{"id":"https://openalex.org/W2173962436","doi":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","title":"Nucleotide excision repair in Escherichia coli","display_name":"Nucleotide excision repair in Escherichia coli","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2173962436","doi":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","mag":"2173962436","pmid":"https://pubmed.ncbi.nlm.nih.gov/2181258","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/372757"},"language":"en","primary_location":{"id":"doi:10.1128/mmbr.54.1.18-51.1990","doi":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","pdf_url":null,"source":{"id":"https://openalex.org/S4210177515","display_name":"Microbiological Reviews","issn_l":"0146-0749","issn":["0146-0749","1070-6275"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiological Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055919829","display_name":"Bennett Van Houten","orcid":"https://orcid.org/0000-0002-4009-2478","observed_orcids":["https://orcid.org/0000-0002-4009-2478"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B Van Houten","raw_affiliation_strings":["Department of Pathology, University of Vermont, Burlington 05405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington 05405","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055919829"],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":null,"apc_paid":null,"fwci":13.9995,"has_fulltext":false,"cited_by_count":441,"citation_normalized_percentile":{"value":0.99412172,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"54","issue":"1","first_page":"18","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":1.0},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9120000004768372},{"id":"https://openalex.org/keywords/dna-damage-recognition","display_name":"DNA damage recognition","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dna-incision","display_name":"DNA incision","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dna-ligation","display_name":"DNA ligation","score":0.984000027179718},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dna-repair-proteins","display_name":"DNA repair proteins","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.8511943817138672},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.7201117277145386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.613903820514679},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.5924367904663086},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5606454610824585},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5009191036224365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35298287868499756},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34609439969062805}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/mmbr.54.1.18-51.1990","doi":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","pdf_url":null,"source":{"id":"https://openalex.org/S4210177515","display_name":"Microbiological Reviews","issn_l":"0146-0749","issn":["0146-0749","1070-6275"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiological Reviews","raw_type":"journal-article"},{"id":"doi:10.1128/mr.54.1.18-51.1990","doi":"https://doi.org/10.1128/mr.54.1.18-51.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mr.54.1.18-51.1990","pdf_url":null,"source":{"id":"https://openalex.org/S4210177515","display_name":"Microbiological Reviews","issn_l":"0146-0749","issn":["0146-0749","1070-6275"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiological Reviews","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:233962","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC372757","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:372757","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/372757","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiol Rev","raw_type":"Text"},{"id":"pmid:2181258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2181258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiological reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/mmbr.54.1.18-51.1990","doi":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mmbr.54.1.18-51.1990","pdf_url":null,"source":{"id":"https://openalex.org/S4210177515","display_name":"Microbiological Reviews","issn_l":"0146-0749","issn":["0146-0749","1070-6275"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiological