{"id":"https://openalex.org/W2173624430","doi":"https://doi.org/10.1146/annurev.ph.49.030187.001141","title":"Red Cell Deformability And Its Relevance To Blood Flow","display_name":"Red Cell Deformability And Its Relevance To Blood Flow","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2173624430","doi":"https://doi.org/10.1146/annurev.ph.49.030187.001141","mag":"2173624430","pmid":"https://pubmed.ncbi.nlm.nih.gov/3551796"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.ph.49.030187.001141","doi":"https://doi.org/10.1146/annurev.ph.49.030187.001141","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.49.030187.001141","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068335042","display_name":"Shu Chien","orcid":"https://orcid.org/0000-0003-0332-285X","observed_orcids":["https://orcid.org/0000-0003-0332-285X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S Chien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068335042"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3178,"has_fulltext":false,"cited_by_count":568,"citation_normalized_percentile":{"value":0.9682076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"49","issue":"1","first_page":"177","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11379","display_name":"Rheology and Fluid Dynamics Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.921999990940094},{"id":"https://openalex.org/keywords/hemorheology","display_name":"hemorheology","score":0.9290000200271606},{"id":"https://openalex.org/keywords/blood-viscosity","display_name":"blood viscosity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.7799999713897705},{"id":"https://openalex.org/keywords/plasma-viscosity","display_name":"plasma viscosity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-aggregation","display_name":"cell aggregation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/circulatory-regulation","display_name":"circulatory regulation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sickle-cells","display_name":"sickle cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-swelling","display_name":"cell swelling","score":0.5849999785423279},{"id":"https://openalex.org/keywords/stress-strain-behavior","display_name":"stress-strain behavior","score":0.7020000219345093},{"id":"https://openalex.org/keywords/blood-flow-resistance","display_name":"blood flow resistance","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.5516914129257202},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5205291509628296},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4209940433502197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3360505700111389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2056727111339569},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.13995862007141113},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.ph.49.030187.001141","doi":"https://doi.org/10.1146/annurev.ph.49.030187.001141","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.49.030187.001141","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"doi:10.1146/annurev.physiol.49.1.177","doi":"https://doi.org/10.1146/annurev.physiol.49.1.177","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.physiol.49.1.177","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"pmid:3551796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3551796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6791910906","display_name":"HUMAN BLOOD CELL MEMBRANES IN HEALTH AND DISEASE","funder_award_id":"P01HL016851","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W132562996","https://openalex.org/W136271931","https://openalex.org/W198946884","https://openalex.org/W1507961739","https://openalex.org/W1575458839","https://openalex.org/W1604383285","https://openalex.org/W1682758370","https://openalex.org/W1976745936","https://openalex.org/W1979053751","https://openalex.org/W1984068900","https://openalex.org/W1986645079","https://openalex.org/W1989775387","https://openalex.org/W1993971815","https://openalex.org/W1994733396","https://openalex.org/W1995868476","https://openalex.org/W1998073588","https://openalex.org/W2014171602","https://openalex.org/W2022507600","https://openalex.org/W2031159210","https://openalex.org/W2032646862","https://openalex.org/W2036402466","https://openalex.org/W2040160289","https://openalex.org/W2045081664","https://openalex.org/W2048859044","https://openalex.org/W2054286516","https://openalex.org/W2055902538","https://openalex.org/W2078755593","https://openalex.org/W2079093080","https://openalex.org/W2086358267","https://openalex.org/W2092597744","https://openalex.org/W2125954910","https://openalex.org/W2130661964","https://openalex.org/W2133709035","https://openalex.org/W2166935330","https://openalex.org/W2171523368","https://openalex.org/W2397937340","https://openalex.org/W2400569133","https://openalex.org/W2407601226","https://openalex.org/W2410034633","https://openalex.org/W2410261980","https://openalex.org/W2412174089","https://openalex.org/W2418076301","https://openalex.org/W2418892415","https://openalex.org/W2428718609","https://openalex.org/W2432976697","https://openalex.org/W2495803895","https://openalex.org/W3169642455","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2093025457","https://openalex.org/W1658194148","https://openalex.org/W2342875231","https://openalex.org/W2566347874","https://openalex.org/W2052474048","https://openalex.org/W1277334389","https://openalex.org/W1966977447","https://openalex.org/W2002216593","https://openalex.org/W1562109614","https://openalex.org/W2162534867"],"abstract_inverted_index":{"The":[0,61,148,193],"resistance":[1],"to":[2,119,125],"blood":[3,13,21,36,44,65,90],"flow":[4],"is":[5,39,103,155],"a":[6,49,104,113,126,135,140,224],"function":[7],"of":[8,12,20,32,84,87,112,198,207],"the":[9,17,30,33,82,85,88,110,160,178,202,208,211],"rheological":[10],"properties":[11],"as":[14,16],"well":[15],"geometric":[18],"features":[19],"vessels.":[22],"While":[23],"circulatory":[24,53,94],"investigations":[25],"generally":[26],"aim":[27],"at":[28],"studying":[29],"functions":[31],"heart":[34],"and":[35,57,74,98,196,205,219],"vessels,":[37],"there":[38],"an":[40],"increasing":[41],"realization":[42],"that":[43,108],"rheology":[45],"can":[46,133,173],"also":[47,174],"play":[48],"significant":[50],"role":[51,83],"in":[52,55,93,116,123,137,183,189],"regulation":[54,95],"health":[56],"disease":[58],"(10,":[59],"11).":[60],"principal":[62],"factors":[63],"determining":[64],"viscosity":[66],"are":[67,217],"hematocrit,":[68],"plasma":[69],"viscos\u00ad":[70],"ity,":[71],"cell":[72,75,91,138],"aggregation,":[73],"deformability":[76,86,226],"(8).":[77],"This":[78],"review":[79],"focuses":[80],"on":[81,201],"red":[89],"(RBC)":[92],"under":[96],"physiological":[97],"pathophysiological":[99],"conditions.":[100],"1":[101],"Deformability":[102],"relatively":[105],"general":[106],"term":[107],"describes":[109],"ability":[111],"body":[114],"(RBCs":[115],"this":[117],"case)":[118],"change":[120,136],"its":[121],"shape":[122],"response":[124],"deforming":[127,149],"force.":[128],"RBC":[129,181],"deformation":[130,199],"(or":[131],"strain)":[132],"involve":[134],"curvature,":[139],"uniaxial":[141],"deformation,":[142],"or":[143,167,186],"area":[144],"expansion":[145],"(3,":[146],"33).":[147],"stress":[150,166],"(force":[151],"per":[152],"unit":[153],"area)":[154],"usually":[156],"applied":[157],"from":[158,176],"outside":[159],"cell,":[161,179],"e.g.":[162,180],"by":[163,223],"fluid":[164],"shear":[165],"local":[168],"membrane":[169],"aspiration,":[170],"but":[171],"it":[172],"originate":[175],"within":[177],"swelling":[182],"hypotonic":[184],"medium":[185],"fiber":[187],"formation":[188],"deoxygenated":[190],"sickle":[191],"cells.":[192],"extent,":[194],"rate,":[195,204],"mode":[197],"depend":[200],"magnitude,":[203],"direction":[206],"stress.":[209],"Therefore,":[210],"stress-strain":[212,214],"(and":[213],"rate)":[215],"relationships":[216],"complex":[218],"cannot":[220],"be":[221],"described":[222],"single":[225],"parameter.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}