{"id":"https://openalex.org/W2174366185","doi":"https://doi.org/10.4269/ajtmh.1997.57.651","title":"A Low-Dose Antimony Treatment in 159 Patients with American Cutaneous Leishmaniasis: Extensive Follow-up Studies (Up to 10 Years)","display_name":"A Low-Dose Antimony Treatment in 159 Patients with American Cutaneous Leishmaniasis: Extensive Follow-up Studies (Up to 10 Years)","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2174366185","doi":"https://doi.org/10.4269/ajtmh.1997.57.651","mag":"2174366185","pmid":"https://pubmed.ncbi.nlm.nih.gov/9430521"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.1997.57.651","doi":"https://doi.org/10.4269/ajtmh.1997.57.651","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1997.57.651","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113614752","display_name":"Manoel P. Oliveira-Neto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286924","display_name":"Instituto Nacional de Infectologia Evandro Chagas","ror":"https://ror.org/03jw34240","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4405286924","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M. P. Oliveira-Neto","raw_affiliation_strings":["Hospital Evandro Chagas, Department of Protozoology, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Evandro Chagas, Department of Protozoology, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286924","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113545306","display_name":"A Schubach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Schubach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110947747","display_name":"M Mattos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Mattos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032015399","display_name":"Sylvio Celso GON\u00c7ALVES-COSTA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. C. Goncalves-Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066399831","display_name":"Claude Pirmez","orcid":"https://orcid.org/0000-0002-7443-0455","observed_orcids":["https://orcid.org/0000-0002-7443-0455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Pirmez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7641,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.90237335,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"57","issue":"6","first_page":"651","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/american-cutaneous-leishmaniasis","display_name":"American tegumentary leishmaniasis","score":0.984000027179718},{"id":"https://openalex.org/keywords/antimonial-therapy","display_name":"antimonial therapy","score":0.7210000157356262},{"id":"https://openalex.org/keywords/leishmania-braziliensis","display_name":"Leishmania braziliensis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7160000205039978},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.7910000085830688},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.8629999756813049},{"id":"https://openalex.org/keywords/children-and-elderly-patients","display_name":"children and elderly patients","score":0.6740000247955322},{"id":"https://openalex.org/keywords/rio-de-janeiro-state","display_name":"Rio de Janeiro state","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6116234660148621},{"id":"https://openalex.org/C541565711","wikidata":"https://www.wikidata.org/wiki/Q1099","display_name":"Antimony","level":2,"score":0.6059509515762329},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5765435695648193},{"id":"https://openalex.org/C2778702967","wikidata":"https://www.wikidata.org/wiki/Q2590966","display_name":"Cutaneous leishmaniasis","level":3,"score":0.5757599472999573},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.5398717522621155},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3432546854019165},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26200050115585327},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077485","descriptor_name":"Meglumine Antimoniate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007892","descriptor_name":"Leishmania braziliensis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008536","descriptor_name":"Meglumine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008536","descriptor_name":"Meglumine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008536","descriptor_name":"Meglumine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4269/ajtmh.1997.57.651","doi":"https://doi.org/10.4269/ajtmh.1997.57.651","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1997.57.651","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},{"id":"pmid:9430521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9430521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2462506978","https://openalex.org/W1975745197","https://openalex.org/W2616887559","https://openalex.org/W2128087619","https://openalex.org/W2104203227","https://openalex.org/W2183639344","https://openalex.org/W1992344713","https://openalex.org/W2000697440","https://openalex.org/W7099125148","https://openalex.org/W2079386786"],"abstract_inverted_index":{"The":[0,141],"efficacy":[1],"of":[2,9,22,49,58,68,76,102,111,148],"an":[3,74],"antimony":[4,59,149],"regimen":[5],"at":[6],"the":[7,20,35,44,47,109,163],"dose":[8,52,147],"20":[10],"mg/kg/day":[11,54],"for":[12,37,55,99],"a":[13,50,145],"3-4-week":[14],"period":[15],"is":[16,41,150],"well":[17],"established":[18],"in":[19,62,90,124,156],"treatment":[21,118],"American":[23],"cutaneous":[24,84],"leishmaniasis.":[25],"Several":[26],"drug":[27],"side":[28],"effects,":[29],"however,":[30],"have":[31],"been":[32],"described":[33],"and":[34,86,101,158,161],"search":[36],"more":[38,153],"suitable":[39],"regimens":[40],"advisable.":[42],"In":[43],"present":[45],"paper,":[46],"effect":[48],"low":[51,146],"(5":[53],"30":[56],"days)":[57],"was":[60],"evaluated":[61],"159":[63],"individuals":[64],"from":[65],"endemic":[66],"regions":[67],"Rio":[69],"de":[70],"Janeiro":[71],"State,":[72],"Brazil,":[73],"area":[75],"Leishmania":[77],"(V.)":[78],"braziliensis":[79],"transmission.":[80],"Patients":[81],"presented":[82],"typical":[83],"lesions":[85],"parasites":[87],"were":[88,97,106,116,122],"demonstrated":[89],"all":[91],"cases.":[92],"One":[93],"hundred":[94],"forty-three":[95],"patients":[96,114,127],"available":[98],"evaluation":[100],"these,":[103],"120":[104],"(84%)":[105],"cured":[107],"by":[108],"end":[110],"therapy.":[112],"Twenty-three":[113],"(16%)":[115],"considered":[117],"failures.":[119],"Side":[120],"effects":[121],"observed":[123],"only":[125],"six":[126],"(4%).":[128],"Extensive":[129],"follow-up":[130],"(up":[131],"to":[132],"10":[133],"years)":[134],"disclosed":[135],"no":[136],"relapses":[137],"or":[138],"mucosal":[139],"lesions.":[140],"results":[142],"show":[143],"that":[144,168],"less":[151],"toxic,":[152],"appropriate,":[154],"especially":[155],"children":[157],"elderly":[159],"people,":[160],"has":[162],"same":[164],"final":[165],"result":[166],"as":[167],"obtained":[169],"with":[170],"larger":[171],"doses.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}