{"id":"https://openalex.org/W2174628005","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a131357","title":"A Clottable Protein (Coagulogen) from Amoebocyte Lysate of Japanese Horseshoe Crab (Tachypleus tridentatus)1. Its Isolation and Biochemical Properties","display_name":"A Clottable Protein (Coagulogen) from Amoebocyte Lysate of Japanese Horseshoe Crab (Tachypleus tridentatus)1. Its Isolation and Biochemical Properties","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W2174628005","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a131357","mag":"2174628005","pmid":"https://pubmed.ncbi.nlm.nih.gov/12148"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a131357","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a131357","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a131357","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078297770","display_name":"Shin Nakamura","orcid":"https://orcid.org/0000-0003-3651-1518","observed_orcids":["https://orcid.org/0000-0003-3651-1518"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin NAKAMURA","raw_affiliation_strings":["Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103469644","display_name":"Sadaaki Iwanaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sadaaki IWANAGA","raw_affiliation_strings":["Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toshie HARADA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshie HARADA","raw_affiliation_strings":["Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103036756","display_name":"Makoto Niwa","orcid":"https://orcid.org/0000-0002-2355-1222","observed_orcids":["https://orcid.org/0000-0002-2355-1222"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto NIWA","raw_affiliation_strings":["Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I317356780"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.8938,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.68488242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"80","issue":"5","first_page":"1011","last_page":"1021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coagulogen","display_name":"coagulogen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tachypleus-tridentatus","display_name":"Tachypleus tridentatus","score":0.8870000243186951},{"id":"https://openalex.org/keywords/horseshoe-crab","display_name":"horseshoe crab","score":0.9440000057220459},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.5659999847412109},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.6269999742507935},{"id":"https://openalex.org/keywords/amino-acid-composition","display_name":"amino acid composition","score":0.8830000162124634},{"id":"https://openalex.org/keywords/n-terminal-sequence","display_name":"N-terminal sequence","score":0.9300000071525574},{"id":"https://openalex.org/keywords/c-terminal-sequence","display_name":"C-terminal sequence","score":0.6890000104904175},{"id":"https://openalex.org/keywords/isoelectric-point","display_name":"isoelectric point","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2776287654","wikidata":"https://www.wikidata.org/wiki/Q1329239","display_name":"Horseshoe crab","level":2,"score":0.7278721332550049},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.4488527774810791},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3456255793571472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3179193139076233},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.29240942001342773},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.10804867744445801}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001181","descriptor_name":"Arthropods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003029","descriptor_name":"Coagulants","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003029","descriptor_name":"Coagulants","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006458","descriptor_name":"Hemolymph","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006737","descriptor_name":"Horseshoe Crabs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a131357","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a131357","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a131357","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:12148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jbiochem:80/5/1011","doi":null,"is_oa":false,"landing_page_url":"http://jb.oxfordjournals.org/cgi/content/short/80/5/1011","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2945275985","https://openalex.org/W171312770","https://openalex.org/W2463064197","https://openalex.org/W2465779597","https://openalex.org/W2150195405","https://openalex.org/W2411433873","https://openalex.org/W1816499466","https://openalex.org/W2106063508","https://openalex.org/W1423560807","https://openalex.org/W2059268218"],"abstract_inverted_index":{"A":[0],"clottable":[1],"protein,":[2],"named":[3],"coagulogen,":[4],"was":[5,61,76,86,93,111,117,188,213,219],"highly":[6],"purified":[7,84],"from":[8,69,124],"the":[9,26,66,73,125,148,181,206,211,237,247],"amoebocyte":[10,74],"lysate":[11,27,75],"of":[12,28,72,83,128,140,154,157,168,180,192,205,210,227,234,246,249],"Japanese":[13],"horseshoe":[14],"crab":[15],"(Tachypleus":[16],"tridentatus)":[17],"by":[18,99,107,147],"a":[19,36,136,155,228],"method":[20],"similar":[21],"to":[22,95,120,159],"that":[23,224,236],"used":[24],"for":[25,174],"Limulus":[29],"polyphemus":[30],"amoebocytes.":[31],"The":[32,80,103,133,202],"isolated":[33],"material":[34],"gave":[35],"single":[37,229],"protein":[38,130,134],"band":[39],"on":[40,131],"analytical":[41],"gel":[42,47,54],"electrophoresis":[43,55],"at":[44],"pH":[45,141],"3.2,":[46],"electrofocusing,":[48],"and":[49,65,89,164,198,215],"sodium":[50],"dodecyl":[51],"sulfate":[52],"(SDS)":[53],"with":[56,244],"or":[57],"without":[58],"2-mercaptoethanol.":[59],"It":[60,152,232],"90":[62],"percent":[63],"coagulable,":[64],"total":[67,156,182],"yield":[68],"10":[70],"ml":[71],"about":[77,97],"40":[78],"mg.":[79],"sedimentation":[81,100],"coefficient":[82],"coagulogen":[85,212],"2.6":[87],"S":[88],"its":[90,216],"molecular":[91,104],"weight":[92,105],"estimated":[94,106],"be":[96],"15,300":[98],"equilibrium":[101],"analysis.":[102],"SDS-gel":[108],"electrophoretic":[109],"analysis":[110],"19,500":[112],"+/-":[113,143],"1,000.":[114],"This":[115],"discrepancy":[116],"apparently":[118],"due":[119],"abnormal":[121],"mobility":[122],"arising":[123],"basic":[126,169],"nature":[127],"this":[129],"electrophoresis.":[132],"had":[135],"high":[137,166],"isoelectric":[138,149],"point":[139],"10.0":[142],"0.2,":[144],"as":[145,221],"measured":[146],"focusing":[150],"technique.":[151],"consisted":[153],"132":[158],"135":[160],"amino":[161,170,183],"acid":[162,184,196],"residues":[163,209,218,241],"contained":[165],"levels":[167],"acids,":[171],"which":[172],"accounted":[173],"more":[175],"than":[176],"16":[177],"per":[178],"cent":[179],"residues.":[185],"No":[186],"methionine":[187],"detected.":[189],"High":[190],"contents":[191],"valine,":[193],"half-cystine,":[194],"glutamic":[195],"(glutamine),":[197],"phenylalanine":[199],"were":[200],"found.":[201],"N-terminal":[203,240],"sequence":[204],"first":[207,238],"three":[208,239],"Ala-Asx-Thr,":[214],"C-terminal":[217],"identified":[220],"phenylalanine,":[222],"indicating":[223],"it":[225],"consists":[226],"polypeptide":[230],"chain.":[231],"is":[233],"interest":[235],"are":[242],"homologous":[243],"those":[245],"Aalpha-chain":[248],"non-human":[250],"primate":[251],"fibrinogen.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
