{"id":"https://openalex.org/W2174831436","doi":"https://doi.org/10.1089/107999001317205268","title":"Characterization of the Antitumor Activities of IFN- \u03b1 8 on Renal Cell Carcinoma Cells In Vitro","display_name":"Characterization of the Antitumor Activities of IFN- \u03b1 8 on Renal Cell Carcinoma Cells In Vitro","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2174831436","doi":"https://doi.org/10.1089/107999001317205268","mag":"2174831436","pmid":"https://pubmed.ncbi.nlm.nih.gov/11798471"},"language":"en","primary_location":{"id":"doi:10.1089/107999001317205268","doi":"https://doi.org/10.1089/107999001317205268","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999001317205268","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon &amp; Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069410225","display_name":"Yoshiaki Yanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Yanai","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082066515","display_name":"Shigeo Horie","orcid":"https://orcid.org/0000-0002-8612-8368","observed_orcids":["https://orcid.org/0000-0002-8612-8368"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo Horie","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109917437","display_name":"Kouzou Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouzou Yamamoto","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Yamauchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yamauchi","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113546236","display_name":"Hakuo Ikegami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hakuo Ikegami","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103372479","display_name":"Masashi Kurimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Kurimoto","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033194585","display_name":"Tadaichi Kitamura","orcid":"https://orcid.org/0000-0003-0546-4069","observed_orcids":["https://orcid.org/0000-0003-0546-4069"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadaichi Kitamura","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3137,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.56189817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"12","first_page":"1129","last_page":"1136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8009999990463257},{"id":"https://openalex.org/keywords/interferon-alpha-subtypes","display_name":"interferon-alpha subtypes","score":0.859000027179718},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/g1-s-cell-cycle-arrest","display_name":"G1/S cell cycle arrest","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hla-class-ii-expression","display_name":"HLA class II expression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7755614519119263},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6326009035110474},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.591460108757019},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5814571976661682},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5637070536613464},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.540835976600647},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5043271780014038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47191789746284485},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46318671107292175},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.44352322816848755},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42328667640686035},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4167836606502533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3267284035682678},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.32505926489830017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3024904727935791},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15834367275238037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11370348930358887},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06790962815284729},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06092217564582825}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/107999001317205268","doi":"https://doi.org/10.1089/107999001317205268","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999001317205268","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon &amp; Cytokine Research","raw_type":"journal-article"},{"id":"pmid:11798471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11798471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1122672300","https://openalex.org/W1505071696","https://openalex.org/W1506416799","https://openalex.org/W1567392757","https://openalex.org/W1607019337","https://openalex.org/W1818602010","https://openalex.org/W1913752987","https://openalex.org/W1982243836","https://openalex.org/W1996687752","https://openalex.org/W1997738769","https://openalex.org/W2001403648","https://openalex.org/W2002786113","https://openalex.org/W2003607887","https://openalex.org/W2012295450","https://openalex.org/W2018227907","https://openalex.org/W2052242127","https://openalex.org/W2073673847","https://openalex.org/W2075256922","https://openalex.org/W2091106956","https://openalex.org/W2093140073","https://openalex.org/W2112435732","https://openalex.org/W2115767710","https://openalex.org/W2138178697","https://openalex.org/W2143372682","https://openalex.org/W2149453254","https://openalex.org/W2157997226","https://openalex.org/W2168218944","https://openalex.org/W2176998837","https://openalex.org/W2255703111","https://openalex.org/W2396393556","https://openalex.org/W2410296839","https://openalex.org/W2414663219","https://openalex.org/W2768600953"],"related_works":["https://openalex.org/W2116339488","https://openalex.org/W2186066864","https://openalex.org/W2315442029","https://openalex.org/W2050315644","https://openalex.org/W7145699120","https://openalex.org/W2097647977","https://openalex.org/W1964597131","https://openalex.org/W1563295247","https://openalex.org/W2121727262","https://openalex.org/W1999330723"],"abstract_inverted_index":{"Interferon-alpha":[0],"(IFN-alpha)":[1],"has":[2,26],"a":[3],"number":[4],"of":[5,11,17,33,45,81,87,97,116,145],"therapeutic":[6],"applications":[7],"in":[8,63,85,113,136,151,154,165],"the":[9,30,34,41,66,76,88,95,114,126,137,158],"treatment":[10],"various":[12],"human":[13],"cancers":[14],"and":[15,24,53,74,99,153],"diseases":[16],"viral":[18],"origin.":[19],"IFN-alpha":[20,47,98,105,146,159],"includes":[21],"several":[22],"subtypes,":[23,48,67],"little":[25],"been":[27],"reported":[28],"on":[29,40],"biologic":[31],"properties":[32],"individual":[35,42],"subtypes.":[36],"Here,":[37],"we":[38],"report":[39],"antitumor":[43,149],"effects":[44,150],"five":[46],"alpha1,":[49],"alpha2,":[50],"alpha5,":[51],"alpha8,":[52],"alpha10,":[54],"against":[55],"six":[56],"renal":[57],"cell":[58,61,72,90],"carcinoma":[59],"(RCC)":[60],"lines":[62,91],"vitro.":[64],"Among":[65],"IFN-alpha8":[68,109,124],"most":[69,111],"potently":[70],"inhibited":[71],"proliferation":[73],"delayed":[75],"G(1)/S":[77],"transition.":[78],"Synergistic":[79],"induction":[80,115],"apoptosis":[82,117],"was":[83,110],"shown":[84],"two":[86],"RCC":[89],"when":[92,118],"treated":[93],"with":[94,103,120],"combination":[96],"IFN-gamma":[100,107],"rather":[101],"than":[102],"either":[104],"or":[106],"alone.":[108],"effective":[112],"combined":[119],"IFN-gamma.":[121],"In":[122],"addition,":[123],"had":[125],"strongest":[127],"ability":[128],"to":[129],"upregulate":[130],"HLA":[131],"class":[132],"II":[133],"antigen":[134],"expression":[135],"subtypes":[138,144,160],"examined.":[139],"These":[140],"data":[141],"indicate":[142],"that":[143],"have":[147],"disparate":[148],"vitro,":[152],"vitro":[155],"distinctions":[156],"among":[157],"should":[161],"be":[162],"appreciated":[163],"more":[164],"clinical":[166],"application.":[167]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
