{"id":"https://openalex.org/W2172448428","doi":"https://doi.org/10.1152/ajpgi.1988.255.2.g143","title":"Dietary regulation of intestinal transport of the dipeptide carnosine","display_name":"Dietary regulation of intestinal transport of the dipeptide carnosine","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W2172448428","doi":"https://doi.org/10.1152/ajpgi.1988.255.2.g143","mag":"2172448428","pmid":"https://pubmed.ncbi.nlm.nih.gov/3407773"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1988.255.2.g143","doi":"https://doi.org/10.1152/ajpgi.1988.255.2.g143","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1988.255.2.g143","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016002022","display_name":"Ronaldo P. Ferraris","orcid":"https://orcid.org/0000-0001-6887-5020","observed_orcids":["https://orcid.org/0000-0001-6887-5020"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. P. Ferraris","raw_affiliation_strings":["Department of Physiology, University of California Medical School, Los Angeles 90024"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California Medical School, Los Angeles 90024","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113911784","display_name":"Jared M. Diamond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Diamond","raw_affiliation_strings":["Department of Physiology, University of California Medical School, Los Angeles 90024"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California Medical School, Los Angeles 90024","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055674420","display_name":"W. W. Kwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. W. Kwan","raw_affiliation_strings":["Department of Physiology, University of California Medical School, Los Angeles 90024"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California Medical School, Los Angeles 90024","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":1.3728,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.83647301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"255","issue":"2","first_page":"G143","last_page":"G150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.1298999935388565,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.06430000066757202,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-carnosine","display_name":"L-carnosine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dipeptide-transport","display_name":"dipeptide transport","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.7710000276565552},{"id":"https://openalex.org/keywords/free-amino-acids","display_name":"free amino acids","score":0.7289999723434448},{"id":"https://openalex.org/keywords/casein-hydrolysis","display_name":"casein hydrolysis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/jejunum","display_name":"jejunum","score":0.9010000228881836},{"id":"https://openalex.org/keywords/duodenum","display_name":"duodenum","score":0.843999981880188},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2780687331","wikidata":"https://www.wikidata.org/wiki/Q413822","display_name":"Carnosine","level":2,"score":0.9879293441772461},{"id":"https://openalex.org/C2776142715","wikidata":"https://www.wikidata.org/wiki/Q193970","display_name":"Casein","level":2,"score":0.8263249397277832},{"id":"https://openalex.org/C2779138802","wikidata":"https://www.wikidata.org/wiki/Q418602","display_name":"Dipeptide","level":3,"score":0.7703331708908081},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.742947518825531},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6740100383758545},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.6520586013793945},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6382006406784058},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.566211998462677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5237714648246765},{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.49533525109291077}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002336","descriptor_name":"Carnosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1988.255.2.g143","doi":"https://doi.org/10.1152/ajpgi.1988.255.2.g143","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1988.255.2.g143","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:3407773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3407773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6888327502","display_name":"PEPTIC ULCER CENTER","funder_award_id":"P01AM017328","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6915744388","display_name":null,"funder_award_id":"GM-14772","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2303844736","https://openalex.org/W2213738419","https://openalex.org/W2149936104","https://openalex.org/W2104406172","https://openalex.org/W2161941892","https://openalex.org/W2335263164","https://openalex.org/W2071715557","https://openalex.org/W2072136033","https://openalex.org/W2009203985","https://openalex.org/W2436638514"],"abstract_inverted_index":{"Uptake":[0],"of":[1,11,20,25,40,73,81,118,128,135],"the":[2,23,37,71,93],"dipeptide":[3],"L-carnosine":[4],"was":[5,29,34,67,86,92],"measured":[6],"in":[7,22,36,57,63,70,95],"everted":[8],"intestinal":[9],"sleeves":[10],"mice":[12,96],"whose":[13],"dietary":[14,126],"protein":[15,21],"level":[16],"or":[17,88],"else":[18],"proportion":[19],"form":[24],"free":[26,107],"amino":[27,108,129],"acids":[28,109],"varied":[30],"experimentally.":[31],"Carnosine":[32,90],"uptake":[33,54,91,122],"highest":[35],"jejunum,":[38],"regardless":[39],"ration.":[41],"Compared":[42],"with":[43],"a":[44,48,115],"low-protein":[45],"(18%)":[46],"ration,":[47],"high-protein":[49],"(72%)":[50],"ration":[51],"stimulated":[52],"carnosine":[53,84,121,142],"by":[55,125],"30-70%":[56],"duodenum":[58],"and":[59,105,132],"jejunum":[60],"(but":[61],"not":[62],"ileum).":[64],"This":[65],"stimulation":[66],"observed":[68],"even":[69],"presence":[72],"peptidase":[74],"inhibitors":[75],"that":[76],"inhibit":[77],"cell":[78],"surface":[79],"hydrolysis":[80,85],"dipeptides.":[82],"Measured":[83],"low":[87],"negligible.":[89],"same":[94],"fed":[97],"54%":[98,101,106],"unhydrolyzed":[99],"casein,":[100,104],"partly":[102],"hydrolyzed":[103],"formulated":[110],"so":[111],"as":[112],"to":[113],"stimulate":[114],"complete":[116],"hydrolysate":[117],"casein.":[119],"Thus":[120],"is":[123],"regulated":[124],"levels":[127],"acids,":[130],"peptides,":[131],"proteins,":[133],"all":[134],"which":[136],"seem":[137],"equally":[138],"effective":[139],"at":[140],"inducing":[141],"transporters.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
