{"id":"https://openalex.org/W2172184041","doi":"https://doi.org/10.1086/383417","title":"Refinement of a Therapeutic Shiga Toxin\u2013Binding Probiotic for Human Trials","display_name":"Refinement of a Therapeutic Shiga Toxin\u2013Binding Probiotic for Human Trials","publication_year":2004,"publication_date":"2004-04-21","ids":{"openalex":"https://openalex.org/W2172184041","doi":"https://doi.org/10.1086/383417","mag":"2172184041","pmid":"https://pubmed.ncbi.nlm.nih.gov/15116289"},"language":"en","primary_location":{"id":"doi:10.1086/383417","doi":"https://doi.org/10.1086/383417","is_oa":false,"landing_page_url":"https://doi.org/10.1086/383417","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046086021","display_name":"Rebecca A. Pinyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rebecca\u00a0A. Pinyon","raw_affiliation_strings":["School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055597053","display_name":"James C. Paton","orcid":"https://orcid.org/0000-0001-9807-5278","observed_orcids":["https://orcid.org/0000-0001-9807-5278"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James\u00a0C. Paton","raw_affiliation_strings":["School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038494526","display_name":"Adrienne W. Paton","orcid":"https://orcid.org/0000-0002-2996-5733","observed_orcids":["https://orcid.org/0000-0002-2996-5733"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adrienne\u00a0W. Paton","raw_affiliation_strings":["School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020668170","display_name":"James A. Botten","orcid":"https://orcid.org/0009-0003-5123-5133","observed_orcids":["https://orcid.org/0009-0003-5123-5133"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James\u00a0A. Botten","raw_affiliation_strings":["School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023033615","display_name":"Renato Morona","orcid":"https://orcid.org/0000-0001-7009-7440","observed_orcids":["https://orcid.org/0000-0001-7009-7440"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Renato Morona","raw_affiliation_strings":["School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5681781"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":1.8615,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.82964286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"189","issue":"9","first_page":"1547","last_page":"1555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shiga-toxin","display_name":"Shiga toxin","score":0.7670000195503235},{"id":"https://openalex.org/keywords/shiga-toxin-receptor","display_name":"Shiga toxin receptor","score":0.7789999842643738},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.5490000247955322},{"id":"https://openalex.org/keywords/escherichia-coli-k-12","display_name":"Escherichia coli K-12","score":0.7960000038146973},{"id":"https://openalex.org/keywords/toxin-neutralization","display_name":"toxin neutralization","score":0.5820000171661377},{"id":"https://openalex.org/keywords/shiga-toxin-producing-escherichia-coli","display_name":"Shiga toxin-producing Escherichia coli","score":0.8700000047683716},{"id":"https://openalex.org/keywords/plasmid-construction","display_name":"plasmid construction","score":0.5339999794960022},{"id":"https://openalex.org/keywords/preclinical-drug-development","display_name":"preclinical drug development","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.73683100938797},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6954429149627686},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6318145990371704},{"id":"https://openalex.org/C2780920689","wikidata":"https://www.wikidata.org/wiki/Q27094615","display_name":"Kanamycin","level":3,"score":0.6092008948326111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5954295992851257},{"id":"https://openalex.org/C2778411228","wikidata":"https://www.wikidata.org/wiki/Q424753","display_name":"Shiga toxin","level":4,"score":0.43568745255470276},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.432415634393692},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3872607350349426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3478953242301941},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.18959829211235046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10129794478416443}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005700","descriptor_name":"Galactosyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005700","descriptor_name":"Galactosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014281","descriptor_name":"Trihexosylceramides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D022622","descriptor_name":"Shiga