{"id":"https://openalex.org/W2172575392","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a130040","title":"Studies on Snake Venom Hemorrhagic Factor I (HR-I) in the Venom of Agkistrodon halys blomhoffii","display_name":"Studies on Snake Venom Hemorrhagic Factor I (HR-I) in the Venom of Agkistrodon halys blomhoffii","publication_year":1972,"publication_date":"1972-12-01","ids":{"openalex":"https://openalex.org/W2172575392","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a130040","mag":"2172575392","pmid":"https://pubmed.ncbi.nlm.nih.gov/4664745"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a130040","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a130040","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a130040","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014438439","display_name":"Genichiro Oshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Genichiro OSHIMA","raw_affiliation_strings":["Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101667","display_name":"Tamotsu Omori\u2010Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamotsu OMORI-SATOH","raw_affiliation_strings":["Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103469644","display_name":"Sadaaki Iwanaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sadaaki IWANAGA","raw_affiliation_strings":["Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103351186","display_name":"Tomoji Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tomoji SUZUKI","raw_affiliation_strings":["Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University Yamada, Suita-shi, Osaka 565","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103351186"],"corresponding_institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":1.0722,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.75580795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"72","issue":"6","first_page":"1483","last_page":"1494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10332","display_name":"Amphibian and Reptile Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mamushi","display_name":"mamushi","score":0.492000013589859},{"id":"https://openalex.org/keywords/snake-venom","display_name":"snake venom","score":0.9670000076293945},{"id":"https://openalex.org/keywords/venom-purification","display_name":"venom purification","score":0.5090000033378601},{"id":"https://openalex.org/keywords/acidic-glycoprotein","display_name":"acidic glycoprotein","score":0.8259999752044678},{"id":"https://openalex.org/keywords/amino-acid-composition","display_name":"amino acid composition","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hemorrhagic-activity","display_name":"hemorrhagic activity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/molecular-weight-determination","display_name":"molecular weight determination","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.792710542678833},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7505513429641724},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.6054232120513916},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.603995680809021},{"id":"https://openalex.org/C96294017","wikidata":"https://www.wikidata.org/wiki/Q308708","display_name":"Isoelectric point","level":3,"score":0.5567229390144348},{"id":"https://openalex.org/C2777608289","wikidata":"https://www.wikidata.org/wiki/Q408626","display_name":"Cystine","level":4,"score":0.48368343710899353},{"id":"https://openalex.org/C51724486","wikidata":"https://www.wikidata.org/wiki/Q908955","display_name":"Column chromatography","level":2,"score":0.43599602580070496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3815811574459076},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25201934576034546},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.058882832527160645}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006821","descriptor_name":"Hyaluronoglucosaminidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006867","descriptor_name":"Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012911","descriptor_name":"Snakes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014688","descriptor_name":"Venoms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a130040","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a130040","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a130040","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:4664745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4664745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022300387","https://openalex.org/W2092713188","https://openalex.org/W2176317295","https://openalex.org/W3107634534","https://openalex.org/W2024498611","https://openalex.org/W1968282103","https://openalex.org/W4233258577","https://openalex.org/W1986493147","https://openalex.org/W2052119671","https://openalex.org/W2087135042"],"abstract_inverted_index":{"One":[0],"of":[1,12,50,52,61,72,123,128,135,189,197,216,223,230,245,261],"two":[2],"hemorrhagic":[3,5,243,259],"factors,":[4],"factor":[6],"I":[7],"(HR-I),":[8],"in":[9,64,145,289],"the":[10,53,65,132,146,149,173,190,214,246,257,280],"venom":[11],"Agkistrodon":[13],"halys":[14],"blomhoffii":[15],"(Mamushi)":[16],"was":[17,152,163,169,175,193,218,235,249,263],"highly":[18],"purified":[19,54,116,247,266],"by":[20,26,160,221,252],"column":[21],"chromatography":[22,32],"on":[23,33,274],"DEAE-cellulose":[24],"followed":[25,220],"vertical":[27],"zone":[28],"electrophoresis":[29],"and":[30,44,98,108,125,140,172,199,204,256],"gel":[31,39,42],"a":[34,47,120,270,286],"Sephadex":[35],"G-100":[36],"column.":[37],"Sedimentation,":[38],"chromatography,":[40],"polyacrylamide":[41],"electrophoresis,":[43],"immunoelectrophoresis":[45],"indicated":[46],"high":[48],"degree":[49],"homogeneity":[51],"material.":[55],"It":[56],"possessed":[57],"no":[58],"detectable":[59],"activities":[60,68],"enzymes":[62],"present":[63],"crude":[66],"venom;":[67],"tested":[69],"are":[70],"those":[71],"proteinases,":[73],"phospholipase":[74],"A's":[75],"[EC":[76,83,103,110],"3.":[77,84,86,89,91,106,111],"1.":[78,79,85,90,104,113],"4],":[80],"nonspecific":[81],"phosphatases":[82],"1":[87],"or":[88],"2],":[92,107],"arginine":[93],"ester":[94],"hydrolases,":[95],"bradykinin":[96],"releasing,":[97],"clotting":[99],"enzymes,":[100],"L-amino-acid":[101],"oxidase":[102],"4.":[105],"hyaluronidase":[109],"2.":[112],"35].":[114],"The":[115,156,165,185,242,265],"HR-I":[117,191,225,234,262,281],"preparation":[118,192],"had":[119,269],"sedimentation":[121],"coefficient":[122,127],"6.08S":[124],"diffusion":[126],"5.40\u00d710\u22127cm2":[129],"sec\u22121.":[130],"Using":[131],"observed":[133],"values":[134],"S20,":[136],"w,":[137,139],"D20,":[138],"v":[141],"(assumed":[142],"as":[143,154],"0.7)":[144],"Svedberg":[147],"equation,":[148],"molecular":[150,157],"weight":[151,158],"calculated":[153],"91,000.":[155],"determined":[159],"Archibald's":[161],"method":[162],"80,000.":[164],"apparent":[166],"isoelectric":[167],"point":[168],"pH":[170,183],"4.70":[171],"mobility":[174],"estimated":[176],"to":[177,237,284],"be":[178,238,285],"\u22123.55\u00d710\u22125cm2":[179],"sec\u22121":[180],"volt\u22121":[181],"at":[182],"8.5.":[184],"amino":[186,212],"acid":[187],"composition":[188],"examined.":[194],"High":[195],"contents":[196],"aspartic":[198],"glutamic":[200],"acids,":[201],"arginine,":[202],"tyrosine,":[203],"half-cystine":[205],"residues":[206],"were":[207],"found.":[208],"Among":[209],"its":[210],"neutral":[211,231],"acids":[213],"content":[215],"tyrosine":[217],"highest":[219],"that":[222],"half-cystine.":[224],"contained":[226],"about":[227],"12":[228],"percent":[229],"sugars.":[232],"Thus,":[233,279],"concluded":[236],"an":[239],"acidic":[240],"glycoprotein.":[241],"activity":[244],"material":[248,267],"completely":[250],"neutralized":[251],"commercial":[253],"Mamushi":[254],"antivenin,":[255],"minimum":[258],"dose":[260],"0.0012\u03bcg.":[264],"also":[268],"potent":[271],"lethal":[272],"effect":[273],"mice":[275],"(L.D.50=0.36":[276],"(0.32\u20130.45)":[277],"mg/kg).":[278],"principle":[282],"seems":[283],"major":[287],"toxin":[288],"this":[290],"venom.":[291]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
