{"id":"https://openalex.org/W2173671065","doi":null,"title":"[Mitochondrial dysfunction in bipolar disorder].","display_name":"[Mitochondrial dysfunction in bipolar disorder].","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W2173671065","mag":"2173671065","pmid":"https://pubmed.ncbi.nlm.nih.gov/16220655"},"language":"ja","primary_location":{"id":"pmid:16220655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16220655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100631067","display_name":"Tadafumi Kato","orcid":"https://orcid.org/0000-0001-7856-3952","observed_orcids":["https://orcid.org/0000-0001-7856-3952"]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tadafumi Kato","raw_affiliation_strings":["RIKEN Brain Science Institute, 2-1 Hirosawa, Wako 351-0198 Japan. kato@brain.riken.go.jp","RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, 351-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Brain Science Institute, 2-1 Hirosawa, Wako 351-0198 Japan. kato@brain.riken.go.jp","institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, 351-0198, Japan","institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100631067"],"corresponding_institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"],"apc_list":null,"apc_paid":null,"fwci":3.3529,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.92021127,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"25","issue":"2","first_page":"61","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.36250001192092896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":1.0},{"id":"https://openalex.org/keywords/chronic-progressive-external-ophthalmoplegia","display_name":"chronic progressive external ophthalmoplegia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.7360000014305115},{"id":"https://openalex.org/keywords/4977-bp-deletion","display_name":"4977 bp deletion","score":0.8330000042915344},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.8619999885559082},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.7238709926605225},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7042372226715088},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5859750509262085},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.512269914150238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49552977085113525},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4212016463279724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40999963879585266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.327363520860672},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32204878330230713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29229241609573364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.282426118850708},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013055","descriptor_name":"Spectrophotometry, Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16220655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16220655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","raw_type":"English Abstract"},{"id":"mag:2173671065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16220655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W39288719","https://openalex.org/W1601079965","https://openalex.org/W2030257975","https://openalex.org/W3108173214","https://openalex.org/W2466067164","https://openalex.org/W7124870672","https://openalex.org/W2170288106","https://openalex.org/W4220841089","https://openalex.org/W2084200218","https://openalex.org/W1993350139"],"abstract_inverted_index":{"Phosphorus":[0],"magnetic":[1],"resonance":[2],"spectroscopic":[3],"studies":[4],"in":[5,27,86,107,114],"bipolar":[6,48,108,115,137],"disorder":[7,22,49,116,138],"revealed":[8,45],"altered":[9,74,101],"brain":[10],"energy":[11],"metabolism":[12],"resembling":[13],"that":[14,136],"of":[15,30,35,47,66,76,148],"chronic":[16],"progressive":[17,146],"external":[18],"ophthalmoplegia":[19],"(CPEO).":[20],"Mood":[21],"is":[23,134,139],"one":[24],"characteristic":[25],"symptom":[26],"several":[28],"families":[29],"CPEO":[31],"caused":[32,143],"by":[33,144],"mutations":[34],"three":[36],"genes,":[37],"ANT1,":[38],"Twinkle,":[39],"and":[40,58,70,73,88,104,119,129],"POLG.":[41],"Molecular":[42],"genetic":[43,112],"analysis":[44],"association":[46],"with":[50],"mitochondrial":[51,97],"DNA":[52],"(mtDNA)":[53],"10398A":[54],"polymorphism,":[55],"3644C":[56],"mutation,":[57,72],"FDUFV2.":[59],"In":[60],"the":[61,145],"postmortem":[62],"brains,":[63],"increased":[64],"levels":[65],"mtDNA":[67],"4977bp":[68],"deletion":[69],"3243G":[71],"expression":[75],"mitochondria-related":[77],"genes":[78],"were":[79],"reported.":[80],"Mitochondria":[81],"play":[82],"an":[83],"important":[84],"role":[85],"neuroplasticity":[87],"apoptotic":[89],"signaling":[90,123],"via":[91],"regulating":[92],"intracellular":[93],"calcium":[94,102],"homeostasis.":[95],"Thus,":[96,132],"dysfunction":[98],"may":[99],"cause":[100],"homeostasis":[103],"neuroplasticity,":[105],"resulting":[106],"disorder.":[109],"Most":[110],"molecular":[111],"findings":[113],"regarding":[117],"mitochondria":[118],"endoplasmic":[120],"reticulum":[121],"stress":[122],"are":[124],"common":[125],"to":[126],"Parkinson's":[127],"disease":[128,142],"diabetes":[130],"mellitus.":[131],"it":[133],"possible":[135],"also":[140],"a":[141],"loss":[147],"some":[149],"neuronal":[150],"cells.":[151]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