Toxin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022641","descriptor_name":"Shiga Toxin 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1086/383417","doi":"https://doi.org/10.1086/383417","is_oa":false,"landing_page_url":"https://doi.org/10.1086/383417","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:15116289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15116289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/3052","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/3052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1086/383417","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1518827890","https://openalex.org/W1905377073","https://openalex.org/W1935102007","https://openalex.org/W1974759126","https://openalex.org/W1976713659","https://openalex.org/W1985027846","https://openalex.org/W1985604744","https://openalex.org/W1985782125","https://openalex.org/W1999650545","https://openalex.org/W1999721665","https://openalex.org/W2001512581","https://openalex.org/W2033626553","https://openalex.org/W2041053334","https://openalex.org/W2079098672","https://openalex.org/W2079179705","https://openalex.org/W2079524849","https://openalex.org/W2089242118","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2103798600","https://openalex.org/W2110704759","https://openalex.org/W2112111992","https://openalex.org/W2113987232","https://openalex.org/W2115177266","https://openalex.org/W2123554027","https://openalex.org/W2128178006","https://openalex.org/W2137994690","https://openalex.org/W2138088531","https://openalex.org/W2144634347","https://openalex.org/W2145458242","https://openalex.org/W2156080241","https://openalex.org/W2158301958"],"related_works":["https://openalex.org/W2059964548","https://openalex.org/W1518827890","https://openalex.org/W2163432797","https://openalex.org/W2113987232","https://openalex.org/W2158301958","https://openalex.org/W2508362523","https://openalex.org/W2034554459","https://openalex.org/W2090743519","https://openalex.org/W1982072530","https://openalex.org/W2352487608"],"abstract_inverted_index":{"We":[0,91,124],"have":[1,45,92],"previously":[2],"constructed":[3],"a":[4,8,36,81,88,95,100,177],"recombinant":[5],"bacterium":[6],"expressing":[7],"modified":[9,178],"lipopolysaccharide":[10],"(LPS)":[11],"mimicking":[12],"the":[13,61,67,76,85,117,127,174,202],"Shiga":[14,54],"toxin":[15,19],"receptor,":[16],"which":[17],"binds":[18],"with":[20,107,148,188],"high":[21],"avidity.":[22],"This":[23],"involved":[24],"cloning":[25],"Neisseria":[26,152],"galactosyl":[27],"transferase":[28],"genes":[29],"(lgtC":[30],"and":[31,84,111,145,160,173,180,183],"lgtE)":[32],"in":[33,35,109],"pK184":[34,144],"derivative":[37,106],"of":[38,50,193,201],"Escherichia":[39],"coli":[40,57,63,103],"R1":[41],"(CWG308).":[42],"Such":[43],"constructs":[44],"considerable":[46],"potential":[47],"for":[48,72],"prevention":[49],"disease":[51],"caused":[52],"by":[53,198],"toxin-producing":[55],"E.":[56,62,102],"(STEC).":[58],"However,":[59],"neither":[60],"host":[64],"strain":[65],"nor":[66],"expression":[68],"plasmid":[69,159,169],"is":[70,78],"suitable":[71],"human":[73,98],"use,":[74],"because":[75],"former":[77],"derived":[79],"from":[80,130,143],"clinical":[82],"isolate":[83],"latter":[86],"contains":[87],"kanamycin-resistance":[89,138],"gene.":[90],"constructed,":[93],"as":[94,122],"prelude":[96],"to":[97],"trials,":[99],"nonpathogenic":[101],"K-12":[104],"C600":[105,163],"deletions":[108],"waaO":[110],"waaB,":[112],"such":[113],"that":[114],"it":[115,134],"has":[116],"same":[118],"LPS":[119,179],"core":[120],"structure":[121],"CWG308.":[123],"also":[125,141],"deleted":[126,142],"thyA":[128],"gene":[129,139],"this":[131,158],"strain,":[132],"rendering":[133],"thymine":[135],"dependent.":[136],"The":[137,168],"was":[140,146,154,170],"replaced":[147],"Salmonella":[149],"typhimurium":[150],"thyA.":[151,167],"lgtCE":[153],"then":[155],"cloned":[156],"into":[157,162],"transformed":[161],"Delta":[164,166],"waaOB":[165],"stably":[171],"maintained,":[172],"construct":[175],"produced":[176],"neutralized":[181],"Stx1":[182],"Stx2c.":[184],"Moreover,":[185],"mice":[186],"challenged":[187],"an":[189],"otherwise":[190],"fatal":[191],"dose":[192],"STEC":[194],"were":[195],"completely":[196],"protected":[197],"oral":[199],"administration":[200],"novel":[203],"construct.":[204]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
