{"id":"https://openalex.org/W2172053715","doi":"https://doi.org/10.1002/art.1780310508","title":"Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis","display_name":"Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W2172053715","doi":"https://doi.org/10.1002/art.1780310508","mag":"2172053715","pmid":"https://pubmed.ncbi.nlm.nih.gov/3259882"},"language":"en","primary_location":{"id":"doi:10.1002/art.1780310508","doi":"https://doi.org/10.1002/art.1780310508","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780310508","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058486417","display_name":"Patricia M. Hopkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Hopkins","raw_affiliation_strings":["Department of Medicine, New York University Medical Center, NY 10016","Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University Medical Center, NY 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120314915","display_name":"Michael H Belmont","orcid":"https://orcid.org/0000-0003-3389-2976","observed_orcids":["https://orcid.org/0000-0003-3389-2976"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Michael Belmont","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072473587","display_name":"Jill P. Buyon","orcid":"https://orcid.org/0000-0002-3852-7129","observed_orcids":["https://orcid.org/0000-0002-3852-7129"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Buyon","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067102350","display_name":"Mark R. Philips","orcid":"https://orcid.org/0000-0002-1179-8156","observed_orcids":["https://orcid.org/0000-0002-1179-8156"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Philips","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030914641","display_name":"Gerald Weissmann","orcid":"https://orcid.org/0000-0002-4285-4552","observed_orcids":["https://orcid.org/0000-0002-4285-4552"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Weissmann","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009863149","display_name":"Steven B. Abramson","orcid":"https://orcid.org/0000-0002-0668-6344","observed_orcids":["https://orcid.org/0000-0002-0668-6344"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven B. Abramson","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009863149"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":3.4998,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.92899774,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"5","first_page":"632","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anaphylatoxins","display_name":"anaphylatoxins","score":0.8330000042915344},{"id":"https://openalex.org/keywords/c3a","display_name":"C3a","score":0.9800000190734863},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":1.0},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/disease-flares","display_name":"disease flares","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lupus-cerebritis","display_name":"lupus cerebritis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/central-nervous-system-involvement","display_name":"central nervous system involvement","score":0.7200000286102295},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.8790000081062317},{"id":"https://openalex.org/keywords/vasoocclusion","display_name":"vasoocclusion","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/disease-activity-prediction","display_name":"disease activity prediction","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C90582226","wikidata":"https://www.wikidata.org/wiki/Q424292","display_name":"Anaphylatoxin","level":4,"score":0.9702030420303345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8166036605834961},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.745071530342102},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5460165143013},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.4848983883857727},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.4801616072654724},{"id":"https://openalex.org/C90630246","wikidata":"https://www.wikidata.org/wiki/Q17854107","display_name":"C4A","level":3,"score":0.4599553346633911},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4599008560180664},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43997079133987427},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43676328659057617},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.42905810475349426},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41144225001335144},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2314116656780243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000706","descriptor_name":"Anaphylatoxins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003182","descriptor_name":"Complement C5","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015926","descriptor_name":"Complement C3a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015936","descriptor_name":"Complement