{"id":"https://openalex.org/W2172196612","doi":"https://doi.org/10.1111/trf.13073","title":"Dual roles of autologous CD8+ T cells in hematopoietic progenitor cell mobilization and engraftment","display_name":"Dual roles of autologous CD8+ T cells in hematopoietic progenitor cell mobilization and engraftment","publication_year":2015,"publication_date":"2015-03-11","ids":{"openalex":"https://openalex.org/W2172196612","doi":"https://doi.org/10.1111/trf.13073","mag":"2172196612","pmid":"https://pubmed.ncbi.nlm.nih.gov/25757596"},"language":"en","primary_location":{"id":"doi:10.1111/trf.13073","doi":"https://doi.org/10.1111/trf.13073","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.13073","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052133479","display_name":"Athena L. Russell","orcid":"https://orcid.org/0000-0001-5478-921X","observed_orcids":["https://orcid.org/0000-0001-5478-921X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Athena Russell","raw_affiliation_strings":["Transfusion Medicine, Department of Pathology, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transfusion Medicine, Department of Pathology, Jacksonville, Florida","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sunita Malik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunita Malik","raw_affiliation_strings":["Transfusion Medicine, Department of Pathology, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transfusion Medicine, Department of Pathology, Jacksonville, Florida","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Litzow","raw_affiliation_strings":["Division of Hematology/Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090561132","display_name":"Dennis A. Gastineau","orcid":"https://orcid.org/0000-0003-2250-9812","observed_orcids":["https://orcid.org/0000-0003-2250-9812"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Gastineau","raw_affiliation_strings":["Division of Hematology/Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091287816","display_name":"Vivek Roy","orcid":"https://orcid.org/0000-0002-5950-4620","observed_orcids":["https://orcid.org/0000-0002-5950-4620"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Roy","raw_affiliation_strings":["Division of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038707560","display_name":"Abba Chedi Zubair","orcid":"https://orcid.org/0000-0003-4827-4740","observed_orcids":["https://orcid.org/0000-0003-4827-4740"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Abba C. Zubair","raw_affiliation_strings":["Transfusion Medicine, Department of Pathology, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transfusion Medicine, Department of Pathology, Jacksonville, Florida","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038707560"],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":0.9273,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.77768901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"55","issue":"7","first_page":"1758","last_page":"1765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cell-mobilization","display_name":"hematopoietic progenitor cell mobilization","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/stromal-cell-derived-factor-1alpha","display_name":"stromal cell-derived factor-1\u03b1","score":0.7649999856948853},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.6520000100135803},{"id":"https://openalex.org/keywords/neutrophil-engraftment","display_name":"neutrophil engraftment","score":0.8619999885559082},{"id":"https://openalex.org/keywords/apheresis-products","display_name":"apheresis products","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.7199259996414185},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6349180936813354},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6238977313041687},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.600292444229126},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.5992559194564819},{"id":"https://openalex.org/C156708679","wikidata":"https://www.wikidata.org/wiki/Q242412","display_name":"Mobilization","level":2,"score":0.5364504456520081},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4605488181114197},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45441731810569763},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4443252980709076},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4158977270126343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3700704574584961},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36903345584869385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34538382291793823},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24607250094413757},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18621385097503662},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0728321373462677},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007937","descriptor_name":"Leukapheresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019650","descriptor_name":"Hematopoietic Stem Cell Mobilization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064592","descriptor_name":"Autografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/trf.13073","doi":"https://doi.org/10.1111/trf.13073","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.13073","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:25757596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25757596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G905846997","display_name":"Characterization of Hematopoietic Stem Cells","funder_award_id":"K23CA102824","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W20228888","https://openalex.org/W154306038","https://openalex.org/W341107009","https://openalex.org/W1532162953","https://openalex.org/W1599081529","https://openalex.org/W1967616608","https://openalex.org/W1970529772","https://openalex.org/W1973861598","https://openalex.org/W1986487511","https://openalex.org/W1987516811","https://openalex.org/W2019046456","https://openalex.org/W2022395885","https://openalex.org/W2024835620","https://openalex.org/W2059470850","https://openalex.org/W2066128121","https://openalex.org/W2083192684","https://openalex.org/W2084292553","https://openalex.org/W2098658264","https://openalex.org/W2114805956","https://openalex.org/W2119865307","https://openalex.org/W2127322547","https://openalex.org/W2172394462","https://openalex.org/W2301552594","https://openalex.org/W2342993619","https://openalex.org/W2402288757"],"related_works":["https://openalex.org/W2550888274","https://openalex.org/W3045927516","https://openalex.org/W3043057247","https://openalex.org/W4401276265","https://openalex.org/W4390933067","https://openalex.org/W1484619047","https://openalex.org/W2129680615","https://openalex.org/W2462846989","https://openalex.org/W2056550360","https://openalex.org/W1983002658"],"abstract_inverted_index":{"BACKGROUND:":[0],"Poor":[1],"marrow":[2],"cellularity":[3],"alone":[4],"cannot":[5],"explain":[6],"poor":[7],"hematopoietic":[8],"progenitor":[9],"cell":[10,24,117],"(HPC)":[11],"mobilization.":[12],"This":[13],"study":[14],"assessed":[15,36,58,87],"the":[16,59,168,170,178,180],"role":[17],"of":[18,61,101,152,160,182],"CD8+":[19,45,64,88,137,153,171,188],"T":[20,65,138,154,189],"cells":[21,66,139,155,190],"in":[22,37,48],"HPC":[23,40,73,130,141,157,192],"mobilization":[25,158,193],"and":[26,33,44,69,124,145,194,197],"engraftment.":[27,96,183,198],"STUDY":[28],"DESIGN":[29],"AND":[30],"METHODS:":[31],"Mobilization":[32],"engraftment":[34,164],"were":[35,51,110],"192":[38],"autologous":[39,63],"donors.":[41],"CD34+,":[42],"CD4+,":[43],"T-cell":[46,89,172],"contents":[47],"apheresis":[49],"products":[50,131,142],"evaluated.":[52],"Using":[53],"a":[54],"chemotaxis":[55],"assay,":[56],"we":[57],"effect":[60],"purified":[62],"from":[67,75,132,143],"low":[68,78,133],"high":[70,76,125,146],"mobilizers":[71,134],"on":[72],"migration":[74],"to":[77,94,113],"stromal":[79],"cell-derived":[80],"factor":[81],"(SDF-1\u03b1)":[82],"concentration":[83],"gradients.":[84],"We":[85,127],"also":[86],"content":[90,173],"association":[91],"with":[92],"days":[93],"neutrophil":[95],"RESULTS:":[97],"The":[98],"median":[99],"number":[100],"CD34+":[102,116,176],"cells/kg":[103],"was":[104],"4.7":[105],"\u00d7":[106],"10(6)":[107],".":[108],"Patients":[109],"categorized":[111],"according":[112],"their":[114],"total":[115],"collection":[118],"quartile":[119],"distribution":[120],"into":[121],"low,":[122],"moderate,":[123],"mobilizers.":[126,147],"found":[128],"that":[129,167],"contained":[135],"more":[136],"than":[140],"moderate":[144],"Chemotaxis":[148],"assays":[149],"showed":[150,166],"depletion":[151],"enhances":[156],"independent":[159],"SDF-1\u03b1":[161],"concentration.":[162],"Neutrophil":[163],"analysis":[165],"higher":[169],"per":[174],"unit":[175],"cell,":[177],"faster":[179],"rate":[181],"CONCLUSION:":[184],"Our":[185],"findings":[186],"suggest":[187],"inhibit":[191],"facilitate":[195],"homing":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
