{"id":"https://openalex.org/W2173940544","doi":null,"title":"An exploration of possible mechanisms underlying the beneficial effects of enriched rehabilitation on post-stroke recovery of function","display_name":"An exploration of possible mechanisms underlying the beneficial effects of enriched rehabilitation on post-stroke recovery of function","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2173940544","mag":"2173940544"},"language":"en","primary_location":{"id":"pmh:oai:research.library.mun.ca:8707","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/8707/1/Clarke_Jared.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/7679c6ed-45a7-409f-8e74-016fda303c34/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://memorial.scholaris.ca/bitstreams/7679c6ed-45a7-409f-8e74-016fda303c34/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028625487","display_name":"Jared Clarke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jared Clarke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028625487"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":0.9710000157356262},{"id":"https://openalex.org/keywords/stroke-recovery","display_name":"stroke recovery","score":0.843999981880188},{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fosb-deltafosb","display_name":"FosB/\u0394FosB","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/perilesional-cortex","display_name":"perilesional cortex","score":0.871999979019165},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.6779999732971191},{"id":"https://openalex.org/keywords/delayed-cell-death","display_name":"delayed cell death","score":0.527999997138977},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/foot-placement","display_name":"foot placement","score":0.7940000295639038},{"id":"https://openalex.org/keywords/forelimb-use","display_name":"forelimb use","score":0.8349999785423279},{"id":"https://openalex.org/keywords/rehabilitation-timing","display_name":"rehabilitation timing","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.7725844383239746},{"id":"https://openalex.org/C2777099045","wikidata":"https://www.wikidata.org/wiki/Q17929096","display_name":"FOSB","level":4,"score":0.7395849823951721},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.6527152061462402},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5998606085777283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5378389358520508},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.48040464520454407},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.47932446002960205},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.47109565138816833},{"id":"https://openalex.org/C53927964","wikidata":"https://www.wikidata.org/wiki/Q3054611","display_name":"Environmental enrichment","level":2,"score":0.46931907534599304},{"id":"https://openalex.org/C2776361831","wikidata":"https://www.wikidata.org/wiki/Q10681911","display_name":"Stroke recovery","level":3,"score":0.46224498748779297},{"id":"https://openalex.org/C115490710","wikidata":"https://www.wikidata.org/wiki/Q4138732","display_name":"Spontaneous recovery","level":2,"score":0.447273313999176},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33785200119018555},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33403104543685913},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3174518942832947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24587690830230713},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.23126256465911865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10948196053504944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:research.library.mun.ca:8707","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/8707/1/Clarke_Jared.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/7679c6ed-45a7-409f-8e74-016fda303c34/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/13891","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14783/13891","pdf_url":null,"source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral thesis"},{"id":"mag:2173940544","doi":null,"is_oa":false,"landing_page_url":"https://research.library.mun.ca/8707/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research.library.mun.ca:8707","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/8707/1/Clarke_Jared.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/7679c6ed-45a7-409f-8e74-016fda303c34/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2173940544.pdf","grobid_xml":"https://content.openalex.org/works/W2173940544.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W8915764","https://openalex.org/W1781000532","https://openalex.org/W1920845131","https://openalex.org/W1964143171","https://openalex.org/W1964374986","https://openalex.org/W1966869460","https://openalex.org/W1967063999","https://openalex.org/W1967995445","https://openalex.org/W1970819754","https://openalex.org/W1972849817","https://openalex.org/W1973795837","https://openalex.org/W1975004539","https://openalex.org/W1982243354","https://openalex.org/W1985600845","https://openalex.org/W1995992313","https://openalex.org/W1997912239","https://openalex.org/W2011343589","https://openalex.org/W2011394277","https://openalex.org/W2026679109","https://openalex.org/W2035174489","https://openalex.org/W2038514344","https://openalex.org/W2040963020","https://openalex.org/W2041318300","https://openalex.org/W2045399511","https://openalex.org/W2045421141","https://openalex.org/W2058364692","https://openalex.org/W2062179905","https://openalex.org/W2063430655","https://openalex.org/W2064052038","https://openalex.org/W2066438557","https://openalex.org/W2075604152","https://openalex.org/W2075808979","https://openalex.org/W2078490096","https://openalex.org/W2086564413","https://openalex.org/W2111289437","https://openalex.org/W2114623260","https://openalex.org/W2118660285","https://openalex.org/W2120024520","https://openalex.org/W2122923365","https://openalex.org/W2124780025","https://openalex.org/W2125796626","https://openalex.org/W2126328573","https://openalex.org/W2129658890","https://openalex.org/W2141711957","https://openalex.org/W2146316243","https://openalex.org/W2147464541","https://openalex.org/W2152609387","https://openalex.org/W2158450617","https://openalex.org/W2159053023","https://openalex.org/W2163407262","https://openalex.org/W2403483468"],"related_works":["https://openalex.org/W1973307171","https://openalex.org/W2050631601","https://openalex.org/W7135650144","https://openalex.org/W4383534297","https://openalex.org/W2141711957","https://openalex.org/W2320625168","https://openalex.org/W2362397512","https://openalex.org/W2075808979","https://openalex.org/W2097390064","https://openalex.org/W2379873910"],"abstract_inverted_index":{"A":[0],"combination":[1,285],"of":[2,30,32,62,88,113,147,176,185,205,225,248,252,266,282,320,328,335],"enriched":[3,10,116,198,259,321],"environment":[4,117,260,322],"and":[5,26,75,106,217,240,268,312,337],"daily":[6,280],"reaching":[7,239,293],"therapy":[8,180,339],"(i.e.":[9],"rehabilitation)":[11],"enhances":[12],"functional":[13,107],"recovery":[14,108,146,156,186,236,265,308,327],"following":[15,78,149,187],"focal":[16,81,188,273],"ischemia":[17],"in":[18,91,136,165,181,237,284,292,309],"rats.":[19],"However,":[20,303],"the":[21,46,60,86,92,103,166,174,182,214,223,226],"mechanisms":[22,47],"contributing":[23],"to":[24,102,122,131,158,179,278,296,301,325],"recovery,":[25],"potentially":[27],"critical":[28,50],"influence":[29],"timing":[31],"rehabilitation,":[33,199],"remain":[34],"unclear.":[35],"--":[36,154,254],"Enriched":[37,83],"rehabilitation":[38,64,84,128,233,350],"is":[39,129,169],"especially":[40],"effective":[41],"when":[42],"initiated":[43],"early,":[44],"however":[45],"underlying":[48],"this":[49],"time":[51],"window":[52],"have":[53],"not":[54,120],"been":[55],"determined.":[56],"Chapter":[57,171,255],"2":[58],"examined":[59,173],"effects":[61,175,263],"early":[63,93,160,232],"on":[65,264],"neuronal":[66],"activation":[67],"(FosB/\u2206FosB),":[68],"delayed":[69],"cell":[70],"death":[71],"(Fluoro":[72],"Jade":[73],"C)":[74],"inflammation":[76],"(ED-1)":[77],"endothelin-1":[79],"induced":[80],"ischemia.":[82,189,274],"increased":[85,98],"activity":[87,99,124],"perilesional":[89],"cortex":[90],"post-stroke":[94],"treatment":[95,215],"period.":[96],"This":[97],"likely":[100],"contributes":[101],"neuroplastic":[104,218],"changes":[105,219],"observed":[109],"with":[110,197,286],"extended":[111],"periods":[112,204,281],"rehabilitation.":[114],"Importantly,":[115],"alone":[118],"did":[119],"lead":[121],"enhanced":[123,235],"suggesting":[125,315],"that":[126,258,316,343],"task-specific":[127,338],"necessary":[130],"promote":[132,326],"maximal":[133],"recovery.":[134],"Changes":[135],"FosB/\u2206FosB":[137],"expression":[138],"provide":[139],"a":[140],"powerful":[141],"approach":[142],"for":[143,194,202],"detecting":[144],"use-dependent":[145],"function":[148],"stroke":[150],"or":[151],"brain":[152],"injury.":[153],"Most":[155],"tends":[157],"occur":[159],"after":[161,272],"stroke,":[162],"while":[163],"improvement":[164,291],"chronic":[167,183,250],"phase":[168,184],"limited.":[170],"3":[172],"periodic":[177],"returns":[178],"Ischemic":[190,275],"rats":[191,276],"were":[192,220],"treated":[193],"nine":[195],"weeks":[196],"then":[200],"returned":[201],"two":[203],"intensive":[206],"tune-up":[207],"therapy.":[208],"Functional":[209],"outcome":[210],"was":[211,245],"assessed":[212],"throughout":[213],"period,":[216],"measured":[221],"at":[222],"end":[224],"study":[227],"using":[228],"Golgi-Cox":[229],"analysis.":[230],"While":[231],"provided":[234],"both":[238],"foot":[241,310],"placement":[242,311],"ability,":[243],"there":[244],"little":[246],"benefit":[247],"more":[249],"phases":[251],"treatment.":[253],"4":[256],"shows":[257],"has":[261],"differential":[262],"skilled":[267],"unskilled":[269,329],"motor":[270,330],"functions":[271],"exposed":[277],"longer":[279],"enrichment,":[283],"reach":[287],"therapy,":[288],"showed":[289,306],"greater":[290],"ability":[294],"compared":[295],"those":[297],"receiving":[298],"less":[299],"exposure":[300],"enrichment.":[302],"all":[304],"groups":[305],"similar":[307],"forelimb":[313],"use,":[314],"even":[317],"short":[318],"durations":[319],"are":[323],"sufficient":[324],"functions.":[331],"The":[332],"synergistic":[333],"effect":[334],"enrichment":[336],"provides":[340],"further":[341],"evidence":[342],"stimulating":[344],"environments":[345],"should":[346],"be":[347],"incorporated":[348],"into":[349],"programs.":[351]},"counts_by_year":[],"updated_date":"2026-09-02T18:50:13.731487","created_date":"2016-06-24T00:00:00"}