C5a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.1780310508","doi":"https://doi.org/10.1002/art.1780310508","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780310508","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:3259882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3259882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4747200383","display_name":"LUNG INFLAMMATION","funder_award_id":"R01HL019721","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5941066038","display_name":"CELL/PROTEIN INTERACTIONS IN CONNECTIVE TISSUE DISEASES","funder_award_id":"2p01am001431-29","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8541708731","display_name":"MECHANISMS OF ARTHRITIS","funder_award_id":"R01AM011949","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W82219056","https://openalex.org/W167449208","https://openalex.org/W188298645","https://openalex.org/W1505032795","https://openalex.org/W1541068518","https://openalex.org/W1576430359","https://openalex.org/W1583938359","https://openalex.org/W1597762674","https://openalex.org/W1896082656","https://openalex.org/W1967833287","https://openalex.org/W1977689811","https://openalex.org/W1999393262","https://openalex.org/W2002983094","https://openalex.org/W2003048916","https://openalex.org/W2005716096","https://openalex.org/W2008201416","https://openalex.org/W2010547290","https://openalex.org/W2026216489","https://openalex.org/W2027944675","https://openalex.org/W2032697327","https://openalex.org/W2071611899","https://openalex.org/W2083318136","https://openalex.org/W2090763136","https://openalex.org/W2135080336","https://openalex.org/W2143286148","https://openalex.org/W2146203649","https://openalex.org/W2163494154","https://openalex.org/W2316085552","https://openalex.org/W2317906013","https://openalex.org/W2330568965","https://openalex.org/W2336809898","https://openalex.org/W2337093996","https://openalex.org/W2338986336","https://openalex.org/W2403011289","https://openalex.org/W2412982206","https://openalex.org/W2427395380","https://openalex.org/W4235949352","https://openalex.org/W4237748954","https://openalex.org/W4245099364","https://openalex.org/W4313311558"],"related_works":["https://openalex.org/W2010547290","https://openalex.org/W2034201329","https://openalex.org/W2033590430","https://openalex.org/W4200607752","https://openalex.org/W2079509852","https://openalex.org/W4387662351","https://openalex.org/W4225274250","https://openalex.org/W2141668042","https://openalex.org/W1975555429","https://openalex.org/W2109789501"],"abstract_inverted_index":{"We":[0,223],"measured":[1],"levels":[2,50,126,179,202],"of":[3,14,62,68,74,84,96,171,187,219,228,233,252,257],"complement":[4,214,241],"anaphylatoxin":[5],"split":[6],"products,":[7],"C3a":[8,31,49,56,88,178,199,229,253],"and":[9,39,155,200,208,238,254],"C5a,":[10],"in":[11,90,112,131,160,203,235,245,267],"the":[12,29,55,97,153,217,260],"circulation":[13,261],"patients":[15,24,92,113,133,142,174,205,237,268],"with":[16,54,93,114,134,163,182,206,213,247,269],"systemic":[17],"lupus":[18,148,165,236,270],"erythematosus":[19],"(SLE).":[20],"In":[21,46,169,249],"23":[22],"SLE":[23,173],"who":[25,143,175],"were":[26,127,176,180],"followed":[27],"serially,":[28],"mean":[30,61,73,87,185],"value":[32,57,186],"was":[33,102,191],"179":[34],"ng/ml":[35,41,64,76],"during":[36,42,145,243],"stable":[37,69],"disease":[38,44,52,70,116,234],"550":[40],"a":[43,60,66,72,81,161,183,192],"flare.":[45],"10":[47],"patients,":[48],"predicted":[51],"activity,":[53],"rising":[58],"from":[59,140],"183":[63],"at":[65],"time":[67],"to":[71,80],"242":[75],"1-2":[77],"months":[78],"prior":[79],"clinical":[82],"exacerbation":[83],"disease.":[85,137],"The":[86],"level":[89],"5":[91,170],"acute":[94,135,147],"dysfunction":[95],"central":[98],"nervous":[99],"system":[100],"(CNS)":[101],"1,297":[103],"ng/ml,":[104],"which":[105],"is":[106,211],"significantly":[107,129],"higher":[108],"than":[109,123],"that":[110,225],"observed":[111],"active":[115],"but":[117],"without":[118],"CNS":[119,136,164],"involvement":[120],"(P":[121],"less":[122],"0.01).":[124],"C5a":[125,255],"also":[128],"elevated":[130],"4":[132],"Pathologic":[138],"specimens":[139],"2":[141],"died":[144],"an":[146],"flare":[149],"revealed":[150,166],"neutrophils":[151],"occluding":[152],"cerebral":[154],"intestinal":[156],"vessels.":[157],"Fluorescein":[158],"angiography":[159],"patient":[162],"vasoocclusive":[167],"retinopathy.":[168],"7":[172],"pregnant,":[177],"elevated,":[181],"group":[184],"310":[188],"ng/ml.":[189],"There":[190],"negative":[193],"correlation":[194],"(r":[195],"=":[196],"-0.59)":[197],"between":[198],"C3":[201,221],"pregnant":[204],"SLE,":[207],"this":[209],"finding":[210],"consistent":[212],"activation":[215,242],"as":[216],"cause":[218],"decreasing":[220],"levels.":[222],"suggest":[224],"serial":[226],"measurements":[227],"can":[230,239],"predict":[231],"flares":[232],"demonstrate":[240],"pregnancy":[244],"women":[246],"SLE.":[248],"addition,":[250],"release":[251],"(mediators":[256],"inflammation)":[258],"into":[259],"may":[262],"elicit":[263],"vascular":[264],"injury,":[265],"particularly":[266],"cerebritis.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}