{"id":"https://openalex.org/W2172053383","doi":"https://doi.org/10.1128/aac.02217-13","title":"UPC2A Is Required for High-Level Azole Antifungal Resistance in Candida glabrata","display_name":"UPC2A Is Required for High-Level Azole Antifungal Resistance in Candida glabrata","publication_year":2014,"publication_date":"2014-05-28","ids":{"openalex":"https://openalex.org/W2172053383","doi":"https://doi.org/10.1128/aac.02217-13","mag":"2172053383","pmid":"https://pubmed.ncbi.nlm.nih.gov/24867980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136023"},"language":"en","primary_location":{"id":"doi:10.1128/aac.02217-13","doi":"https://doi.org/10.1128/aac.02217-13","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.02217-13","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136023","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071306295","display_name":"Sarah Whaley","orcid":"https://orcid.org/0000-0001-5851-0490","observed_orcids":["https://orcid.org/0000-0001-5851-0490"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210156806","display_name":"Le Bonheur Children's Hospital","ror":"https://ror.org/056wg8a82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210156806"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah G. Whaley","raw_affiliation_strings":["Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4210156806"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052491908","display_name":"Kelly E. Caudle","orcid":"https://orcid.org/0000-0002-5663-3793","observed_orcids":["https://orcid.org/0000-0002-5663-3793"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210156806","display_name":"Le Bonheur Children's Hospital","ror":"https://ror.org/056wg8a82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210156806"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly E. Caudle","raw_affiliation_strings":["Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4210156806"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054027455","display_name":"John\u2010Paul Vermitsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106998","display_name":"Medical Diagnostic Laboratories (United States)","ror":"https://ror.org/01gjnjy30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John-Paul Vermitsky","raw_affiliation_strings":["Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA","institution_ids":["https://openalex.org/I4210106998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008541590","display_name":"Sean G. Chadwick","orcid":"https://orcid.org/0000-0001-9752-1221","observed_orcids":["https://orcid.org/0000-0001-9752-1221"]},"institutions":[{"id":"https://openalex.org/I4210106998","display_name":"Medical Diagnostic Laboratories (United States)","ror":"https://ror.org/01gjnjy30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean G. Chadwick","raw_affiliation_strings":["Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA","institution_ids":["https://openalex.org/I4210106998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064739067","display_name":"Geoffrey Toner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106998","display_name":"Medical Diagnostic Laboratories (United States)","ror":"https://ror.org/01gjnjy30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Toner","raw_affiliation_strings":["Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA","institution_ids":["https://openalex.org/I4210106998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082260796","display_name":"Katherine S. Barker","orcid":"https://orcid.org/0000-0002-3824-6829","observed_orcids":["https://orcid.org/0000-0002-3824-6829"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210156806","display_name":"Le Bonheur Children's Hospital","ror":"https://ror.org/056wg8a82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210156806"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine S. Barker","raw_affiliation_strings":["Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA","Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4210156806"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068715797","display_name":"Scott E. Gygax","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106998","display_name":"Medical Diagnostic Laboratories (United States)","ror":"https://ror.org/01gjnjy30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Gygax","raw_affiliation_strings":["Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Femeris Women's Health Research Center, Medical Diagnostic Laboratories, L.L.C., Genesis Biotechnology Group, Hamilton, New Jersey, USA","institution_ids":["https://openalex.org/I4210106998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059280370","display_name":"Phillip David Rogers","orcid":"https://orcid.org/0000-0002-4401-0679","observed_orcids":["https://orcid.org/0000-0002-4401-0679"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210156806","display_name":"Le Bonheur Children's Hospital","ror":"https://ror.org/056wg8a82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210156806"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. David Rogers","raw_affiliation_strings":["Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA","Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4210156806"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8353,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.85880758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"58","issue":"8","first_page":"4543","last_page":"4554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":0.8970000147819519},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ergosterol-biosynthesis","display_name":"ergosterol biosynthesis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/erg11","display_name":"ERG11","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fluconazole-susceptibility","display_name":"fluconazole susceptibility","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sterol-biosynthesis-inhibitors","display_name":"sterol biosynthesis inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.8679355382919312},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.851654052734375},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.8381669521331787},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.7573866844177246},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.6866085529327393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6497138738632202},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.6020343899726868},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5741273164749146},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.44539573788642883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36830830574035645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2777097821235657},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.1601312756538391},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.08532699942588806}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001393","descriptor_name":"Azoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025141","descriptor_name":"Drug Resistance, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/aac.02217-13","doi":"https://doi.org/10.1128/aac.02217-13","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.02217-13","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4136023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:24867980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24867980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.835.1216","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.835.1216","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aac.asm.org/content/early/2014/05/21/AAC.02217-13.