{"id":"https://openalex.org/W2174637668","doi":"https://doi.org/10.1073/pnas.1508521112","title":"Synthetic biology devices for in vitro and in vivo diagnostics","display_name":"Synthetic biology devices for in vitro and in vivo diagnostics","publication_year":2015,"publication_date":"2015-11-23","ids":{"openalex":"https://openalex.org/W2174637668","doi":"https://doi.org/10.1073/pnas.1508521112","mag":"2174637668","pmid":"https://pubmed.ncbi.nlm.nih.gov/26598662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4664311"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1508521112","doi":"https://doi.org/10.1073/pnas.1508521112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1508521112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4664311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060277141","display_name":"Shimyn Slomovic","orcid":"https://orcid.org/0000-0003-4873-3222","observed_orcids":["https://orcid.org/0000-0003-4873-3222"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shimyn Slomovic","raw_affiliation_strings":["Institute for Medical Engineering &amp; Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Engineering &amp; Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013374621","display_name":"Keith Pardee","orcid":"https://orcid.org/0000-0002-3812-8013","observed_orcids":["https://orcid.org/0000-0002-3812-8013"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Pardee","raw_affiliation_strings":["Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065209470","display_name":"James J. Collins","orcid":"https://orcid.org/0000-0002-5560-8246","observed_orcids":["https://orcid.org/0000-0002-5560-8246"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Collins","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA 02142","Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139;","Institute for Medical Engineering &amp; Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139;","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Institute for Medical Engineering &amp; Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0019,"has_fulltext":false,"cited_by_count":316,"citation_normalized_percentile":{"value":0.8973262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"112","issue":"47","first_page":"14429","last_page":"14435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.2912999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.09589999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.8939999938011169},{"id":"https://openalex.org/keywords/in-vitro-diagnostics","display_name":"in vitro diagnostics","score":0.6309999823570251},{"id":"https://openalex.org/keywords/in-vivo-diagnosis","display_name":"in vivo diagnosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.6200000047683716},{"id":"https://openalex.org/keywords/pathogen-detection","display_name":"pathogen detection","score":0.7129999995231628},{"id":"https://openalex.org/keywords/rare-diseases","display_name":"rare diseases","score":0.7850000262260437},{"id":"https://openalex.org/keywords/biomolecular-engineering","display_name":"biomolecular engineering","score":0.5370000004768372},{"id":"https://openalex.org/keywords/medical-diagnostics","display_name":"medical diagnostics","score":0.46399998664855957},{"id":"https://openalex.org/keywords/environmental-diagnostics","display_name":"environmental diagnosis","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.8829734325408936},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5379389524459839},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5282788872718811},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.44083172082901},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43827682733535767},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4344814419746399},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.39597535133361816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3459215462207794},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22124570608139038},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.17313852906227112},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0993802547454834}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057089","descriptor_name":"Pathology, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1508521112","doi":"https://doi.org/10.1073/pnas.1508521112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1508521112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4664311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4664311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:26598662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26598662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/108679","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/108679","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"National Academy of Sciences (U.S.)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4664311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4664311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G277562485","display_name":null,"funder_award_id":"FA9550-14-1-0060","funder_id":"https://openalex.org/F4320338279","funder_display_name":"Air Force Office of Scientific Research"},{"id":"https://openalex.org/G4445756990","display_name":null,"funder_award_id":"HDTRA1-14-1-0006","funder_id":"https://openalex.org/F4320332186","funder_display_name":"Defense Threat Reduction Agency"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332186","display_name":"Defense Threat Reduction