{"id":"https://openalex.org/W2172264800","doi":"https://doi.org/10.1017/s1461145710001392","title":"CREB-mediated alterations in the amygdala transcriptome: coordinated regulation of immune response genes following cocaine","display_name":"CREB-mediated alterations in the amygdala transcriptome: coordinated regulation of immune response genes following cocaine","publication_year":2010,"publication_date":"2010-12-08","ids":{"openalex":"https://openalex.org/W2172264800","doi":"https://doi.org/10.1017/s1461145710001392","mag":"2172264800","pmid":"https://pubmed.ncbi.nlm.nih.gov/21138621","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3970411"},"language":"en","primary_location":{"id":"doi:10.1017/s1461145710001392","doi":"https://doi.org/10.1017/s1461145710001392","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s1461145710001392","pdf_url":"https://academic.oup.com/ijnp/article-pdf/14/8/1111/17486915/14-8-1111.pdf","source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ijnp/article-pdf/14/8/1111/17486915/14-8-1111.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077122812","display_name":"Laurel E. Ecke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurel E. Ecke","raw_affiliation_strings":["Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028791736","display_name":"Jessica N. Cleck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica N. Cleck","raw_affiliation_strings":["Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090966761","display_name":"Peter White","orcid":"https://orcid.org/0000-0002-5218-5903","observed_orcids":["https://orcid.org/0000-0002-5218-5903"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter White","raw_affiliation_strings":["Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015126110","display_name":"Jonathan Schug","orcid":"https://orcid.org/0000-0001-6885-7869","observed_orcids":["https://orcid.org/0000-0001-6885-7869"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Schug","raw_affiliation_strings":["Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031470555","display_name":"Lauren Mifflin","orcid":"https://orcid.org/0000-0003-1607-5851","observed_orcids":["https://orcid.org/0000-0003-1607-5851"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Mifflin","raw_affiliation_strings":["Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022907334","display_name":"Julie A. Blendy","orcid":"https://orcid.org/0000-0003-1705-9001","observed_orcids":["https://orcid.org/0000-0003-1705-9001"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julie A. Blendy","raw_affiliation_strings":["Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022907334"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2042,"currency":"GBP","value_usd":2693},"apc_paid":null,"fwci":0.2581,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52748086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"8","first_page":"1111","last_page":"1126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.7799999713897705},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.8410000205039978},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.925000011920929},{"id":"https://openalex.org/keywords/immune-response-genes","display_name":"immune response genes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/stress-induced-reinstatement","display_name":"stress-induced reinstatement","score":0.8050000071525574},{"id":"https://openalex.org/keywords/drug-reward","display_name":"drug reward","score":0.38999998569488525},{"id":"https://openalex.org/keywords/extinction","display_name":"extinction","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5440000295639038},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.8857218027114868},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7243624925613403},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5273916125297546},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.521750807762146},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.5052548050880432},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4502718150615692},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44941481947898865},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.42321357131004333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4067814350128174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36006835103034973},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34618914127349854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17797502875328064},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005108","descriptor_name":"Extinction, Psychological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1017/s1461145710001392","doi":"https://doi.org/10.1017/s1461145710001392","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s1461145710001392","pdf_url":"https://academic.oup.com/ijnp/article-pdf/14/8/1111/17486915/14-8-1111.pdf","source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},{"id":"pmid:21138621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21138621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of neuropsychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2953234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3970411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3970411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3970411","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Neuropsychopharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1017/s1461145710001392","doi":"https://doi.org/10.1017/s1461145710001392","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s1461145710001392","pdf_url":"https://academic.oup.com/ijnp/article-pdf/14/8/1111/17486915/14-8-1111.pdf","source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G336117965","display_name":null,"funder_award_id":"DA011649","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3670406423","display_name":"Molecular genetic analysis of drug addiction","funder_award_id":"R01DA011649","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7728229954","display_name":"The Role of Alpha Synuclein in Cocaine Mediated Behavior","funder_award_id":"F31DA019757","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000899652","display_name":"T32 Translational Addiction Research Fellowship Program","funder_award_id":"T32DA028874","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2172264800.pdf","grobid_xml":"https://content.openalex.org/works/W2172264800.