{"id":"https://openalex.org/W2172242829","doi":"https://doi.org/10.1039/c0sm00712a","title":"Structure\u2013activity relationships of Candida rugosa lipase immobilized on polylactic acid nanoparticles","display_name":"Structure\u2013activity relationships of Candida rugosa lipase immobilized on polylactic acid nanoparticles","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2172242829","doi":"https://doi.org/10.1039/c0sm00712a","mag":"2172242829"},"language":"en","primary_location":{"id":"doi:10.1039/c0sm00712a","doi":"https://doi.org/10.1039/c0sm00712a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c0sm00712a","pdf_url":null,"source":{"id":"https://openalex.org/S6377669","display_name":"Soft Matter","issn_l":"1744-683X","issn":["1744-683X","1744-6848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Soft Matter","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054010218","display_name":"Laura Chronopoulou","orcid":"https://orcid.org/0000-0002-2178-9608","observed_orcids":["https://orcid.org/0000-0002-2178-9608"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Chronopoulou","raw_affiliation_strings":["Department of Chemistry, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076010644","display_name":"Gihan Salah Kamel","orcid":"https://orcid.org/0000-0003-0854-1920","observed_orcids":["https://orcid.org/0000-0003-0854-1920"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gihan Kamel","raw_affiliation_strings":["Department of Physics, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068762871","display_name":"Carolina Sparago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carolina Sparago","raw_affiliation_strings":["Department of Chemistry, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080543721","display_name":"F. Bordi","orcid":"https://orcid.org/0000-0001-6373-5176","observed_orcids":["https://orcid.org/0000-0001-6373-5176"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federico Bordi","raw_affiliation_strings":["Department of Physics, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000052813","display_name":"S. Lupi","orcid":"https://orcid.org/0000-0001-7002-337X","observed_orcids":["https://orcid.org/0000-0001-7002-337X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Lupi","raw_affiliation_strings":["Department of Physics, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068971253","display_name":"Marco Diociaiuti","orcid":"https://orcid.org/0000-0002-0749-2824","observed_orcids":["https://orcid.org/0000-0002-0749-2824"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Diociaiuti","raw_affiliation_strings":["Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanit\u00e0, viale Regina Elena 299, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanit\u00e0, viale Regina Elena 299, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057831201","display_name":"Cleofe Palocci","orcid":"https://orcid.org/0000-0001-5583-8941","observed_orcids":["https://orcid.org/0000-0001-5583-8941"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cleofe Palocci","raw_affiliation_strings":["Department of Chemistry, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Sapienza Universit\u00e0 of Rome, Piazzale Aldo Moro 5, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057831201"],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":1.3687,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.78540593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"2653","last_page":"2653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-rugosa-lipase","display_name":"Candida rugosa lipase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/enzyme-immobilization","display_name":"enzyme immobilization","score":0.8949999809265137},{"id":"https://openalex.org/keywords/poly-lactic-acid-nanoparticles","display_name":"polylactic acid nanoparticles","score":0.9309999942779541},{"id":"https://openalex.org/keywords/poly-d-l-lactide","display_name":"poly(D,L-lactide)","score":0.8230000138282776},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8299999833106995},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/enzymatic-stability","display_name":"enzymatic stability","score":0.6299999952316284},{"id":"https://openalex.org/keywords/physisorption","display_name":"physisorption","score":0.7400000095367432},{"id":"https://openalex.org/keywords/bioconjugates","display_name":"bioconjugates","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ftir-spectroscopy","display_name":"FTIR spectroscopy","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2991821551","wikidata":"https://www.wikidata.org/wiki/Q131260","display_name":"Candida rugosa","level":4,"score":0.8557020425796509},{"id":"https://openalex.org/C2781162966","wikidata":"https://www.wikidata.org/wiki/Q413769","display_name":"Polylactic