{"id":"https://openalex.org/W2172407028","doi":"https://doi.org/10.1146/annurev.ge.15.120181.001043","title":"INTEGRATION AND EXCISION OF BACTERIOPHAGE \u03bb: THE MECHANISM OF CONSERVATIVE SITE SPECIFIC RECOMBINATION","display_name":"INTEGRATION AND EXCISION OF BACTERIOPHAGE \u03bb: THE MECHANISM OF CONSERVATIVE SITE SPECIFIC RECOMBINATION","publication_year":1981,"publication_date":"1981-12-01","ids":{"openalex":"https://openalex.org/W2172407028","doi":"https://doi.org/10.1146/annurev.ge.15.120181.001043","mag":"2172407028","pmid":"https://pubmed.ncbi.nlm.nih.gov/6461289"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.ge.15.120181.001043","doi":"https://doi.org/10.1146/annurev.ge.15.120181.001043","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ge.15.120181.001043","pdf_url":null,"source":{"id":"https://openalex.org/S92134727","display_name":"Annual Review of Genetics","issn_l":"0066-4197","issn":["0066-4197","1545-2948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113530452","display_name":"Howard A. Nash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard A. Nash","raw_affiliation_strings":["Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113530452"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"],"apc_list":null,"apc_paid":null,"fwci":42.5094,"has_fulltext":false,"cited_by_count":254,"citation_normalized_percentile":{"value":0.9997982,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"143","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteriophage-lambda","display_name":"bacteriophage lambda","score":0.9959999918937683},{"id":"https://openalex.org/keywords/site-specific-recombination","display_name":"site-specific recombination","score":0.8859999775886536},{"id":"https://openalex.org/keywords/integrative-recombination","display_name":"integrative recombination","score":0.8259999752044678},{"id":"https://openalex.org/keywords/int-gene","display_name":"int gene","score":0.5759999752044678},{"id":"https://openalex.org/keywords/integration-host-factor","display_name":"integration host factor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/crossover-sites","display_name":"crossover sites","score":0.6010000109672546},{"id":"https://openalex.org/keywords/strand-exchange","display_name":"strand exchange","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dna-pairing","display_name":"DNA pairing","score":0.5199999809265137},{"id":"https://openalex.org/keywords/supercoiling","display_name":"supercoiling","score":0.9570000171661377},{"id":"https://openalex.org/keywords/recombination-proteins","display_name":"recombination proteins","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.809260368347168},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.801177978515625},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.7294437289237976},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6021668910980225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.50199294090271},{"id":"https://openalex.org/C119898374","wikidata":"https://www.wikidata.org/wiki/Q7531737","display_name":"Site-specific recombination","level":5,"score":0.41668838262557983},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33288347721099854},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.17630472779273987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12179762125015259},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.07953739166259766},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07091355323791504},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001287","descriptor_name":"Attachment Sites, Microbiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003434","descriptor_name":"Crossing Over, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008242","descriptor_name":"Lysogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.ge.15.120181.001043","doi":"https://doi.org/10.1146/annurev.ge.15.120181.001043","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ge.15.120181.001043","pdf_url":null,"source":{"id":"https://openalex.org/S92134727","display_name":"Annual Review of