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1507259159","https://openalex.org/W1522048223","https://openalex.org/W1524081744","https://openalex.org/W1532530881","https://openalex.org/W1754082247","https://openalex.org/W1962727914","https://openalex.org/W1962839343","https://openalex.org/W1964374986","https://openalex.org/W1980225069","https://openalex.org/W1983271020","https://openalex.org/W1984184799","https://openalex.org/W1997248080","https://openalex.org/W1998674360","https://openalex.org/W2001074622","https://openalex.org/W2001413268","https://openalex.org/W2010158373","https://openalex.org/W2010455608","https://openalex.org/W2018128016","https://openalex.org/W2020401730","https://openalex.org/W2022391976","https://openalex.org/W2032463884","https://openalex.org/W2044823814","https://openalex.org/W2047660522","https://openalex.org/W2054838803","https://openalex.org/W2058147277","https://openalex.org/W2061418383","https://openalex.org/W2067098171","https://openalex.org/W2074604677","https://openalex.org/W2074953876","https://openalex.org/W2081098333","https://openalex.org/W2082235403","https://openalex.org/W2082868130","https://openalex.org/W2083356913","https://openalex.org/W2083466345","https://openalex.org/W2084931825","https://openalex.org/W2088597001","https://openalex.org/W2094014555","https://openalex.org/W2097740790","https://openalex.org/W2097852397","https://openalex.org/W2106726734","https://openalex.org/W2109918049","https://openalex.org/W2120865735","https://openalex.org/W2122683221","https://openalex.org/W2127938920","https://openalex.org/W2133559478","https://openalex.org/W2133707124","https://openalex.org/W2136511531","https://openalex.org/W2139786039","https://openalex.org/W2141546803","https://openalex.org/W2143241514","https://openalex.org/W2147352089","https://openalex.org/W2147773916","https://openalex.org/W2148186685","https://openalex.org/W2150652550","https://openalex.org/W2152390421","https://openalex.org/W2154850432","https://openalex.org/W2157744411","https://openalex.org/W2163383667","https://openalex.org/W2165220936","https://openalex.org/W2166329962","https://openalex.org/W2167299800","https://openalex.org/W4406058881"],"related_works":["https://openalex.org/W2001074622","https://openalex.org/W63915100","https://openalex.org/W7095703764","https://openalex.org/W1970878746","https://openalex.org/W2065095391","https://openalex.org/W42951332","https://openalex.org/W1928329059","https://openalex.org/W4411160625","https://openalex.org/W2215472916","https://openalex.org/W4417498471"],"abstract_inverted_index":{"The":[0,32],"neuronal":[1],"circuitry":[2],"underlying":[3],"stress-":[4,43],"and":[5,71,101,140,189,193],"drug-induced":[6],"reinstatement":[7,47],"of":[8,48,61,98,125,135,163,167,173,178,201],"cocaine-seeking":[9],"has":[10],"been":[11],"relatively":[12],"well":[13],"characterized;":[14],"however,":[15],"less":[16],"is":[17,40],"known":[18],"regarding":[19],"the":[20,65,75,85,96,108,129,159,171,179,186,199],"long-term":[21,152,180],"molecular":[22,54,181],"changes":[23,182],"following":[24,95],"cocaine":[25,99,120,149],"administration":[26],"that":[27,52,107,148,183,195],"may":[28,56],"promote":[29],"future":[30],"reinstatement.":[31,62],"transcription":[33,69],"factor":[34,70],"cAMP":[35],"response":[36,142],"element-binding":[37],"protein":[38],"(CREB)":[39],"necessary":[41],"for":[42],"but":[44],"not":[45],"cocaine-induced":[46],"conditioned":[49],"reward,":[50],"suggesting":[51],"different":[53,151],"mechanisms":[55],"underlie":[57],"these":[58],"two":[59],"types":[60],"To":[63],"explore":[64],"relationship":[66],"between":[67],"this":[68],"reinstatement,":[72,94],"we":[73],"utilized":[74],"place-conditioning":[76],"paradigm":[77],"to":[78,198],"examine":[79],"alterations":[80,153],"in":[81,84,92,128,138,154,170],"gene":[82,155,168],"expression":[83,156,169],"amygdala,":[86],"a":[87,133,144],"neural":[88],"substrate":[89],"critically":[90],"involved":[91,127,137],"stress-induced":[93],"development":[97],"reward":[100],"subsequent":[102],"extinction.":[103],"Our":[104],"findings":[105],"demonstrate":[106],"amygdala":[109],"transcriptome":[110],"was":[111],"altered":[112],"by":[113,118],"CREB":[114],"deficiency":[115],"more":[116],"than":[117],"previous":[119],"experience,":[121],"with":[122],"an":[123],"over-representation":[124],"genes":[126,136,192],"immune":[130,141],"response.":[131],"However,":[132],"subset":[134],"stress":[139],"demonstrated":[143],"drug\u00d7genotype":[145],"interaction,":[146],"indicating":[147],"produces":[150],"depending":[157],"on":[158],"presence":[160],"or":[161],"absence":[162],"CREB.":[164],"This":[165],"profile":[166],"context":[172],"addiction":[174,187],"enhances":[175],"our":[176],"understanding":[177],"occur":[184],"throughout":[185],"cycle":[188],"identifies":[190],"novel":[191],"pathways":[194],"might":[196],"lead":[197],"creation":[200],"better":[202],"therapeutic":[203],"agents.":[204]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}