Reviews","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":183,"referenced_works":["https://openalex.org/W63898219","https://openalex.org/W82581107","https://openalex.org/W155752128","https://openalex.org/W181491611","https://openalex.org/W1029530443","https://openalex.org/W1485160972","https://openalex.org/W1485697008","https://openalex.org/W1488153834","https://openalex.org/W1489672007","https://openalex.org/W1490222790","https://openalex.org/W1497324858","https://openalex.org/W1499426087","https://openalex.org/W1501073575","https://openalex.org/W1501430524","https://openalex.org/W1520113831","https://openalex.org/W1523431458","https://openalex.org/W1531234455","https://openalex.org/W1531743144","https://openalex.org/W1542514302","https://openalex.org/W1542814728","https://openalex.org/W1545562984","https://openalex.org/W1552284012","https://openalex.org/W1554150300","https://openalex.org/W1554627281","https://openalex.org/W1571552114","https://openalex.org/W1581042042","https://openalex.org/W1584011323","https://openalex.org/W1584034351","https://openalex.org/W1584887355","https://openalex.org/W1597807983","https://openalex.org/W1605692660","https://openalex.org/W1618220520","https://openalex.org/W1711722884","https://openalex.org/W1762691437","https://openalex.org/W1786563662","https://openalex.org/W1799938784","https://openalex.org/W1894282637","https://openalex.org/W1904888002","https://openalex.org/W1940781171","https://openalex.org/W1953277120","https://openalex.org/W1960547817","https://openalex.org/W1966193664","https://openalex.org/W1966685967","https://openalex.org/W1967638733","https://openalex.org/W1967784067","https://openalex.org/W1967964316","https://openalex.org/W1967972013","https://openalex.org/W1969107625","https://openalex.org/W1970558504","https://openalex.org/W1970761658","https://openalex.org/W1971383671","https://openalex.org/W1972014292","https://openalex.org/W1972900772","https://openalex.org/W1973073879","https://openalex.org/W1974169508","https://openalex.org/W1978224363","https://openalex.org/W1978768301","https://openalex.org/W1978853657","https://openalex.org/W1978873413","https://openalex.org/W1980000114","https://openalex.org/W1980854423","https://openalex.org/W1980895773","https://openalex.org/W1982362890","https://openalex.org/W1984232514","https://openalex.org/W1984455251","https://openalex.org/W1985180452","https://openalex.org/W1990889686","https://openalex.org/W1991548363","https://openalex.org/W1992052760","https://openalex.org/W1992964095","https://openalex.org/W1994743317","https://openalex.org/W1994784611","https://openalex.org/W1997668061","https://openalex.org/W1998705813","https://openalex.org/W1998895748","https://openalex.org/W2000215876","https://openalex.org/W2002957935","https://openalex.org/W2003821398","https://openalex.org/W2006412822","https://openalex.org/W2008561915","https://openalex.org/W2009468812","https://openalex.org/W2013260256","https://openalex.org/W2014509983","https://openalex.org/W2015313250","https://openalex.org/W2016430241","https://openalex.org/W2017063443","https://openalex.org/W2018485959","https://openalex.org/W2020046973","https://openalex.org/W2021895822","https://openalex.org/W2023883550","https://openalex.org/W2024125884","https://openalex.org/W2025388536","https://openalex.org/W2029699871","https://openalex.org/W2030333654","https://openalex.org/W2033860973","https://openalex.org/W2034943064","https://openalex.org/W2035208098","https://openalex.org/W2036272159","https://openalex.org/W2039565853","https://openalex.org/W2040713089","https://openalex.org/W2042204220","https://openalex.org/W2043995349","https://openalex.org/W2044198505","https://openalex.org/W2044198642","https://openalex.org/W2044669396","https://openalex.org/W2045560862","https://openalex.org/W2049403730","https://openalex.org/W2049427229","https://openalex.org/W2050217369","https://openalex.org/W2050879305","https://openalex.org/W2051217723","https://openalex.org/W2051569170","https://openalex.org/W2053690536","https://openalex.org/W2057297771","https://openalex.org/W2059901912","https://openalex.org/W2060522508","https://openalex.org/W2062487245","https://openalex.org/W2063160020","https://openalex.org/W2063443838","https://openalex.org/W2064049133","https://openalex.org/W2064066975","https://openalex.org/W2065536935","https://openalex.org/W2066904721","https://openalex.org/W2068373