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.840.3792","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.840.3792","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aac.asm.org/content/58/8/4543.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4136023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3948348711","display_name":"Novel Azole Resistance Mechanisms in Candida albicans","funder_award_id":"R01AI058145","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1726796702","https://openalex.org/W1899514055","https://openalex.org/W1971071885","https://openalex.org/W1984325151","https://openalex.org/W1987925654","https://openalex.org/W1989849863","https://openalex.org/W1990474165","https://openalex.org/W2001438935","https://openalex.org/W2017522599","https://openalex.org/W2024014185","https://openalex.org/W2036011240","https://openalex.org/W2046310075","https://openalex.org/W2049689302","https://openalex.org/W2053715559","https://openalex.org/W2058240781","https://openalex.org/W2070300912","https://openalex.org/W2071269777","https://openalex.org/W2077245994","https://openalex.org/W2084577762","https://openalex.org/W2087561016","https://openalex.org/W2088611499","https://openalex.org/W2095490493","https://openalex.org/W2097771377","https://openalex.org/W2099078121","https://openalex.org/W2099294595","https://openalex.org/W2103920488","https://openalex.org/W2104445943","https://openalex.org/W2107013040","https://openalex.org/W2107169184","https://openalex.org/W2108027055","https://openalex.org/W2108846692","https://openalex.org/W2108989058","https://openalex.org/W2110895138","https://openalex.org/W2116145373","https://openalex.org/W2118236446","https://openalex.org/W2118755494","https://openalex.org/W2119797129","https://openalex.org/W2121025359","https://openalex.org/W2121069993","https://openalex.org/W2122531610","https://openalex.org/W2125496447","https://openalex.org/W2125823722","https://openalex.org/W2127080406","https://openalex.org/W2128071392","https://openalex.org/W2130969207","https://openalex.org/W2131249166","https://openalex.org/W2133189384","https://openalex.org/W2134827411","https://openalex.org/W2135228917","https://openalex.org/W2136753636","https://openalex.org/W2140936126","https://openalex.org/W2144149632","https://openalex.org/W2147739065","https://openalex.org/W2147779148","https://openalex.org/W2155558077","https://openalex.org/W2157149808","https://openalex.org/W2158530375","https://openalex.org/W2160849328","https://openalex.org/W2162171804","https://openalex.org/W2163476686","https://openalex.org/W2166069926","https://openalex.org/W2167143090","https://openalex.org/W2169755129","https://openalex.org/W2172046963","https://openalex.org/W2172104036"],"related_works":["https://openalex.org/W7095193202","https://openalex.org/W7099458739","https://openalex.org/W3202652055","https://openalex.org/W3160178516","https://openalex.org/W3182347951","https://openalex.org/W4226145385","https://openalex.org/W2046705160","https://openalex.org/W2127080406","https://openalex.org/W4405703578","https://openalex.org/W2162171804"],"abstract_inverted_index":{"Candida":[0,8,37],"glabrata,":[1],"the":[2,22,40,45,48,53,87,106,153,224],"second":[3],"most":[4],"common":[5],"cause":[6],"of":[7,15,25,43,50,73,102,108,142,149,189,194,208],"infections,":[9],"is":[10,204,212],"associated":[11],"with":[12,128],"high":[13],"rates":[14],"mortality":[16],"and":[17,29,34,65,98,115,132,135,145,155,172,187,191,211],"often":[18],"exhibits":[19],"resistance":[20,215],"to":[21,78,86,162,216],"azole":[23,80,177,235],"class":[24],"antifungal":[26],"agents.":[27],"Upc2":[28,35,91],"Ecm22":[30],"in":[31,36,52,69,92,95,110,130,136,138,151,159,169,184,220],"Saccharomyces":[32],"cerevisiae":[33,97],"albicans":[38],"are":[39],"transcriptional":[41],"regulators":[42],"ERG11,":[44],"gene":[46],"encoding":[47],"target":[49,232],"azoles":[51],"ergosterol":[54,185,209],"biosynthesis":[55,94,164,197,210,218],"pathway.":[56],"Recently":[57],"two":[58],"homologs":[59],"for":[60,90,214,233],"these":[61],"transcription":[62],"factors,":[63],"UPC2A":[64,103,131,150,225],"UPC2B,":[66],"were":[67],"identified":[68],"C.":[70,99,117,221],"glabrata.":[71,222],"One":[72],"these,":[74],"UPC2A,":[75],"was":[76],"shown":[77],"influence":[79],"susceptibility.":[81],"We":[82],"hypothesized":[83],"that":[84,202],"due":[85],"global":[88],"role":[89],"sterol":[93,163,196,217],"S.":[96],"albicans,":[100],"disruption":[101],"would":[104],"enhance":[105],"activity":[107,178,236],"fluconazole":[109,170],"both":[111,152],"azole-susceptible":[112],"dose-dependent":[113],"(SDD)":[114],"-resistant":[116,146],"glabrata":[118],"clinical":[119,143],"isolates.":[120,147],"To":[121],"test":[122],"this":[123,238],"hypothesis,":[124],"we":[125],"constructed":[126],"mutants":[127],"disruptions":[129],"UPC2B":[133],"alone":[134],"combination":[137],"a":[139,167,182,205,229],"matched":[140],"pair":[141],"azole-SDD":[144],"Disruption":[148],"SDD":[154],"resistant":[156],"isolates":[157],"resulted":[158],"increased":[160],"susceptibility":[161],"inhibitors,":[165],"including":[166],"reduction":[168],"MIC":[171],"minimum":[173],"fungicidal":[174],"concentration,":[175],"enhanced":[176],"by":[179],"time-kill":[180],"analysis,":[181],"decrease":[183],"content,":[186],"downregulation":[188],"baseline":[190],"inducible":[192],"expression":[193],"several":[195],"genes.":[198],"Our":[199],"results":[200],"indicate":[201],"Upc2A":[203],"key":[206],"regulator":[207],"essential":[213],"inhibitors":[219],"Therefore,":[223],"pathway":[226],"may":[227],"represent":[228],"potential":[230],"cotherapeutic":[231],"enhancing":[234],"against":[237],"organism.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}