{"id":"https://openalex.org/W2175131571","doi":null,"title":"The use of dynamic nuclear polarization (13)C-pyruvate MRS in cancer.","display_name":"The use of dynamic nuclear polarization (13)C-pyruvate MRS in cancer.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2175131571","mag":"2175131571","pmid":"https://pubmed.ncbi.nlm.nih.gov/26550544","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620180"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3610610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620180","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078550381","display_name":"Henrik Gutte","orcid":"https://orcid.org/0000-0001-5494-5323","observed_orcids":["https://orcid.org/0000-0001-5494-5323"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Gutte","raw_affiliation_strings":["Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033672920","display_name":"Adam Espe Hansen","orcid":"https://orcid.org/0000-0002-6457-1537","observed_orcids":["https://orcid.org/0000-0002-6457-1537"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Adam Espe Hansen","raw_affiliation_strings":["Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088700870","display_name":"Helle Hjorth Johannesen","orcid":"https://orcid.org/0000-0001-9172-5004","observed_orcids":["https://orcid.org/0000-0001-9172-5004"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Helle Hjorth Johannesen","raw_affiliation_strings":["Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056174655","display_name":"Andreas Clemmensen","orcid":"https://orcid.org/0000-0001-7669-1133","observed_orcids":["https://orcid.org/0000-0001-7669-1133"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Andreas Ettrup Clemmensen","raw_affiliation_strings":["Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051798578","display_name":"Jan Henrik Ardenkj\u00e6r\u2010Larsen","orcid":"https://orcid.org/0000-0001-6167-6926","observed_orcids":["https://orcid.org/0000-0001-6167-6926"]},"institutions":[{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jan Henrik Ardenkj\u00e6r-Larsen","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre Denmark ; Department of Electrical Engineering, Technical University of Denmark Kgs Lyngby, Denmark ; GE Healthcare, Br\u00f8ndby Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre Denmark ; Department of Electrical Engineering, Technical University of Denmark Kgs Lyngby, Denmark ; GE Healthcare, Br\u00f8ndby Denmark","institution_ids":["https://openalex.org/I2801942218","https://openalex.org/I2802567020","https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006783007","display_name":"Carsten Haagen Nielsen","orcid":"https://orcid.org/0009-0009-6632-7835","observed_orcids":["https://orcid.org/0009-0009-6632-7835"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Carsten Haagen Nielsen","raw_affiliation_strings":["Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044660787","display_name":"Andreas Kj\u00e6r","orcid":"https://orcid.org/0000-0002-2706-5547","observed_orcids":["https://orcid.org/0000-0002-2706-5547"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Andreas Kj\u00e6r","raw_affiliation_strings":["Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5604,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.89534884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":"5","first_page":"548","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamic-nuclear-polarization","display_name":"dynamic nuclear polarization","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hyperpolarized-1-13c-pyruvate","display_name":"hyperpolarized [1-13C]pyruvate","score":0.9300000071525574},{"id":"https://openalex.org/keywords/magnetic-resonance-spectroscopy","display_name":"magnetic resonance spectroscopy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.8610000014305115},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.781000018119812},{"id":"https://openalex.org/keywords/early-treatment-response","display_name":"early treatment response","score":0.7540000081062317},{"id":"https://openalex.org/keywords/metabolic-imaging","display_name":"metabolic imaging","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9169489145278931},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.37982016801834106}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3610610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26550544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26550544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nuclear medicine and molecular imaging","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/eccd05c0-b333-4ddf-90a0-22180e2e6f10","doi":null,"is_oa":true,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620171","pdf_url":"http://www.ajnmmi.us/files/ajnmmi0010834.pdf","source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Borgwardt , H G , Espe Hansen , A , Hjort Johannesen , H , Clemmensen , A E , Ardenkj\u00e6r-Larsen , J H , Haagen Nielsen , C & Kj\u00e6r , A 2015 , ' The use of dynamic nuclear polarization 13 C-pyruvate MRS in cancer ' , American Journal of Nuclear Medicine and Molecular Imaging , vol. 5 , no. 5 , pp. 548-560 . < http://www.ajnmmi.us/files/ajnmmi0010834.pdf >","raw_type":"article"},{"id":"mag:2175131571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26550544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3610610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4620180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323124","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19"},{"id":"https://openalex.org/F4320323939","display_name":"Copenhagen Graduate School for Nanoscience and Nanotechnology","ror":"https://ror.org/035b05819"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2175131571.pdf","grobid_xml":"https://content.openalex.org/works/W2175131571.