{"id":"https://openalex.org/W2172358397","doi":null,"title":"Posttranscriptional Gene Regulation: Novel Pathways for Glucocorticoids' Anti-inflammatory Action.","display_name":"Posttranscriptional Gene Regulation: Novel Pathways for Glucocorticoids' Anti-inflammatory Action.","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2172358397","mag":"2172358397","pmid":"https://pubmed.ncbi.nlm.nih.gov/23905055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3728791"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2723492","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3728791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3728791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073265989","display_name":"Cristiana Stellato","orcid":"https://orcid.org/0000-0002-1294-8355","observed_orcids":["https://orcid.org/0000-0002-1294-8355"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cristiana Stellato","raw_affiliation_strings":["Department of Medicine, University of Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073265989"],"corresponding_institution_ids":["https://openalex.org/I131729948"],"apc_list":null,"apc_paid":null,"fwci":0.3148,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.49851318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":null,"first_page":"67","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9610000252723694},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.921999990940094},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.6909999847412109},{"id":"https://openalex.org/keywords/synthetic-glucocorticoids","display_name":"synthetic glucocorticoids","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.7048635482788086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6867556571960449},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6278660893440247},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6138814091682434},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5845326781272888},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5668368339538574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5502300262451172},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47342613339424133},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45757293701171875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39864465594291687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.337324857711792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27810266613960266}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2723492","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3728791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23905055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23905055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational medicine @ UniSa","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3728791","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3728791/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Med UniSa","raw_type":"Text"},{"id":"mag:2172358397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23905055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2723492","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3728791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W27411732","https://openalex.org/W144423133","https://openalex.org/W1526700155","https://openalex.org/W1566770290","https://openalex.org/W1598071025","https://openalex.org/W1610775872","https://openalex.org/W1634810315","https://openalex.org/W1822060589","https://openalex.org/W1897688441","https://openalex.org/W1925850732","https://openalex.org/W1942562504","https://openalex.org/W1966985603","https://openalex.org/W1970491226","https://openalex.org/W1972278770","https://openalex.org/W1975767403","https://openalex.org/W1989336885","https://openalex.org/W1990985882","https://openalex.org/W1992935306","https://openalex.org/W1993296518","https://openalex.org/W1994712042","https://openalex.org/W1999716006","https://openalex.org/W2001866502","https://openalex.org/W2006473625","https://openalex.org/W2007031153","https://openalex.org/W2010931467","https://openalex.org/W2013994555","https://openalex.org/W2014209078","https://openalex.org/W2014320920","https://openalex.org/W2014869583","https://openalex.org/W2024276071","https://openalex.org/W2029140175","https://openalex.org/W2037877578","https://openalex.org/W2039656289","https://openalex.org/W2045714098","https://openalex.org/W2046864190","https://openalex.org/W2046993758","https://openalex.org/W2048178760","https://openalex.org/W2054791134","https://openalex.org/W2056364365","https://openalex.org/W2058217451","https://openalex.org/W2060369707","https://openalex.org/W2060708740","https://openalex.org/W2061202161","https://openalex.org/W2061841671","https://openalex.org/W2062465863","https://openalex.org/W2064072413","https://openalex.org/W2064492560","https://openalex.org/W2064513293","https://openalex.org/W2066281315","https://openalex.org/W2068054277","https://openalex.org/W2069066096","https://openalex.org/W2073424121","https://openalex.org/W2074915514","https://openalex.org/W2083381199","https://openalex.org/W2088290283","https://openalex.org/W2089001345","https://openalex.org/W2090703970","https://openalex.org/W2091795818","https://openalex.org/W2094057765","https://openalex.org/W2095831813","https://openalex.org/W2097617110","https://openalex.org/W2099029060","https://openalex.org/W2102791251","https://openalex.org/W2103177465","https://openalex.org/W2105450045","https://openalex.org/W2120865181","https://openalex.org/W2123592143","https://openalex.org/W2123700527","https://openalex.org/W2127264152","https://openalex.org/W2129649868","https://openalex.org/W2133269723","https://openalex.org/W2136752130","https://openalex.org/W2139437132","https://openalex.org/W2144280528","https://openalex.org/W2144737095","https://openalex.org/W2145175114","https://openalex.org/W2145619015","https://openalex.org/W2147373017","https://openalex.org/W2147397196","https://openalex.org/W2147596164","https://openalex.org/W2150691073","https://openalex.org/W2152006080","https://openalex.org/W2152087455","https://openalex.org/W2152745012","https://openalex.org/W2155905959","https://openalex.org/W2157525175","https://openalex.org/W2159379486","https://openalex.org/W2161693225","https://openalex.org/W2411000180","https://openalex.org/W2592182392","https://openalex.org/W2605977348"],"related_works":["https://openalex.org/W2299388749","https://openalex.org/W2110105375","https://openalex.org/W7098442040","https://openalex.org/W2095831813","https://openalex.org/W1634810315","https://openalex.org/W2030033188","https://openalex.org/W2120865181","https://openalex.org/W2126836839","https://openalex.org/W3024561096","https://openalex.org/W1745264954"],"abstract_inverted_index":{"Posttranscriptional":[0],"gene":[1,17,46,159],"regulation":[2],"(PTR)":[3],"is":[4,65],"a":[5,69],"fundamental":[6],"biological":[7],"process":[8],"that":[9,21,171],"integrates":[10],"with":[11],"the":[12,24,43,60,74,79,85,99,107,114,131,135,149,155,173,179,193],"master":[13],"transcriptional":[14,36],"control":[15],"of":[16,45,63,94,116,134,148,152,158,175,181,196],"expression,":[18],"in":[19,23,53,101,109,113,122,128,178],"ways":[20],"only":[22],"last":[25],"decade":[26],"have":[27],"been":[28],"increasingly":[29],"understood":[30],"[1,":[31],"2].":[32],"While":[33],"epigenetic":[34],"and":[35,71,82,103,111,118,125,164,167],"events":[37],"shape":[38],"cell":[39],"response":[40,54,76,137],"qualitatively,":[41],"deciding":[42],"pattern":[44],"expression":[47,87,115],"to":[48,55,66,84,98],"'switch":[49],"on":[50],"or":[51,57,138],"off'":[52],"endogenous":[56],"environmental":[58],"triggers,":[59],"key":[61],"task":[62],"PTR":[64],"act":[67],"as":[68,184,186,190],"'rheostat'":[70],"rapidly":[72],"adapt":[73],"cellular":[75],"by":[77],"providing":[78],"appropriate":[80],"amplitude":[81,110],"timing":[83],"protein":[86],"patterns":[88],"[3,":[89],"4].":[90],"The":[91],"pivotal":[92],"role":[93,174],"this":[95],"mechanism":[96],"comes":[97],"forefront":[100],"inflammatory":[102],"immune":[104,136],"response,":[105],"where":[106],"changes":[108],"duration":[112],"dangerous":[117],"protective":[119],"genes":[120],"are":[121,126],"delicate":[123],"balance,":[124],"critical":[127],"determining":[129],"either":[130],"successful":[132],"resolution":[133],"its":[139],"chronic":[140,182],"overexpression":[141],"[5].":[142],"This":[143],"brief":[144],"review":[145],"introduces":[146],"members":[147],"main":[150],"classes":[151],"molecules":[153,177],"mediating":[154],"cytoplasmic":[156],"arm":[157],"regulation,":[160],"namely":[161],"RNA-binding":[162],"proteins":[163],"micro-RNA":[165],"(miRNA),":[166],"summarizes":[168],"experimental":[169],"data":[170],"underscore":[172],"these":[176],"pathophysiology":[180],"inflammation,":[183],"well":[185],"their":[187],"promising":[188],"value":[189],"mechanisms":[191],"conveying":[192],"anti-inflammatory":[194],"effect":[195],"synthetic":[197],"glucocorticoids.":[198]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
