{"id":"https://openalex.org/W2172050865","doi":"https://doi.org/10.1080/01926230701584130","title":"N-ethyl-N-nitrosourea (ENU)-Induced Meningiomatosis and Meningioma in p16 INK4a /p19 ARF Tumor Suppressor Gene-Deficient Mice","display_name":"N-ethyl-N-nitrosourea (ENU)-Induced Meningiomatosis and Meningioma in p16 INK4a /p19 ARF Tumor Suppressor Gene-Deficient Mice","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2172050865","doi":"https://doi.org/10.1080/01926230701584130","mag":"2172050865","pmid":"https://pubmed.ncbi.nlm.nih.gov/17943659","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2367108"},"language":"en","primary_location":{"id":"doi:10.1080/01926230701584130","doi":"https://doi.org/10.1080/01926230701584130","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01926230701584130","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2367108","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024068875","display_name":"James P. Morrison","orcid":"https://orcid.org/0000-0003-3975-1461","observed_orcids":["https://orcid.org/0000-0003-3975-1461"]},"institutions":[{"id":"https://openalex.org/I4210126295","display_name":"Charles River Laboratories (United States)","ror":"https://ror.org/03ndmsg87","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Morrison","raw_affiliation_strings":["Charles River Laboratories, Pathology Associates, Durham, North Carolina 27703"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles River Laboratories, Pathology Associates, Durham, North Carolina 27703","institution_ids":["https://openalex.org/I4210126295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034280320","display_name":"Hiroshi Satoh","orcid":"https://orcid.org/0000-0003-4618-8873","observed_orcids":["https://orcid.org/0000-0003-4618-8873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Satoh","raw_affiliation_strings":["Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, 134-8630 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, 134-8630 Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074589674","display_name":"Julie F. Foley","orcid":"https://orcid.org/0000-0001-9726-2821","observed_orcids":["https://orcid.org/0000-0001-9726-2821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Foley","raw_affiliation_strings":["Laboratory of Experimental Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"John L. Horton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John L. Horton","raw_affiliation_strings":["Laboratory of Experimental Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001941341","display_name":"June K. Dunnick","orcid":"https://orcid.org/0000-0002-0449-674X","observed_orcids":["https://orcid.org/0000-0002-0449-674X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"June K. Dunnick","raw_affiliation_strings":["Environmental Toxicology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Toxicology Program","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110254923","display_name":"Grace E. Kissling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace E. Kissling","raw_affiliation_strings":["Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058161719","display_name":"David E. Malarkey","orcid":"https://orcid.org/0000-0002-2573-8533","observed_orcids":["https://orcid.org/0000-0002-2573-8533"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David E. Malarkey","raw_affiliation_strings":["Laboratory of Experimental Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Pathology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058161719"],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4587,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.72587808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"35","issue":"6","first_page":"838","last_page":"845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meningioma","display_name":"meningioma","score":0.8059999942779541},{"id":"https://openalex.org/keywords/meningiomatosis","display_name":"meningiomatosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9639999866485596},{"id":"https://openalex.org/keywords/p19arf","display_name":"p19ARF","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7749999761581421},{"id":"https://openalex.org/keywords/n-ethyl-n-nitrosourea","display_name":"N-ethyl-N-nitrosourea","score":0.8930000066757202},{"id":"https://openalex.org/keywords/chemical-carcinogenesis","display_name":"chemical carcinogenesis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6297094821929932},{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.5615808963775635},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5139889121055603},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.5052734017372131},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5034860968589783},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5034565329551697},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4952148497104645},{"id":"https://openalex.org/C191548132","wikidata":"https://www.wikidata.org/wiki/Q2355306","display_name":"Histogenesis","level":3,"score":0.46232178807258606},{"id":"https://openalex.org/C2909685333","wikidata":"https://www.wikidata.org/wiki/Q287629","display_name":"Ethylnitrosourea","level":4,"score":0.41988930106163025},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.41808077692985535},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.38122227