{"id":"https://openalex.org/W2174147605","doi":"https://doi.org/10.7580/kjlm.2015.39.2.27","title":"A Detailed Analysis of Alcohol Pharmacokinetics in Healthy Korean Men","display_name":"A Detailed Analysis of Alcohol Pharmacokinetics in Healthy Korean Men","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2174147605","doi":"https://doi.org/10.7580/kjlm.2015.39.2.27","mag":"2174147605"},"language":"en","primary_location":{"id":"doi:10.7580/kjlm.2015.39.2.27","doi":"https://doi.org/10.7580/kjlm.2015.39.2.27","is_oa":true,"landing_page_url":"https://doi.org/10.7580/kjlm.2015.39.2.27","pdf_url":null,"source":{"id":"https://openalex.org/S2764539832","display_name":"Korean Journal of Legal Medicine","issn_l":"1225-0589","issn":["1225-0589","2287-2078","2383-5702","2383-5710"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Legal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.7580/kjlm.2015.39.2.27","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013714341","display_name":"Sung\u2010Yup Cho","orcid":"https://orcid.org/0000-0002-2720-6952","observed_orcids":["https://orcid.org/0000-0002-2720-6952"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Yup Cho","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110671479","display_name":"Hye Kyung Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Kyung Han","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112268486","display_name":"Kwang-Hee Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang-Hee Shin","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089819378","display_name":"Hyungmi An","orcid":"https://orcid.org/0000-0002-4148-8423","observed_orcids":["https://orcid.org/0000-0002-4148-8423"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyungmi An","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076937960","display_name":"Kyung\u2010Sang Yu","orcid":"https://orcid.org/0000-0003-0921-7225","observed_orcids":["https://orcid.org/0000-0003-0921-7225"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Sang Yu","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028861037","display_name":"Byoung\u2010Joon Song","orcid":"https://orcid.org/0000-0002-3954-3497","observed_orcids":["https://orcid.org/0000-0002-3954-3497"]},"institutions":[{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Byoung-Joon Song","raw_affiliation_strings":["Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210121815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101704185","display_name":"Seong Ho Yoo","orcid":"https://orcid.org/0000-0001-5294-0596","observed_orcids":["https://orcid.org/0000-0001-5294-0596"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seong Ho Yoo","raw_affiliation_strings":["Institute of Forensic Medicine and Department of Forensic Medicine, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Forensic Medicine and Department of Forensic Medicine, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101704185"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.09666819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"39","issue":"2","first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcohol-pharmacokinetics","display_name":"alcohol pharmacokinetics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/blood-alcohol-concentration","display_name":"blood alcohol concentration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/breath-alcohol-concentration","display_name":"breath alcohol concentration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aldh2-polymorphism","display_name":"ALDH2 polymorphism","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mitochondrial-aldehyde-dehydrogenase-2","display_name":"mitochondrial aldehyde dehydrogenase 2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/alcohol-dose","display_name":"alcohol dose","score":0.48899999260902405},{"id":"https://openalex.org/keywords/alcohol-elimination-rate","display_name":"alcohol elimination rate","score":0.6110000014305115},{"id":"https://openalex.org/keywords/alcohol-absorption","display_name":"alcohol absorption","score":0.4519999921321869},{"id":"https://openalex.org/keywords/korean-men","display_name":"Korean men","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7792105674743652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5067353844642639},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.46258091926574707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.344634473323822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17685630917549133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7580/kjlm.2015.39.2.27","doi":"https://doi.org/10.7580/kjlm.2015.39.2.27","is_oa":true,"landing_page_url":"https://doi.org/10.7580/kjlm.2015.39.2.27","pdf_url":null,"source":{"id":"https://openalex.org/S2764539832","display_name":"Korean