{"id":"https://openalex.org/W2174044679","doi":null,"title":"Neuromodulation of hippocampal single cell- and network activity by human cerebrospinal fluid","display_name":"Neuromodulation of hippocampal single cell- and network activity by human cerebrospinal fluid","publication_year":2015,"publication_date":"2015-11-24","ids":{"openalex":"https://openalex.org/W2174044679","mag":"2174044679"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/40445","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/40445","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022902398","display_name":"Andreas Bj\u00f6refeldt","orcid":"https://orcid.org/0000-0002-1230-3610","observed_orcids":["https://orcid.org/0000-0002-1230-3610"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Andreas Bj\u00f6refeldt","raw_affiliation_strings":["University of Gothenburg"],"raw_orcid":"https://orcid.org/0000-0002-1230-3610","affiliations":[{"raw_affiliation_string":"University of Gothenburg","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022902398"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cerebrospinal-fluid","display_name":"human cerebrospinal fluid","score":0.8619999885559082},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gabaergic-interneurons","display_name":"GABAergic interneurons","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fast-spiking-interneurons","display_name":"fast-spiking interneurons","score":0.968999981880188},{"id":"https://openalex.org/keywords/resting-membrane-potential","display_name":"resting membrane potential","score":0.8009999990463257},{"id":"https://openalex.org/keywords/action-potential-threshold","display_name":"action potential threshold","score":0.9919999837875366},{"id":"https://openalex.org/keywords/afterhyperpolarization","display_name":"afterhyperpolarization","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gamma-oscillations","display_name":"gamma oscillations","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cholinergic-mechanisms","display_name":"cholinergic mechanisms","score":0.8090000152587891},{"id":"https://openalex.org/keywords/extracellular-fluid","display_name":"extracellular fluid","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8386303186416626},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.7332077026367188},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7174035906791687},{"id":"https://openalex.org/C93872552","wikidata":"https://www.wikidata.org/wiki/Q4690722","display_name":"Afterhyperpolarization","level":3,"score":0.6592738032341003},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.5929667949676514},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5426036715507507},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.4998202323913574},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.48081958293914795},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.46374189853668213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4311717748641968},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.4281645119190216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3864269554615021},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.3079678416252136},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2852669656276703},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2396261990070343},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2098993957042694},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1230866014957428}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/40445","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/40445","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2174044679","doi":null,"is_oa":false,"landing_page_url":"https://guoa.ub.gu.se/bitstream/2077/40445/6/gupea_2077_40445_6.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W19846723","https://openalex.org/W118472675","https://openalex.org/W138817596","https://openalex.org/W206721049","https://openalex.org/W1242004530","https://openalex.org/W1483605554","https://openalex.org/W1514551523","https://openalex.org/W1525542820","https://openalex.org/W1570612396","https://openalex.org/W1642400879","https://openalex.org/W1653233231","https://openalex.org/W1840705577","https://openalex.org/W1853766545","https://openalex.org/W1863139788","https://openalex.org/W1891830549","https://openalex.org/W1967611229","https://openalex.org/W1968019923","https://openalex.org/W1970242204","https://openalex.org/W1970792572","https://openalex.org/W1971880089","https://openalex.org/W1973275441","https://openalex.org/W1976197643","https://openalex.org/W1976280690","https://openalex.org/W1977052337","https://openalex.org/W1977417451","https://openalex.org/W1979465510","https://openalex.org/W1981587038","https://openalex.org/W1981761337","https://openalex.org/W1983967034","https://openalex.org/W1984660568","https://openalex.org/W1993835964","https://openalex.org/W1994667935","https://openalex.org/W1996236451","https://openalex.org/W1997379973","https://openalex.org/W2001747917","https://openalex.org/W2001947879","https://openalex.org/W2001954021","https://openalex.org/W2007031766","https://openalex.org/W2008027377","https://openalex.org/W2009362065","https://openalex.org/W2014332408","https://openalex.org/W2020244809","https://openalex.org/W2020425432","https://openalex.org/W2023925279","https://openalex.org/W2024187681","https://openalex.org/W2025687881","https://openalex.org/W2028274352","https://openalex.org/W2032118090","https://openalex.org/W2032924239","https://openalex.org/W2034961437","https://openalex