{"id":"https://openalex.org/W2175122437","doi":"https://doi.org/10.1371/journal.pone.0143062","title":"The Safety of a Conservative Fluid Replacement Strategy in Adults Hospitalised with Malaria","display_name":"The Safety of a Conservative Fluid Replacement Strategy in Adults Hospitalised with Malaria","publication_year":2015,"publication_date":"2015-11-18","ids":{"openalex":"https://openalex.org/W2175122437","doi":"https://doi.org/10.1371/journal.pone.0143062","mag":"2175122437","pmid":"https://pubmed.ncbi.nlm.nih.gov/26581060","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4651424"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0143062","doi":"https://doi.org/10.1371/journal.pone.0143062","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143062","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143062&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143062&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010909343","display_name":"Ne Myo Aung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ne Myo Aung","raw_affiliation_strings":["Insein General Hospital, Yangon, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insein General Hospital, Yangon, Myanmar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072746394","display_name":"Kaung Myat","orcid":"https://orcid.org/0000-0001-5776-4966","observed_orcids":["https://orcid.org/0000-0001-5776-4966"]},"institutions":[{"id":"https://openalex.org/I4405277779","display_name":"Yangon General Hospital","ror":"https://ror.org/03vyfst28","country_code":"MM","type":"healthcare","lineage":["https://openalex.org/I4405277779"]},{"id":"https://openalex.org/I4405277830","display_name":"Khon Kaen Hospital","ror":"https://ror.org/0413wwt45","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277830"]}],"countries":["MM","TH"],"is_corresponding":false,"raw_author_name":"Myat Kaung","raw_affiliation_strings":["Hpa-an Hospital, Hpa-an, Kayin State, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hpa-an Hospital, Hpa-an, Kayin State, Myanmar","institution_ids":["https://openalex.org/I4405277779","https://openalex.org/I4405277830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542790","display_name":"Tint Tint Kyi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tint Tint Kyi","raw_affiliation_strings":["Insein General Hospital, Yangon, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insein General Hospital, Yangon, Myanmar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103867073","display_name":"Myat Phone Kyaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myat Phone Kyaw","raw_affiliation_strings":["Department of Medical Research (Lower Myanmar), Yangon, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research (Lower Myanmar), Yangon, Myanmar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045364529","display_name":"Myo Chit Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258815","display_name":"Myanmar Medical Association","ror":"https://ror.org/018beez50","country_code":"MM","type":"nonprofit","lineage":["https://openalex.org/I4405258815"]}],"countries":["MM"],"is_corresponding":false,"raw_author_name":"Myo Min","raw_affiliation_strings":["Myanmar Medical Association, Yangon, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myanmar Medical Association, Yangon, Myanmar","institution_ids":["https://openalex.org/I4405258815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017121398","display_name":"Zaw Win Htet","orcid":"https://orcid.org/0000-0001-6913-5198","observed_orcids":["https://orcid.org/0000-0001-6913-5198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zaw Win Htet","raw_affiliation_strings":["Insein General Hospital, Yangon, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insein General Hospital, Yangon, Myanmar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032095213","display_name":"Nicholas M. Anstey","orcid":"https://orcid.org/0000-0002-2192-0506","observed_orcids":["https://orcid.org/0000-0002-2192-0506"]},"institutions":[{"id":"https://openalex.org/I29894533","display_name":"Charles Darwin University","ror":"https://ror.org/048zcaj52","country_code":"AU","type":"education","lineage":["https://openalex.org/I29894533"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas M. Anstey","raw_affiliation_strings":["Menzies School of Health Research, Charles Darwin University, Darwin, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Menzies School of Health Research, Charles Darwin University, Darwin, Australia","institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023618896","display_name":"Mar Mar Kyi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar Mar Kyi","raw_affiliation_strings":["Insein General Hospital, Yangon, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insein General Hospital, Yangon, Myanmar","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021449612","display_name":"Josh Hanson","orcid":"https://orcid.org/0000-0002-1423-3839","observed_orcids":["https://orcid.org/0000-0002-1423-3839"]},"institutions":[{"id":"https://openalex.org/I29894533","display_name":"Charles Darwin University","ror":"https://ror.org/048zcaj52","country_code":"AU","type":"education","lineage":["https://openalex.org/I29894533"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Josh