{"id":"https://openalex.org/W2172257728","doi":"https://doi.org/10.1164/ajrccm.160.4.9808118","title":"Bronchopulmonary Segmental Lavage with Surfaxin (KL4-Surfactant) for Acute Respiratory Distress Syndrome","display_name":"Bronchopulmonary Segmental Lavage with Surfaxin (KL4-Surfactant) for Acute Respiratory Distress Syndrome","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2172257728","doi":"https://doi.org/10.1164/ajrccm.160.4.9808118","mag":"2172257728","pmid":"https://pubmed.ncbi.nlm.nih.gov/10508806"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.160.4.9808118","doi":"https://doi.org/10.1164/ajrccm.160.4.9808118","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.160.4.9808118","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038467578","display_name":"Thomas E. Wiswell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"THOMAS E. WISWELL","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103528648","display_name":"Robert M. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT M. SMITH","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111994964","display_name":"L Katz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LAURENCE B. KATZ","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017069466","display_name":"Lisa Mastroianni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LISA MASTROIANNI","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086834016","display_name":"DAVIES Y. WONG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVIES Y. WONG","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063007897","display_name":"David C. Willms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID WILLMS","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110001336","display_name":"Stephen O. Heard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEPHEN HEARD","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"MARK WILSON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARK WILSON","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050831518","display_name":"Robert Duncan Hite","orcid":"https://orcid.org/0000-0002-2625-8750","observed_orcids":["https://orcid.org/0000-0002-2625-8750"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. DUNCAN HITE","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108076104","display_name":"Antonio Anzueto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANTONIO ANZUETO","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019286494","display_name":"Susan D. Revak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SUSAN D. REVAK","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111823341","display_name":"Charles G. Cochrane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I1334972020","display_name":"Sharp Memorial Hospital","ror":"https://ror.org/01gynte55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334972020","https://openalex.org/I4405280159"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHARLES G. COCHRANE","raw_affiliation_strings":["Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Division of Pulmonary Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Discovery Laboratories, Doylestown, Pennsylvania; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California; Division of Pulmonology, Sharp Memorial Hospital, San Diego, California; Department of Anesthesiology and the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts; Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston-Salem, North","institution_ids":["https://openalex.org/I1334972020","https://openalex.org/I166722992","https://openalex.org/I36258959","https://openalex.org/I4210162397","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8951,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.96312235,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"160","issue":"4","first_page":"1188","last_page":"1195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.968999981880188},{"id":"https://openalex.org/keywords/synthetic-surfactants","display_name":"synthetic surfactants","score":0.7620000243186951},{"id":"https://openalex.org/keywords/surfactin","display_name":"surfactin","score":0.6159999966621399},{"id":"https://openalex.org/keywords/bronchoscopic-lavage","display_name":"bronchoscopic lavage","score":0.7580000162124634},{"id":"https://openalex.org/keywords/surfactant-replacement-therapy","display_name":"surfactant therapy","score":0.5600000023841858},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7620000243186951},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.4860000014305115},{"id":"https://openalex.org/keywords/positive-end-expiratory-pressure","display_name":"positive end-expiratory