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1418024927","https://openalex.org/W1505831072","https://openalex.org/W1574100447","https://openalex.org/W1812576394","https://openalex.org/W1903017334","https://openalex.org/W1912319529","https://openalex.org/W1964264772","https://openalex.org/W1966726954","https://openalex.org/W1971859682","https://openalex.org/W1973153810","https://openalex.org/W1975107578","https://openalex.org/W1975822731","https://openalex.org/W1981711832","https://openalex.org/W1985166963","https://openalex.org/W1986007087","https://openalex.org/W1987664220","https://openalex.org/W1990556342","https://openalex.org/W1991744090","https://openalex.org/W1993268545","https://openalex.org/W1999565461","https://openalex.org/W2009996186","https://openalex.org/W2018719373","https://openalex.org/W2019607817","https://openalex.org/W2024643977","https://openalex.org/W2026049928","https://openalex.org/W2030801816","https://openalex.org/W2031263585","https://openalex.org/W2034211857","https://openalex.org/W2043680485","https://openalex.org/W2050805040","https://openalex.org/W2053334137","https://openalex.org/W2055141202","https://openalex.org/W2059900570","https://openalex.org/W2063322641","https://openalex.org/W2066037984","https://openalex.org/W2066183103","https://openalex.org/W2076833535","https://openalex.org/W2077126840","https://openalex.org/W2077672512","https://openalex.org/W2080830389","https://openalex.org/W2083518294","https://openalex.org/W2084541894","https://openalex.org/W2088272414","https://openalex.org/W2091723288","https://openalex.org/W2097259163","https://openalex.org/W2098260404","https://openalex.org/W2100313731","https://openalex.org/W2109414919","https://openalex.org/W2113776729","https://openalex.org/W2117272999","https://openalex.org/W2119305996","https://openalex.org/W2122733132","https://openalex.org/W2132063042","https://openalex.org/W2132495825","https://openalex.org/W2135707765","https://openalex.org/W2136115306","https://openalex.org/W2137052325","https://openalex.org/W2142136953","https://openalex.org/W2155263737","https://openalex.org/W2160085140","https://openalex.org/W2162525969","https://openalex.org/W2162755211","https://openalex.org/W2168021523","https://openalex.org/W2328240776","https://openalex.org/W2342969098","https://openalex.org/W4211024301"],"related_works":["https://openalex.org/W3140514696","https://openalex.org/W4200567656","https://openalex.org/W2027479550","https://openalex.org/W7101044910","https://openalex.org/W2115682896","https://openalex.org/W1985166963","https://openalex.org/W2128736902","https://openalex.org/W2029910746","https://openalex.org/W2053334137","https://openalex.org/W2748057461"],"abstract_inverted_index":{"In":[0,203],"recent":[1],"years":[2],"there":[3],"has":[4,81,96,220],"been":[5,97,159],"an":[6,273],"immense":[7],"development":[8,91],"of":[9,25,51,65,68,77,86,92,112,136,138,179,186,216,236,243,260,279,297,302],"new":[10,34,94],"targeted":[11],"anti-cancer":[12],"drugs.":[13],"For":[14],"practicing":[15],"precision":[16],"medicine,":[17],"a":[18,43,75,116,123,227,241,246],"sensitive":[19,228],"method":[20,95,132,229],"imaging":[21,152,301],"for":[22,30,46,230,234],"non-invasive,":[23],"assessment":[24,235],"early":[26,237],"treatment":[27,238],"response":[28,239],"and":[29,54,80,122,143,156,189,198,233,266],"assisting":[31],"in":[32,48,74,87,184,221,240,263,277,292],"developing":[33],"drugs":[35],"is":[36,42,63,171,208],"warranted.":[37],"Magnetic":[38],"Resonance":[39],"Spectroscopy":[40],"(MRS)":[41],"potent":[44],"technique":[45],"non-invasive":[47],"vivo":[49,88],"investigation":[50,85],"tissue":[52],"chemistry":[53],"cellular":[55],"metabolism.":[56,89],"Hyperpolarization":[57],"by":[58],"Dynamic":[59],"Nuclear":[60],"Polarization":[61],"(DNP)":[62],"capable":[64],"creating":[66],"solutions":[67],"molecules":[69,79],"with":[70,115,147,252],"polarized":[71],"nuclear":[72,102],"spins":[73],"range":[76],"biological":[78],"enabled":[82],"the":[83,101,110,113,120,127,131,162,166,180,195,199,205,253,258],"real-time":[84],"The":[90,214,270],"this":[93],"demonstrated":[98],"to":[99,119,174,211,225,256,284,294],"enhance":[100],"polarization":[103],"more":[104,288],"than":[105],"10,000-fold,":[106],"thereby":[107],"significantly":[108],"increasing":[109],"sensitivity":[111],"MRS":[114,300],"spatial":[117],"resolution":[118,125],"millimeters":[121],"temporal":[124],"at":[126],"subsecond":[128],"range.":[129],"Furthermore,":[130],"enables":[133],"measuring":[134],"kinetics":[135],"conversion":[137],"substrates":[139,157],"into":[140],"cell":[141],"metabolites":[142],"can":[144],"be":[145,226],"integrated":[146],"anatomical":[148],"proton":[149],"magnetic":[150],"resonance":[151,191],"(MRI).":[153],"Many":[154],"nuclei":[155],"have":[158],"hyperpolarized":[160,181,261,298],"using":[161],"DNP":[163,217],"method.":[164],"Currently,":[165],"most":[167],"widely":[168],"used":[169],"compound":[170],"(13)C-pyruvate":[172,182,219,262],"due":[173,210],"favoring":[175],"technicalities.":[176],"Intravenous":[177],"injection":[178],"results":[183],"appearance":[185],"(13)C-lactate,":[187],"(13)C-alanine":[188],"(13)C-bicarbonate":[190],"peaks":[192],"depending":[193],"on":[194],"tissue,":[196],"disease":[197],"metabolic":[200],"state":[201],"probed.":[202],"cancer,":[204],"lactate":[206],"level":[207],"increased":[209,212],"glycolysis.":[213],"use":[215,296],"enhanced":[218],"preclinical":[222],"studies":[223,289],"shown":[224],"detecting":[231],"cancer":[232,268,282],"variety":[242],"cancers.":[244],"Recently,":[245],"first-in-man":[247],"31-patient":[248],"study":[249,271],"was":[250],"conducted":[251],"primary":[254],"objective":[255],"assess":[257],"safety":[259],"healthy":[264],"subjects":[265],"prostate":[267,281],"patients.":[269],"showed":[272],"elevated":[274],"(13)C-lactate/(13)C-pyruvate":[275],"ratio":[276],"regions":[278],"biopsy-proven":[280],"compared":[283],"noncancerous":[285],"tissue.":[286],"However,":[287],"are":[290],"needed":[291],"order":[293],"establish":[295],"(13)C":[299],"cancer.":[303]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