Hanson","raw_affiliation_strings":["Menzies School of Health Research, Charles Darwin University, Darwin, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Menzies School of Health Research, Charles Darwin University, Darwin, Australia","institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021449612"],"corresponding_institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.4955,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89012334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"11","first_page":"e0143062","last_page":"e0143062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.8730000257492065},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.878000020980835},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.6269999742507935},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9459999799728394},{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mixed-malaria-infection","display_name":"mixed malaria infection","score":0.6029999852180481},{"id":"https://openalex.org/keywords/normal-saline","display_name":"normal saline","score":0.7710000276565552},{"id":"https://openalex.org/keywords/plasma-lactate","display_name":"plasma lactate","score":0.7549999952316284},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4189999997615814},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.5210000276565552},{"id":"https://openalex.org/keywords/renal-replacement-therapy","display_name":"renal replacement therapy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.819785475730896},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.6369041800498962},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.5325080156326294},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5307103991508484},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.5304949283599854},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.5051210522651672},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.47824540734291077},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.4781162142753601},{"id":"https://openalex.org/C2777808716","wikidata":"https://www.wikidata.org/wiki/Q4529664","display_name":"Fluid replacement","level":2,"score":0.44688481092453003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44679996371269226},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.42270708084106445},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37166184186935425},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33820199966430664},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.16568365693092346},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11985951662063599}],"mesh":[{"descriptor_ui":"D000140","descriptor_name":"Acidosis, Lactic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002052","descriptor_name":"Myanmar","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0143062","doi":"https://doi.org/10.1371/journal.pone.0143062","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143062","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143062&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3627977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4651424","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4651424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4651424","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26581060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26581060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Clinical Trial"},{"id":"pmh:oai:espace.cdu.edu.au:cdu:59200","doi":null,"is_oa":true,"landing_page_url":"http://espace.cdu.edu.au/view/cdu:59200","pdf_url":"http://espace.cdu.edu.au/view/cdu:59200","source":{"id":"https://openalex.org/S4306401536","display_name":"CDU eSpace Institutional Repository (Charles Darwin University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I29894533","host_organization_name":"Charles Darwin University","host_organization_lineage":["https://openalex.org/I29894533"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4751352fe8fb4341855e1732d4bf995f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4751352fe8fb4341855e1732d4bf995f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 11, p e0143062 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0143062","doi":"https://doi.org/10.1371/journal.pone.0143062","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143062","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143062&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G4219421103","display_name":"Improving the medical care of adults admitted to hospital with severe malaria","funder_award_id":"1054195","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G801224714","display_name":"Tropical Disease - immunity, pathogenesis and vaccine development: global translation","funder_award_id":"1037304","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8970450113","display_name":"Pathophysiology and treatment of malaria and other tropical infectious diseases prevalent in our region","funder_award_id":"1042072","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2175122437.pdf","grobid_xml":"https://content.openalex.org/works/W2175122437.