.org/W2035946761","https://openalex.org/W2039072874","https://openalex.org/W2041244640","https://openalex.org/W2041253743","https://openalex.org/W2041359982","https://openalex.org/W2045530566","https://openalex.org/W2046868433","https://openalex.org/W2047750300","https://openalex.org/W2048234565","https://openalex.org/W2048419276","https://openalex.org/W2048775846","https://openalex.org/W2052405761","https://openalex.org/W2052515926","https://openalex.org/W2054889018","https://openalex.org/W2057213277","https://openalex.org/W2059690890","https://openalex.org/W2060589548","https://openalex.org/W2063109997","https://openalex.org/W2063216597","https://openalex.org/W2067842357","https://openalex.org/W2068463072","https://openalex.org/W2071075048","https://openalex.org/W2079994575","https://openalex.org/W2084072056","https://openalex.org/W2084955173","https://openalex.org/W2085905906","https://openalex.org/W2087666006","https://openalex.org/W2087976728","https://openalex.org/W2088081549","https://openalex.org/W2090592195","https://openalex.org/W2091883322","https://openalex.org/W2095265457","https://openalex.org/W2104481975","https://openalex.org/W2106081526","https://openalex.org/W2110161683","https://openalex.org/W2112601177","https://openalex.org/W2114241875","https://openalex.org/W2116161842","https://openalex.org/W2118925636","https://openalex.org/W2120543763","https://openalex.org/W2124787480","https://openalex.org/W2127389037","https://openalex.org/W2128752949","https://openalex.org/W2132124584","https://openalex.org/W2135555498","https://openalex.org/W2139676310","https://openalex.org/W2141807462","https://openalex.org/W2149561999","https://openalex.org/W2154608615","https://openalex.org/W2155262999","https://openalex.org/W2156075637","https://openalex.org/W2157256907","https://openalex.org/W2160087707","https://openalex.org/W2161245436","https://openalex.org/W2162013747","https://openalex.org/W2163071226","https://openalex.org/W2165826392","https://openalex.org/W2168788678","https://openalex.org/W2169865452","https://openalex.org/W2170814877","https://openalex.org/W2171269012","https://openalex.org/W2171668474","https://openalex.org/W2172513721","https://openalex.org/W2259364305","https://openalex.org/W2269384636","https://openalex.org/W2284650449","https://openalex.org/W2291381512","https://openalex.org/W2410446460","https://openalex.org/W2412292598","https://openalex.org/W2440659224","https://openalex.org/W2465125709","https://openalex.org/W2993440152"],"related_works":["https://openalex.org/W1586529489","https://openalex.org/W2269384636","https://openalex.org/W2958839073","https://openalex.org/W3020684106","https://openalex.org/W2323031919","https://openalex.org/W2140928453","https://openalex.org/W2030553912","https://openalex.org/W7217187915","https://openalex.org/W1976736355","https://openalex.org/W2921641749"],"abstract_inverted_index":{"Neuromodulation":[0],"is":[1,29],"a":[2,62,184],"key":[3],"process":[4],"determining":[5],"the":[6,44,94,120,126,142,179,205],"function":[7],"of":[8,47,69,96,152,198],"central":[9],"neurons.":[10],"The":[11,73],"brain":[12,59,215],"extracellular":[13,78,216],"fluid":[14,50,66,217],"contains":[15],"numerous":[16],"neuromodulatory":[17,45],"substances":[18],"(neuromodulators),":[19],"but":[20],"how":[21],"they":[22],"collective":[23],"influence":[24,46],"neuronal":[25,222],"activity":[26,223],"in":[27,54,107,110,141,158,166,178,192,207,214,220,224],"vivo":[28],"not":[30],"known.":[31],"This":[32],"thesis":[33,209],"work":[34],"attempts":[35],"to":[36,82],"shed":[37],"light":[38],"on":[39,52,98],"this":[40,208],"issue":[41],"by":[42],"examining":[43],"human":[48],"cerebrospinal":[49,65],"(hCSF)":[51],"neurons":[53,153],"rat":[55],"and":[56,77,86,124,138,145,161,187],"mouse":[57],"hippocampal":[58],"slices,":[60],"using":[61],"matched":[63],"artificial":[64],"(aCSF,":[67],"devoid":[68],"neuromodulators)":[70],"as":[71],"control.":[72],"methodology":[74],"comprises":[75],"intracellular":[76],"recording":[79],"techniques":[80],"and,":[81],"lesser":[83],"extent,":[84],"biochemical":[85],"histological":[87],"procedures.":[88],"In":[89,130],"paper":[90,131,167],"I":[91],"we":[92,133,169],"examine":[93],"effect":[95],"hCSF":[97,105,148,172],"CA1":[99,143,193],"pyramidal":[100,194],"cells.":[101],"We":[102],"find":[103],"that":[104,147,171,212],"induces":[106,173],"vivo-like":[108],"properties":[109],"these":[111],"neurons,":[112],"powerfully":[113],"boosting":[114],"spontaneous":[115,174],"action":[116,127,162],"potential":[117,123,128,163],"firing,":[118],"depolarizing":[119],"resting":[121],"membrane":[122],"lowering":[125],"threshold.":[129,164],"II":[132],"record":[134],"from":[135],"GABAergic":[136],"fast-spiking":[137],"non-fast-spiking":[139],"interneurons":[140],"hippocampus":[144],"show":[146,170],"excites":[149],"both":[150],"types":[151],"through":[154,196],"mechanisms":[155],"involving":[156],"reductions":[157],"afterhyperpolarization":[159],"amplitudes":[160],"Finally,":[165],"III,":[168],"network":[175],"gamma":[176],"oscillations":[177],"CA3":[180],"stratum":[181],"pyramidale,":[182],"via":[183],"cholinergic":[185],"mechanism,":[186],"enhances":[188],"electrical":[189],"theta":[190],"resonance":[191],"cells":[195],"potentiation":[197],"two":[199],"separate":[200],"voltage-gated":[201],"conductances.":[202],"Taken":[203],"together,":[204],"findings":[206],"project":[210],"suggest":[211],"neuromodulators":[213],"significantly":[218],"contribute":[219],"shaping":[221],"vivo.":[225]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}