{"id":"https://openalex.org/W2175806459","doi":"https://doi.org/10.3109/02699052.2015.1077993","title":"Plasma brain-derived neurotrophic factor levels after severe traumatic brain injury","display_name":"Plasma brain-derived neurotrophic factor levels after severe traumatic brain injury","publication_year":2015,"publication_date":"2015-11-10","ids":{"openalex":"https://openalex.org/W2175806459","doi":"https://doi.org/10.3109/02699052.2015.1077993","mag":"2175806459","pmid":"https://pubmed.ncbi.nlm.nih.gov/26555864"},"language":"en","primary_location":{"id":"doi:10.3109/02699052.2015.1077993","doi":"https://doi.org/10.3109/02699052.2015.1077993","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02699052.2015.1077993","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101707058","display_name":"Daniel Simon","orcid":"https://orcid.org/0000-0003-1122-8468","observed_orcids":["https://orcid.org/0000-0003-1122-8468"]},"institutions":[{"id":"https://openalex.org/I51882195","display_name":"Universidade Luterana do Brasil","ror":"https://ror.org/00kde4z41","country_code":"BR","type":"education","lineage":["https://openalex.org/I51882195"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniel Simon","raw_affiliation_strings":["a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","b Laborat\u00f3rio de Biomarcadores do Trauma , Universidade Luterana do Brasil , Canoas , Brazil , and","c Curso de Medicina , Universidade Luterana do Brasil , Canoas , Brazil","Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil","Laborat\u00f3rio de Biomarcadores do Trauma, Universidade Luterana do Brasil, Canoas, Brazil, and","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","institution_ids":[]},{"raw_affiliation_string":"b Laborat\u00f3rio de Biomarcadores do Trauma , Universidade Luterana do Brasil , Canoas , Brazil , and","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"c Curso de Medicina , Universidade Luterana do Brasil , Canoas , Brazil","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"Laborat\u00f3rio de Biomarcadores do Trauma, Universidade Luterana do Brasil, Canoas, Brazil, and","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040504465","display_name":"Rita Iara Moreira do Nascimento","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rita Iara Moreira do Nascimento","raw_affiliation_strings":["a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","institution_ids":[]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035564899","display_name":"\u00c9dison Moraes Rodrigues Filho","orcid":"https://orcid.org/0000-0002-9750-3653","observed_orcids":["https://orcid.org/0000-0002-9750-3653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edison Moraes Rodrigues Filho","raw_affiliation_strings":["a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","institution_ids":[]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030858820","display_name":"Jane Bencke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51882195","display_name":"Universidade Luterana do Brasil","ror":"https://ror.org/00kde4z41","country_code":"BR","type":"education","lineage":["https://openalex.org/I51882195"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jane Bencke","raw_affiliation_strings":["b Laborat\u00f3rio de Biomarcadores do Trauma , Universidade Luterana do Brasil , Canoas , Brazil , and","Laborat\u00f3rio de Biomarcadores do Trauma, Universidade Luterana do Brasil, Canoas, Brazil, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Laborat\u00f3rio de Biomarcadores do Trauma , Universidade Luterana do Brasil , Canoas , Brazil , and","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"Laborat\u00f3rio de Biomarcadores do Trauma, Universidade Luterana do Brasil, Canoas, Brazil, and","institution_ids":["https://openalex.org/I51882195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017385038","display_name":"Andr\u00e9a Regner","orcid":"https://orcid.org/0000-0002-6657-7991","observed_orcids":["https://orcid.org/0000-0002-6657-7991"]},"institutions":[{"id":"https://openalex.org/I51882195","display_name":"Universidade Luterana do Brasil","ror":"https://ror.org/00kde4z41","country_code":"BR","type":"education","lineage":["https://openalex.org/I51882195"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Andrea Regner","raw_affiliation_strings":["a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","b Laborat\u00f3rio de Biomarcadores do Trauma , Universidade Luterana do Brasil , Canoas , Brazil , and","c Curso de Medicina , Universidade Luterana do Brasil , Canoas , Brazil","Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil","Laborat\u00f3rio de Biomarcadores do Trauma, Universidade Luterana do Brasil, Canoas, Brazil, and","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade ","institution_ids":[]},{"raw_affiliation_string":"b Laborat\u00f3rio de Biomarcadores do Trauma , Universidade Luterana do Brasil , Canoas , Brazil , and","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"c Curso de Medicina , Universidade Luterana do Brasil , Canoas , Brazil","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"Laborat\u00f3rio de Biomarcadores do Trauma, Universidade Luterana do Brasil, Canoas, Brazil, and","institution_ids":["https://openalex.org/I51882195"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular Aplicada \u00e0 Sa\u00fade,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017385038"],"corresponding_institution_ids":["https://openalex.org/I51882195"],"apc_list":null,"apc_paid":null,"fwci":1.5003,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.82055921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"1","first_page":"23","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11467","display_name":"Trauma and Emergency Care Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/severe-traumatic-brain-injury","display_name":"severe traumatic brain