{"id":"https://openalex.org/W2173594933","doi":"https://doi.org/10.18632/oncotarget.6365","title":"Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells","display_name":"Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells","publication_year":2015,"publication_date":"2015-11-22","ids":{"openalex":"https://openalex.org/W2173594933","doi":"https://doi.org/10.18632/oncotarget.6365","mag":"2173594933","pmid":"https://pubmed.ncbi.nlm.nih.gov/26595805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4747172"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.6365","doi":"https://doi.org/10.18632/oncotarget.6365","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.6365","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6365&path%5B%5D=17393","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6365&path%5B%5D=17393","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061744289","display_name":"Kaitlyn M. Dykstra","orcid":"https://orcid.org/0000-0002-8447-8364","observed_orcids":["https://orcid.org/0000-0002-8447-8364"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn M. Dykstra","raw_affiliation_strings":["Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967141","display_name":"Cheryl L. Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Allen","raw_affiliation_strings":["Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040256621","display_name":"Ella J. Born","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ella J. Born","raw_affiliation_strings":["Department of Internal Medicine, University of Iowa, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102253124","display_name":"Huaxiang Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaxiang Tong","raw_affiliation_strings":["Penn State Hershey Cancer Institute, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn State Hershey Cancer Institute, Hershey, PA, USA","institution_ids":["https://openalex.org/I4405268258"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005732386","display_name":"Sarah A. Holstein","orcid":"https://orcid.org/0000-0002-9342-5635","observed_orcids":["https://orcid.org/0000-0002-9342-5635"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah A. Holstein","raw_affiliation_strings":["Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA","Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005732386"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":null,"apc_paid":null,"fwci":1.4297,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.77982536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"39","first_page":"41535","last_page":"41549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/isoprenoid-biosynthesis","display_name":"isoprenoid biosynthesis","score":0.828000009059906},{"id":"https://openalex.org/keywords/rab-gtpases","display_name":"Rab GTPases","score":0.7789999842643738},{"id":"https://openalex.org/keywords/geranylgeranyltransferase-inhibitors","display_name":"geranylgeranyltransferase inhibitors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/prenylation","display_name":"prenylation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.49799999594688416},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8849999904632568},{"id":"https://openalex.org/keywords/er-to-golgi-trafficking","display_name":"ER-Golgi trafficking","score":0.8859999775886536},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bafilomycin-a1","display_name":"bafilomycin A1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/aggresomes","display_name":"aggresomes","score":0.765999972820282},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8896252512931824},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6688145399093628},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.5825545787811279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4708406925201416},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4397938847541809},{"id":"https://openalex.org/C2781373781","wikidata":"https://www.wikidata.org/wiki/Q168790","display_name":"Brefeldin A","level":4,"score":0.4227631688117981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4145217537879944},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39859071373939514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29709917306900024},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2734197974205017},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.24416476488113403},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.1805797815322876},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017368","descriptor_name":"Protein Prenylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.6365","doi":"https://doi.org/10.18632/oncotarget.6365","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.6365","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6365&path%5B%5D=17393","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3772930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4747172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4747172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4747172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:26595805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26595805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.6365","doi":"https://doi.org/10.18632/oncotarget.6365","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.6365","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6365&path%5B%5D=17393","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2827494669","display_name":"Rab Geranylgeranylation: a Novel Therapeutic Target in Multiple Myeloma","funder_award_id":"R01CA172070","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306274","display_name":"Roy J. Carver Charitable Trust","ror":"https://ror.org/01ah2ch91"},{"id":"https://openalex.org/F4320306571","display_name":"American Society of Hematology","ror":"https://ror.org/02nw48b86"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2173594933.pdf","grobid_xml":"https://content.openalex.org/works/W2173594933.