{"id":"https://openalex.org/W2173789978","doi":null,"title":"Missense mutations in the PML/RARalpha ligand binding domain in ATRA-resistant As(2)O(3) sensitive relapsed acute promyelocytic leukemia.","display_name":"Missense mutations in the PML/RARalpha ligand binding domain in ATRA-resistant As(2)O(3) sensitive relapsed acute promyelocytic leukemia.","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2173789978","mag":"2173789978","pmid":"https://pubmed.ncbi.nlm.nih.gov/10553155"},"language":"en","primary_location":{"id":"pmid:10553155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10553155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unimore.it/bitstream/11380/613044/1/963.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080861890","display_name":"Roberto Marasca","orcid":"https://orcid.org/0000-0002-6431-6878","observed_orcids":["https://orcid.org/0000-0002-6431-6878","https://orcid.org/0000-0001-6763-3273"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Marasca","raw_affiliation_strings":["Department of Medical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073994020","display_name":"Patrizia Zucchini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Zucchini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001285087","display_name":"Sara Galimberti","orcid":"https://orcid.org/0000-0002-4620-0038","observed_orcids":["https://orcid.org/0000-0002-4620-0038","https://orcid.org/0000-0001-7899-5966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Galimberti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G Leonardi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Leonardi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005331587","display_name":"Paola Vaccari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Vaccari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076927239","display_name":"Amedea Donelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Donelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008526145","display_name":"Mario Luppi","orcid":"https://orcid.org/0000-0002-0373-1154","observed_orcids":["https://orcid.org/0000-0002-0373-1154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Luppi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071634163","display_name":"Massimiliano Petrini","orcid":"https://orcid.org/0000-0002-8942-0890","observed_orcids":["https://orcid.org/0000-0002-8942-0890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Petrini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113999875","display_name":"Giuseppe Torelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Torelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8622,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.67676913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"84","issue":"11","first_page":"963","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pml-raralpha","display_name":"PML-RAR\u03b1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.9509999752044678},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid-resistance","display_name":"all-trans retinoic acid resistance","score":0.9710000157356262},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.921999990940094},{"id":"https://openalex.org/keywords/relapsed-leukemia","display_name":"relapsed leukemia","score":0.7229999899864197},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.8306733965873718},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.7305030226707458},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.608238697052002},{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.5746066570281982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.490178644657135},{"id":"https://openalex.org/C111441629","wikidata":"https://www.wikidata.org/wiki/Q18030615","display_name":"Promyelocytic leukemia protein","level":5,"score":0.4775593876838684},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.4292908310890198},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.42455971240997314},{"id":"https://openalex.org/C119775778","wikidata":"https://www.wikidata.org/wiki/Q18031040","display_name":"Retinoic acid receptor alpha","level":5,"score":0.4147071838378906},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3979162573814392},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.3798116445541382},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3658314347267151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34134534001350403},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25743550062179565},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.2558820843696594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22497284412384033},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10079756379127502},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"pmid:10553155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10553155