{"id":"https://openalex.org/W2176205501","doi":"https://doi.org/10.1002/cbic.201500578","title":"Cover Picture: Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases (ChemBioChem 17/2015)","display_name":"Cover Picture: Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases (ChemBioChem 17/2015)","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2176205501","doi":"https://doi.org/10.1002/cbic.201500578","mag":"2176205501"},"language":"en","primary_location":{"id":"doi:10.1002/cbic.201500578","doi":"https://doi.org/10.1002/cbic.201500578","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbic.201500578","pdf_url":null,"source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023228856","display_name":"Sonja Sarge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sonja Sarge","raw_affiliation_strings":["Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070327668","display_name":"Ilka Haase","orcid":"https://orcid.org/0000-0001-8527-0461","observed_orcids":["https://orcid.org/0000-0001-8527-0461"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ilka Haase","raw_affiliation_strings":["Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060786264","display_name":"Boris A. Illarionov","orcid":"https://orcid.org/0009-0007-8489-0651","observed_orcids":["https://orcid.org/0009-0007-8489-0651"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Boris Illarionov","raw_affiliation_strings":["Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006072202","display_name":"Dietmar Laudert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dietmar Laudert","raw_affiliation_strings":["DSM Nutritional Products, P. O. Box 2676, 4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Nutritional Products, P. O. Box 2676, 4002 Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109070205","display_name":"Hans\u2010Peter Hohmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans\u2010Peter Hohmann","raw_affiliation_strings":["DSM Nutritional Products, P. O. Box 2676, 4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Nutritional Products, P. O. Box 2676, 4002 Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068798153","display_name":"Adelbert Bacher","orcid":"https://orcid.org/0000-0001-5174-4139","observed_orcids":["https://orcid.org/0000-0001-5174-4139"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adelbert Bacher","raw_affiliation_strings":["Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006304159","display_name":"Markus J. Fischer","orcid":"https://orcid.org/0000-0001-7243-4199","observed_orcids":["https://orcid.org/0000-0001-7243-4199"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus Fischer","raw_affiliation_strings":["Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006304159"],"corresponding_institution_ids":["https://openalex.org/I159176309"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06839471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"17","first_page":"2405","last_page":"2405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riboflavin-biosynthesis","display_name":"riboflavin biosynthesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hydrolytic-enzymes","display_name":"hydrolytic enzymes","score":0.7839999794960022},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.687685489654541},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6542825698852539},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6461724638938904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5403417348861694},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5367160439491272},{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.4957652986049652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4581214189529419},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.4471207857131958},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.4257064163684845},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4053717255592346},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.2515650987625122}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/cbic.201500578","doi":"https://doi.org/10.1002/cbic.201500578","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbic.201500578","pdf_url":null,"source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1836050378","https://openalex.org/W1991302112","https://openalex.org/W4408879763","https://openalex.org/W2490763523","https://openalex.org/W2135383001","https://openalex.org/W1597934400","https://openalex.org/W1995721113","https://openalex.org/W1535184858","https://openalex.org/W2015732160","https://openalex.org/W10193788"],"abstract_inverted_index":{"The":[0,35],"cover":[1],"picture":[2],"shows":[3,38],"the":[4,19,23,42,72,79,89,96,131],"biosynthesis":[5],"of":[6,9,41,45,91,98,113],"riboflavin.":[7],"Enzymes":[8],"B.":[10,46,84],"subtilis":[11,47,85],"involved":[12],"in":[13,26,49,71,130,141],"this":[14,27,50],"pathway":[15],"are":[16,33],"indicated":[17],"and":[18,31],"enzymes":[20],"identified":[21],"for":[22],"first":[24],"time":[25],"paper":[28],"(YcsE,":[29],"YitU":[30,107],"YwtE)":[32],"highlighted.":[34],"left":[36],"corner":[37],"a":[39,111],"dendrogram":[40],"HAD-like":[43],"proteins":[44,86],"studied":[48],"work.":[51],"Three":[52],"HAD":[53],"members":[54],"were":[55],"found":[56,129],"to":[57],"dephosphorylate":[58],"5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione":[59],"5\u2019-phosphate":[60],"(ARP-P)":[61],"at":[62,81,100,110],"rates":[63],"\u22650.7":[64],"\u00b5mol":[65,116],"mg\u22121":[66,117],"min\u22121":[67],"with":[68],"KM":[69],"values":[70],"double-digit":[73],"\u00b5M":[74],"range.":[75],"Several":[76],"others":[77],"catalyse":[78,88,95],"reaction":[80],"lower":[82],"rates.":[83,105],"that":[87],"hydrolysis":[90,97],"ARP-P":[92],"can":[93,127],"also":[94],"FMN":[99,109],"similar":[101],"or":[102],"higher":[103],"respective":[104],"Notably,":[106],"dephosphorylates":[108],"rate":[112],"about":[114,119],"17":[115],"min\u22121,":[118],"10":[120],"times":[121],"faster":[122],"than":[123],"ARP-P.":[124],"More":[125],"details":[126],"be":[128],"Communication":[132],"by":[133],"M.":[134],"Fischer":[135],"et":[136],"al.":[137],"on":[138],"page":[139],"2466":[140],"Issue":[142],"17,":[143],"2015":[144],"(DOI:":[145],"10.1002/cbic.201500352).":[146]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}