54],"found":[55],"a":[57,111,118,151],"subpopulation":[58],"targets,":[61],"many":[62],"them":[64],"bearing":[65],"both":[66],"hypoxia":[67,112],"elements":[69],"elements,":[73],"regulated":[75,98],"normoxia":[79],"hypoxia.":[81],"Interestingly,":[82],"gene":[85,109],"itself":[86],"also":[87],"bears":[88],"an":[89],"element,":[92],"its":[94],"expression":[95,105],"directly":[97],"ER\u03b1.":[100],"Clinical":[101],"data":[102],"revealed":[103],"or":[110],"metagene":[113],"signature":[114],"associated":[116],"poor":[119],"outcome":[120],"to":[121,131,136,148],"treatment":[123],"ER\u03b1(+)":[125,137],"cancer.":[127],"was":[129],"able":[130],"confer":[132],"resistance":[135],"findings":[142],"define,":[143],"for":[144],"first":[146],"time":[147],"our":[149],"knowledge,":[150],"regulatory":[153],"pathway":[154],"between":[155],"HIF-1\u03b1,":[158],"which":[159],"might":[160],"modulate":[161],"hormone":[162],"treatment.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
