{"id":"https://openalex.org/W2173531201","doi":"https://doi.org/10.1016/j.bmcl.2005.06.104","title":"SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist","display_name":"SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist","publication_year":2005,"publication_date":"2005-08-03","ids":{"openalex":"https://openalex.org/W2173531201","doi":"https://doi.org/10.1016/j.bmcl.2005.06.104","mag":"2173531201","pmid":"https://pubmed.ncbi.nlm.nih.gov/16061378"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2005.06.104","doi":"https://doi.org/10.1016/j.bmcl.2005.06.104","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2005.06.104","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004511044","display_name":"Howard Sard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159259","display_name":"Organix (United States)","ror":"https://ror.org/052qet256","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard Sard","raw_affiliation_strings":["Organix Inc., 240 Salem Street, Woburn, MA 01801, USA. sard@organixinc.com","Organix, Inc., 240 Salem Street, Woburn, MA 01801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organix Inc., 240 Salem Street, Woburn, MA 01801, USA. sard@organixinc.com","institution_ids":["https://openalex.org/I4210159259"]},{"raw_affiliation_string":"Organix, Inc., 240 Salem Street, Woburn, MA 01801, USA","institution_ids":["https://openalex.org/I4210159259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020894218","display_name":"Govindaraj Kumaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159259","display_name":"Organix (United States)","ror":"https://ror.org/052qet256","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Govindaraj Kumaran","raw_affiliation_strings":["Organix, Inc., 240 Salem Street, Woburn, MA 01801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organix, Inc., 240 Salem Street, Woburn, MA 01801, USA","institution_ids":["https://openalex.org/I4210159259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043580942","display_name":"Cynthia Morency","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159259","display_name":"Organix (United States)","ror":"https://ror.org/052qet256","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Morency","raw_affiliation_strings":["Organix, Inc., 240 Salem Street, Woburn, MA 01801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organix, Inc., 240 Salem Street, Woburn, MA 01801, USA","institution_ids":["https://openalex.org/I4210159259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007856961","display_name":"Bryan L. Roth","orcid":"https://orcid.org/0000-0002-0561-6520","observed_orcids":["https://orcid.org/0000-0002-0561-6520","https://orcid.org/0000-0001-8632-7503"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan L. Roth","raw_affiliation_strings":["Case Western Reserve University Medical School, 10900 Euclid Avenue, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University Medical School, 10900 Euclid Avenue, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012930508","display_name":"Beth A. Compton-Toth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Ann Toth","raw_affiliation_strings":["Case Western Reserve University Medical School, 10900 Euclid Avenue, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University Medical School, 10900 Euclid Avenue, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101808828","display_name":"Ping He","orcid":"https://orcid.org/0000-0001-9918-1929","observed_orcids":["https://orcid.org/0000-0001-9918-1929"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping He","raw_affiliation_strings":["Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061168719","display_name":"Louis Shuster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis Shuster","raw_affiliation_strings":["Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004511044"],"corresponding_institution_ids":["https://openalex.org/I4210159259"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":3.0144,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.90602046,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"20","first_page":"4555","last_page":"4559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht2c-receptor-agonist","display_name":"5-HT2C receptor agonist","score":0.8849999904632568},{"id":"https://openalex.org/keywords/serotonin-receptor-pharmacology","display_name":"serotonin receptor pharmacology","score":0.6579999923706055},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.7789999842643738},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tryptamine-derivatives","display_name":"tryptamine derivatives","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2776502132","wikidata":"https://www.wikidata.org/wiki/Q208118","display_name":"Psilocybin","level":3,"score":0.9440007209777832},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8172459602355957},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7831059694290161},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5516706705093384},{"id":"https://openalex.org/C124315065","wikidata":"https://www.wikidata.org/wiki/Q194270","display_name":"Hallucinogen","level":2,"score":0.4933241903781891},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4810345768928528},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3481404781341553},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2796211838722229},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2023666799068451},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0609266459941864}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011562","descriptor_name":"Psilocybin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011562","descriptor_name":"Psilocybin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058826","descriptor_name":"Serotonin 5-HT2 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2005.06.104","doi":"https://doi.org/10.1016/j.bmcl.2005.06.104","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2005.06.104","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:16061378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16061378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2251897864","display_name":"Molecular Mechanisms of 5-HT Receptor Actions","funder_award_id":"K02MH001366","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3575428589","display_name":"Indole Analogs as Novel Treatments for OCD","funder_award_id":"R43MH063529","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W212243276","https://openalex.org/W1907730096","https://openalex.org/W1937517990","https://openalex.org/W1967681543","https://openalex.org/W1970371846","https://openalex.org/W1973660081","https://openalex.org/W1979710987","https://openalex.org/W1981598408","https://openalex.org/W1983871703","https://openalex.org/W2003830048","https://openalex.org/W2023331513","https://openalex.org/W2025634563","https://openalex.org/W2054759608","https://openalex.org/W2057174717","https://openalex.org/W2064468738","https://openalex.org/W2069513027","https://openalex.org/W2080816683","https://openalex.org/W2085444790","https://openalex.org/W2146916583","https://openalex.org/W2426006819","https://openalex.org/W2464166541"],"related_works":["https://openalex.org/W2952807918","https://openalex.org/W3110733646","https://openalex.org/W4225399213","https://openalex.org/W2177844142","https://openalex.org/W4394993604","https://openalex.org/W4391991129","https://openalex.org/W1999928070","https://openalex.org/W2153775030","https://openalex.org/W2092354594","https://openalex.org/W4298350490"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}