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1508661542","https://openalex.org/W1525770659","https://openalex.org/W1534829748","https://openalex.org/W1544981048","https://openalex.org/W1569812687","https://openalex.org/W1821118727","https://openalex.org/W1845237317","https://openalex.org/W1890655587","https://openalex.org/W1969144125","https://openalex.org/W1972401702","https://openalex.org/W1976531450","https://openalex.org/W1977645267","https://openalex.org/W1988620153","https://openalex.org/W2001149281","https://openalex.org/W2005142336","https://openalex.org/W2015228313","https://openalex.org/W2016797132","https://openalex.org/W2020739404","https://openalex.org/W2027484665","https://openalex.org/W2029178634","https://openalex.org/W2033933079","https://openalex.org/W2040722278","https://openalex.org/W2045389135","https://openalex.org/W2051682623","https://openalex.org/W2052169053","https://openalex.org/W2052403003","https://openalex.org/W2056274991","https://openalex.org/W2065237775","https://openalex.org/W2068288454","https://openalex.org/W2069708743","https://openalex.org/W2077274888","https://openalex.org/W2077945404","https://openalex.org/W2078526927","https://openalex.org/W2089955565","https://openalex.org/W2093829053","https://openalex.org/W2100605768","https://openalex.org/W2104788669","https://openalex.org/W2111567059","https://openalex.org/W2114605993","https://openalex.org/W2115205637","https://openalex.org/W2124644922","https://openalex.org/W2127916470","https://openalex.org/W2133709362","https://openalex.org/W2142044474","https://openalex.org/W2146124002","https://openalex.org/W2157219248","https://openalex.org/W2162770644","https://openalex.org/W2164778558","https://openalex.org/W2167624273","https://openalex.org/W2406592483","https://openalex.org/W2417464115","https://openalex.org/W2792139654"],"related_works":["https://openalex.org/W2535858208","https://openalex.org/W2029178634","https://openalex.org/W4313470048","https://openalex.org/W2561376254","https://openalex.org/W2505632790","https://openalex.org/W2559627413","https://openalex.org/W2040722278","https://openalex.org/W2981551691","https://openalex.org/W2001149281","https://openalex.org/W2552534120"],"abstract_inverted_index":{"//":[0,72],"Kaitlyn":[1],"M.":[2],"Dykstra":[3],"1":[4,8,23],",":[5,9,14],"Cheryl":[6],"Allen":[7],"Ella":[10],"J.":[11],"Born":[12],"2":[13,34],"Huaxiang":[15],"Tong":[16],"3":[17,46],"and":[18,140,155,264,279],"Sarah":[19,68],"A.":[20,69],"Holstein":[21],"1,4":[22],"Department":[24,35,56],"of":[25,36,40,57,104,114,129,178,205,207,239,259,286],"Medicine,":[26,38],"Roswell":[27,59],"Park":[28,60],"Cancer":[29,50,61],"Institute,":[30,51,62],"Buffalo,":[31,63],"NY,":[32,64],"USA":[33,45,54,65],"Internal":[37],"University":[39],"Iowa,":[41],"Iowa":[42],"City,":[43],"IA,":[44],"Penn":[47],"State":[48],"Hershey":[49],"Hershey,":[52],"PA,":[53],"4":[55],"Immunology,":[58],"Correspondence":[66],"to:":[67],"Holstein,":[70],"email:":[71],"Keywords":[73],":":[74,81,86,91],"myeloma,":[75],"RabGTPase,":[76],"autophagy,":[77],"prenylation,":[78],"isoprenoid":[79,116,208],"Received":[80],"July":[82],"15,":[83],"2015":[84,89,94],"Accepted":[85],"November":[87,92],"16,":[88],"Published":[90],"22,":[93],"Abstract":[95],"Multiple":[96],"myeloma":[97],"(MM)":[98],"is":[99,147,211,222,268],"characterized":[100],"by":[101,149,214],"the":[102,115,172,175,230,236],"production":[103],"monoclonal":[105,260],"protein":[106,138,263,267],"(MP).":[107],"We":[108,191],"have":[109,160,164],"shown":[110,162],"previously":[111],"that":[112,193,251,265],"disruption":[113,128,206],"biosynthetic":[117],"pathway":[118],"(IBP)":[119],"causes":[120],"a":[121,127,197,203,223,270],"block":[122],"in":[123,143,184,200],"MP":[124],"secretion":[125],"through":[126],"Rab":[130],"GTPase":[131],"activity,":[132],"leading":[133],"to":[134,163,256],"an":[135],"enhanced":[136],"unfolded":[137],"response":[139],"subsequent":[141],"apoptosis":[142],"MM":[144,185],"cells.":[145],"Autophagy":[146],"induced":[148],"cellular":[150,224],"stressors":[151],"including":[152],"nutrient":[153],"deprivation":[154],"ER":[156,255],"stress.":[157],"IBP":[158,179,194,219,252],"inhibitors":[159,180,253,290],"been":[161],"disparate":[165],"effects":[166,177,238],"on":[167,181],"autophagy.":[168],"Here":[169],"we":[170],"define":[171],"mechanisms":[173],"underlying":[174],"differential":[176],"autophagic":[182],"flux":[183],"cells":[186],"utilizing":[187],"specific":[188,287],"pharmacological":[189],"inhibitors.":[190],"demonstrate":[192],"inhibition":[195],"induces":[196],"net":[198],"increase":[199],"autophagy":[201,221,231],"as":[202,227,277,291],"consequence":[204],"biosynthesis":[209],"which":[210],"not":[212,243,269],"recapitulated":[213],"direct":[215],"geranylgeranyl":[216,244],"transferase":[217,245],"inhibition.":[218,246],"inhibitor-induced":[220],"defense":[225],"mechanism":[226],"treatment":[228],"with":[229],"inhibitor":[232],"bafilomycin":[233],"A1":[234],"enhances":[235],"cytotoxic":[237],"GGPP":[240],"depletion,":[241],"but":[242],"Immunofluorescence":[247],"microscopy":[248],"studies":[249,282],"revealed":[250],"disrupt":[254],"Golgi":[257],"trafficking":[258],"light":[261],"chain":[262],"this":[266],"substrate":[271],"for":[272],"alternative":[273],"degradative":[274],"pathways":[275],"such":[276],"aggresomes":[278],"autophagosomes.":[280],"These":[281],"support":[283],"further":[284],"development":[285],"GGTase":[288],"II":[289],"anti-myeloma":[292],"agents.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}