{"id":"https://openalex.org/W2175433060","doi":"https://doi.org/10.1093/ndt/gfv367","title":"The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats","display_name":"The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats","publication_year":2015,"publication_date":"2015-10-28","ids":{"openalex":"https://openalex.org/W2175433060","doi":"https://doi.org/10.1093/ndt/gfv367","mag":"2175433060","pmid":"https://pubmed.ncbi.nlm.nih.gov/26516203"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfv367","doi":"https://doi.org/10.1093/ndt/gfv367","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfv367","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040271448","display_name":"Hitoshi Minakuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hitoshi Minakuchi","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089373241","display_name":"Shu Wakino","orcid":"https://orcid.org/0000-0003-1677-8397","observed_orcids":["https://orcid.org/0000-0003-1677-8397"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shu Wakino","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112016202","display_name":"Kozi Hosoya","orcid":"https://orcid.org/0009-0009-1735-7325","observed_orcids":["https://orcid.org/0009-0009-1735-7325"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kozi Hosoya","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083489897","display_name":"Keiko Sueyasu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Sueyasu","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101581484","display_name":"Kazuhiro Hasegawa","orcid":"https://orcid.org/0000-0003-3113-4522","observed_orcids":["https://orcid.org/0000-0003-3113-4522"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Hasegawa","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111118375","display_name":"Keisuke Shinozuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Shinozuka","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005631544","display_name":"Ayumi Yoshifuji","orcid":"https://orcid.org/0000-0001-8246-8675","observed_orcids":["https://orcid.org/0000-0001-8246-8675"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayumi Yoshifuji","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071721885","display_name":"Koji Futatsugi","orcid":"https://orcid.org/0000-0002-5636-970X","observed_orcids":["https://orcid.org/0000-0002-5636-970X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Futatsugi","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004064456","display_name":"Motoaki Komatsu","orcid":"https://orcid.org/0009-0002-9106-2452","observed_orcids":["https://orcid.org/0009-0002-9106-2452"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoaki Komatsu","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015476095","display_name":"Takeshi Kanda","orcid":"https://orcid.org/0000-0003-3587-5037","observed_orcids":["https://orcid.org/0000-0003-3587-5037"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Kanda","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008929134","display_name":"Hirobumi Tokuyama","orcid":"https://orcid.org/0009-0002-8715-2471","observed_orcids":["https://orcid.org/0009-0002-8715-2471"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirobumi Tokuyama","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036863557","display_name":"K\u00f4ichi Hayashi","orcid":"https://orcid.org/0000-0001-5064-8874","observed_orcids":["https://orcid.org/0000-0001-5064-8874"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Hayashi","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077665206","display_name":"Hiroshi Itoh","orcid":"https://orcid.org/0000-0003-2514-4919","observed_orcids":["https://orcid.org/0000-0003-2514-4919"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Itoh","raw_affiliation_strings":["Department of Internal Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040271448"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":1.8677,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.8538867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"3","first_page":"413","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.21780000627040863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dimethylarginine-dimethylaminohydrolase","display_name":"dimethylarginine dimethylaminohydrolase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ddah1","display_name":"DDAH1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ddah2","display_name":"DDAH2","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8289999961853027},{"id":"https://openalex.org/keywords/subtotal-nephrectomy","display_name":"subtotal nephrectomy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9139999747276306},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.871999979019165},{"id":"https://openalex.org/keywords/uremic-toxins","display_name":"uremic toxins","score":0.8040000200271606},{"id":"https://openalex.org/keywords/indoxyl-sulfate","display_name":"indoxyl sulfate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ectopic-fat-deposition","display_name":"ectopic fat deposition","score":0.7599999904632568},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.6809999942779541},{"id":"https://openalex.org/keywords/triglyceride-accumulation","display_name":"triglyceride accumulation","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8602501749992371},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8585837483406067},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7988297939300537},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.7451191544532776},{"id":"https://openalex.org/C2779877776","wikidata":"https://www.wikidata.org/wiki/Q752685","display_name":"Asymmetric dimethylarginine","level":4,"score":0.6651886701583862},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5550355911254883},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.4833816885948181},{"id":"https://openalex.org/C2780941825","wikidata":"https://www.wikidata.org/wiki/Q1538213","display_name":"Lipodystrophy","level":5,"score":0.45910003781318665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43796902894973755},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.42089593410491943},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.40455639362335205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30039653182029724},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.21469077467918396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08400291204452515},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/ndt/gfv367","doi":"https://doi.org/10.1093/ndt/gfv367","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfv367","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:26516203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26516203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:ndt:31/3/413","doi":null,"is_oa":false,"landing_page_url":"http://ndt.oxfordjournals.org/cgi/content/short/31/3/413","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1599717232","display_name":"Pathophysiology