{"id":"https://openalex.org/W2172098526","doi":null,"title":"A meta-analysis review of the effects of recombinant bovine somatotropin. 2. Effects on animal health, reproductive performance, and culling.","display_name":"A meta-analysis review of the effects of recombinant bovine somatotropin. 2. Effects on animal health, reproductive performance, and culling.","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2172098526","mag":"2172098526","pmid":"https://pubmed.ncbi.nlm.nih.gov/14620861","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/280709"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:101550","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC280709","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC280709","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081942763","display_name":"Ian R. Dohoo","orcid":"https://orcid.org/0000-0001-9270-2680","observed_orcids":["https://orcid.org/0000-0001-9270-2680"]},"institutions":[{"id":"https://openalex.org/I22188714","display_name":"University of Prince Edward Island","ror":"https://ror.org/02xh9x144","country_code":"CA","type":"education","lineage":["https://openalex.org/I22188714"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"I R Dohoo","raw_affiliation_strings":["Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island C1A 4P3. dohoo@upei.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island C1A 4P3. dohoo@upei.ca","institution_ids":["https://openalex.org/I22188714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042638602","display_name":"Luc DesC\u00f4teaux","orcid":"https://orcid.org/0000-0002-3153-2160","observed_orcids":["https://orcid.org/0000-0002-3153-2160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L DesC\u00f4teaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111492242","display_name":"Kristina D. Leslie","orcid":"https://orcid.org/0009-0000-7470-6274","observed_orcids":["https://orcid.org/0009-0000-7470-6274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Leslie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112211525","display_name":"A. H. Fredeen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Fredeen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041934814","display_name":"W Shewfelt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Shewfelt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Preston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Preston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007277757","display_name":"Patricia M. Dowling","orcid":"https://orcid.org/0000-0002-4076-094X","observed_orcids":["https://orcid.org/0000-0002-4076-094X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Dowling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5198,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.50456621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"67","issue":"4","first_page":"252","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13338","display_name":"Pharmacological Effects and Assays","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-bovine-somatotropin","display_name":"recombinant bovine somatotropin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dairy-cows","display_name":"dairy cattle","score":0.890999972820282},{"id":"https://openalex.org/keywords/clinical-mastitis","display_name":"clinical mastitis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/reproductive-performance","display_name":"reproductive performance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/services-per-conception","display_name":"service per conception","score":0.7149999737739563},{"id":"https://openalex.org/keywords/days-open","display_name":"days open","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lameness","display_name":"lameness","score":0.7490000128746033},{"id":"https://openalex.org/keywords/culling","display_name":"culling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ketosis","display_name":"ketosis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.699999988079071},{"id":"https://openalex.org/keywords/growth-promoters","display_name":"growth promoters","score":0.31700000166893005},{"id":"https://openalex.org/keywords/animal-health","display_name":"animal health","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C52991690","wikidata":"https://www.wikidata.org/wiki/Q1740042","display_name":"Culling","level":3,"score":0.9124892950057983},{"id":"https://openalex.org/C177752829","wikidata":"https://www.wikidata.org/wiki/Q277287","display_name":"Bovine somatotropin","level":4,"score":0.6843060255050659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6147028207778931},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5277267694473267},{"id":"https://openalex.org/C2776344049","wikidata":"https://www.wikidata.org/wiki/Q835061","display_name":"Mastitis","level":2,"score":0.504754900932312},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.47194212675094604},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.40303122997283936},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.3824925422668457},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.369611918926239},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.34507790207862854},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.322634756565094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26534491777420044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2568472921848297},{"id":"https://openalex.org/C194775826","wikidata":"https://www.wikidata.org/wiki/Q209542","display_name":"Herd","level":2,"score":0.12216982245445251},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007662","descriptor_name":"Ketosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007662","descriptor_name":"Ketosis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D007794","descriptor_name":"Lameness, Animal","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008414","descriptor_name":"Mastitis, Bovine","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010298","descriptor_name":"Parity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:101550","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC280709","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:280709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/280709","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can