{"id":"https://openalex.org/W2175681793","doi":null,"title":"Formation of EpCAM Oligomers and Their Potential Effect in Regulating Breast Cancer","display_name":"Formation of EpCAM Oligomers and Their Potential Effect in Regulating Breast Cancer","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2175681793","mag":"2175681793"},"language":"en","primary_location":{"id":"pmh:oai:openscholarship.wustl.edu:undergrad_research-1075","doi":null,"is_oa":false,"landing_page_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1075&context=undergrad_research","pdf_url":null,"source":{"id":"https://openalex.org/S4377196400","display_name":"Open Scholarship Institutional Repository (Washington University in St. Louis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Research Symposium Posters","raw_type":"text"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ryan Jacobs","orcid":"https://orcid.org/0000-0001-7814-7959","observed_orcids":["https://orcid.org/0000-0001-7814-7959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan Jacobs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7814-7959","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062867029","display_name":"Narendra V. Sankpal","orcid":"https://orcid.org/0000-0001-6987-8143","observed_orcids":["https://orcid.org/0000-0001-6987-8143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narendra V. Sankpal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6987-8143","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004593862","display_name":"Piyush Kumar Sharma","orcid":"https://orcid.org/0000-0002-6247-3503","observed_orcids":["https://orcid.org/0000-0002-6247-3503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piyush Kumar Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6247-3503","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087445024","display_name":"Lincoln Muhoro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lincoln Muhoro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008456176","display_name":"Timothy P. Fleming","orcid":"https://orcid.org/0000-0002-8661-1210","observed_orcids":["https://orcid.org/0000-0002-8661-1210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy P. Fleming","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8661-1210","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061892063","display_name":"William E. Gillanders","orcid":"https://orcid.org/0000-0002-0465-3071","observed_orcids":["https://orcid.org/0000-0002-0465-3071","https://orcid.org/0009-0008-7335-6039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. Gillanders","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0465-3071","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02469136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.9240000247955322},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ph-dependent-oligomerization","display_name":"pH-dependent oligomerization","score":0.6389999985694885},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8100000023841858},{"id":"https://openalex.org/keywords/epithelial-cancers","display_name":"epithelial cancers","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cell-signaling-regulation","display_name":"cell signaling regulation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7167108654975891},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44230571389198303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3695276975631714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30852603912353516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19806495308876038}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:openscholarship.wustl.edu:undergrad_research-1075","doi":null,"is_oa":false,"landing_page_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1075&context=undergrad_research","pdf_url":null,"source":{"id":"https://openalex.org/S4377196400","display_name":"Open Scholarship Institutional Repository (Washington University in St. Louis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Research Symposium Posters","raw_type":"text"},{"id":"pmh:oai:openscholarship.wustl.edu:vol11-1071","doi":null,"is_oa":false,"landing_page_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1071&context=vol11","pdf_url":null,"source":{"id":"https://openalex.org/S4377196400","display_name":"Open Scholarship Institutional Repository (Washington University in St. Louis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Volume 11","raw_type":"text"},{"id":"mag:2175681793","doi":null,"is_oa":false,"landing_page_url":"https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1075&context=undergrad_research","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044689258","https://openalex.org/W2889277487","https://openalex.org/W3030271176","https://openalex.org/W4398135754","https://openalex.org/W2180671180","https://openalex.org/W2093215115","https://openalex.org/W2137841218","https://openalex.org/W1959671403","https://openalex.org/W6946341021","https://openalex.org/W3005119354"],"abstract_inverted_index":{"Epithelial":[0],"cell":[1,36,89,141,212],"adhesion":[2],"molecule":[3,8],"(EpCAM)":[4],"is":[5,10,24],"a":[6,63,83],"signaling":[7,213],"that":[9,58,79,143,157,176],"expressed":[11],"at":[12],"high":[13,145],"levels":[14],"in":[15,32,38,87,130,137,180,195,218],"epithelial":[16,34,139,219],"carcinoma":[17,35],"cells.":[18],"The":[19],"purpose":[20],"of":[21,47,62,147,210],"this":[22,73],"study":[23],"to":[25,40,100,132,188],"better":[26],"understand":[27],"EpCAM":[28,66,80,112,120,125,150,158,177,183],"interactions":[29,44,192,207],"with":[30,85,118,186],"itself":[31,86,187],"human":[33,88,138],"lines":[37,142],"order":[39],"determine":[41],"how":[42,205],"such":[43,206],"affect":[45,208],"regulation":[46,209],"downstream":[48,211],"cell-signaling":[49],"pathways.":[50],"A":[51],"crystal":[52,74],"structure":[53,75],"has":[54],"already":[55],"been":[56],"elucidated":[57],"shows":[59],"the":[60,133,164],"formation":[61],"mutated":[64],"recombinant":[65,111],"dimer":[67,84],"between":[68],"its":[69],"extracellular":[70],"domains.":[71],"Using":[72,110],"model,":[76],"we":[77,123,155,173],"hypothesized":[78],"can":[81,174],"form":[82,101,126,189],"lines.":[90],"Chemical":[91],"cross-linking":[92],"experiments":[93],"were":[94,152],"performed":[95],"under":[96],"various":[97],"reaction":[98,165],"conditions":[99],"not":[102],"only":[103,149],"dimers,":[104],"but":[105],"also":[106,184],"trimers":[107,127],"and":[108,114,128,182,215],"tetramers.":[109],"proteins":[113],"293T":[115],"cells":[116],"transfected":[117],"an":[119],"expression":[121,146],"vector,":[122],"observed":[124],"tetramers":[129],"addition":[131],"expected":[134],"dimers.":[135],"However,":[136],"cancer":[140],"have":[144],"EpCAM,":[148],"dimers":[151,179],"observed.":[153],"Finally,":[154],"noticed":[156],"oligomers":[159],"formed":[160],"more":[161,168,196],"readily":[162],"as":[163],"environment":[166],"became":[167],"basic.":[169],"From":[170],"these":[171],"results,":[172],"conclude":[175],"forms":[178],"cells,":[181],"interacts":[185],"oligomers.":[190],"These":[191,199],"are":[193],"strengthened":[194],"basic":[197],"conditions.":[198],"results":[200],"provide":[201],"evidence":[202],"for":[203],"investigating":[204],"pathways":[214],"tumor":[216],"growth":[217],"cancers,":[220],"especially":[221],"breast":[222],"cancer.":[223]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