Agency","ror":"https://ror.org/04tz64554"},{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W110331391","https://openalex.org/W1645305843","https://openalex.org/W1649997932","https://openalex.org/W1910303568","https://openalex.org/W1964535590","https://openalex.org/W1965163468","https://openalex.org/W1965305472","https://openalex.org/W1966298788","https://openalex.org/W1973873896","https://openalex.org/W1976815031","https://openalex.org/W1978447041","https://openalex.org/W1979192889","https://openalex.org/W1984126604","https://openalex.org/W1984741522","https://openalex.org/W1986134476","https://openalex.org/W1990003795","https://openalex.org/W1990076574","https://openalex.org/W1990530150","https://openalex.org/W1991161955","https://openalex.org/W1994028898","https://openalex.org/W1996175254","https://openalex.org/W1997227467","https://openalex.org/W2001052181","https://openalex.org/W2014872524","https://openalex.org/W2021059161","https://openalex.org/W2021099440","https://openalex.org/W2023281573","https://openalex.org/W2026571103","https://openalex.org/W2030190695","https://openalex.org/W2030513350","https://openalex.org/W2031512086","https://openalex.org/W2033612573","https://openalex.org/W2033746983","https://openalex.org/W2033790337","https://openalex.org/W2035709881","https://openalex.org/W2036051969","https://openalex.org/W2049044362","https://openalex.org/W2055398497","https://openalex.org/W2057254497","https://openalex.org/W2063616884","https://openalex.org/W2066234893","https://openalex.org/W2067556994","https://openalex.org/W2068408712","https://openalex.org/W2070599701","https://openalex.org/W2071463351","https://openalex.org/W2071476884","https://openalex.org/W2071829817","https://openalex.org/W2073812166","https://openalex.org/W2074225681","https://openalex.org/W2074789242","https://openalex.org/W2075515367","https://openalex.org/W2082398508","https://openalex.org/W2086913532","https://openalex.org/W2090429649","https://openalex.org/W2093479877","https://openalex.org/W2095300485","https://openalex.org/W2106852013","https://openalex.org/W2108379967","https://openalex.org/W2108407690","https://openalex.org/W2109389103","https://openalex.org/W2109727090","https://openalex.org/W2111870329","https://openalex.org/W2112444085","https://openalex.org/W2112495562","https://openalex.org/W2114001343","https://openalex.org/W2117653437","https://openalex.org/W2120831623","https://openalex.org/W2121987905","https://openalex.org/W2124013800","https://openalex.org/W2125524975","https://openalex.org/W2126384811","https://openalex.org/W2128029143","https://openalex.org/W2131781913","https://openalex.org/W2134759932","https://openalex.org/W2134999083","https://openalex.org/W2146806799","https://openalex.org/W2149786401","https://openalex.org/W2149981735","https://openalex.org/W2153078859","https://openalex.org/W2154283129","https://openalex.org/W2155578830","https://openalex.org/W2155752821","https://openalex.org/W2159844490","https://openalex.org/W2161133492","https://openalex.org/W2162642438","https://openalex.org/W2165044010","https://openalex.org/W2165354120","https://openalex.org/W2167862219","https://openalex.org/W2169779483","https://openalex.org/W2174688478","https://openalex.org/W2331828106","https://openalex.org/W2950851734","https://openalex.org/W4205730233","https://openalex.org/W4236366502"],"related_works":["https://openalex.org/W3161589711","https://openalex.org/W4413922696","https://openalex.org/W2470521612","https://openalex.org/W4206366390","https://openalex.org/W2904994546","https://openalex.org/W7161485890","https://openalex.org/W2524831637","https://openalex.org/W7161834825","https://openalex.org/W4405172520","https://openalex.org/W7217688495"],"abstract_inverted_index":{"There":[0],"is":[1,122],"a":[2],"growing":[3],"need":[4],"to":[5,18,33,59,71,86,103,125],"enhance":[6],"our":[7],"capabilities":[8,102],"in":[9,128,146],"medical":[10],"and":[11,57,61,79,114,160],"environmental":[12],"diagnostics.":[13,43],"Synthetic":[14,74,92],"biologists":[15],"have":[16],"begun":[17],"focus":[19],"their":[20],"biomolecular":[21],"engineering":[22],"approaches":[23],"toward":[24,127],"this":[25],"goal,":[26],"offering":[27],"promising":[28,154],"results":[29],"that":[30],"could":[31,132],"lead":[32],"the":[34,84,107,151],"development":[35],"of":[36,39,89,137,153],"new":[37,101],"classes":[38],"inexpensive,":[40],"rapidly":[41,65],"deployable":[42],"Many":[44],"conventional":[45],"diagnostics":[46],"rely":[47],"on":[48,150],"antibody-based":[49],"platforms":[50],"that,":[51],"although":[52],"exquisitely":[53],"sensitive,":[54],"are":[55],"slow":[56],"costly":[58],"generate":[60],"cannot":[62],"readily":[63],"confront":[64],"emerging":[66],"pathogens":[67],"or":[68],"be":[69],"applied":[70],"orphan":[72],"diseases.":[73],"biology,":[75,148],"with":[76],"its":[77],"rational":[78],"short":[80],"design-to-production":[81],"cycles,":[82],"has":[83],"potential":[85],"overcome":[87],"many":[88],"these":[90],"limitations.":[91],"biology":[93],"devices,":[94],"such":[95],"as":[96],"engineered":[97],"gene":[98],"circuits,":[99],"bring":[100],"molecular":[104,108],"diagnostics,":[105,130],"expanding":[106],"detection":[109],"palette,":[110],"creating":[111],"dynamic":[112],"sensors,":[113],"untethering":[115],"reactions":[116],"from":[117],"laboratory":[118],"equipment.":[119],"The":[120],"field":[121],"also":[123],"beginning":[124],"move":[126],"vivo":[129],"which":[131],"provide":[133],"near":[134],"real-time":[135],"surveillance":[136],"multiple":[138],"pathological":[139],"conditions.":[140],"Here,":[141],"we":[142],"describe":[143],"current":[144],"efforts":[145],"synthetic":[147],"focusing":[149],"translation":[152],"technologies":[155],"into":[156],"pragmatic":[157],"diagnostic":[158],"tools":[159],"platforms.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":50},{"year":2019,"cited_by_count":37},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