injury","score":0.8740000128746033},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.7599999904632568},{"id":"https://openalex.org/keywords/icu-mortality","display_name":"ICU mortality","score":0.9390000104904175},{"id":"https://openalex.org/keywords/polytrauma","display_name":"polytrauma","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8476686477661133},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6242470145225525},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6100667119026184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5591872930526733},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4129064679145813},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3974047899246216},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3913514316082001},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32089507579803467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2842470407485962},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.14673766493797302},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0696249008178711}],"mesh":[{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015600","descriptor_name":"Glasgow Coma Scale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/02699052.2015.1077993","doi":"https://doi.org/10.3109/02699052.2015.1077993","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02699052.2015.1077993","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},{"id":"pmid:26555864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26555864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain injury","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1505106692","https://openalex.org/W1551374885","https://openalex.org/W1597356000","https://openalex.org/W1974630536","https://openalex.org/W1975682269","https://openalex.org/W1977822992","https://openalex.org/W1980764967","https://openalex.org/W1983836947","https://openalex.org/W1984259765","https://openalex.org/W1990959776","https://openalex.org/W1997012788","https://openalex.org/W2006478507","https://openalex.org/W2006681093","https://openalex.org/W2011892319","https://openalex.org/W2012844571","https://openalex.org/W2013333707","https://openalex.org/W2015479033","https://openalex.org/W2023541862","https://openalex.org/W2026811615","https://openalex.org/W2042346047","https://openalex.org/W2042961233","https://openalex.org/W2043131801","https://openalex.org/W2043912900","https://openalex.org/W2044480877","https://openalex.org/W2048292311","https://openalex.org/W2048957533","https://openalex.org/W2051440255","https://openalex.org/W2058696184","https://openalex.org/W2059392218","https://openalex.org/W2061438637","https://openalex.org/W2064196845","https://openalex.org/W2067624621","https://openalex.org/W2068811322","https://openalex.org/W2070989549","https://openalex.org/W2071764269","https://openalex.org/W2084226102","https://openalex.org/W2093382741","https://openalex.org/W2096170120","https://openalex.org/W2099030247","https://openalex.org/W2104780192","https://openalex.org/W2111152232","https://openalex.org/W2112720959","https://openalex.org/W2115818030","https://openalex.org/W2119304118","https://openalex.org/W2123011659","https://openalex.org/W2135380777","https://openalex.org/W2149818957","https://openalex.org/W2161278623","https://openalex.org/W2413073095","https://openalex.org/W2736091234"],"related_works":["https://openalex.org/W1505106692","https://openalex.org/W2042346047","https://openalex.org/W2121908055","https://openalex.org/W222739660","https://openalex.org/W7167228306","https://openalex.org/W2026811615","https://openalex.org/W4283014416","https://openalex.org/W2161278623","https://openalex.org/W2585833877","https://openalex.org/W1980764967"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Severe":[1,94],"traumatic":[2],"brain":[3],"injury":[4,196],"(TBI)":[5],"is":[6],"associated":[7,45,97],"with":[8,46,54,98,111,170,188],"a":[9,99],"30-70%":[10],"mortality":[11,51,101],"rate.":[12],"Nevertheless,":[13,130],"in":[14,52,139,159],"clinical":[15],"practice":[16],"there":[17,131],"are":[18,44],"no":[19,133],"effective":[20],"biomarkers":[21],"for":[22],"the":[23,32,106,119,140,160],"prediction":[24],"of":[25,105,195],"fatal":[26,191],"outcome":[27,192],"following":[28,197],"severe":[29,55,67,109,120,198],"TBI.":[30,56,199],"Therefore,":[31],"aim":[33],"was":[34,81,96,123],"to":[35],"determine":[36],"whether":[37],"brain-derived":[38],"neurotrophic":[39],"factor":[40],"(BDNF)":[41],"plasma":[42,78,115],"levels":[43,138],"intensive":[47],"care":[48],"unit":[49],"(ICU)":[50],"patients":[53,64,107],"METHODS:":[57],"This":[58],"prospective":[59],"study":[60],"enrolled":[61],"120":[62],"male":[63],"who":[65],"suffered":[66],"TBI":[68,95,110,121,162,169],"(Glasgow":[69],"Coma":[70],"Scale":[71],"3-8":[72],"at":[73,83],"emergency":[74,90],"room":[75,91],"admission).":[76,92],"The":[77,113],"BDNF":[79,116,137,183],"level":[80],"determined":[82],"ICU":[84],"admission":[85],"(mean":[86],"6.4":[87],"hours":[88],"after":[89],"RESULTS:":[93],"35%":[100],"rate":[102],"and":[103],"64%":[104],"presented":[108],"multi-trauma.":[112],"mean":[114],"concentration":[117],"among":[118],"victims":[122],"704.2":[124],"\u00b1":[125,143,150,164,174],"63.4":[126],"pg":[127,145,152,166,176],"ml(-1)":[128],"(\u00b1SEM).":[129],"were":[132],"significant":[134],"differences":[135],"between":[136],"survivor":[141],"(700.2":[142],"82.8":[144],"ml(-1))":[146,153,167,177],"or":[147,158,168,193],"non-survivor":[148],"(711.6":[149],"97.4":[151],"groups":[154,172],"(p":[155,178],"=":[156,179],"0.238)":[157],"isolated":[161],"(800.4":[163],"117.4":[165],"multi-trauma":[171],"(650.5":[173],"73.9":[175],"0.109).":[180],"CONCLUSIONS:":[181],"Plasma":[182],"concentrations":[184],"did":[185],"not":[186],"correlate":[187],"either":[189],"short-term":[190],"type":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}