pressure","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.934219479560852},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.7956531047821045},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.74262535572052},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.7258765697479248},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.5723252892494202},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5503189563751221},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5006380081176758},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3967011570930481},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.35309094190597534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.277160108089447},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018893","descriptor_name":"Bronchoalveolar Lavage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm.160.4.9808118","doi":"https://doi.org/10.1164/ajrccm.160.4.9808118","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.160.4.9808118","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:10508806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10508806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1898899939","https://openalex.org/W1971305507","https://openalex.org/W1974210742","https://openalex.org/W1984192680","https://openalex.org/W1996845136","https://openalex.org/W1998227969","https://openalex.org/W2002354843","https://openalex.org/W2004194649","https://openalex.org/W2007603804","https://openalex.org/W2009822304","https://openalex.org/W2010753913","https://openalex.org/W2040297517","https://openalex.org/W2040427593","https://openalex.org/W2057559930","https://openalex.org/W2059570229","https://openalex.org/W2067506567","https://openalex.org/W2069394636","https://openalex.org/W2079104130","https://openalex.org/W2083209568","https://openalex.org/W2099253666","https://openalex.org/W2130703491","https://openalex.org/W2141491150","https://openalex.org/W2167570039","https://openalex.org/W2173543268","https://openalex.org/W2319595345","https://openalex.org/W2333620606","https://openalex.org/W2334530874","https://openalex.org/W2428017246","https://openalex.org/W2528498646","https://openalex.org/W4230861726"],"related_works":["https://openalex.org/W2386149924","https://openalex.org/W2067506567","https://openalex.org/W2093526620","https://openalex.org/W1500506007","https://openalex.org/W2380236684","https://openalex.org/W1945985830","https://openalex.org/W1971305507","https://openalex.org/W2350025081","https://openalex.org/W2029606525","https://openalex.org/W2128299030"],"abstract_inverted_index":{"We":[0],"performed":[1,53],"a":[2,16,41,72,82,87,106,192],"trial":[3],"to":[4,44,122,137,153,171,178,197],"assess":[5],"the":[6,47,101,110,144,155,158,161,185],"safety":[7],"and":[8,130,173,194],"tolerability":[9],"of":[10,29,36,46,58,71,75,100,184],"sequential":[11],"bronchopulmonary":[12,49],"segmental":[13,229],"lavage":[14,108,230],"with":[15,24,86,109,187,202,231],"dilute":[17,188],"synthetic":[18],"surfactant":[19],"(Surfaxin)":[20],"in":[21,33,77,127,200],"12":[22],"adults":[23],"ARDS.":[25,203],"Patients":[26],"received":[27,67,96,119,124],"one":[28,68],"three":[30],"dosing":[31,135],"regimens":[32],"which":[34],"aliquots":[35,99],"Surfaxin":[37,76,189,232],"were":[38,131,147],"administered":[39],"via":[40],"wedged":[42],"bronchoscope":[43],"each":[45,78],"19":[48],"segments.":[50],"Suctioning":[51],"was":[52],"10-30":[54],"s":[55],"after":[56,164],"instillation":[57],"individual":[59],"aliquots.":[60],"Group":[61,90,113,128],"1":[62],"patients":[63,92,115,126,142,201],"(n":[64,93,116],"=":[65,94,117],"3)":[66],"30-ml":[69,84,98],"aliquot":[70,85],"2.5-mg/ml":[73,102],"concentration":[74,103],"segment,":[79],"followed":[80,104],"by":[81,105,125],"second":[83],"10-mg/ml":[88,111],"concentration.":[89,112],"2":[91,129],"4)":[95],"two":[97],"third":[107],"3":[114],"5)":[118],"therapy":[120],"identical":[121],"that":[123],"eligible":[132],"for":[133,234],"repeat":[134],"6":[136],"24":[138],"h":[139,163],"later.":[140],"All":[141],"tolerated":[143],"procedure.":[145],"There":[146],"no":[148],"serious":[149],"adverse":[150],"experiences":[151],"ascribed":[152],"either":[154],"procedure":[156],"or":[157],"surfactant.":[159],"In":[160],"96":[162],"treatment":[165],"initiation,":[166],"FI(O(2))":[167],"decreased":[168,175],"from":[169,176],"0.80":[170],"0.52":[172],"PEEP":[174],"10.3":[177],"7.6":[179],"cm":[180],"H(2)O.":[181],"Bronchoscopic":[182],"\"cleansing\"":[183],"lungs":[186],"may":[190],"offer":[191],"safe":[193],"feasible":[195],"approach":[196],"improving":[198],"outcomes":[199],"Wiswell":[204],"TE,":[205],"Smith":[206],"RM,":[207],"Katz":[208],"LB,":[209],"Mastroianni":[210],"L,":[211],"Wong":[212],"DY,":[213],"Willms":[214],"D,":[215],"Heard":[216],"S,":[217],"Wilson":[218],"M,":[219],"Hite":[220],"RD,":[221],"Anzueto":[222],"A,":[223],"Revak":[224],"SD,":[225],"Cochrane":[226],"CG.":[227],"Bronchopulmonary":[228],"(KL(4)-surfactant)":[233],"acute":[235],"respiratory":[236],"distress":[237],"syndrome.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}