Journal of Legal Medicine","issn_l":"1225-0589","issn":["1225-0589","2287-2078","2383-5702","2383-5710"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Legal Medicine","raw_type":"journal-article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/219374","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/219374","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.7580/kjlm.2015.39.2.27","doi":"https://doi.org/10.7580/kjlm.2015.39.2.27","is_oa":true,"landing_page_url":"https://doi.org/10.7580/kjlm.2015.39.2.27","pdf_url":null,"source":{"id":"https://openalex.org/S2764539832","display_name":"Korean Journal of Legal Medicine","issn_l":"1225-0589","issn":["1225-0589","2287-2078","2383-5702","2383-5710"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Legal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W315650956","https://openalex.org/W1480568644","https://openalex.org/W1503086187","https://openalex.org/W1803760021","https://openalex.org/W1974883412","https://openalex.org/W1989543688","https://openalex.org/W1993709190","https://openalex.org/W1995928536","https://openalex.org/W2016521143","https://openalex.org/W2019808156","https://openalex.org/W2032904838","https://openalex.org/W2063961787","https://openalex.org/W2092683244","https://openalex.org/W2095288885","https://openalex.org/W2099969424","https://openalex.org/W2104547476","https://openalex.org/W2109414865","https://openalex.org/W2110147077","https://openalex.org/W2124345456","https://openalex.org/W2130695438","https://openalex.org/W2144821195","https://openalex.org/W2149793095","https://openalex.org/W2155543018","https://openalex.org/W2160313238","https://openalex.org/W2162674639"],"related_works":["https://openalex.org/W2217581030","https://openalex.org/W2061189421","https://openalex.org/W2245326142","https://openalex.org/W1602735022","https://openalex.org/W2981646706","https://openalex.org/W2363747610","https://openalex.org/W2079190371","https://openalex.org/W2031430261","https://openalex.org/W1921395678","https://openalex.org/W2284936219"],"abstract_inverted_index":{"To":[0],"determine":[1],"blood":[2],"alcohol":[3,16,27,45,54,107,230],"concentration":[4,17,28,113],"(BAC)":[5],"by":[6,30,194],"extrapolation,":[7],"an":[8],"understanding":[9],"of":[10,25,37,53,59,88,140,190,204,214,229,234],"basal":[11],"pharmacokinetics":[12,228],"is":[13,40],"indispensable.":[14],"Breath":[15],"(BrAC)":[18],"has":[19],"been":[20],"used":[21],"for":[22,211],"the":[23,35,50,56,66,71,76,106,111,115,121,126,129,134,175,188,202,212,218,227,232],"determination":[24,36,213,233],"body":[26],"replaced":[29],"BAC":[31,89,176,191,235],"in":[32,44,75,98,105,147,151,153,217,236],"Korea.":[33],"Therefore,":[34],"BAC/BrAC":[38],"ratio":[39],"a":[41,84,208],"key":[42],"problem":[43],"pharmacokinetics.":[46],"Among":[47],"several":[48],"factors,":[49],"ingested":[51,109],"dose":[52,108],"and":[55,78,90,133,174,192,231],"allelic":[57],"variation":[58],"mitochondrial":[60],"aldehyde":[61],"dehydrogenase":[62],"2":[63],"(ALDH2)":[64],"are":[65],"most":[67],"significant":[68],"factors":[69],"influencing":[70],"pharmacokinetic":[72,86],"parameters,":[73],"particularly":[74,216],"absorption":[77,122],"elimination":[79,136,177],"phases.":[80],"This":[81],"study":[82],"shows":[83],"detailed":[85],"analysis":[87],"BrAC":[91,193,205],"associated":[92],"with":[93],"genetic":[94],"polymorphism":[95],"including":[96],"ALDH2":[97,149],"42":[99],"healthy":[100],"Korean":[101],"men.":[102],"The":[103,138],"change":[104],"influenced":[110],"maximum":[112],"(Cmax),":[114],"time":[116],"to":[117,144],"reach":[118],"Cmax":[119,154],"(Tmax),":[120],"rate":[123,178],"constant":[124],"(K01),":[125],"area":[127],"under":[128],"concentration-time":[130],"curve":[131],"(AUClast),":[132],"hourly":[135],"rate.":[137],"conversion":[139],"wild-type":[141],"487Glu":[142],"(ALDH2*1)":[143],"487Lys":[145],"(ALDH2*2)":[146],"human":[148],"resulted":[150],"changes":[152],"(ALDH2*1/*1,":[155,166,179],"0.03\u00b10.01":[156],"g/dL":[157,163],"[\u00b1standard":[158],"deviation]":[159],"vs.":[160,169,182],"ALDH2*1/*2,":[161,170,183],"0.05\u00b10.004":[162],"[P<0.01]),":[164],"AUClast":[165],"4.48\u00b12.19":[167],"g?min/dL":[168,172],"7.52\u00b11.26":[171],"[P<0.05]),":[173],"0.05\u00b10.02":[180],"g/L/hr":[181,185],"0.09\u00b10.01":[184],"[P<0.05]).":[186],"Moreover,":[187],"comparison":[189],"Bland-Altman":[195],"plot":[196],"showed":[197],"good":[198,209],"agreement,":[199],"suggesting":[200],"that":[201],"measurement":[203],"can":[206],"be":[207],"alternative":[210],"BAC,":[215],"post-absorption":[219],"phase.":[220],"These":[221],"results":[222],"provide":[223],"fundamental":[224],"information":[225],"about":[226],"forensics.":[237]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}