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/613044","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/613044","pdf_url":"https://iris.unimore.it/bitstream/11380/613044/1/963.full.pdf","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1028.8026","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1028.8026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.haematologica.org/content/haematol/84/11/963.full.pdf","raw_type":"text"},{"id":"pmh:oai:arpi.unipi.it:11568/161511","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/161511","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arpi.unipi.it:11568/170662","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/170662","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:46765ebdcca94da58ea6a8f87fbd8d75","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/46765ebdcca94da58ea6a8f87fbd8d75","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 84, Iss 11 (1999)","raw_type":"article"},{"id":"mag:2173789978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10553155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/613044","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/613044","pdf_url":"https://iris.unimore.it/bitstream/11380/613044/1/963.full.pdf","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2173789978.pdf","grobid_xml":"https://content.openalex.org/works/W2173789978.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1539454494","https://openalex.org/W2047456191","https://openalex.org/W2213868747","https://openalex.org/W2314037093","https://openalex.org/W2327237185","https://openalex.org/W2402421550","https://openalex.org/W2421553221"],"related_works":["https://openalex.org/W7100564271","https://openalex.org/W2077872976","https://openalex.org/W7039701482","https://openalex.org/W2574020092","https://openalex.org/W1750460473","https://openalex.org/W2125733324","https://openalex.org/W2518743105","https://openalex.org/W1158911408","https://openalex.org/W2894652054","https://openalex.org/W7095209782"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,112,212],"OBJECTIVE:":[2],"Acute":[3],"promyelocytic":[4],"leukemia":[5],"is":[6],"characterized":[7],"by":[8,34,126,135],"the":[9,15,37,43,47,54,57,93,99,117,120,158,166,169,193,196,240],"chromosomal":[10],"translocation":[11],"t(15;17)":[12],"which":[13],"yields":[14],"fusion":[16],"product":[17],"PML/RARa.":[18],"All-trans":[19],"retinoic":[20],"acid":[21,189],"probably":[22],"induces":[23],"differentiation":[24],"of":[25,42,46,53,56,95,101,119,143,168,195,223,245],"atypical":[26],"promyelocytes":[27],"and":[28,67,104,146,184,204],"clinical":[29,75,85,203,231],"remission":[30,206],"in":[31,62,68,98,165,226,242],"APL":[32,64,71,81,144,178,232,246],"patients":[33,72,83,200],"binding":[35,39],"to":[36,77,87,181,185,192,218,230,258],"ligand":[38],"domain":[40],"(LBD)":[41],"RARa":[44,197],"portion":[45],"PML-RARa":[48],"chimeric":[49,122],"protein.":[50,198],"Structural":[51],"alterations":[52],"LBD":[55,100,118,167,214],"PML/RARa":[58,102,121,170],"have":[59,250],"been":[60],"revealed":[61],"ATRA-resistant":[63,159,252],"cell":[65],"lines":[66],"a":[69,161,220],"few":[70],"with":[73,84,107,209],"acquired":[74,224],"resistance":[76,86],"ATRA":[78,88],"therapy.":[79],"Two":[80],"relapsed":[82,247],"therapy":[89],"were":[90,124,148],"evaluated":[91],"for":[92,253],"presence":[94],"nucleotide":[96],"mutations":[97,216],"gene":[103,171],"then":[105],"treated":[106],"arsenic":[108,259],"trioxide":[109],"(As2O3).":[110],"DESIGN":[111],"METHODS:":[113],"DNA":[114],"fragments":[115],"from":[116,150],"transcript":[123],"obtained":[125],"reverse-transcribed":[127],"polymerase":[128],"chain":[129],"reaction.":[130],"Direct":[131],"sequencing":[132],"was":[133,172],"performed":[134],"an":[136,182,186],"unambiguous":[137],"bi-directional":[138],"automatic":[139],"analysis.":[140],"Samples":[141],"representative":[142],"onset":[145],"relapse":[147],"analyzed":[149],"both":[151,155],"patients.":[152],"RESULTS:":[153],"In":[154],"patients,":[156,248],"at":[157,177],"relapse,":[160],"missense":[162,215],"point":[163],"mutation":[164],"found.":[173],"The":[174,234],"mutations,":[175],"absent":[176],"onset,":[179],"led":[180],"Arg272Gln":[183],"Arg276Trp":[187],"amino":[188],"substitution,":[190],"according":[191],"sequence":[194],"Both":[199],"had":[201],"complete":[202],"hematologic":[205],"after":[207],"treatment":[208],"As2O3.":[210],"INTERPRETATION":[211],"CONCLUSIONS:":[213],"appear":[217],"be":[219],"significant":[221],"mechanism":[222],"ATRA-resistance":[225],"vivo,":[227],"closely":[228],"related":[229],"relapse.":[233],"two":[235],"cases":[236],"reported":[237],"here":[238],"provide":[239],"first":[241],"vivo":[243],"evidence":[244],"who":[249],"become":[251],"molecular":[254],"reasons,":[255],"being":[256],"sensitive":[257],"trioxide.":[260]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}