Genetics","issn_l":"0066-4197","issn":["0066-4197","1545-2948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genetics","raw_type":"journal-article"},{"id":"pmid:6461289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6461289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W19136782","https://openalex.org/W65934054","https://openalex.org/W97205194","https://openalex.org/W1553719876","https://openalex.org/W1596440061","https://openalex.org/W1970061155","https://openalex.org/W1972424827","https://openalex.org/W1973610703","https://openalex.org/W1979973203","https://openalex.org/W1990155439","https://openalex.org/W1997807533","https://openalex.org/W2001528983","https://openalex.org/W2006683274","https://openalex.org/W2009877744","https://openalex.org/W2019807322","https://openalex.org/W2020490067","https://openalex.org/W2027154691","https://openalex.org/W2027378092","https://openalex.org/W2033114193","https://openalex.org/W2046644634","https://openalex.org/W2050300010","https://openalex.org/W2052849829","https://openalex.org/W2054290067","https://openalex.org/W2055020223","https://openalex.org/W2056649927","https://openalex.org/W2058090935","https://openalex.org/W2063954098","https://openalex.org/W2065662326","https://openalex.org/W2069109754","https://openalex.org/W2083324699","https://openalex.org/W2087370799","https://openalex.org/W2089223300","https://openalex.org/W2092249022","https://openalex.org/W2092303595","https://openalex.org/W2114624600","https://openalex.org/W2128671406","https://openalex.org/W2129131602","https://openalex.org/W2130972387","https://openalex.org/W2157045466","https://openalex.org/W2162780621","https://openalex.org/W2174616248","https://openalex.org/W2317988143","https://openalex.org/W2323717883","https://openalex.org/W2328727528","https://openalex.org/W2328729335","https://openalex.org/W2330039477","https://openalex.org/W2991697203"],"related_works":["https://openalex.org/W2089199331","https://openalex.org/W2330039477","https://openalex.org/W1596440061","https://openalex.org/W2098171983","https://openalex.org/W1540688842","https://openalex.org/W880029171","https://openalex.org/W1584436066","https://openalex.org/W2592931538","https://openalex.org/W2027154691","https://openalex.org/W7098264705"],"abstract_inverted_index":{"INTRODUCTION":[0],"143":[3],"A":[4,102],"INTEGRATIVE":[5],"RECOMBINATION":[6,119],"145":[9,14,21],"Attachment":[10],"Sites":[11],"Site":[15],"of":[16,23,74,93,112],"the":[17,24],"crossover":[18],"Size":[22],"attachment":[25],"sites":[26,30],"\u2022\u2022\u2022\u2022\u2022\u2022\u2022...\u2022....\u2022\u2022\u2022\u2022\u2022.........\u2022\u2022\u2022\u2022..\u2022....\u2022\u2022\u2022\u2022\u2022.......\u2022\u2022\u2022\u2022\u2022.\u2022.......\u2022.\u2022.........\u2022\u2022\u2022.\u2022...":[27],"146":[28],"Secondary":[29],"\u2022\u2022.\u2022\u2022\u2022.....":[31],".\u2022...\u2022.":[32],"\u2022\u2022\u2022\u2022\u2022.....\u2022.\u2022\u2022\u2022\u2022......":[33],"...\u2022.\u2022\u2022\u2022.....":[34],"\u2022\u2022...\u2022\u2022\u2022\u2022.....":[35],".\u2022.":[36,55,86],"\u2022\u2022\u2022\u2022":[37],"\u2022\u2022...\u2022...":[38],".\u2022.\u2022..\u2022\u2022..":[39],"148":[40],"Recombination":[41,133],"Proteins":[42],"and":[43,82],"Their":[44],"Genes":[45],"151":[48,59],"The":[49,110,123],"int":[50],"gene":[51],"product":[52],".\u2022\u2022\u2022\u2022\u2022\u2022\u2022\u2022\u2022...":[56],".\u2022\u2022\u2022\u2022\u2022\u2022\u2022\u2022.....\u2022\u2022\u2022\u2022\u2022\u2022":[57],"\u2022\u2022\u2022\u2022...\u2022\u2022\u2022\u2022\u2022\u2022\u2022\u2022\u2022.\u2022\u2022\u2022.\u2022\u2022\u2022\u2022\u2022\u2022...\u2022\u2022\u2022":[58],"Integration":[60],"host":[61],"factor":[62],"1'3":[65],"Stoichiometry":[66],".\u2022.....":[69],"155":[72,91],"Mechanism":[73],"Strand":[75],"Exchang":[76],"e":[77],"1":[80],"Breakage":[81],"reunion":[83],"Pairing":[92],"parental":[94],"DNA-a":[95],"model":[96],"for":[97],"recombination":[98,106],"156":[101],"propased":[103],"intermediate":[104],"in":[105],"158":[109],"role":[111],"supercoiling":[113],"159":[116,122],"LAMBDA":[117],"EXCISIVE":[118],"Xis":[124],"Gene":[125],"160":[128],"An":[129],"Hypothesis":[130],"Concerning":[131],"Excisive":[132],"161":[136],"SUMMARY":[137],"163":[140]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}