of non-diabetic/obesity induced renal injuries","funder_award_id":"26461236","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W62553524","https://openalex.org/W1749647045","https://openalex.org/W1773423156","https://openalex.org/W1927710737","https://openalex.org/W1967455875","https://openalex.org/W1971017609","https://openalex.org/W1973053094","https://openalex.org/W1973969197","https://openalex.org/W1977795048","https://openalex.org/W1980099051","https://openalex.org/W1980220077","https://openalex.org/W1981268963","https://openalex.org/W1984731226","https://openalex.org/W1985842225","https://openalex.org/W1987504685","https://openalex.org/W1998205437","https://openalex.org/W1998776130","https://openalex.org/W1999859905","https://openalex.org/W2006209425","https://openalex.org/W2007231956","https://openalex.org/W2008352575","https://openalex.org/W2009172922","https://openalex.org/W2009395159","https://openalex.org/W2017676683","https://openalex.org/W2020092321","https://openalex.org/W2024746608","https://openalex.org/W2024936668","https://openalex.org/W2037709367","https://openalex.org/W2037721658","https://openalex.org/W2042309671","https://openalex.org/W2045918150","https://openalex.org/W2050679442","https://openalex.org/W2051999166","https://openalex.org/W2058343608","https://openalex.org/W2063382200","https://openalex.org/W2070215280","https://openalex.org/W2074452479","https://openalex.org/W2075607015","https://openalex.org/W2075705443","https://openalex.org/W2079787384","https://openalex.org/W2079962809","https://openalex.org/W2083285004","https://openalex.org/W2085952650","https://openalex.org/W2089625417","https://openalex.org/W2089727303","https://openalex.org/W2093341621","https://openalex.org/W2098915805","https://openalex.org/W2104333499","https://openalex.org/W2104357975","https://openalex.org/W2118345202","https://openalex.org/W2123893097","https://openalex.org/W2123960426","https://openalex.org/W2124821727","https://openalex.org/W2125320237","https://openalex.org/W2128125950","https://openalex.org/W2129050578","https://openalex.org/W2131816370","https://openalex.org/W2133371348","https://openalex.org/W2136188720","https://openalex.org/W2141458792","https://openalex.org/W2142699432","https://openalex.org/W2150119335","https://openalex.org/W2156148515","https://openalex.org/W2165274818","https://openalex.org/W2378376721"],"related_works":["https://openalex.org/W2035849319","https://openalex.org/W1994067896","https://openalex.org/W3047552848","https://openalex.org/W3141885229","https://openalex.org/W2619283564","https://openalex.org/W2119861336","https://openalex.org/W7117421979","https://openalex.org/W2135717321","https://openalex.org/W2092644411","https://openalex.org/W2117156673"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"lipodystrophy-like":[2,224,244],"phenotype":[3,245],"has":[4],"been":[5],"suggested":[6],"in":[7,125,144,149,155,167,190,240],"early":[8],"chronic":[9],"kidney":[10],"disease":[11],"(CKD).":[12],"It":[13],"includes":[14],"adipose":[15,126,169,192,241],"tissue":[16,129,170,193,242],"atrophy,":[17],"systemic":[18],"insulin":[19,41,118,123,204],"resistance":[20],"(IR),":[21],"dyslipidemia":[22],"and":[23,49,53,68,99,105,117,133,152,163,176,180,203],"ectopic":[24,248],"lipid":[25,147],"accumulation.":[26],"To":[27],"elucidate":[28],"its":[29],"pathogenesis,":[30],"we":[31],"investigated":[32],"the":[33,150,168,191,237],"role":[34],"of":[35,91,142,160,171,194,216,236],"two":[36],"uremic":[37],"toxins":[38],"that":[39],"affect":[40],"sensitivity:":[42],"an":[43],"endogenous":[44],"nitric":[45],"oxide":[46],"synthase":[47],"inhibitor,":[48],"asymmetric":[50],"dimethylarginine":[51,95],"(ADMA)":[52],"indoxyl":[54],"sulfate":[55],"(IS).":[56],"METHODS:":[57],"Six-week-old":[58],"Sprague-Dawley":[59],"rats":[60],"were":[61,76,101,108,207,229],"rendered":[62],"CKD":[63],"by":[64,209,227],"subtotal":[65],"nephrectomy":[66],"(Nx)":[67],"compared":[69],"with":[70,81,211],"sham-operated":[71],"rats.":[72,157,173,196],"Cultured":[73],"3T3-L1":[74],"fibroblasts":[75],"differentiated":[77],"into":[78],"mature":[79],"adipocytes":[80],"or":[82,221],"without":[83],"ADMA.":[84],"Transgenic":[85],"(Tg)":[86],"mice":[87,218],"overexpressing":[88,219],"each":[89,214],"isoform":[90],"ADMA":[92,197],"degrading":[93],"enzyme,":[94],"dimethylaminohydrolase":[96],"1":[97],"(DDAH1)":[98],"DDAH2":[100,177],"subject":[102],"to":[103,121],"Nx":[104,112,156,172,195,228],"their":[106],"phenotypes":[107,225],"investigated.":[109],"RESULTS:":[110],"In":[111,213,232],"rats,":[113],"IR":[114,143],"was":[115],"evident":[116],"stimulation":[119],"failed":[120],"activate":[122],"signaling":[124],"tissues.":[127],"Adipose":[128],"weight,":[130],"adipocyte":[131,134,199],"size":[132],"differentiation":[135],"marker":[136],"expressions":[137,178],"decreased":[138],"as":[139],"a":[140,181],"consequence":[141],"Nx.":[145],"Tissue":[146,158],"content":[148],"liver":[151],"muscle":[153],"increased":[154,166,189],"levels":[159],"ADMA,":[161],"IS":[162,183],"oxidative":[164],"stress":[165],"Both":[174],"DDAH1":[175,220],"decreased,":[179],"putative":[182],"receptor,":[184,187],"aryl":[185],"hydrocarbon":[186],"expression":[188],"inhibited":[198],"differentiation,":[200],"triglyceride":[201],"accumulation":[202],"signaling,":[205],"which":[206],"reversed":[208],"pretreatment":[210],"cGMP.":[212],"type":[215],"Tg":[217],"DDAH2,":[222],"all":[223],"induced":[226],"reversed.":[230],"CONCLUSIONS:":[231],"mild":[233],"CKD,":[234],"dysregulation":[235],"ADMA/DDAH":[238],"pathway":[239],"triggers":[243],"changes,":[246],"including":[247],"fat":[249],"depositions.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
