{"id":"https://openalex.org/W2175246397","doi":"https://doi.org/10.1146/annurev.ph.58.030196.003415","title":"The Movement of Kinesin Along Microtubules","display_name":"The Movement of Kinesin Along Microtubules","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2175246397","doi":"https://doi.org/10.1146/annurev.ph.58.030196.003415","mag":"2175246397","pmid":"https://pubmed.ncbi.nlm.nih.gov/8815816"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.ph.58.030196.003415","doi":"https://doi.org/10.1146/annurev.ph.58.030196.003415","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.58.030196.003415","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2175246397"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085327397","display_name":"Jonathon Howard","orcid":"https://orcid.org/0000-0003-0086-1196","observed_orcids":["https://orcid.org/0000-0003-0086-1196"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Howard","raw_affiliation_strings":["Department of Physiology & Biophysics, University of Washington, Seattle 98195-7290, USA","Department of Physiology and Biophysics, University of Washington, Seattle, 98195-7290, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Biophysics, University of Washington, Seattle 98195-7290, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Washington, Seattle, 98195-7290, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085327397"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":4.659,"has_fulltext":false,"cited_by_count":246,"citation_normalized_percentile":{"value":0.95694604,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"58","issue":"1","first_page":"703","last_page":"729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinesin","display_name":"kinesin","score":1.0},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9610000252723694},{"id":"https://openalex.org/keywords/molecular-motors","display_name":"molecular motors","score":0.9549999833106995},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/coiled-coil-dimerization","display_name":"coiled-coil dimerization","score":0.8230000138282776},{"id":"https://openalex.org/keywords/rotary-motion","display_name":"rotary motion","score":0.5490000247955322},{"id":"https://openalex.org/keywords/microtubule-protofilaments","display_name":"microtubule protofilaments","score":0.7020000219345093},{"id":"https://openalex.org/keywords/motor-efficiency","display_name":"motor efficiency","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.9689589738845825},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.916985273361206},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.6049307584762573},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.5916427969932556},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.5906323194503784},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5580230951309204},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.5295653939247131},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.49511662125587463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.454265296459198},{"id":"https://openalex.org/C55988834","wikidata":"https://www.wikidata.org/wiki/Q903650","display_name":"Coiled coil","level":2,"score":0.42418625950813293},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3468441367149353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26963070034980774},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22188487648963928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1928335428237915},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.14496788382530212},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.13080108165740967},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10369858145713806}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.ph.58.030196.003415","doi":"https://doi.org/10.1146/annurev.ph.58.030196.003415","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.58.030196.003415","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"doi:10.1146/annurev.physiol.58.1.703","doi":"https://doi.org/10.1146/annurev.physiol.58.1.703","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.physiol.58.1.703","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"pmid:8815816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8815816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2986122305","display_name":null,"funder_award_id":"AR40593","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W318380599","https://openalex.org/W789458867","https://openalex.org/W1263268564","https://openalex.org/W1432483648","https://openalex.org/W1446681367","https://openalex.org/W1487975069","https://openalex.org/W1495707073","https://openalex.org/W1526403580","https://openalex.org/W1618766618","https://openalex.org/W1881571321","https://openalex.org/W1964164501","https://openalex.org/W1965675171","https://openalex.org/W1973038113","https://openalex.org/W1979507216","https://openalex.org/W1982946753","https://openalex.org/W1993762028","https://openalex.org/W1995950964","https://openalex.org/W1999219397","https://openalex.org/W2002127644","https://openalex.org/W2004290556","https://openalex.org/W2007084342","https://openalex.org/W2010848611","https://openalex.org/W2012454516","https://openalex.org/W2014827729","https://openalex.org/W2015396827","https://openalex.org/W2017457274","https://openalex.org/W2024645073","https://openalex.org/W2028856869","https://openalex.org/W2038705916","https://openalex.org/W2044629144","https://openalex.org/W2044730950","https://openalex.org/W2045062671","https://openalex.org/W2055290772","https://openalex.org/W2056695965","https://openalex.org/W2059158601","https://openalex.org/W2069953906","https://openalex.org/W2082631326","https://openalex.org/W2085266415","https://openalex.org/W2086061329","https://openalex.org/W2102340487","https://openalex.org/W2116441099","https://openalex.org/W2121141482","https://openalex.org/W2145992318","https://openalex.org/W2149374899","https://openalex.org/W2152516404","https://openalex.org/W2169832500","https://openalex.org/W2170640142","https://openalex.org/W2176030573","https://openalex.org/W2294810206","https://openalex.org/W2463695542","https://openalex.org/W2902326093"],"related_works":["https://openalex.org/W2131994738","https://openalex.org/W2614139204","https://openalex.org/W1992353528","https://openalex.org/W1998198313","https://openalex.org/W3131254931","https://openalex.org/W2790261707","https://openalex.org/W2029573541","https://openalex.org/W2089898142","https://openalex.org/W2009241039"],"abstract_inverted_index":{"The":[0,44,93],"molecular":[1],"motor":[2,83],"kinesin":[3,35,46,78,96,132],"is":[4,22,54,98],"a":[5,18,86,126,136,141],"homodimer":[6],"containing":[7],"two":[8,129],"heads-globular":[9],"domains":[10,32],"each":[11],"of":[12,41,51,70,95,102,125,131],"which":[13],"has":[14,37],"an":[15,38],"ATP-":[16],"and":[17,59,114],"microtubule-binding":[19],"site.":[20],"It":[21],"argued":[23],"by":[24,65],"analogy":[25],"to":[26,56,122],"other":[27],"proteins":[28],"with":[29],"coiled-coil":[30],"dimerization":[31],"that":[33,81,118],"the":[34,49,52,57,60,68,71,100,105,128],"dimer":[36],"approximate":[39],"axis":[40],"rotational":[42],"symmetry.":[43],"path":[45],"follows":[47],"along":[48],"surface":[50],"microtubule":[53],"parallel":[55],"protofilaments,":[58],"steps":[61],"are":[62],"likely":[63],"separated":[64],"8":[66],"nm,":[67],"length":[69],"tubulin":[72],"dimer.":[73],"Micromechanical":[74],"recordings":[75],"from":[76,109],"single":[77],"molecules":[79],"indicate":[80],"one":[82],"can":[84],"exert":[85],"force":[87],"as":[88,90],"great":[89],"5":[91],"pN.":[92],"efficiency":[94],"probably":[97],"in":[99,119,135],"order":[101,120],"50%,":[103],"considering":[104],"free":[106],"energy":[107],"available":[108],"ATP":[110],"hydrolysis.":[111],"Structural,":[112],"mechanical,":[113],"biochemical":[115],"experiments":[116],"suggest":[117],"not":[121],"let":[123],"go":[124],"microtubule,":[127],"heads":[130],"might":[133],"move":[134],"coordinated":[137],"manner,":[138],"perhaps":[139],"undergoing":[140],"rotary":[142],"motion.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2025-10-10T00:00:00"}