{"id":"https://openalex.org/W2174016629","doi":"https://doi.org/10.1146/annurev.pa.20.040180.003053","title":"Radioligand Binding Studies of Adrenergic Receptors: New Insights into Molecular and Physiological Regulation","display_name":"Radioligand Binding Studies of Adrenergic Receptors: New Insights into Molecular and Physiological Regulation","publication_year":1980,"publication_date":"1980-04-01","ids":{"openalex":"https://openalex.org/W2174016629","doi":"https://doi.org/10.1146/annurev.pa.20.040180.003053","mag":"2174016629","pmid":"https://pubmed.ncbi.nlm.nih.gov/6247962"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.pa.20.040180.003053","doi":"https://doi.org/10.1146/annurev.pa.20.040180.003053","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.pa.20.040180.003053","pdf_url":null,"source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112279470","display_name":"Brian B. Hoffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B B Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080672788","display_name":"Robert J. Lefkowitz","orcid":"https://orcid.org/0000-0003-1472-7545","observed_orcids":["https://orcid.org/0000-0003-1472-7545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Lefkowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.9925,"has_fulltext":false,"cited_by_count":310,"citation_normalized_percentile":{"value":0.99809036,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"1","first_page":"581","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenergic-receptors","display_name":"adrenergic receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.925000011920929},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":1.0},{"id":"https://openalex.org/keywords/radioligand-binding","display_name":"radioligand binding","score":0.9819999933242798},{"id":"https://openalex.org/keywords/receptor-regulation","display_name":"receptor regulation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.8656662702560425},{"id":"https://openalex.org/C2909005528","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand Assay","level":3,"score":0.666863203048706},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6266888380050659},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.589592695236206},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.492818146944046},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44543907046318054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43324345350265503},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3585541844367981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30079174041748047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22440731525421143}],"mesh":[{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006150","descriptor_name":"Guanine Nucleotides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.pa.20.040180.003053","doi":"https://doi.org/10.1146/annurev.pa.20.040180.003053","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.pa.20.040180.003053","pdf_url":null,"source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},{"id":"pmid:6247962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6247962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of pharmacology and toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W40657813","https://openalex.org/W116707866","https://openalex.org/W129838049","https://openalex.org/W169714974","https://openalex.org/W187642477","https://openalex.org/W1484657457","https://openalex.org/W1484817245","https://openalex.org/W1488907873","https://openalex.org/W1519748854","https://openalex.org/W1537544947","https://openalex.org/W1544485440","https://openalex.org/W1544622500","https://openalex.org/W1765120154","https://openalex.org/W1863678882","https://openalex.org/W1919501860","https://openalex.org/W1936333617","https://openalex.org/W1965579612","https://openalex.org/W1971836830","https://openalex.org/W1972910494","https://openalex.org/W1975225670","https://openalex.org/W1976782333","https://openalex.org/W1979581199","https://openalex.org/W1986406640","https://openalex.org/W1989786199","https://openalex.org/W1990880840","https://openalex.org/W1995502143","https://openalex.org/W1996972993","https://openalex.org/W2000528455","https://openalex.org/W2001373716","https://openalex.org/W2001954238","https://openalex.org/W2003814102","https://openalex.org/W2005736372","https://openalex.org/W2013496424","https://openalex.org/W2014748341","https://openalex.org/W2015335242","https://openalex.org/W2019552715","https://openalex.org/W2019659346","https://openalex.org/W2022326509","https://openalex.org/W2027342520","https://openalex.org/W2029287429","https://openalex.org/W2036199911","https://openalex.org/W2037086860","https://openalex.org/W2037263230","https://openalex.org/W2040346152","https://openalex.org/W2043516771","https://openalex.org/W2044895354","https://openalex.org/W2054375586","https://openalex.org/W2062546678","https://openalex.org/W2064198082","https://openalex.org/W2065518490","https://openalex.org/W2068015386","https://openalex.org/W2068483361","https://openalex.org/W2081963773","https://openalex.org/W2082002150","https://openalex.org/W2086193772","https://openalex.org/W2086617002","https://openalex.org/W2089124522","https://openalex.org/W2090898810","https://openalex.org/W2094491913","https://openalex.org/W2106359312","https://openalex.org/W2108442115","https://openalex.org/W2128472423","https://openalex.org/W2134462531","https://openalex.org/W2262940771","https://openalex.org/W2336350647","https://openalex.org/W2338243600","https://openalex.org/W2342102423","https://openalex.org/W2397085952","https://openalex.org/W2411405954","https://openalex.org/W2412169518","https://openalex.org/W2414233442","https://openalex.org/W2416080723","https://openalex.org/W2433680266","https://openalex.org/W2436785750","https://openalex.org/W2441763996"],"related_works":["https://openalex.org/W2041700875","https://openalex.org/W1574565103","https://openalex.org/W2464830678","https://openalex.org/W7097358360","https://openalex.org/W596357992","https://openalex.org/W2487785957","https://openalex.org/W2162522568","https://openalex.org/W2505007524","https://openalex.org/W2093450490","https://openalex.org/W90655786"],"abstract_inverted_index":{"The":[0,23],"advent":[1],"of":[2,12,19,29,39,49,65,73,76,128,150,172],"direct":[3,26],"radioligand":[4,157],"binding":[5,27],"studies":[6,28,115],"has":[7,57,80,152],"altered":[8],"the":[9,13,17,47,53,74,126,129,148,166],"entire":[10],"complexion":[11],"experimental":[14],"approach":[15],"to":[16,59,85,124,142,164],"study":[18,165],"adrenergic":[20,130],"recep\u00ad":[21],"tors.":[22],"first":[24],"successful":[25],",8-adrenergic":[30,144],"receptors":[31,41,145,168],"were":[32],"reported":[33],"in":[34,43,62,169],"1974":[35],"(1-3)":[36],"and":[37],"those":[38],"a.-adrenergic":[40],"only":[42],"1976":[44],"(4-6).":[45],"Nonetheless,":[46],"application":[48],"these":[50],"methods":[51],"over":[52],"past":[54],"several":[55,96],"years":[56],"led":[58],"rapid":[60],"progress":[61],"a":[63,134,170],"number":[64],"areas.":[66],"In":[67,109],"this":[68,77],"article":[69],"we":[70,91,111],"review":[71],"some":[72],"highlights":[75],"progress.":[78],"It":[79],"not":[81],"been":[82,153],"our":[83],"goal":[84],"be":[86],"encyclopedic":[87],"or":[88,136],"all-encompassing.":[89],"Rather,":[90],"have":[92,104,112,159],"deliberately":[93],"se\u00ad":[94],"lected":[95],"areas":[97],"for":[98],"more":[99],"extensive":[100],"coverage.":[101],"These":[102,175],"choices":[103],"been,":[105],"obviously,":[106],"subjective":[107],"ones.":[108],"general":[110],"focused":[113],"on":[114],"that":[116,122],"provide":[117],"new":[118],"insights":[119],"into":[120],"factors":[121],"appear":[123],"regulate":[125],"function":[127],"receptors,":[131],"either":[132],"at":[133],"physiological":[135],"biochemical":[137],"level.":[138],"Only":[139],"material":[140],"related":[141],"a.and":[143],"published":[146],"through":[147],"end":[149],"1978":[151],"systematically":[154],"considered.":[155],"Several":[156],"antagonists":[158],"bee":[160],"n":[161],"widely":[162],"used":[163],",8adrenergic":[167],"variety":[171],"tissue":[173],"systems.":[174],"are":[176],"(-)":[177],"PH]":[178]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
