{"id":"https://openalex.org/W2176205167","doi":"https://doi.org/10.1016/j.bmcl.2005.03.058","title":"4-Alkyl and 4,4\u2032-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis","display_name":"4-Alkyl and 4,4\u2032-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis","publication_year":2005,"publication_date":"2005-04-14","ids":{"openalex":"https://openalex.org/W2176205167","doi":"https://doi.org/10.1016/j.bmcl.2005.03.058","mag":"2176205167","pmid":"https://pubmed.ncbi.nlm.nih.gov/15863310"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2005.03.058","doi":"https://doi.org/10.1016/j.bmcl.2005.03.058","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2005.03.058","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085162570","display_name":"Kristina M. K. Kutterer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristina M.K. Kutterer","raw_affiliation_strings":["Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA. kutterk@wyeth.com","Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA. kutterk@wyeth.com","institution_ids":["https://openalex.org/I4403928396"]},{"raw_affiliation_string":"Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066858267","display_name":"Jamie M. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie M. Davis","raw_affiliation_strings":["Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110741798","display_name":"Guy Singh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy Singh","raw_affiliation_strings":["Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020554965","display_name":"Youjun Yang","orcid":"https://orcid.org/0000-0001-7085-6048","observed_orcids":["https://orcid.org/0000-0001-7085-6048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youjun Yang","raw_affiliation_strings":["Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000246819","display_name":"William K. Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Hu","raw_affiliation_strings":["Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101678","display_name":"Anatoly I. Severin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anatoly Severin","raw_affiliation_strings":["Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105472624","display_name":"Beth A. Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beth A. Rasmussen","raw_affiliation_strings":["Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Discovery Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050659847","display_name":"Girija Krishnamurthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Girija Krishnamurthy","raw_affiliation_strings":["Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyeth Research, Chemical and Screening Sciences, 401 N. Middletown Rd, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111731379","display_name":"Amedeo A. Failli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amedeo Failli","raw_affiliation_strings":["Wyeth Research, Chemical and Screening Sciences, 865 Ridge Road, Monmouth Junction, NJ 08852, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyeth Research, Chemical and Screening Sciences, 865 Ridge Road, Monmouth Junction, NJ 08852, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108214403","display_name":"Alan H. Katz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan H. Katz","raw_affiliation_strings":["Wyeth Research, Chemical and Screening Sciences, 865 Ridge Road, Monmouth Junction, NJ 08852, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyeth Research, Chemical and Screening Sciences, 865 Ridge Road, Monmouth Junction, NJ 08852, USA","institution_ids":["https://openalex.org/I4403928396"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085162570"],"corresponding_institution_ids":["https://openalex.org/I4403928396"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.7863,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.90201163,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"10","first_page":"2527","last_page":"2531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.21060000360012054,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.10540000349283218,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazolidine-derivatives","display_name":"pyrazolidine derivatives","score":0.6100000143051147},{"id":"https://openalex.org/keywords/murb","display_name":"MurB","score":0.7760000228881836},{"id":"https://openalex.org/keywords/penicillin-binding-proteins","display_name":"penicillin-binding proteins","score":0.6340000033378601},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9700000286102295},{"id":"https://openalex.org/keywords/penicillin-resistance","display_name":"penicillin resistance","score":0.9179999828338623},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.824999988079071},{"id":"https://openalex.org/keywords/enzyme-binding-affinity","display_name":"enzyme affinity","score":0.6050000190734863},{"id":"https://openalex.org/keywords/microwave-assisted-synthesis","display_name":"microwave-assisted synthesis","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9227956533432007},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.7821793556213379},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.7638565301895142},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.6239256858825684},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49364933371543884},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37087470293045044},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3505023717880249},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3242153525352478},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23412233591079712},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19964668154716492}],"mesh":[{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2005.03.058","doi":"https://doi.org/10.1016/j.bmcl.2005.03.058","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2005.03.058","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:15863310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15863310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1561325021","https://openalex.org/W1972607316","https://openalex.org/W1983478827","https://openalex.org/W1991615708","https://openalex.org/W1994695688","https://openalex.org/W2016236095","https://openalex.org/W2952830562"],"related_works":["https://openalex.org/W2135219074","https://openalex.org/W2176028587","https://openalex.org/W3043774458","https://openalex.org/W4375955667","https://openalex.org/W4307035018","https://openalex.org/W6977364996","https://openalex.org/W2136515555","https://openalex.org/W3193859558","https://openalex.org/W798863398","https://openalex.org/W7167485454"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}