{"id":"https://openalex.org/W2172008285","doi":"https://doi.org/10.4070/kcj.2005.35.5.345","title":"Gene Therapy for Heart Failure","display_name":"Gene Therapy for Heart Failure","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2172008285","doi":"https://doi.org/10.4070/kcj.2005.35.5.345","mag":"2172008285"},"language":"en","primary_location":{"id":"doi:10.4070/kcj.2005.35.5.345","doi":"https://doi.org/10.4070/kcj.2005.35.5.345","is_oa":false,"landing_page_url":"https://doi.org/10.4070/kcj.2005.35.5.345","pdf_url":null,"source":{"id":"https://openalex.org/S4210212079","display_name":"Korean Circulation Journal","issn_l":"1225-164X","issn":["1225-164X","1738-5520","1738-5555"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","kci-registered","poland-40","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Circulation Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111501637","display_name":"Jang Whan Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]},{"id":"https://openalex.org/I4210161026","display_name":"Chungbuk National University Hospital","ror":"https://ror.org/05529q263","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I163753206","https://openalex.org/I4210161026"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jang Whan Bae","raw_affiliation_strings":["Department of Internal Medicine, Chungbuk National University College of Medicine, Medical Research Institute, Chungbuk National University, Cheongju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chungbuk National University College of Medicine, Medical Research Institute, Chungbuk National University, Cheongju, Korea","institution_ids":["https://openalex.org/I163753206","https://openalex.org/I4210161026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041807954","display_name":"Myeong\u2010Chan Cho","orcid":"https://orcid.org/0000-0002-0047-0227","observed_orcids":["https://orcid.org/0000-0002-0047-0227"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]},{"id":"https://openalex.org/I4210161026","display_name":"Chungbuk National University Hospital","ror":"https://ror.org/05529q263","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I163753206","https://openalex.org/I4210161026"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myeong Chan Cho","raw_affiliation_strings":["Department of Internal Medicine, Chungbuk National University College of Medicine, Medical Research Institute, Chungbuk National University, Cheongju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chungbuk National University College of Medicine, Medical Research Institute, Chungbuk National University, Cheongju, Korea","institution_ids":["https://openalex.org/I163753206","https://openalex.org/I4210161026"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1439,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.45349719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"5","first_page":"345","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":1.0},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.7770000100135803},{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.972000002861023},{"id":"https://openalex.org/keywords/heart-failure-pathogenesis","display_name":"heart failure pathogenesis","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8797184228897095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8562975525856018},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6080970764160156},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5529206991195679},{"id":"https://openalex.org/C2994510025","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Medical therapy","level":2,"score":0.494549959897995},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4937814176082611},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.44005680084228516},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.42966726422309875},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3969513475894928},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3502534031867981},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30988943576812744},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23229125142097473},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06301015615463257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4070/kcj.2005.35.5.345","doi":"https://doi.org/10.4070/kcj.2005.35.5.345","is_oa":false,"landing_page_url":"https://doi.org/10.4070/kcj.2005.35.5.345","pdf_url":null,"source":{"id":"https://openalex.org/S4210212079","display_name":"Korean Circulation Journal","issn_l":"1225-164X","issn":["1225-164X","1738-5520","1738-5555"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","kci-registered","poland-40","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Circulation Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W91862947","https://openalex.org/W1209532334","https://openalex.org/W1964659656","https://openalex.org/W1988510447","https://openalex.org/W1998630678","https://openalex.org/W2003950618","https://openalex.org/W2004786427","https://openalex.org/W2013167680","https://openalex.org/W2016678987","https://openalex.org/W2022372111","https://openalex.org/W2028775384","https://openalex.org/W2029375351","https://openalex.org/W2030858573","https://openalex.org/W2038671576","https://openalex.org/W2043698693","https://openalex.org/W2043852940","https://openalex.org/W2045242923","https://openalex.org/W2048303185","https://openalex.org/W2048867275","https://openalex.org/W2050824263","https://openalex.org/W2054241501","https://openalex.org/W2054271984","https://openalex.org/W2067454244","https://openalex.org/W2081368816","https://openalex.org/W2081464862","https://openalex.org/W2097340844","https://openalex.org/W2103879047","https://openalex.org/W2105182192","https://openalex.org/W2107590406","https://openalex.org/W2116896253","https://openalex.org/W2138426211","https://openalex.org/W2140627582","https://openalex.org/W2141244095","https://openalex.org/W2142377849","https://openalex.org/W2149733176","https://openalex.org/W2155135498","https://openalex.org/W2157581901","https://openalex.org/W2163627966","https://openalex.org/W2164323243","https://openalex.org/W2471513139"],"related_works":["https://openalex.org/W2137572671","https://openalex.org/W2376934302","https://openalex.org/W2482878993","https://openalex.org/W2167729163","https://openalex.org/W2995591878","https://openalex.org/W4399680268","https://openalex.org/W4386865301","https://openalex.org/W2125823792","https://openalex.org/W2035316013","https://openalex.org/W7099155604"],"abstract_inverted_index":{"Heart":[0],"failure":[1,37,89],"is":[2,38,96],"an":[3],"important":[4],"public":[5],"medical":[6],"problem":[7],"in":[8,64],"the":[9,23,28,53,65,72,85,91],"developed":[10],"countries.":[11],"Although":[12],"there":[13],"are":[14,43],"numerous":[15],"and":[16,47,84],"fascinating":[17],"medicines":[18],"given":[19],"by":[20],"physicians":[21],"for":[22,34,103],"treatment":[24],"of":[25,55,74,81,87],"heart":[26,36,88,104],"failure,":[27],"general":[29],"5":[30],"year":[31],"survival":[32],"rate":[33],"advanced":[35],"only":[39],"about":[40],"50%.":[41],"There":[42],"still":[44],"many":[45],"theoretical":[46],"practical":[48],"problems":[49],"to":[50,58],"overcome":[51],"before":[52],"application":[54],"gene":[56,75,94],"therapy":[57,95],"cardiovascular":[59],"disease":[60],"becomes":[61],"a":[62,99],"reality":[63],"future.":[66],"With":[67],"our":[68],"increased":[69],"knowledge":[70],"on":[71],"development":[73],"delivery,":[76],"vector":[77],"systems,":[78],"molecular":[79],"basis":[80],"cardiac":[82],"dysfunction,":[83],"pathogenesis":[86],"at":[90],"cell":[92],"level,":[93],"emerging":[97],"as":[98],"new":[100],"therapeutic":[101],"option":[102],"failure.":[105],"(Korean":[106],"Circulation":[107],"J":[108],"2005;35:345-352)":[109]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}