787971497},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3053414225578308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2211328148841858},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21447941660881042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12685316801071167},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09713578224182129},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005038","descriptor_name":"Ethylnitrosourea","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008579","descriptor_name":"Meningioma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008579","descriptor_name":"Meningioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/01926230701584130","doi":"https://doi.org/10.1080/01926230701584130","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01926230701584130","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:17943659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17943659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1380387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2367108","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2367108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2367108","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicol Pathol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1380387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2367108","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7295373465","display_name":null,"funder_award_id":"Z99-ES999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1523966693","https://openalex.org/W1601233953","https://openalex.org/W1982919976","https://openalex.org/W1983571075","https://openalex.org/W1998767721","https://openalex.org/W2001480633","https://openalex.org/W2017235640","https://openalex.org/W2032918876","https://openalex.org/W2047979277","https://openalex.org/W2049085719","https://openalex.org/W2049571882","https://openalex.org/W2058492530","https://openalex.org/W2065891752","https://openalex.org/W2066291669","https://openalex.org/W2067167454","https://openalex.org/W2070755750","https://openalex.org/W2076984763","https://openalex.org/W2084912361","https://openalex.org/W2092915247","https://openalex.org/W2111010459","https://openalex.org/W2113739039","https://openalex.org/W2135432931","https://openalex.org/W2148754918","https://openalex.org/W2162505525","https://openalex.org/W2418583293","https://openalex.org/W2512906422"],"related_works":["https://openalex.org/W2017235640","https://openalex.org/W2096820805","https://openalex.org/W2084912361","https://openalex.org/W2019730349","https://openalex.org/W1899036713","https://openalex.org/W1976969143","https://openalex.org/W147465974","https://openalex.org/W2003223749","https://openalex.org/W3010673540","https://openalex.org/W2029631440"],"abstract_inverted_index":{"The":[0,90,108],"cyclin-dependent":[1],"kinase":[2],"(CDK)":[3],"inhibitor":[4,11],"p16(INK4a)":[5],"and":[6,55,101,115,166,190],"the":[7,16,41,70,137,185,192],"MDM2":[8],"ubiquitin":[9],"ligase":[10],"p19(ARF)":[12],"are":[13,156],"critical":[14],"to":[15,65,125],"regulation":[17],"of":[18,43,69,98,139,168,187,194],"cell":[19],"cycle":[20],"progression.":[21],"Their":[22],"loss":[23],"by":[24,118],"deletion,":[25],"mutation":[26],"or":[27],"epigenetic":[28],"silencing":[29],"is":[30],"a":[31,66,86,126,132,145,157],"common":[32,158],"molecular":[33],"alteration":[34],"in":[35,46,94,104,152,177],"many":[36],"human":[37],"cancers.":[38],"To":[39],"investigate":[40],"role":[42],"p16(INK4a)/p19(ARF)":[44],"deficiency":[45],"CNS":[47],"tumor":[48],"pathogenesis,":[49],"pregnant":[50],"mice":[51,77,154,179],"bearing":[52],"p16(-/-)/p19(-/-),":[53],"p16(+/-)/p19(+/-),":[54],"p16(+/+)/p19(+/+)":[56],"embryos":[57],"were":[58],"exposed":[59],"transplacentally":[60],"on":[61],"gestation":[62],"day":[63],"14":[64],"single":[67],"dose":[68],"potent":[71],"carcinogen,":[72],"ethylnitrosourea":[73],"(ENU).":[74],"p16(+/-)/p19(+/-)":[75,178],"male":[76],"treated":[78],"with":[79,85,123,131],"ENU":[80,173],"developed":[81],"meningial":[82],"proliferative":[83],"lesions":[84,109],"high":[87],"incidence":[88,91],"(5/10).":[89],"was":[92],"lower":[93],"other":[95],"ENU-treated":[96],"animals":[97],"both":[99],"sexes":[100],"none":[102],"occurred":[103],"saline-treated":[105],"control":[106],"animals.":[107],"ranged":[110],"from":[111],"widespread":[112],"meningeal":[113,175,188],"proliferation":[114],"plaque-like":[116],"thickening":[117],"neoplastic":[119],"spindle":[120],"cells":[121],"consistent":[122,130],"meningiomatosis":[124],"larger":[127],"discrete":[128],"mass":[129],"meningioma.":[133],"Ultrastructural":[134],"analysis":[135],"revealed":[136],"presence":[138],"intercellular":[140],"junctions":[141],"between":[142,164],"cells,":[143],"supporting":[144],"meningothelial":[146],"histogenesis.":[147],"Spontaneous":[148],"meningiomas":[149],"occur":[150],"rarely":[151],"wild-type":[153],"but":[155],"neoplasm":[159],"afflicting":[160],"humans,":[161],"accounting":[162],"for":[163],"13":[165],"26%":[167],"primary":[169],"intracranial":[170],"neoplasms.":[171],"This":[172],"inducible":[174],"lesion":[176],"may":[180],"provide":[181],"additional":[182],"insight":[183],"into":[184],"pathogenesis":[186],"neoplasia":[189],"aid":[191],"development":[193],"therapeutics.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}