acid","level":3,"score":0.7927461266517639},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.7786113023757935},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.7529962062835693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5760361552238464},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.5671480298042297},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5433692336082458},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.5256263613700867},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4006859362125397},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.3058854341506958},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.28023189306259155},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2794148921966553},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20051121711730957},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1039/c0sm00712a","doi":"https://doi.org/10.1039/c0sm00712a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c0sm00712a","pdf_url":null,"source":{"id":"https://openalex.org/S6377669","display_name":"Soft Matter","issn_l":"1744-683X","issn":["1744-683X","1744-6848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Soft Matter","raw_type":"journal-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/384779","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000288162500053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1556135072","https://openalex.org/W1781120710","https://openalex.org/W1966034856","https://openalex.org/W1979879859","https://openalex.org/W1984156263","https://openalex.org/W1988680128","https://openalex.org/W1988728868","https://openalex.org/W2001264570","https://openalex.org/W2007002347","https://openalex.org/W2009084300","https://openalex.org/W2009560698","https://openalex.org/W2021993870","https://openalex.org/W2024492503","https://openalex.org/W2032847856","https://openalex.org/W2033989837","https://openalex.org/W2034091369","https://openalex.org/W2034827408","https://openalex.org/W2034959585","https://openalex.org/W2035278817","https://openalex.org/W2049847993","https://openalex.org/W2053325179","https://openalex.org/W2060240514","https://openalex.org/W2070645646","https://openalex.org/W2076166680","https://openalex.org/W2077406961","https://openalex.org/W2080852098","https://openalex.org/W2082396982","https://openalex.org/W2092584741","https://openalex.org/W2102264945","https://openalex.org/W2120549005","https://openalex.org/W2121459092","https://openalex.org/W2128635872","https://openalex.org/W2159426997","https://openalex.org/W2167862119","https://openalex.org/W2169147830"],"related_works":["https://openalex.org/W7006172904","https://openalex.org/W6990869898","https://openalex.org/W2092584741","https://openalex.org/W3174744169","https://openalex.org/W4285730682","https://openalex.org/W1978014231","https://openalex.org/W2043985842","https://openalex.org/W1982508953","https://openalex.org/W6949895769","https://openalex.org/W4385856784"],"abstract_inverted_index":{"Interfacing":[0],"proteins":[1],"with":[2,47,100],"nanostructured":[3,21],"materials":[4],"offers":[5],"the":[6,18,60,78,91,101,121,131,135],"possibility":[7],"to":[8,27,43,77],"obtain":[9,44],"novel":[10],"bioconjugates":[11],"for":[12,59],"many":[13],"applications.":[14],"We":[15],"report":[16],"herein":[17],"ability":[19],"of":[20,51,63,71,94,134],"poly-DL-lactic":[22],"acid":[23],"(PDLLA)":[24],"based":[25],"carriers":[26],"enhance":[28],"enzymatic":[29],"activity":[30,68],"and":[31,69,74,90,123],"stability.":[32],"PDLLA":[33],"was":[34],"processed":[35],"using":[36,107],"an":[37,48],"innovative":[38],"patented":[39],"methodology":[40],"that":[41,54],"permitted":[42],"spherical":[45],"nanoparticles":[46],"average":[49],"diameter":[50],"220":[52],"nm":[53],"were":[55,81,104],"used":[56],"as":[57],"carrier":[58,103],"physical":[61],"adsorption":[62],"Candida":[64],"rugosalipase":[65],"(CRL).":[66],"Enzymatic":[67],"stability":[70],"CRL":[72,95],"before":[73],"after":[75],"conjugation":[76],"nanopolymeric":[79,102],"support":[80],"evaluated":[82],"in":[83,120],"different":[84],"conditions":[85],"(pH,":[86],"T,":[87],"organic":[88],"solvents)":[89],"conformational":[92,132],"changes":[93],"produced":[96],"by":[97,106],"its":[98],"interaction":[99],"investigated":[105],"Fourier":[108],"Transform":[109],"Infrared":[110],"(FTIR)":[111],"spectroscopy.":[112],"A":[113],"comparative":[114],"study":[115],"between":[116],"X-ray":[117],"diffraction":[118],"data":[119],"literature":[122],"experimental":[124],"FTIR":[125],"results":[126],"gave":[127],"deeper":[128],"insight":[129],"into":[130],"features":[133],"immobilized":[136],"protein.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