J Vet Res","raw_type":"Text"},{"id":"pmid:14620861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14620861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","raw_type":"Journal Article"},{"id":"mag:2172098526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14620861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:101550","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC280709","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6875}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W147320836","https://openalex.org/W284823757","https://openalex.org/W1478968882","https://openalex.org/W1963904885","https://openalex.org/W1964435302","https://openalex.org/W1965001231","https://openalex.org/W1966339619","https://openalex.org/W1967187371","https://openalex.org/W1977919947","https://openalex.org/W1978156296","https://openalex.org/W1981741769","https://openalex.org/W1983214617","https://openalex.org/W2000184854","https://openalex.org/W2001813156","https://openalex.org/W2003601466","https://openalex.org/W2018814075","https://openalex.org/W2018834402","https://openalex.org/W2038051735","https://openalex.org/W2044593354","https://openalex.org/W2050209372","https://openalex.org/W2063740099","https://openalex.org/W2068309082","https://openalex.org/W2072872810","https://openalex.org/W2078379657","https://openalex.org/W2079417640","https://openalex.org/W2080575519","https://openalex.org/W2091366420","https://openalex.org/W2104510143","https://openalex.org/W2106657783","https://openalex.org/W2129154922","https://openalex.org/W2139220643","https://openalex.org/W2148291232","https://openalex.org/W2148608646","https://openalex.org/W2150068536","https://openalex.org/W2157823046","https://openalex.org/W2159282971","https://openalex.org/W2163449812","https://openalex.org/W2164676928","https://openalex.org/W2170343083","https://openalex.org/W2402229286","https://openalex.org/W4300659002"],"related_works":["https://openalex.org/W2159282971","https://openalex.org/W2018834402","https://openalex.org/W2784902632","https://openalex.org/W2148608646","https://openalex.org/W2282379197","https://openalex.org/W2463661071","https://openalex.org/W2052129473","https://openalex.org/W3142640184","https://openalex.org/W3174579803","https://openalex.org/W6996172676"],"abstract_inverted_index":{"This":[0],"manuscript":[1],"presents":[2,114],"the":[3,9,34,45,100,115,118,121,133,142,155,158,161,171,208,217,224,240,275,284,292,296],"results":[4],"of":[5,8,11,67,106,117,120,135,157,163,168,173,207,226,242,246,267,274,286,295],"a":[6,50,174,197,220],"review":[7],"effects":[10,156],"recombinant":[12],"bovine":[13,127],"somatotropin":[14,128],"(rBST)":[15],"on":[16,74,123,160,191,213,223,252,256],"dairy":[17],"cattle":[18],"health,":[19],"reproductive":[20],"performance,":[21],"and":[22,57,195],"culling,":[23,253],"that":[24,77,85,258],"was":[25,42,60,69,129,147,188,228],"carried":[26],"out":[27],"by":[28,33,44,96,102,138,179],"an":[29,235,264],"expert":[30],"panel":[31,41],"established":[32,43],"Canadian":[35],"Veterinary":[36],"Medical":[37],"Association":[38],"(CVMA).":[39],"The":[40],"CVMA":[46],"in":[47,55,63,89,108,200,239,270,277,291],"response":[48],"to":[49,71,131,150,177,262,282],"request":[51],"from":[52,80,99],"Health":[53,97],"Canada":[54,98],"1998":[56],"their":[58],"report":[59],"made":[61],"public":[62],"1999.":[64],"A":[65,110],"series":[66],"meta-analyses":[68],"used":[70],"combine":[72],"data":[73,149,251],"health-related":[75],"parameters":[76],"were":[78,94],"extracted":[79],"all":[81],"randomized":[82],"clinical":[83,136,244],"trials":[84],"had":[86,210,234],"been":[87],"published":[88],"peer-reviewed":[90],"journals":[91],"or":[92],"which":[93,184],"provided":[95],"submission":[101],"Monsanto":[103],"for":[104],"registration":[105],"rBST":[107,169,233],"Canada.":[109],"companion":[111],"paper":[112],"(1)":[113],"estimates":[116],"effect":[119,190,212,222],"drug":[122,159,209,276],"production":[124],"parameters.":[125],"Recombinant":[126],"found":[130],"increase":[132,199,238,265],"risk":[134,172,225,241,266,285],"mastitis":[137],"approximately":[139,180],"25%":[140],"during":[141],"treatment":[143],"period":[144,280,294],"but":[145,216,254],"there":[146,187,260],"insufficient":[148],"draw":[151],"firm":[152],"conclusions":[153],"about":[154,219],"prevalence":[162],"subclinical":[164],"intra-mammary":[165],"infections.":[166],"Use":[167,206,273],"increased":[170],"cow":[175],"failing":[176],"conceive":[178],"40%.":[181],"For":[182],"cows":[183],"did":[185],"conceive,":[186],"no":[189,211],"services":[192],"per":[193],"conception":[194],"only":[196],"small":[198],"average":[201],"days":[202],"open":[203],"(5":[204],"days).":[205],"gestation":[214],"length,":[215],"information":[218],"possible":[221],"twinning":[227],"equivocal.":[229],"Cows":[230],"treated":[231],"with":[232],"estimated":[236],"55%":[237],"developing":[243],"signs":[245],"lameness.":[247],"Few":[248],"studies":[249],"reported":[250],"based":[255],"those":[257],"did,":[259],"appeared":[261,281],"be":[263],"culling":[268],"evident":[269],"multiparous":[271],"cows.":[272],"1":[278],"lactation":[279],"reduce":[283],"metabolic":[287],"diseases":[288],"(particularly":[289],"ketosis)":[290],"early":[293],"subsequent":[297],"lactation.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}