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1564331285","https://openalex.org/W1673362020","https://openalex.org/W1767153609","https://openalex.org/W1839670086","https://openalex.org/W1863611044","https://openalex.org/W1966186276","https://openalex.org/W1973054359","https://openalex.org/W1994086811","https://openalex.org/W1999039174","https://openalex.org/W2000803055","https://openalex.org/W2002770567","https://openalex.org/W2020599221","https://openalex.org/W2030009002","https://openalex.org/W2031205187","https://openalex.org/W2045212073","https://openalex.org/W2046754389","https://openalex.org/W2054938569","https://openalex.org/W2074459220","https://openalex.org/W2075578280","https://openalex.org/W2075722850","https://openalex.org/W2078330556","https://openalex.org/W2083775164","https://openalex.org/W2085138589","https://openalex.org/W2096883458","https://openalex.org/W2097786723","https://openalex.org/W2117590566","https://openalex.org/W2131812123","https://openalex.org/W2132269368","https://openalex.org/W2141138557","https://openalex.org/W2147840577","https://openalex.org/W2148087131","https://openalex.org/W2148729295","https://openalex.org/W2156672474","https://openalex.org/W2162693177","https://openalex.org/W2165721969","https://openalex.org/W2167943921","https://openalex.org/W2314787815","https://openalex.org/W2317923971","https://openalex.org/W2319300120","https://openalex.org/W2398574602","https://openalex.org/W2581605534","https://openalex.org/W4211101162","https://openalex.org/W4211113784","https://openalex.org/W4299572512","https://openalex.org/W4300875451","https://openalex.org/W7073953038"],"related_works":["https://openalex.org/W2000803055","https://openalex.org/W2970477783","https://openalex.org/W3134350571","https://openalex.org/W2085138589","https://openalex.org/W2465060729","https://openalex.org/W4205091008","https://openalex.org/W4410976690","https://openalex.org/W1997757557","https://openalex.org/W4386506086","https://openalex.org/W4409061415"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,311],"conservative":[2,267,312],"approach":[3],"to":[4,122,153,274,296],"fluid":[5,41,118,132,263,268,286,313],"resuscitation":[6,314],"improves":[7],"survival":[8],"in":[9,22,37,185,195,204,217,226,234,247,252,279,292,318],"children":[10],"with":[11,24,30,43,255,265,321],"severe":[12,305],"malaria;":[13],"however,":[14],"this":[15],"strategy":[16,315],"has":[17],"not":[18],"been":[19],"formally":[20],"evaluated":[21],"adults":[23,66,319],"the":[25,102,140,143,205,235,266,280,293,297],"disease.":[26],"METHODS:":[27],"Adults":[28],"hospitalised":[29,320],"malaria":[31],"at":[32,47,88,201,229],"two":[33],"tertiary":[34],"referral":[35],"hospitals":[36,282],"Myanmar":[38],"received":[39,109,285],"intravenous":[40,117],"replacement":[42,166,264,269,287],"isotonic":[44],"saline,":[45],"administered":[46],"a":[48,52,110,124,162,256],"maintenance":[49],"rate":[50],"using":[51],"simple":[53],"weight-based":[54],"algorithm.":[55],"Clinical":[56],"and":[57,79,96,119,134,198,232],"biochemical":[58],"indices":[59],"were":[60,87,120,137,271],"followed":[61],"sequentially.":[62],"RESULTS:":[63],"Of":[64],"61":[65,150],"enrolled,":[67],"34":[68],"(56%)":[69],"had":[70,190,284],"Plasmodium":[71,76],"falciparum":[72,94],"mono-infection,":[73],"17":[74,218],"(28%)":[75,219],"vivax":[77],"mono-infection":[78],"10":[80],"(16%)":[81],"mixed":[82],"infection;":[83],"27":[84],"(44%)":[85],"patients":[86,108,151,188],"high":[89],"risk":[90],"of":[91,106,116,126,142,147],"death":[92],"(P.":[93],"infection":[95],"RCAM":[97],"score":[98],"\u2265":[99],"2).":[100],"In":[101],"first":[103,144],"six":[104],"hours":[105,146,194,203,231],"hospitalisation":[107],"mean":[111,125],"1.7":[112],"ml/kg/hour":[113,128],"(range:":[114,129],"1.3-2.2)":[115],"able":[121],"drink":[123],"0.8":[127],"0-3).":[130],"Intravenous":[131],"administration":[133],"oral":[135],"intake":[136],"similar":[138],"for":[139,164],"remainder":[141],"48":[145,230],"hospitalisation.":[148],"All":[149],"survived":[152],"discharge.":[154],"No":[155],"patient":[156,237,254],"developed":[157],"Adult":[158],"Respiratory":[159],"Distress":[160],"Syndrome,":[161],"requirement":[163],"renal":[165],"therapy":[167],"or":[168,224,250],"hypotension":[169],"(mean":[170],"arterial":[171],"pressure":[172],"<":[173,308],"60":[174],"mmHg).":[175],"Plasma":[176,208],"lactate":[177,249],"was":[178,199,210,222,242],"elevated":[179,211],"(>":[180,212],"2":[181],"mmol/L)":[182],"on":[183,215,259],"enrolment":[184,216],"26":[186],"(43%)":[187],"but":[189,221],"declined":[191],"by":[192,238,289],"6":[193],"25":[196],"(96%)":[197],"declining":[200,233],"24":[202],"other":[206,236],"patient.":[207],"creatinine":[209,251],"120":[213],"\u03bcmol/L)":[214],"patients,":[220],"normal":[223,257],"falling":[225],"16":[227],"(94%)":[228],"72":[239],"hours.":[240],"There":[241],"no":[243],"clinically":[244],"meaningful":[245],"increase":[246],"plasma":[248],"any":[253],"value":[258],"enrolment.":[260],"Patients":[261],"receiving":[262],"algorithm":[270],"more":[272,304],"likely":[273],"survive":[275],"than":[276],"historical":[277],"controls":[278],"same":[281],"who":[283],"guided":[288],"clinical":[290],"judgement":[291],"year":[294],"prior":[295],"study":[298],"(p":[299,307],"=":[300],"0.03),":[301],"despite":[302],"having":[303],"disease":[306],"0.001).":[309],"CONCLUSIONS:":[310],"appears":[316],"safe":[317],"malaria.":[322]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}