542","https://openalex.org/W2073038177","https://openalex.org/W2073512404","https://openalex.org/W2073606539","https://openalex.org/W2075330542","https://openalex.org/W2077823345","https://openalex.org/W2078049644","https://openalex.org/W2078157295","https://openalex.org/W2078767371","https://openalex.org/W2078865456","https://openalex.org/W2080111833","https://openalex.org/W2080610707","https://openalex.org/W2081000174","https://openalex.org/W2081745003","https://openalex.org/W2082318422","https://openalex.org/W2082405177","https://openalex.org/W2082927796","https://openalex.org/W2084481406","https://openalex.org/W2086062199","https://openalex.org/W2088295238","https://openalex.org/W2088689026","https://openalex.org/W2089068314","https://openalex.org/W2089081139","https://openalex.org/W2089292706","https://openalex.org/W2093521719","https://openalex.org/W2102154371","https://openalex.org/W2112255591","https://openalex.org/W2114989573","https://openalex.org/W2115007679","https://openalex.org/W2115150990","https://openalex.org/W2117784594","https://openalex.org/W2121086021","https://openalex.org/W2123846442","https://openalex.org/W2124100270","https://openalex.org/W2124415994","https://openalex.org/W2126758146","https://openalex.org/W2126816359","https://openalex.org/W2128295060","https://openalex.org/W2130663998","https://openalex.org/W2132521738","https://openalex.org/W2133174507","https://openalex.org/W2137638712","https://openalex.org/W2140061924","https://openalex.org/W2140158396","https://openalex.org/W2144206181","https://openalex.org/W2148065761","https://openalex.org/W2148883135","https://openalex.org/W2151490451","https://openalex.org/W2151938785","https://openalex.org/W2152101699","https://openalex.org/W2159254728","https://openalex.org/W2161279963","https://openalex.org/W2172260025","https://openalex.org/W2174274173","https://openalex.org/W2299901116","https://openalex.org/W2397820816","https://openalex.org/W2498973504","https://openalex.org/W2579943967","https://openalex.org/W2616415536","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1999503964","https://openalex.org/W1586619880","https://openalex.org/W2053690536","https://openalex.org/W2140592281","https://openalex.org/W7096036180","https://openalex.org/W2047688181","https://openalex.org/W1879532024","https://openalex.org/W19189422","https://openalex.org/W1608467849","https://openalex.org/W2073301400"],"abstract_inverted_index":{"One":[0,66],"of":[1,14,36,41,62,67,72,83,91,117,132,141,147,160],"the":[2,34,42,68,76,99,114,122,128,157,161,178],"best-studied":[3],"DNA":[4,15,23,100,118],"repair":[5,20,64,70],"pathways":[6],"is":[7,75,131,167],"nucleotide":[8,48],"excision":[9,49],"repair,":[10],"a":[11,30,59,88,102,109,138,145],"process":[12],"consisting":[13],"damage":[16,125],"recognition,":[17],"incision,":[18],"excision,":[19],"resynthesis,":[21],"and":[22,97],"ligation.":[24],"Escherichia":[25],"coli":[26,47],"has":[27],"served":[28],"as":[29],"model":[31],"organism":[32],"for":[33,124],"study":[35],"this":[37,55,63,73,84],"process.":[38],"Recently,":[39],"many":[40],"proteins":[43],"that":[44,120],"mediate":[45],"E.":[46],"have":[50,152],"been":[51,153],"purified":[52],"to":[53,58,94,96,155,169],"homogeneity;":[54],"had":[56],"led":[57],"molecular":[60],"description":[61],"pathway.":[65],"key":[69],"enzymes":[71],"pathway":[74],"UvrABC":[77,106,129,162],"nuclease":[78,163],"complex.":[79,164],"The":[80,105],"individual":[81],"subunits":[82],"enzyme":[85],"cooperate":[86],"in":[87,148],"complex":[89,107,130,173],"series":[90],"partial":[92],"reactions":[93],"bind":[95],"incise":[98],"near":[101],"damaged":[103],"nucleotide.":[104],"displays":[108],"remarkable":[110],"substrate":[111],"diversity.":[112],"Defining":[113],"structural":[115],"features":[116],"lesions":[119],"provide":[121],"specificity":[123],"recognition":[126],"by":[127],"great":[133],"importance,":[134],"since":[135],"it":[136],"represents":[137],"unique":[139],"form":[140],"protein-DNA":[142],"interaction.":[143],"Using":[144],"number":[146],"vitro":[149],"assays,":[150],"researchers":[151],"able":[154],"elucidate":[156],"action":[158],"mechanism":[159],"Current":[165],"research":[166],"devoted":[168],"understanding":[170],"how":[171],"these":[172],"events":[174],"are":[175],"mediated":[176],"within":[177],"living":[179],"cell.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}